AbstractFollowing improvement and integration of novel genome sequencing
techniques, a new stage light has been shone upon circular RNAs (circRNA) in
regard to their structure and functionality. In comparison to their linear
counterparts, circRNA possess a multitude of remarkable functions such as
microRNA (miRNA) sponging, RNA-binding protein (RBP) regulation and
translational capabilities whose ... hiện toàn bộ
Abstract MicroRNAs (miRNAs) are a number of small non-coding RNAs playing a
regulatory part in gene expression. Many virus-encoded miRNAs have been found,
which manifests that viruses as well apply the basic pattern of gene regulation,
however, mostly in viruses transcribed from double-stranded DNA genomes. It is
still in dispute if RNA viruses could encode miRNAs because the excision of
miRNA mig... hiện toàn bộ
Abstract Background Bovine milk exosomes are studied for their roles as
bioactive food compounds and as vehicles for drug delivery. Both lines of
investigation converge on immune function, e.g., immune regulation by absorption
of microRNAs encapsulated in milk exosomes across species boundaries, and the
possibility of exosomes and their cargos triggering an immune response if used
in drug delivery... hiện toàn bộ
M. Shoff, Timberly Booker, Blair R. Leavitt, David C. Harmon, Karl Kingsley, Katherine M. Howard
Abstract Background Oral squamous cell carcinomas (OSCC) secrete exosomes into
the surrounding extracellular environment to promote the horizontal transfer of
bioactive molecules including microRNA (miRNA). The primary objective of this
study was to explore potential differences in miRNA content between OSCC and
OSCC stem cells. Methods The OSCC cell lines SCC4, SCC15, SCC25 and CAL27 were
used in... hiện toàn bộ
Abstract Procambarus clarkii is one of the important economic species in China
and has been served as tasty food in recent years after being introduced to
Nanjing. Significant problems of environment factors, such as salinity, pH and
temperature, especially salinity, has the potential to result in significant
economic losses in many crayfish-producing farms in China. miRNAs are a kind of
~ 22 nucl... hiện toàn bộ
Jennifer K. Spinler, Numan Oezguen, Jessica K. Runge, Ruth Ann Luna, Vivekanudeep Karri, Jian Yang, Kendal D. Hirschi
Global estimations of 4 billion people living on plant-based diets signify
tremendous diversity in plant consumption and their assorted miRNAs, which
presents a challenging model to experimentally address how plant-based miRNAs
impact the microbiome. Here we establish baseline gut microbiome composition for
a mouse model deficient in the specific mammalian miR-146a shown to alter gut
microbiomes. ... hiện toàn bộ
Intracellular target identification of microRNA (miRNA), which is essential for
understanding miRNA-involved cellular processes, is currently the most
challenging task in miRNA-related studies. Although bioinformatic methods have
been developed as the most efficient strategy for miRNA target identification,
high-throughput experimental strategies are still highly demanded. In this
review paper, we... hiện toàn bộ