EMBO Molecular Medicine

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RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease
EMBO Molecular Medicine - Tập 9 Số 5 - Trang 589-604 - 2017
Huanhuan Zhu, Fangzhou Lou, Qianqian Yin, Yuanyuan Gao, Yang Sun, Jing Bai, Zhenyao Xu, Zhaoyuan Liu, Wei Cai, Ke Fang, Yukui Zhang, Hong Zhou, Hong Wang, Gang Wang, Xiang Chen, Hongxin Zhang, Zhugang Wang, Florent Ginhoux, Chuanjian Lu, Bing Su, Honglin Wang
Activation of rapid oestrogen signalling in aggressive human breast cancers
EMBO Molecular Medicine - Tập 4 Số 11 - Trang 1200-1213 - 2012
Coralie Poulard, Isabelle Treilleux, Emilie Lavergne, Katia Bouchekioua‐Bouzaghou, Sophie Goddard‐Léon, Sylvie Chabaud, Olivier Trédan, Laura Corbo, Muriel Le Romancer
AbstractOestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in breast cancer remains poorly defined. We have previously shown that methylation of ERα is required for the formation of the ERα/Src/PI3K complex and that ERα is hypermethylated in a subset of breast canc...... hiện toàn bộ
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria
EMBO Molecular Medicine - Tập 13 Số 10 - 2021
Álvaro González‐Domínguez, Raúl Montañez, Beatriz Castejón‐Vega, Jéssica Núñez‐Vasco, Débora Lendines‐Cordero, Chun Wang, Gabriel Mbalaviele, José M. Navarro‐Pando, Elísabet Alcocer‐Gómez, Mario D. Cordero
The 28‐amino acid form of an APLP1‐derived Aβ‐like peptide is a surrogate marker for Aβ42 production in the central nervous system
EMBO Molecular Medicine - Tập 1 Số 4 - Trang 223-235 - 2009
Kanta Yanagida, Masayasu Okochi, Shinji Tagami, Taisuke Nakayama, Takashi Kodama, Kouhei Nishitomi, Jingwei Jiang, Kohji Mori, Shinichi Tatsumi, Tetsuaki Arai, Takeshi Ikeuchi, Kensaku Kasuga, Takahiko Tokuda, Masaki Kondo, Masaki Ikeda, Kentaro Deguchi, Hiroaki Kazui, Toshihisa Tanaka, Takashi Morihara, Ryota Hashimoto, Takashi Kudo, Harald Steiner, Christian Haass, Kuniaki Tsuchiya, Haruhiko Akiyama, Ryozo Kuwano, Masatoshi Takeda
Plasmodium falciparum var genes expressed in children with severe malaria encode CIDR α1 domains
EMBO Molecular Medicine - Tập 8 Số 8 - Trang 839-850 - 2016
Jakob S. Jespersen, Christian W. Wang, Sixbert I. Mkumbaye, Daniel T. R. Minja, Bent Petersen, Louise Turner, Jens E. V. Petersen, John Lusingu, Thor G. Theander, Thomas Lavstsen
Low‐dose TNF augments fracture healing in normal and osteoporotic bone by up‐regulating the innate immune response
EMBO Molecular Medicine - Tập 7 Số 5 - Trang 547-561 - 2015
James Chan, Graeme E. Glass, Adel Ersek, Andrew Freidin, Graham V. Williams, Kate H.C. Gowers, Ana Isabel Espirito Santo, Rosemary Jeffery, W Otto, Richard Poulsom, Marc Feldmann, Sara M. Rankin, Nicole J. Horwood, Jagdeep Nanchahal
AbstractThe mechanism by which trauma initiates healing remains unclear. Precise understanding of these events may define interventions for accelerating healing that could be translated to the clinical arena. We previously reported that addition of low‐dose recombinant human TNF (rh... hiện toàn bộ
The amyloid hypothesis of Alzheimer's disease at 25 years
EMBO Molecular Medicine - Tập 8 Số 6 - Trang 595-608 - 2016
Dennis J. Selkoe, John Hardy
Human colon cancer epithelial cells harbour active HEDGEHOG‐GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
EMBO Molecular Medicine - Tập 1 Số 6-7 - Trang 338-351 - 2009
Frédéric Varnat, Arnaud Duquet, Monica Malerba, Marie Zbinden, Christophe Mas, Pascal Gervaz, Ariel Ruiz i Altaba
Functional systemic CD 4 immunity is required for clinical responses to PD ‐L1/ PD ‐1 blockade therapy
EMBO Molecular Medicine - Tập 11 Số 7 - 2019
Miren Zuazo, Hugo Arasanz, G. Fernández-Hinojal, María Jesús García-Granda, María Gato, Ana Bocanegra, M. Rico, Berta Hernández, Lucía Teijeira, Idoia Morilla, María José Lecumberri, Ángela Fernández de Lascoiti, Ruth Vera, Grazyna Kochan, David Escors
Sequential treatment with 5‐aza‐2′‐deoxycytidine and deacetylase inhibitors reactivates HIV‐1
EMBO Molecular Medicine - Tập 8 Số 2 - Trang 117-138 - 2016
Sophie Bouchat, Nadège Delacourt, Anna Kula, Gilles Darcis, Benoît Van Driessche, Francis Corazza, Jean‐Stéphane Gatot, Adeline Mélard, Caroline Vanhulle, Kabamba Kabeya, Marion Pardons, Véronique Avettand-Fènoël, Nathan Clumeck, Stéphane De Wit, Olivier Rohr, Christine Katlama, Carine Van Lint
AbstractReactivation of HIV gene expression in latently infected cells together with an efficient cART has been proposed as an adjuvant therapy aimed at eliminating/decreasing the reservoir size. Results from hiện toàn bộ
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