The role of neuropeptide somatostatin in the brain and its application in treating neurological disordersExperimental and Molecular Medicine - Tập 53 Số 3 - Trang 328-338 - 2021
Yoseb Song, Jiwon Yoon, Seung‐Hee Lee
AbstractSomatostatin (SST) is a well-known neuropeptide that is expressed throughout the brain. In the cortex, SST is expressed in a subset of GABAergic neurons and is known as a protein marker of inhibitory interneurons. Recent studies have identified the key functions of SST in modulating cortical circuits in the brain and cognitive function. Furthermore, reduced...... hiện toàn bộ
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complexExperimental and Molecular Medicine - Tập 52 Số 2 - Trang 183-191 - 2020
Youn‐Sang Jung, Jae‐Il Park
AbstractWnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects suc...... hiện toàn bộ