Experimental Hematology & Oncology

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IL-39 promotes chronic graft-versus-host disease by increasing T and B Cell pathogenicity
Experimental Hematology & Oncology - Tập 11 - Trang 1-15 - 2022
Kangkang Lv, Bo Hu, Mingzhu Xu, Li Wan, Ziqi Jin, Mimi Xu, Yuanyuan Du, Kunpeng Ma, Quansheng Lv, Yang Xu, Lei Lei, Huanle Gong, Haiyan Liu, Depei Wu, Yuejun Liu
Chronic graft-versus-host disease (cGVHD) remains a major complication during the late phase of allogeneic hematopoietic stem cell transplantation (allo-HSCT). IL-39, a newly described pro-inflammatory cytokine belonging to the IL-12 family, plays a role in lupus development. Recently, IL-39 has been identified as a pathogenic factor in acute GVHD (aGVHD). However, the role of IL-39 in the pathoge...... hiện toàn bộ
An integrated view of the role of miR-130b/301b miRNA cluster in prostate cancer
Experimental Hematology & Oncology - - 2018
Rafael Sebastián Fort, Cecilia Mathó, Carolina Oliveira-Rizzo, Beatríz Garat, José Sotelo‐Silveira, Marı́a Ana Duhagon
Heat-killed Prevotella intermedia promotes the progression of oral squamous cell carcinoma by inhibiting the expression of tumor suppressors and affecting the tumor microenvironment
Experimental Hematology & Oncology - - 2024
Yifan Zhou, Yao Qin, Jingjing Ma, Zhiyuan Li, Weiwei Heng, Lei Zhang, Hong Liu, Ruowei Li, Miaomiao Zhang, Qiao Peng, Pei Ye, Ning Duan, Ting Liu, Wenmei Wang, Xiang Wang
Oral microbial dysbiosis contributes to the development of oral squamous cell carcinoma (OSCC). Our previous study showed that Prevotella intermedia (P. intermedia) were enriched in the oral mucosal surface, plaque, and saliva of patients with OSCC. Intratumoral microbiome could reshape the immune system and influence the development of various tumors. However, the invasion status of human OSCC ti...... hiện toàn bộ
Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study
Experimental Hematology & Oncology - Tập 9 Số 1 - 2020
Liqing Ning, Chuanyu Hu, Pingfan Lu, Yimei Que, Dengju Li
AbstractBackgroundOutcomes of chronic myeloid leukemia (CML) has been improved dramatically in the past two decades, but survival levels of CML patients varied in regions. Comprehensive epidemiological research is necessary to evaluate the global burden of CML.MethodsA...... hiện toàn bộ
AP-1 family transcription factors: a diverse family of proteins that regulate varied cellular activities in classical hodgkin lymphoma and ALK+ ALCL
Experimental Hematology & Oncology - - 2021
Zuoqiao Wu, Mary Nicoll, Robert J. Ingham
Classical Hodgkin lymphoma (cHL) and anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) are B and T cell lymphomas respectively, which express the tumour necrosis factor receptor superfamily member, CD30. Another feature shared by cHL and ALK+ ALCL is the aberrant expression of multiple members of the activator protein-1 (AP-1) family of transcription factors which inc...... hiện toàn bộ
Dual EGFR blockade with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial
Experimental Hematology & Oncology - Tập 9 Số 1 - Trang 1-8 - 2020
Subbiah, Vivek, Dumbrava, Ecaterina Ileana, Jiang, Yunfang, Thein, Kyaw Z., Naing, Aung, Hong, David S., Fu, Siqing, Piha-Paul, Sarina A., Tsimberidou, Apostolia M., Janku, Filip, Meric-Bernstam, Funda, Kurzrock, Razelle, Falchook, Gerald
Angiogenesis and activation of the epidermal growth factor (EGFR) pathway play an essential role in tumor proliferation and metastasis. Targeting angiogenesis or EGFR alone does not yield adequate tumor control in most solid tumors. Overcoming intrinsic and/or acquired resistance may need a doublet or triplet therapy strategy. Herein, we report the safety and feasibility of dual EGFR blockade with...... hiện toàn bộ
Diagnostic and therapeutic challenges of EBV-positive mucocutaneous ulcer: a case report and systematic review of the literature
Experimental Hematology & Oncology - Tập 5 - Trang 1-14 - 2016
Toni K. Roberts, Xueyan Chen, Jay Justin Liao
Epstein–Barr virus-positive mucocutaneous ulcer (EBVMCU) is a recently recognized B cell lymphoproliferative disorder that is driven by latent EBV infection and causes discrete ulcerations in the oropharynx, gastrointestinal tract, and skin. Local attenuation of immunosurveillance associated with iatrogenic immunosuppressant use, primary immunodeficiency, or age-associated immunosenescence has bee...... hiện toàn bộ
Neoadjuvant treatment of melanoma: case reports and review
Experimental Hematology & Oncology - Tập 2 - Trang 1-8 - 2013
Shachar Laks, Kevin A Brueske, Eddy C Hsueh
Neoadjuvant therapy is an under-utilized regimen for the treatment of metastatic melanoma. The use of this approach has been increasing in other tumor types. Neoadjuvant therapy may reduce occult circulating tumor cell burden in the face of bulky disease and afford a real time evaluation of treatment effectiveness. Neoadjuvant approach can also provide preoperative histologic and molecular analysi...... hiện toàn bộ
Serologic response and safety of COVID-19 vaccination in HSCT or CAR T-cell recipients: a systematic review and meta-analysis
Experimental Hematology & Oncology -
Chenghao Ge, Kelei Du, Mingjie Luo, Kaini Shen, Yangzhong Zhou, Ke Guo, Yang Liu, Cong Yin, Yang Li, Guanqiao Li, Xiaoyuan Chen
Abstract Background Patients receiving hematopoietic stem cell transplantation (HSCT) or chimeric antigen receptor T cell (CAR T-cell) therapy are immunocompromised and at high risk of viral infection, including SAR2-CoV-2 infection. However, the effectiveness and safety of COVID-19 vaccines in thes...... hiện toàn bộ
Lymphocytes from chronic lymphocytic leukaemia undergo ABL1-linked amoeboid motility and homotypic interaction as an early adaptive change to ex vivo culture
Experimental Hematology & Oncology - Tập 3 - Trang 1-14 - 2014
Claire V Hutchinson, Shiva Natarajan, Suzanne M Johnson, Julie A Adams, Karen S Rees-Unwin, John Burthem
Those stimuli that together promote the survival, differentiation and proliferation of the abnormal B-lymphocytes of chronic lymphocytic leukaemia (CLL) are encountered within tissues, where together they form the growth-supporting microenvironment. Different tissue-culture systems promote the survival of the neoplastic lymphocytes from CLL, partly replicating the in vivo tissue environment of the...... hiện toàn bộ
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