Fibrogenesis & Tissue Repair
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Connective tissue growth factor in tumor pathogenesis
Fibrogenesis & Tissue Repair - Tập 5 - Trang 1-7 - 2012
Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in
the wound repair process where it promotes myofibroblast differentiation and
angiogenesis. Similar mechanisms are active in tumor-reactive stroma where CTGF
is expressed. Other potential roles include prevention of hypoxia-induced
apoptosis and promoting epithelial-mesenchymal transistion (EMT). CTGF
expression in tumors...
Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases
Fibrogenesis & Tissue Repair - Tập 6 - Trang 1-10 - 2013
The proteoglycan biglycan (BGN) is involved in collagen fibril assembly and its
fragmentation is likely to be associated with collagen turnover during the
pathogenesis of diseases which involve dysregulated extracellular matrix
remodeling (ECMR), such as rheumatoid arthritis (RA) and liver fibrosis. The
scope of the present study was to develop a novel enzyme-linked immunosorbent
assay (ELISA) for...
Fibrosis in systemic sclerosis: common and unique pathobiology
Fibrogenesis & Tissue Repair - Tập 5 - Trang 1-6 - 2012
Fibrosis in systemic sclerosis (SSc), a complex polygenic disease associated
with autoimmunity and proliferative/obliterative vasculopathy, shares
pathobiologic features in common with other fibrosing illnesses, but also has
distinguishing characteristics. Fibroblast activation induced by transforming
growth factor-β (TGF-β), Wnts and innate immune receptors, along with oxidative
stress and reacti...
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
Fibrogenesis & Tissue Repair - Tập 1 - Trang 1-58 - 2008
Reactive oxygen species (ROS) generated within cells or, more generally, in a
tissue environment, may easily turn into a source of cell and tissue injury.
Aerobic organisms have developed evolutionarily conserved mechanisms and
strategies to carefully control the generation of ROS and other oxidative
stress-related radical or non-radical reactive intermediates (that is, to
maintain redox homeostas...
Prospects for clinical use of reprogrammed cells for autologous treatment of macular degeneration
Fibrogenesis & Tissue Repair - Tập 8 - Trang 1-9 - 2015
Since the discovery of induced pluripotent stem cells (iPSC) in 2006, the
symptoms of many human diseases have been reversed in animal models with iPSC
therapy, setting the stage for future clinical development. From the animal data
it is clear that iPSC are rapidly becoming the lead cell type for cell
replacement therapy and for the newly developing field of iPSC-derived body
organ transplantatio...
Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty
Fibrogenesis & Tissue Repair - - 2009
Arthrofibrosis, occurring in 3%-4% of patients following total knee arthroplasty
(TKA), is a challenging condition for which there is no defined cause. The
hypothesis for this study was that disregulated production of reactive oxygen
species (ROS) and nitrogen species (RNS) mediates matrix protein and DNA
modifications, which result in excessive fibroblastic proliferation. We found
increased numbe...
Molecular and cellular mechanisms of pulmonary fibrosis
Fibrogenesis & Tissue Repair - Tập 5 - Trang 1-24 - 2012
Pulmonary fibrosis is a chronic lung disease characterized by excessive
accumulation of extracellular matrix (ECM) and remodeling of the lung
architecture. Idiopathic pulmonary fibrosis is considered the most common and
severe form of the disease, with a median survival of approximately three years
and no proven effective therapy. Despite the fact that effective treatments are
absent and the preci...
Autologous keratinocyte suspension in platelet concentrate accelerates and enhances wound healing – a prospective randomized clinical trial on skin graft donor sites: platelet concentrate and keratinocytes on donor sites
Fibrogenesis & Tissue Repair - Tập 6 - Trang 1-8 - 2013
Wound healing involves complex mechanisms, which, if properly chaperoned, can
enhance patient recovery. The abilities of platelets and keratinocytes may be
harnessed in order to stimulate wound healing through the formation of platelet
clots, the release of several growth factors and cytokines, and cell
proliferation. The aim of the study was to test whether autologous keratinocyte
suspensions in ...
Therapeutic management of intestinal fibrosis induced by radiation therapy: from molecular profiling to new intervention strategies et vice et versa
Fibrogenesis & Tissue Repair - Tập 5 - Trang 1-7 - 2012
Chronic toxicities of locoregional and systemic oncological treatments commonly
develop in long-term cancer survivors. Amongst these toxicities,
post-radiotherapeutic complications alter patient's quality of life. Reduction
of exposure of normal tissues can be achieved by optimization of radiotherapy.
Furthermore, understanding of the fibrogenic mechanisms has provided targets to
prevent, mitigate...
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