Fibrogenesis & Tissue Repair
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Connective tissue growth factor in tumor pathogenesis
Fibrogenesis & Tissue Repair - Tập 5 - Trang 1-7 - 2012
Key roles for connective tissue growth factor (CTGF/CCN2) are demonstrated in the wound repair process where it promotes myofibroblast differentiation and angiogenesis. Similar mechanisms are active in tumor-reactive stroma where CTGF is expressed. Other potential roles include prevention of hypoxia-induced apoptosis and promoting epithelial-mesenchymal transistion (EMT). CTGF expression in tumors......
Discoidin domain receptors regulate the migration of primary human lung fibroblasts through collagen matrices
Fibrogenesis & Tissue Repair - Tập 5 - Trang 1-9 - 2012
The two discoidin domain receptors (DDRs), DDR1 and DDR2 are receptor tyrosine kinases (RTKs) with the unique ability among RTKs to respond to collagen. We have previously shown that collagen I induces DDR1 and matrix metalloproteinase (MMP)-10 expression through DDR2 activation and a Janus kinase (JAK)2 and extracellular signal-regulated kinase (ERK)1/2-mediated mechanism in primary human lung fi......
A phage-targeting strategy for the design of spatiotemporal drug delivery from grafted matrices
Fibrogenesis & Tissue Repair - Tập 4 - Trang 1-16 - 2011
The natural response to injury is dynamic and normally consists of complex temporal and spatial cellular changes in gene expression, which, when acting in synchrony, result in patent tissue repair and, in some instances, regeneration. However, current therapeutic regiments are static and most rely on matrices, gels and engineered skin tissue. Accordingly, there is a need to design next-generation ......
Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases
Fibrogenesis & Tissue Repair - Tập 6 - Trang 1-10 - 2013
The proteoglycan biglycan (BGN) is involved in collagen fibril assembly and its fragmentation is likely to be associated with collagen turnover during the pathogenesis of diseases which involve dysregulated extracellular matrix remodeling (ECMR), such as rheumatoid arthritis (RA) and liver fibrosis. The scope of the present study was to develop a novel enzyme-linked immunosorbent assay (ELISA) for......
Redox mechanisms in hepatic chronic wound healing and fibrogenesis
Fibrogenesis & Tissue Repair - Tập 1 - Trang 1-58 - 2008
Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have developed evolutionarily conserved mechanisms and strategies to carefully control the generation of ROS and other oxidative stress-related radical or non-radical reactive intermediates (that is, to maintain redox homeostas......
Prospects for clinical use of reprogrammed cells for autologous treatment of macular degeneration
Fibrogenesis & Tissue Repair - Tập 8 - Trang 1-9 - 2015
Since the discovery of induced pluripotent stem cells (iPSC) in 2006, the symptoms of many human diseases have been reversed in animal models with iPSC therapy, setting the stage for future clinical development. From the animal data it is clear that iPSC are rapidly becoming the lead cell type for cell replacement therapy and for the newly developing field of iPSC-derived body organ transplantatio......
Reactive oxygen and nitrogen species induce protein and DNA modifications driving arthrofibrosis following total knee arthroplasty
Fibrogenesis & Tissue Repair - - 2009
Arthrofibrosis, occurring in 3%-4% of patients following total knee arthroplasty (TKA), is a challenging condition for which there is no defined cause. The hypothesis for this study was that disregulated production of reactive oxygen species (ROS) and nitrogen species (RNS) mediates matrix protein and DNA modifications, which result in excessive fibroblastic proliferation. We found increased numbe......
Molecular and cellular mechanisms of pulmonary fibrosis
Fibrogenesis & Tissue Repair - Tập 5 - Trang 1-24 - 2012
Pulmonary fibrosis is a chronic lung disease characterized by excessive accumulation of extracellular matrix (ECM) and remodeling of the lung architecture. Idiopathic pulmonary fibrosis is considered the most common and severe form of the disease, with a median survival of approximately three years and no proven effective therapy. Despite the fact that effective treatments are absent and the preci......
Autologous keratinocyte suspension in platelet concentrate accelerates and enhances wound healing – a prospective randomized clinical trial on skin graft donor sites: platelet concentrate and keratinocytes on donor sites
Fibrogenesis & Tissue Repair - Tập 6 - Trang 1-8 - 2013
Wound healing involves complex mechanisms, which, if properly chaperoned, can enhance patient recovery. The abilities of platelets and keratinocytes may be harnessed in order to stimulate wound healing through the formation of platelet clots, the release of several growth factors and cytokines, and cell proliferation. The aim of the study was to test whether autologous keratinocyte suspensions in ......
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