Experimental and Molecular Medicine
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The role of neuropeptide somatostatin in the brain and its application in treating neurological disorders Abstract Somatostatin (SST) is a well-known neuropeptide that is expressed throughout the brain. In the cortex, SST is expressed in a subset of GABAergic neurons and is known as a protein marker of inhibitory interneurons. Recent studies have identified the key functions of SST in modulating cortical circuits in the brain and cognitive function. Furthermore, reduced expression of SST is a hallmark of various neurological disorders, including Alzheimer’s disease and depression. In this review, we summarize the current knowledge on SST expression and function in the brain. In particular, we describe the physiological roles of SST-positive interneurons in the cortex. We further describe the causal relationship between pathophysiological changes in SST function and various neurological disorders, such as Alzheimer’s disease. Finally, we discuss potential treatments and possibility of novel drug developments for neurological disorders based on the current knowledge on the function of SST and SST analogs in the brain derived from experimental and clinical studies.
Experimental and Molecular Medicine - Tập 53 Số 3 - Trang 328-338 - 2021
Protectin DX increases alveolar fluid clearance in rats with lipopolysaccharide-induced acute lung injury
Experimental and Molecular Medicine - Tập 50 Số 4 - Trang 1-13 - 2018
Mechanisms of aging-related proteinopathies in Caenorhabditis elegans
Experimental and Molecular Medicine - Tập 48 Số 10 - Trang e263-e263
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex Abstract Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects such as impairment of tissue homeostasis and regeneration. Recently, several studies have identified cancer-specific Wnt signaling regulators. In this review, we discuss the Wnt inhibitors currently being used in clinical trials and suggest how additional cancer-specific regulators could be utilized to treat Wnt signaling-associated cancer.
Experimental and Molecular Medicine - Tập 52 Số 2 - Trang 183-191 - 2020
The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5
Experimental and Molecular Medicine - Tập 47 Số 12 - Trang e200-e200
Biomedical significance of endothelial cell specific growth factor, angiopoietin
Experimental and Molecular Medicine - Tập 34 Số 1 - Trang 1-11
Regulation of leptin gene expression by insulin and growth hormone in mouse adipocytes
Experimental and Molecular Medicine - Tập 33 Số 4 - Trang 234-239
CKβ8-1 alters expression of cyclin E in colony forming units-granulocyte macrophage (CFU-GM) lineage from human cord blood CD34+ cells
Experimental and Molecular Medicine - Tập 37 Số 6 - Trang 619-623
Writing, erasing and reading histone lysine methylations
Experimental and Molecular Medicine - Tập 49 Số 4 - Trang e324-e324
Molecules and their functions in autophagy
Experimental and Molecular Medicine - Tập 44 Số 2 - Trang 73 - 2012
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