EMBO Reports
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Species‐specific impact of the autophagy machinery on Chikungunya virus infection
EMBO Reports - Tập 14 Số 6 - Trang 534-544 - 2013
Chikungunya virus (CHIKV) is a recently re‐emerged arbovirus that triggers
autophagy. Here, we show that CHIKV interacts with components of the autophagy
machinery during its replication cycle, inducing a cytoprotective effect. The
autophagy receptor p62 protects cells from death by binding ubiquitinated capsid
and targeting it to autophagolysosomes. By contrast, the human autophagy
receptor NDP52...
Werner's syndrome protein (WRN) migrates Holliday junctions and co‐localizes with RPA upon replication arrest
EMBO Reports - Tập 1 Số 1 - Trang 80-84 - 2000
Individuals affected by the autosomal recessive disorder Werner's syndrome (WS)
develop many of the symptoms characteristic of premature ageing. Primary
fibroblasts cultured from WS patients exhibit karyotypic abnormalities and a
reduced replicative life span. The WRN gene encodes a 3′–5′ DNA helicase, and is
a member of the RecQ family, which also includes the product of the Bloom's
syndrome gene...
Sex and gender differences in health
EMBO Reports - Tập 13 Số 7 - Trang 596-603 - 2012
The new concept of evidence‐based sex and gender medicine—which includes the
fundamental differences of biology and behaviour between women and men—should
improve health care for both sexes.
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α
EMBO Reports - Tập 3 Số 10 - Trang 975-981 - 2002
In mammalian cells, as in Schizosaccharomyces pombe and Drosophila, HP1 proteins
bind histone H3 tails methylated on lysine 9 (K9). However, whereas
K9‐methylated H3 histones are distributed throughout the nucleus, HP1 proteins
are enriched in pericentromeric heterochromatin. This observation suggests that
the methyl‐binding property of HP1 may not be sufficient for its heterochromatin
targeting. ...
Circ HIPK 3 sponges miR‐558 to suppress heparanase expression in bladder cancer cells
EMBO Reports - Tập 18 Số 9 - Trang 1646-1659 - 2017
Presenilin‐dependent γ‐secretase processing of β‐amyloid precursor protein at a site corresponding to the S3 cleavage of Notch
EMBO Reports - Tập 2 Số 9 - Trang 835-841 - 2001
The presenilin (PS)‐dependent site 3 (S3) cleavage of Notch liberates its
intracellular domain (NICD), which is required for Notch signaling. The similar
γ‐secretase cleavage of the β‐amyloid precursor protein (βAPP) results in the
secretion of amyloid β‐peptide (Aβ). However, little is known about the
corresponding C‐terminal cleavage product (CTFγ). We have now identified CTFγ in
brain tissue, i...
Mitochondrial shape changes: orchestrating cell pathophysiology
EMBO Reports - Tập 11 Số 9 - Trang 678-684 - 2010
Mitochondria are highly dynamic organelles, the location, size and distribution
of which are controlled by a family of proteins that modulate mitochondrial
fusion and fission. Recent evidence indicates that mitochondrial morphology is
crucial for cell physiology, as changes in mitochondrial shape have been linked
to neurodegeneration, calcium signalling, lifespan and cell death. Because
immune cel...
Schistosomal extracellular vesicle‐enclosed miRNAs modulate host T helper cell differentiation
EMBO Reports - Tập 21 Số 1 - 2020
AbstractDuring the chronic stage of Schistosoma infection, the female lays
fertile eggs, triggering a strong anti‐parasitic type 2 helper T‐cell (Th2)
immune response. It is unclear how this Th2 response gradually declines even
though the worms live for years and continue to produce eggs. Here, we show that
Schistosoma mansoni downregulates Th2 differentiation in an antigen‐presenting
cell‐indepen...
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