Experimental Hematology & Oncology

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CD57+ T-cells are a subpopulation of T-follicular helper cells in nodular lymphocyte predominant Hodgkin lymphoma
Experimental Hematology & Oncology - - 2015
Ahmad Sattarzadeh, Arjan Diepstra, Bea Rutgers, Anke van den Berg, Lydia Visser
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is characterized by lymphocyte-predominant (LP) cells in a background of CD4+ CD57+ T-cells. These cells are normally present in the germinal center of lymphoid tissues. The cells rosetting LP cells are described to be PD-1 and BCL-6 positive, which are markers of T-follicular helper cells. This study was designed to address the question: are...... hiện toàn bộ
Successful administration of chimeric antigen receptor (CAR) T-cell therapy in patients requiring hemodialysis
Experimental Hematology & Oncology - Tập 11 - Trang 1-3 - 2022
Bradley D. Hunter, Daanish Hoda, Andy Nguyen, Launce Gouw, Bryan Huber, Ryan R. Jensen, Justine Preedit, Andrew Evens, Esther Huang, Jiyeon Park, Dennis L. Cooper
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed/refractory B-cell malignancies. However, there is no data on the safety and efficacy of CAR T-cell therapy in patients with end stage renal disease (ESRD) requiring dialysis. In this report, we present two patients with DLBCL and ESRD who were successfully treated with different CAR T-cell products. Patient...... hiện toàn bộ
An expanded biomarker panel for the detection of prostate cancer from urine DNA
Experimental Hematology & Oncology - Tập 8 Số 1 - 2019
Igor Brikun, Deborah Nusskern, Diha Freije
A novel E-cadherin/SOX9 axis regulates cancer stem cells in multiple myeloma by activating Akt and MAPK pathways
Experimental Hematology & Oncology - Tập 11 - Trang 1-6 - 2022
Parinya Samart, Yon Rojanasakul, Surapol Issaragrisil, Sudjit Luanpitpong
Cancer stem cells (CSCs) have been identified in multiple myeloma (MM) and are widely regarded as a key driver of MM initiation and progression. E-cadherin, in addition to its established role as a marker for epithelial-mesenchymal transition, also plays critical roles in controlling the aggressive behaviors of various tumor cells. Here, we show that depletion of E-cadherin in MM cells remarkably ...... hiện toàn bộ
Research progress on dendritic cell vaccines in cancer immunotherapy
Experimental Hematology & Oncology - Tập 11 - Trang 1-22 - 2022
Jifeng Yu, Hao Sun, Weijie Cao, Yongping Song, Zhongxing Jiang
Dendritic cell (DC) vaccines induce specific immune responses that can selectively eliminate target cells. In recent years, many studies have been conducted to explore DC vaccination in the treatment of hematological malignancies, including acute myeloid leukemia and myelodysplastic syndromes, as well as other nonleukemia malignancies. There are at least two different strategies that use DCs to pr...... hiện toàn bộ
Thalidomide and its analogues in the treatment of Multiple Myeloma
Experimental Hematology & Oncology - Tập 1 - Trang 1-8 - 2012
Tahir Latif, Nabeel Chauhan, Rashid Khan, Andrea Moran, Saad Z Usmani
Multiple myeloma is an incurable malignant disorder of mature B-cells that predominantly affects the elderly. The immunomodulatory drug (IMiD) thalidomide and its newer analogs demonstrate increased antitumor activity, and have had a positive impact on the natural history of multiple myeloma. Recent advances in the clinical application of these agents and in our understanding of their mechanism of...... hiện toàn bộ
Development of human prostate cancer stem cells involves epigenomic alteration and PI3K/AKT pathway activation
Experimental Hematology & Oncology - - 2020
Jingjing Wu, Shundong Cang, Christina Liu, Whitman Ochiai, Jen Wei Chiao
Abstract Background Human prostate cancer spheres endowed with stem cell properties have been obtained from androgen-dependent cell line LNCaP after exposure to an epigenomic modulator phenethyl isothiocynate (PEITC). Sphere cells can self-renew and grow with androgen, and also without androgen. Lit...... hiện toàn bộ
Challenges and strategies associated with CAR-T cell therapy in blood malignancies
Experimental Hematology & Oncology - - 2024
Zhaoyun Liu, Wenhui Lei, Hao Wang, Xiaohan Liu, Rong Fu
Cellular immunotherapy, particularly CAR-T cells, has shown potential in the improvement of outcomes in patients with refractory and recurrent malignancies of the blood. However, achieving sustainable long-term complete remission for blood cancer remains a challenge, with resistance and relapse being expected outcomes for many patients. Although many studies have attempted to clarify the mechanism...... hiện toàn bộ
DLC1 deficiency at diagnosis predicts poor prognosis in acute myeloid leukemia
Experimental Hematology & Oncology - Tập 11 - Trang 1-5 - 2022
Xueqian Li, Jiaqian Qi, Xiaofei Song, Xiaoyan Xu, Tingting Pan, Hong Wang, Jingyi Yang, Yue Han
Acute myeloid leukemia (AML) is a complex, heterogeneous malignant hematologic disease. Although multiple prognostic-related genes gave been explored in previous studies, there are still many genes whose prognostic value remains unclear. In this study, a total of 1532 AML patients from three GEO databases were included, five genes with potential prognostic value (DLC1, NF1B, DENND5B, TANC2 and ELA...... hiện toàn bộ
Are Australian clinicians monitoring medication adherence in hematological cancer survivors? Two cross-sectional studies
Experimental Hematology & Oncology - Tập 4 Số 1 - 2015
Marita Lynagh, Tara Clinton‐McHarg, Alix Hall, Rob Sanson‐Fisher, William Stevenson, Campbell Tiley, Alessandra Bisquera
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