Experimental and Molecular Medicine
SCOPUS (1996-2025)SCIE-ISI
1226-3613
2092-6413
Hàn Quốc
Cơ quản chủ quản: Korean Society of Med. Biochemistry and Mol. Biology , Springer Nature
Lĩnh vực:
Molecular MedicineMedicine (miscellaneous)Molecular BiologyClinical BiochemistryBiochemistry
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ROS in cancer therapy: the bright side of the moon
Tập 52 Số 2 - Trang 192-203 - 2020
AbstractReactive oxygen species (ROS) constitute a group of highly reactive
molecules that have evolved as regulators of important signaling pathways. It is
now well accepted that moderate levels of ROS are required for several cellular
functions, including gene expression. The production of ROS is elevated in tumor
cells as a consequence of increased metabolic rate, gene mutation and relative
hyp...
Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicine
Tập 45 Số 11 - Trang e54-e54
AbstractMesenchymal stem cells (MSCs) are partially defined by their ability to
differentiate into tissues including bone, cartilage and adipose in vitro, but
it is their trophic, paracrine and immunomodulatory functions that may have the
greatest therapeutic impact in vivo. Unlike pharmaceutical treatments that
deliver a single agent at a specific dose, MSCs are site regulated and secrete
bioacti...
Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
Tập 38 Số 4 - Trang 333-347
Amino acids in cancer
Tập 52 Số 1 - Trang 15-30 - 2020
AbstractOver 90 years ago, Otto Warburg’s seminal discovery of aerobic
glycolysis established metabolic reprogramming as one of the first
distinguishing characteristics of cancer1. The field of cancer metabolism
subsequently revealed additional metabolic alterations in cancer by focusing on
central carbon metabolism, including the citric acid cycle and pentose phosphate
pathway. Recent reports hav...
Intracellular sensing of viral genomes and viral evasion
Tập 51 Số 12 - Trang 1-13 - 2019
AbstractDuring viral infection, virus-derived cytosolic nucleic acids are
recognized by host intracellular specific sensors. The efficacy of this
recognition system is crucial for triggering innate host defenses, which then
stimulate more specific adaptive immune responses against the virus. Recent
studies show that signal transduction pathways activated by sensing proteins are
positively or negat...
Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunity
Tập 52 Số 9 - Trang 1475-1485 - 2020
AbstractCancer immunotherapy with immune checkpoint inhibitors (ICIs) has
revolutionized the treatment of advanced cancers. However, the tumor
microenvironment (TME) functions as a formidable barrier that severely impairs
the efficacy of ICIs. While the crosstalk between tumor vessels and immune cells
determines the nature of anti-tumor immunity, it is skewed toward a destructive
cycle in growing ...
Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model
Tập 50 Số 4 - Trang 1-14 - 2018
Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex
Tập 52 Số 2 - Trang 183-191 - 2020
AbstractWnt/β-catenin signaling is implicated in many physiological processes,
including development, tissue homeostasis, and tissue regeneration. In human
cancers, Wnt/β-catenin signaling is highly activated, which has led to the
development of various Wnt signaling inhibitors for cancer therapies.
Nonetheless, the blockade of Wnt signaling causes side effects such as
impairment of tissue homeost...