Augmenter of liver regeneration

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Hagiya M, Francavilla A, Polimeno L, Ihara I, Sakai H, Seki T, Shimonishi M, Porter KA, Starzl TE: Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: expression of biologically active recombinant ALR and demonstration of tissue distribution. Proc Natl Acad Sci U S A. 1994, 8142: 8146-Correction in Proc Natl Acad Sci U S A 1995, 92:3076

Giorda R, Hagiya M, Seki T, Shimonishi M, Sakai H, Michaelson J, Francavilla A, Starzl TE, Trucco M: Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. Mol Med. 1996, 2: 97-108.

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Gandhi CR, Murase N, Starzl TE: Cholera toxin-sensitive GTP-binding protein-coupled activation of augmenter of liver regeneration (ALR) receptor and its function in rat Kupffer cells. J Cell Physiol. 2010, 222: 365-373. 10.1002/jcp.21957.

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Hofhaus G, Lee JE, Tews I, Rosenberg B, Lisowsky T: The N-terminal cysteine pair of yeast sulfhydryl oxidase Erv1p is essential for in vivo activity and interacts with the primary redox centre. Eur J Biochem. 2003, 270: 1528-1535. 10.1046/j.1432-1033.2003.03519.x.

Lee J, Hofhaus G, Lisowsky T: Erv1p from Saccharomyces cerevisiae is a FAD-linked sulfhydryl oxidase. FEBS Lett. 2000, 477: 62-66. 10.1016/S0014-5793(00)01767-1.

Thasler WE, Schlott T, Thelen P, Hellerbrand C, Bataille F, Lichtenauer M, Schlitt HJ, Jauch KW, Weiss TS: Expression of augmenter of liver regeneration (ALR) in human liver cirrhosis and carcinoma. Histopathology. 2005, 47: 57-66. 10.1111/j.1365-2559.2005.02172.x.

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Thirunavukkarasu C, Wang LF, Harvey SAK, Watkins SC, Chaillet JR, Starzl TE, Gandhi CR: Augmenter of liver regeneration: an important intracellular survival factor for hepatocytes. J Hepatology. 2008, 48: 578-588. 10.1016/j.jhep.2007.12.010.

Hofhaus G, Stein G, Polimeno L, Francavilla A, Lisowsky T: Highly divergent amino termini of the homologous human ALR and yeast scERV gene products define species differences in cellular localization. Eur J Cell Biol. 1999, 78: 349-356. 10.1016/S0171-9335(99)80069-7.

Dayoub R, Thasler WE, Bosserhoff AK, Singer T, Jauch KW, Schlitt HJ, Weiss TS: Regulation of polyamine synthesis in human hepatocytes by hepatotrophic factor augmenter of liver regeneration. Biochem Biophys Res Commun. 2006, 345: 181-187. 10.1016/j.bbrc.2006.04.040.

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Ilowski M, Putz C, Weiss TS, Brand S, Jauch KW, Hengstler JG, Thasler WE: Augmenter of liver regeneration causes different kinetics of ERK1/2 and Akt/PKB phosphorylation than EGF and induces hepatocyte proliferation in an EGF receptor independent and liver specific manner. Biochem Biophys Res Commun. 2010, 394: 915-920. 10.1016/j.bbrc.2010.03.074.

Thasler WE, Dayoub R, Mühlbauer M, Hellerbrand C, Singer T, Gräbe A, Jauch KW, Schlitt HJ, Weiss TS: Repression of cytochrome P450 activity in human hepatocytes in vitro by a novel hepatotrophic factor, augmenter of liver regeneration. J Pharmacol Exp Ther. 2006, 316: 822-829.

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