European Journal of Epidemiology

Experiments are described demonstrating that experimental insemination with autologous or homologous sperm into the ventral prostate or bladder neck of outbred Zbar male rats induces intravesical precipitation or stones. These observations suggest that clinical conditions resulting in intravesical sperm may be contributory to bladder lithiasis in man and may have relevance to its prevalence in men vs. women.

This prospective cohort study has been performed to evaluate the changes in student nurses smoking habits and beliefs during their training. The source of information was an anonymous questionnaire about tobacco smoking, administered to students who entered the first year of School of Nursing in Florence in 1991– 1992, 1992–1993 and 1993–1994. Five hundred and thirty-six (95%) of these student nurses completed the questionnaire. Five hundred and one (93%) of these 536 respondents completed the questionnaire again at the end of the third (final) year of training. Student nurses who smoked increased the average number of cigarettes smoked per day (p < 0.01) and the degree of dependence to nicotine (p < 0.01). Tobacco smoking remained widespread and the percentage of ex-smokers who started smoking again increased (p < 0.05). The knowledge about the health hazards due to tobacco smoking remained generic and the prevalence of current smokers among student nurses and health care workers was overestimated. We conclude that Nursing School does not succeed in reducing the smoking habits of students. Effective antitobacco strategies and smoking cessation services still need be organized in Italy.

Smoking is one of the most established risk factors for multiple sclerosis (MS). The aim of this study was to investigate how age at smoking debut, duration, intensity and cumulative dose of smoking, and smoking cessation influence the association between smoking and MS risk. In two Swedish population-based case–control studies (7,883 cases, 9,264 controls), subjects with different smoking habits were compared regarding MS risk, by calculating odds ratios with 95 % confidence intervals. We observed a clear dose response association between cumulative dose of smoking and MS risk (p value for trend <10−35). Both duration and intensity of smoking contributed independently to the increased risk of MS. However, the detrimental effect of smoking abates a decade after smoking cessation regardless of the cumulative dose of smoking. Age at smoking debut did not affect the association between smoking and MS. Smoking increases the risk of MS in a dose response manner. However, in contrary to several other risk factors for MS that seem to affect the risk only if the exposure takes place during a specific period in life, smoking affects MS risk regardless of age at exposure, and the detrimental effect slowly abates after smoking cessation.

The capture-recapture method is often confronted, when assessing completeness of surveys, to problems of dependence of data sources. The objective of this paper is to discuss the application of capture-recapture methods to choose the optimal combination of sources for a surveillance system. Our approach is based on: (1) using multiple sources, (2) assessing dependence between sources and between pools of dependent sources and other sources, (3) ruling out combinations that yield biased estimates, and (4) choosing the combinations of sources that have the best ratio between precision and applicability. We studied the independence for each pair of sources by computing the capture-recapture odds ratio. We characterized all combinations of sources by their sensitivity, coefficient of variation of the estimated number of cases, and level of resources needed to ascertain cases. Application of the approach is illustrated by data from a survey of thyroid cancer in New Caledonia, where five sources were used to estimate the incidence. The five sources provided 119 cases; the exhaustivity of sources and combinations of sources varied from 27.1 to 99.2%. Determination of dependence revealed ten dependencies out of 22 combinations. Coefficients of variation of the estimated number of cases varied from 0.83 to 27.79. The preferred combination included four sources and had a sensitivity of 97.5 and a coefficient of variation of 0.94. An assessment of dependence, based on simple criteria, can be used to choose the best combination of sources for a registry or a surveillance system.

Isolation of N. meningitidis from the male urethra has become more common in recent years and this has been attributed to sexual activities and changes in social attitudes. We describe a further case of acute urethritis caused by transmission of N. meningitidis occurring after a single sexual contact (fellatio) in a heterosexual man. The urethritis was initially diagnosed as being caused by N. gonorrhoeae on a presumptive basis, then attributed to N. meningitidis serogroup Y. This case shows the need of accurate diagnostic procedures in all cases resembling gonococcal urethritis.

Pertussis in healthcare workers is of particular concern, as they can be in contact with infected patients and may transmit the infection to susceptible patients, co-workers and other contacts. This study was carried out to examine the prevalence of pertussis antibodies in hospital personnel. A total of 487 healthcare workers ≥25 years in age and students (19–24 years) in hospital training were recruited. The overall prevalence of pertussis antibody determined by ELISA was 51.7%. No significant differences on prevalence by age group (19–24, 25–34, 35–44 and ≥45 years) and occupation (student, physician, nursing personnel and non-healthcare occupations) were found. In Spain, health care personnel in a general hospital will not have a significantly higher risk of serologically detectable contact with B. pertussis. Fifty percent of physicians and nursing personnel working in hospital were seronegative for pertussis antibody. A high percentage of these subjects will be susceptible to infection.

There are only few studies of the association between preterm birth and risk of chronic lung disease in old age. The aim of this study was to assess the association between poor fetal growth, preterm birth, sex and risk of asthma and Chronic Obstructive Pulmonary Disease (COPD) in adulthood. We have followed up a cohort of all infants born preterm (<35 weeks) or with low birth weight (<2,000 and <2,100 g for girls and boys, respectively) and an equal number of controls in a source population of 250,000 individuals born from 1925 through 1949 in Sweden (6,425 subjects in total). Cases of asthma and COPD were identified through the Swedish Patient Register and we considered cohort subjects as cases if they had a main or additional discharge diagnosis of asthma or COPD. For any obstructive airways disease, there was a statistically significant increase in risk with decreasing birth weight and gestational duration among women but not among men. Compared to women born at term, women born before 32 weeks of gestation had a hazard ratio for any obstructive airways disease and asthma of 2.77 (95 % CI 1.39–5.54) and 5.67 (1.73–18.6), respectively. Low birth weight and preterm birth are risk factors for obstructive airways disease also among the old, but the importance of these risk factors differs between the sexes.

A phage typing of 202 strains of Mycobacterium tuberculosis isolated in Central and Northwest Spain was carried out. The commonest phage type was A (64%) and within this type a0 (45%). This was followed in frequency by phage type B (26%) and in last place type I (10%). No relationship was observed between the phage type and the geographical or anatomical origin of the strains.