EMBO Molecular Medicine

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RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease
EMBO Molecular Medicine - Tập 9 Số 5 - Trang 589-604 - 2017
Huanhuan Zhu, Fangzhou Lou, Qianqian Yin, Yuanyuan Gao, Yang Sun, Jing Bai, Zhenyao Xu, Zhaoyuan Liu, Wei Cai, Ke Fang, Yukui Zhang, Hong Zhou, Hong Wang, Gang Wang, Xiang Chen, Hongxin Zhang, Zhugang Wang, Florent Ginhoux, Chuanjian Lu, Bing Su, Honglin Wang
Activation of rapid oestrogen signalling in aggressive human breast cancers
EMBO Molecular Medicine - Tập 4 Số 11 - Trang 1200-1213 - 2012
Coralie Poulard, Isabelle Treilleux, Emilie Lavergne, Katia Bouchekioua‐Bouzaghou, Sophie Goddard‐Léon, Sylvie Chabaud, Olivier Trédan, Laura Corbo, Muriel Le Romancer
AbstractOestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in breast cancer remains poorly defined. We have previously shown that methylation of ERα is required for the formation of the ERα/Src/PI3K complex and that ERα is hypermethylated in a subset of breast canc...... hiện toàn bộ
The 28‐amino acid form of an APLP1‐derived Aβ‐like peptide is a surrogate marker for Aβ42 production in the central nervous system
EMBO Molecular Medicine - Tập 1 Số 4 - Trang 223-235 - 2009
Kanta Yanagida, Masayasu Okochi, Shinji Tagami, Taisuke Nakayama, Takashi Kodama, Kouhei Nishitomi, Jingwei Jiang, Kohji Mori, Shinichi Tatsumi, Tetsuaki Arai, Takeshi Ikeuchi, Kensaku Kasuga, Takahiko Tokuda, Masaki Kondo, Masaki Ikeda, Kentaro Deguchi, Hiroaki Kazui, Toshihisa Tanaka, Takashi Morihara, Ryota Hashimoto, Takashi Kudo, Harald Steiner, Christian Haass, Kuniaki Tsuchiya, Haruhiko Akiyama, Ryozo Kuwano, Masatoshi Takeda
Plasmodium falciparum var genes expressed in children with severe malaria encode CIDR α1 domains
EMBO Molecular Medicine - Tập 8 Số 8 - Trang 839-850 - 2016
Jakob S. Jespersen, Christian W. Wang, Sixbert I. Mkumbaye, Daniel T. R. Minja, Bent Petersen, Louise Turner, Jens E. V. Petersen, John Lusingu, Thor G. Theander, Thomas Lavstsen
Low‐dose TNF augments fracture healing in normal and osteoporotic bone by up‐regulating the innate immune response
EMBO Molecular Medicine - Tập 7 Số 5 - Trang 547-561 - 2015
James Chan, Graeme E. Glass, Adel Ersek, Andrew Freidin, Graham V. Williams, Kate H.C. Gowers, Ana Isabel Espirito Santo, Rosemary Jeffery, W Otto, Richard Poulsom, Marc Feldmann, Sara M. Rankin, Nicole J. Horwood, Jagdeep Nanchahal
AbstractThe mechanism by which trauma initiates healing remains unclear. Precise understanding of these events may define interventions for accelerating healing that could be translated to the clinical arena. We previously reported that addition of low‐dose recombinant human TNF (rh... hiện toàn bộ
Human colon cancer epithelial cells harbour active HEDGEHOG‐GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion
EMBO Molecular Medicine - Tập 1 Số 6-7 - Trang 338-351 - 2009
Frédéric Varnat, Arnaud Duquet, Monica Malerba, Marie Zbinden, Christophe Mas, Pascal Gervaz, Ariel Ruiz i Altaba
IGSF 10 mutations dysregulate gonadotropin‐releasing hormone neuronal migration resulting in delayed puberty
EMBO Molecular Medicine - Tập 8 Số 6 - Trang 626-642 - 2016
Sasha Howard, Leonardo Guasti, Gerard Ruiz‐Babot, Alessandra Mancini, Alessia David, Helen Storr, Lou Metherell, Michael J.E. Sternberg, Claudia Cabrera, Helen R. Warren, Michael R. Barnes, Richard Quinton, Nicolás de Roux, Jacques Young, Anne Jouinot, Karoliina Wehkalampi, Valentina Andrè, Yoav Gothilf, Anna Cariboni, Leo Dunkel
Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease
EMBO Molecular Medicine - Tập 5 Số 10 - Trang 1556-1568 - 2013
Orit Harari‐Steinberg, Sally Metsuyanim, Dorit Omer, Yehudit Gnatek, Rotem Gershon, Sara Pri‐Chen, Derya D. Ozdemir, Yaniv Lerenthal, Tzahi Noiman, H Ben-Hur, Zvi Vaknin, David F. Schneider, Bruce J. Aronow, Ronald S. Goldstein, Peter Hohenstein, Benjamin Dekel
The orphan receptor TR3 participates in angiotensin II‐induced cardiac hypertrophy by controlling mTOR signalling
EMBO Molecular Medicine - Tập 5 Số 1 - Trang 137-148 - 2013
R. Wang, Jianping He, Maolong Su, Jie Luo, Ming Xu, Xiao‐Dan Du, Hang‐Zi Chen, Weijia Wang, Yuan Wang, Nan Zhang, Bixing Zhao, Wenxiu Zhao, Zhonggui Shan, Jiahuai Han, Chawnshang Chang, Qiao Wu
AbstractAngiotensin II (AngII) induces cardiac hypertrophy and increases the expression of TR3. To determine whether TR3 is involved in the regulation of the pathological cardiac hypertrophy induced by AngII, we established mouse and rat hypertrophy models using chronic AngII administration. Our results reveal that a deficiency of TR3 in mice or the knockdown of TR...... hiện toàn bộ
RGS 9‐2 rescues dopamine D2 receptor levels and signaling in DYT 1 dystonia mouse models
EMBO Molecular Medicine - Tập 11 Số 1 - 2019
Paola Bonsi, Giulia Ponterio, Valentina Vanni, Annalisa Tassone, Giuseppe Sciamanna, Sara Migliarini, Giuseppina Martella, Maria Meringolo, Benjamin Dehay, Évelyne Doudnikoff, Venetia Zachariou, Julie Jacquemyn, Nicola Biagio Mercuri, Marcello D’Amelio, Massimo Pasqualetti, Erwan Bézard, Antonio Pisani
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