Endocrine
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Thyroid-specific changes following treatment with biological therapies in patients with rheumatic diseases
Endocrine - Tập 50 - Trang 146-153 - 2015
Biological anti-rheumatic agents (BAA) may induce autoimmune phenomena. Evidence on thyroid-specific effects of these agents is relatively limited. We studied prospectively, over 3 years, 36 rheumatic patients treated with BAA (18 Infliximab and 18 Rituximab) and no prior exposure to biological therapies (group-1), with respect to their thyroid function, thyroid antibody titers, and thyroid ultras......
The collagen matrix regulates the survival and function of pancreatic islets
Endocrine - - Trang 1-11 - 2023
The extracellular matrix (ECM) provides an appropriate microenvironment for many kinds of cells, including pancreatic cells. Collagens are the most abundant components of the ECM. Type I, IV, V and VI collagen has been detected in pancreatic islets, and each type plays important role in the proliferation, survival, function and differentiation of pancreatic cells. In some cases, collagens show beh......
Bone safety of dual-release hydrocortisone in patients with hypopituitarism
Endocrine - Tập 60 - Trang 528-531 - 2018
Insulin-like growth factor-1 causes a switch-like reduction of endogenous growth hormone mRNA in rat MtT/S somatotroph cells
Endocrine - Tập 13 - Trang 71-79 - 2000
Reduction of mRNA expression from the endogenous GH gene by insulin-like growth factor 1 (IGF-1) in somatotroph-like rat MtT/S cells was measured. GH mRNA levels were reduced by 65 nMIGF-1 treatment in a time-dependent manner over 5 d of culture with a calculated GH mRNA half-life of 50 h, in line with previous values from primary cultures. Inhibition of inositol 3-phosphate kinase by wortmannin o......
Impact of anti-oestrogen therapy on lipoprotein(a) in postmenopausal women: a systematic review and meta-analysis of double-blind placebo-controlled clinical studies
Endocrine - Tập 80 - Trang 292-302 - 2022
The potential mechanisms of endocrine therapy for thrombosis remain currently unclear, and more studies are warranted for further investigation and elucidation. However, high plasma concentration of lipoprotein(a) (Lp(a)) is a recognized prothrombotic factor. The aim of our study was to systematically evaluate the effect of different anti-oestrogen therapy on plasma Lp(a) level in postmenopausal w......
Progression and dormancy in metastatic thyroid cancer: concepts and clinical implications
Endocrine - Tập 70 - Trang 24-35 - 2020
Distant metastasis classically has been defined as a late-stage event in cancer progression. However, it has become clear that metastases also may occur early in the “lifetime” of a cancer and that they may remain stable at distant sites. This stability of metastatic cancer deposits has been termed “metastatic dormancy” or, as we term it, “metastatic progression dormancy” as the progression either......
Study of the role of novel RF-amide neuropeptides in affecting growth hormone secretion in a representative non-human primate (Macaca mulatta)
Endocrine - Tập 42 - Trang 658-663 - 2012
RF amide peptide family with distinctive terminal –Arg–Phe–NH2 signature is evolutionarily conserved from invertebrates to mammals. These neuropeptides have been shown to affect diverse functions in invertebrates and vertebrates including influencing pituitary hormone secretion. More recently, two members of this family 26-amino acid and 43-amino acid RF amide peptide (26RFa and 43RFa, respectivel......
Impact of microvascular complications on the outcomes of diabetic foot in type 2 diabetic patients with documented peripheral artery disease
Endocrine - Tập 80 - Trang 71-78 - 2022
Microvascular disease (MVD) is associated with amputation linked to peripheral artery disease (PAD) in the general population. No study evaluated the impact of diabetic microvascular complications on the outcomes of vascular diabetic foot ulcers (DFU). The aim of the study was to investigate whether retinopathy, nephropathy, and polyneuropathy can predict the outcomes of DFU in type 2 diabetic pat......
Erratum to: Prevalence and significance of thyroid uptake detected by 18F-FDG PET
Endocrine - Tập 40 - Trang 303-303 - 2011
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