Experimental Hematology & Oncology

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IL-39 promotes chronic graft-versus-host disease by increasing T and B Cell pathogenicity
Experimental Hematology & Oncology - Tập 11 - Trang 1-15 - 2022
Kangkang Lv, Bo Hu, Mingzhu Xu, Li Wan, Ziqi Jin, Mimi Xu, Yuanyuan Du, Kunpeng Ma, Quansheng Lv, Yang Xu, Lei Lei, Huanle Gong, Haiyan Liu, Depei Wu, Yuejun Liu
Chronic graft-versus-host disease (cGVHD) remains a major complication during the late phase of allogeneic hematopoietic stem cell transplantation (allo-HSCT). IL-39, a newly described pro-inflammatory cytokine belonging to the IL-12 family, plays a role in lupus development. Recently, IL-39 has been identified as a pathogenic factor in acute GVHD (aGVHD). However, the role of IL-39 in the pathoge...... hiện toàn bộ
Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment
Experimental Hematology & Oncology - - 2024
Yifan Zhou, Yao Qin, Jingjing Ma, Zhiyuan Li, Weiwei Heng, Lei Zhang, Hong Liu, Ruowei Li, Miaomiao Zhang, Qiao Peng, Pei Ye, Ning Duan, Ting Liu, Wenmei Wang, Xiang Wang
Oral microbial dysbiosis contributes to the development of oral squamous cell carcinoma (OSCC). Our previous study showed that Prevotella intermedia (P. intermedia) were enriched in the oral mucosal surface, plaque, and saliva of patients with OSCC. Intratumoral microbiome could reshape the immune system and influence the development of various tumors. However, the invasion status of human OSCC ti...... hiện toàn bộ
AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL
Experimental Hematology & Oncology - - 2021
Zuoqiao Wu, Mary Nicoll, Robert J. Ingham
Classical Hodgkin lymphoma (cHL) and anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) are B and T cell lymphomas respectively, which express the tumour necrosis factor receptor superfamily member, CD30. Another feature shared by cHL and ALK+ ALCL is the aberrant expression of multiple members of the activator protein-1 (AP-1) family of transcription factors which inc...... hiện toàn bộ
Neoadjuvant treatment of melanoma: case reports and review
Experimental Hematology & Oncology - Tập 2 - Trang 1-8 - 2013
Shachar Laks, Kevin A Brueske, Eddy C Hsueh
Neoadjuvant therapy is an under-utilized regimen for the treatment of metastatic melanoma. The use of this approach has been increasing in other tumor types. Neoadjuvant therapy may reduce occult circulating tumor cell burden in the face of bulky disease and afford a real time evaluation of treatment effectiveness. Neoadjuvant approach can also provide preoperative histologic and molecular analysi...... hiện toàn bộ
RHO GTPase family in hepatocellular carcinoma
Experimental Hematology & Oncology -
Tiantian Wang, Dean Rao, Chengpeng Yu, Jiaqi Sheng, Yiming Luo, Limin Xia, Wenjie Huang
AbstractRHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly conserved in eukaryotic species and have important biological functions, including actin cytoskeleton reorganization, cell proliferation, cell polarity, and vesicular transport. Recent studies indicate that RHO GTPases participate in the proliferation, migration, invasion and m...... hiện toàn bộ
SEPHS1 promotes SMAD2/3/4 expression and hepatocellular carcinoma cells invasion
Experimental Hematology & Oncology - Tập 10 - Trang 1-12 - 2021
Shu Yang, Hongying Zhang, Hua Yang, Jin Zhang, Jiao Wang, Ting Luo, Yangfu Jiang, Hui Hua
Hepatocellular carcinoma (HCC) is one of the common cancers that are very aggressive. The secreted cytokine transforming growth factor-β (TGF-β) promotes cancer metastasis by multiple mechanisms such as epithelial-mesenchymal transition and immune evasion. The canonical TGF-β signaling is largely mediated by smooth muscle actin/mothers against decapentaplegic (SMAD) proteins. The current study aim...... hiện toàn bộ
Non-invasive urine testing of EGFR activating mutation and T790M resistance mutation in non-small cell lung cancer
Experimental Hematology & Oncology - Tập 5 - Trang 1-6 - 2016
David Berz, Victoria M. Raymond, Jordan H. Garst, Mark G. Erlander
The increasing understanding of non-small cell lung cancer (NSCLC) biology over the last two decades has led to the identification of multiple molecular targets. This led to the development of multiple targeted therapies in the primary and secondary resistance setting and the epidermal growth factor receptor (EGFR) gene remains the most frequently observed molecular target in NSCLC. Tissue biopsie...... hiện toàn bộ
A case of minor BCR-ABL1 positive acute lymphoblastic leukemia following essential thrombocythemia and originating from a clone distinct from that harboring the JAK2-V617F mutation
Experimental Hematology & Oncology - Tập 3 Số 1 - 2014
Yuya Nagai, Masahiro Kawahara, Noriko Sugino, Yayoi Shimazu, Masakatsu Hishizawa, Kouhei Yamashita, Norimitsu Kadowaki, Akifumi Takaori‐Kondo
R-CHOP with dose-attenuated radiation therapy could induce good prognosis in gastric diffuse large B cell lymphoma
Experimental Hematology & Oncology - Tập 1 - Trang 1-6 - 2012
Yuko Mishima, Yasuhito Terui, Masahiro Yokoyama, Noriko Nishimura, Sakura Sakajiri, Kyoko Ueda, Yasutoshi Kuboki, Kenji Nakano, Kazuhito Suzuki, Eriko Nara, Naoko Tsuyama, Kengo Takeuchi, Masahiko Oguchi, Kiyohiko Hatake
The treatment strategy for gastric diffuse large cell lymphoma (DLBCL) has not been standardized in such as to the cycles of chemotherapy, dose of radiation, or necessity for the surgery. Although the results of CHOP or R-CHOP treatments have demonstrated the good prognosis, the treatments have been controversial in many cases. We retrospectively analyzed 40 gastric DLBCL patients receiving chemot...... hiện toàn bộ
Cytokine-based models for efficient differentiation between infection and cytokine release syndrome in patients with hematological malignancies
Experimental Hematology & Oncology - - 2024
Linqin Wang, Yuqi Lv, Linghui Zhou, Shenghao Wu, Yuanyuan Zhu, Shan Fu, Shuyi Ding, Ruimin Hong, Mingming Zhang, Hanjing Yu, Alex H. Chang, Guoqing Wei, Yongxian Hu, He Huang
Although the efficacy of chimeric antigen receptor (CAR)-T cell therapy has been widely demonstrated, its clinical application is hampered by the complexity and fatality of its side effects. Cytokine release syndrome (CRS) is the most common toxicity following CAR-T cell infusion, and its symptoms substantially overlap with those of infection. Whereas, current diagnostic t...... hiện toàn bộ
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