Experimental and Molecular Medicine
SCOPUS (1996-2023)SCIE-ISI
1226-3613
2092-6413
Hàn Quốc
Cơ quản chủ quản: Korean Society of Med. Biochemistry and Mol. Biology , Springer Nature
Lĩnh vực:
Molecular MedicineMedicine (miscellaneous)Molecular BiologyClinical BiochemistryBiochemistry
Các bài báo tiêu biểu
ROS in cancer therapy: the bright side of the moonAbstract Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rat... ...
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Mesenchymal stem cells: environmentally responsive therapeutics for regenerative medicineAbstract Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into tissues including bone, cartilage and adipose in vitro , but it is their trophic, paracrine and immunomodulatory functions that may have the greatest therapeutic impact in vivo . Unlike pharmaceutical treatments that... ...
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Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
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Amino acids in cancerAbstract Over 90 years ago, Otto Warburg’s seminal discovery of aerobic glycolysis established metabolic reprogramming as one of the first distinguishing characteristics of cancer1 . The field of cancer metabolism subsequently revealed additional metabolic alterations in cancer by focusing on central carbon metabolism, including the citric acid c... ...
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Intracellular sensing of viral genomes and viral evasionAbstract During viral infection, virus-derived cytosolic nucleic acids are recognized by host intracellular specific sensors. The efficacy of this recognition system is crucial for triggering innate host defenses, which then stimulate more specific adaptive immune responses against the virus. Recent studies show that signal transduction pathways activated by sensing... ...
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Combination of anti-angiogenic therapy and immune checkpoint blockade normalizes vascular-immune crosstalk to potentiate cancer immunityAbstract Cancer immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced cancers. However, the tumor microenvironment (TME) functions as a formidable barrier that severely impairs the efficacy of ICIs. While the crosstalk between tumor vessels and immune cells determines the nature of anti-tumor immunity, it is skewed towar... ...
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Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model
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Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complexAbstract Wnt/β-catenin signaling is implicated in many physiological processes, including development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin signaling is highly activated, which has led to the development of various Wnt signaling inhibitors for cancer therapies. Nonetheless, the blockade of Wnt signaling causes side effects suc... ...
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