AbstractFollowing improvement and integration of novel genome sequencing
techniques, a new stage light has been shone upon circular RNAs (circRNA) in
regard to their structure and functionality. In comparison to their linear
counterparts, circRNA possess a multitude of remarkable functions such as
microRNA (miRNA) sponging, RNA-binding protein (RBP) regulation and
translational capabilities whose ... hiện toàn bộ
Abstract MicroRNAs (miRNAs) are a number of small non-coding RNAs playing a
regulatory part in gene expression. Many virus-encoded miRNAs have been found,
which manifests that viruses as well apply the basic pattern of gene regulation,
however, mostly in viruses transcribed from double-stranded DNA genomes. It is
still in dispute if RNA viruses could encode miRNAs because the excision of
miRNA mig... hiện toàn bộ
Abstract Background Bovine milk exosomes are studied for their roles as
bioactive food compounds and as vehicles for drug delivery. Both lines of
investigation converge on immune function, e.g., immune regulation by absorption
of microRNAs encapsulated in milk exosomes across species boundaries, and the
possibility of exosomes and their cargos triggering an immune response if used
in drug delivery... hiện toàn bộ
M. Shoff, Timberly Booker, Blair R. Leavitt, David C. Harmon, Karl Kingsley, Katherine M. Howard
Abstract Background Oral squamous cell carcinomas (OSCC) secrete exosomes into
the surrounding extracellular environment to promote the horizontal transfer of
bioactive molecules including microRNA (miRNA). The primary objective of this
study was to explore potential differences in miRNA content between OSCC and
OSCC stem cells. Methods The OSCC cell lines SCC4, SCC15, SCC25 and CAL27 were
used in... hiện toàn bộ
Abstract Procambarus clarkii is one of the important economic species in China
and has been served as tasty food in recent years after being introduced to
Nanjing. Significant problems of environment factors, such as salinity, pH and
temperature, especially salinity, has the potential to result in significant
economic losses in many crayfish-producing farms in China. miRNAs are a kind of
~ 22 nucl... hiện toàn bộ
Liang Li, Susu Mao, Jin Wang, Xin Ding, Jane Y. Zen
Neuroinflammation can be induced under several conditions including pathogen
infection such as virus. As the main immune cells in brain, microglia activation
plays a pivotal role in neuroinflammation by responding to the invading
pathogens (viral DNA/RNA) through toll-like receptors. Chronic activation of
microglia caused by sustained viral infection will lead to persistent release of
pro-inflamma... hiện toàn bộ
MicroRNAs (miRNAs) are naturally occurring, small non-coding RNAs that mediate
posttranscriptional regulation. Based on the level of sequence complementarity,
miRNAs lead to the degradation of target mRNAs or the suppression of mRNA
translation, thereby inhibiting the synthesis of proteins and achieving the
regulation of genes. miRNAs, which exhibit tissue- and temporal- specific
expression, are i... hiện toàn bộ