EMBO Reports
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Species‐specific impact of the autophagy machinery on Chikungunya virus infectionChikungunya virus (CHIKV) is a recently re‐emerged arbovirus that triggers autophagy. Here, we show that CHIKV interacts with components of the autophagy machinery during its replication cycle, inducing a cytoprotective effect. The autophagy receptor p62 protects cells from death by binding ubiquitinated capsid and targeting it to autophagolysosomes. By contrast, the human autophagy recept... ...
EMBO Reports - Tập 14 Số 6 - Trang 534-544 - 2013
Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrestIndividuals affected by the autosomal recessive disorder Werner's syndrome (WS) develop many of the symptoms characteristic of premature ageing. Primary fibroblasts cultured from WS patients exhibit karyotypic abnormalities and a reduced replicative life span. The WRN gene encodes a 3′–5′ DNA helicase, and is a member of the RecQ family, which also includes the p... ...
EMBO Reports - Tập 1 Số 1 - Trang 80-84 - 2000
Sex and gender differences in healthThe new concept of evidence‐based sex and gender medicine—which includes the fundamental differences of biology and behaviour between women and men—should improve health care for both sexes.
EMBO Reports - Tập 13 Số 7 - Trang 596-603 - 2012
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1αIn mammalian cells, as in Schizosaccharomyces pombe and Drosophila , HP1 proteins bind histone H3 tails methylated on lysine 9 (K9). However, whereas K9‐methylated H3 histones are distributed throughout the nucleus, HP1 proteins are enriched in pericentromeric heterochromatin. This observation suggests that the methyl‐binding property of... ...
EMBO Reports - Tập 3 Số 10 - Trang 975-981 - 2002
Circ HIPK 3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells
EMBO Reports - Tập 18 Số 9 - Trang 1646-1659 - 2017
Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of NotchThe presenilin (PS)‐dependent site 3 (S3) cleavage of Notch liberates its intracellular domain (NICD), which is required for Notch signaling. The similar γ‐secretase cleavage of the β‐amyloid precursor protein (βAPP) results in the secretion of amyloid β‐peptide (Aβ). However, little is known about the corresponding C‐terminal cleavage product (CTFγ). We have now identified CTFγ in brain t... ...
EMBO Reports - Tập 2 Số 9 - Trang 835-841 - 2001
Mitochondrial shape changes: orchestrating cell pathophysiologyMitochondria are highly dynamic organelles, the location, size and distribution of which are controlled by a family of proteins that modulate mitochondrial fusion and fission. Recent evidence indicates that mitochondrial morphology is crucial for cell physiology, as changes in mitochondrial shape have been linked to neurodegeneration, calcium signalling, lifespan and cell death. Because im... ...
EMBO Reports - Tập 11 Số 9 - Trang 678-684 - 2010
Schistosomal extracellular vesicle‐enclosed miRNAs modulate host T helper cell differentiationAbstract During the chronic stage of Schistosoma infection, the female lays fertile eggs, triggering a strong anti‐parasitic type 2 helper T‐cell (Th2) immune response. It is unclear how this Th2 response gradually declines even though the worms live for years and continue to produce eggs. Here, we show that Schistosoma manson... ...
EMBO Reports - Tập 21 Số 1 - 2020
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