EMBO Molecular Medicine

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RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease
EMBO Molecular Medicine - Tập 9 Số 5 - Trang 589-604 - 2017
Huanhuan Zhu, Fangzhou Lou, Qianqian Yin, Yuanyuan Gao, Yang Sun, Jing Bai, Zhenyao Xu, Zhaoyuan Liu, Wei Cai, Ke Fang, Yukui Zhang, Hong Zhou, Hong Wang, Gang Wang, Xiang Chen, Hongxin Zhang, Zhugang Wang, Florent Ginhoux, Chuanjian Lu, Bing Su, Honglin Wang
Activation of rapid oestrogen signalling in aggressive human breast cancers
EMBO Molecular Medicine - Tập 4 Số 11 - Trang 1200-1213 - 2012
Coralie Poulard, Isabelle Treilleux, Emilie Lavergne, Katia Bouchekioua‐Bouzaghou, Sophie Goddard‐Léon, Sylvie Chabaud, Olivier Trédan, Laura Corbo, Muriel Le Romancer
AbstractOestrogen receptors can mediate rapid activation of cytoplasmic signalling cascades by recruiting Src and PI3K. However, the involvement of this pathway in breast cancer remains poorly defined. We have previously shown that methylation of ERα is required for the formation of the ERα/Src/PI3K complex and that ERα is hypermethylated in a subset of breast canc...... hiện toàn bộ
Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria
EMBO Molecular Medicine - Tập 13 Số 10 - 2021
Álvaro González‐Domínguez, Raúl Montañez, Beatriz Castejón‐Vega, Jéssica Núñez‐Vasco, Débora Lendines‐Cordero, Chun Wang, Gabriel Mbalaviele, José M. Navarro‐Pando, Elísabet Alcocer‐Gómez, Mario D. Cordero
Chemokines: established and novel targets in atherosclerosis
EMBO Molecular Medicine - Tập 3 Số 12 - Trang 713-725 - 2011
Rory R. Koenen, Christian Weber
AbstractIn their role as small chemotactic cytokines, chemokines are crucial mediators and regulators of leukocyte trafficking during immune surveillance and inflammation. Their involvement in the development and progression of inflammatory diseases has been subject of intense investigation. Concordantly, the chemokine system has been explored in search for therape...... hiện toàn bộ
The 28‐amino acid form of an APLP1‐derived Aβ‐like peptide is a surrogate marker for Aβ42 production in the central nervous system
EMBO Molecular Medicine - Tập 1 Số 4 - Trang 223-235 - 2009
Kanta Yanagida, Masayasu Okochi, Shinji Tagami, Taisuke Nakayama, Takashi Kodama, Kouhei Nishitomi, Jingwei Jiang, Kohji Mori, Shinichi Tatsumi, Tetsuaki Arai, Takeshi Ikeuchi, Kensaku Kasuga, Takahiko Tokuda, Masaki Kondo, Masaki Ikeda, Kentaro Deguchi, Hiroaki Kazui, Toshihisa Tanaka, Takashi Morihara, Ryota Hashimoto, Takashi Kudo, Harald Steiner, Christian Haass, Kuniaki Tsuchiya, Haruhiko Akiyama, Ryozo Kuwano, Masatoshi Takeda
Inhibition of Sema4D/PlexinB1 signaling alleviates vascular dysfunction in diabetic retinopathy
EMBO Molecular Medicine - Tập 12 Số 2 - 2020
Jiehong Wu, Yanan Li, An‐Qi Chen, Candong Hong, Chunlin Zhang, Hailing Wang, Yifan Zhou, Pengcheng Li, Yong Wang, Ling Mao, Bowei Li, Quanwei He, Huijuan Jin, Zhenyu Yue, Bo Hu
Plasmodium falciparum var genes expressed in children with severe malaria encode CIDR α1 domains
EMBO Molecular Medicine - Tập 8 Số 8 - Trang 839-850 - 2016
Jakob S. Jespersen, Christian W. Wang, Sixbert I. Mkumbaye, Daniel T. R. Minja, Bent Petersen, Louise Turner, Jens E. V. Petersen, John Lusingu, Thor G. Theander, Thomas Lavstsen
Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine
EMBO Molecular Medicine - Tập 2 Số 5 - Trang 146-158 - 2010
Dora Dias‐Santagata, Sara Akhavanfard, S David, Kathy Vernovsky, Georgiana Kuhlmann, Susan L. Boisvert, Hannah Stubbs, Ultan McDermott, Jeffrey Settleman, Eunice L. Kwak, Jeffrey W. Clark, Steven J. Isakoff, Lecia V. Sequist, Jeffrey A. Engelman, Thomas J. Lynch, Daniel A. Haber, David N. Louis, Leif W. Ellisen, Darrell R. Borger, A. John Iafrate
AbstractTargeted cancer therapy requires the rapid and accurate identification of genetic abnormalities predictive of therapeutic response. We sought to develop a high‐throughput genotyping platform that would allow prospective patient selection to the best available therapies, and that could readily and inexpensively be adopted by most clinical laboratories. We de...... hiện toàn bộ
Low‐dose TNF augments fracture healing in normal and osteoporotic bone by up‐regulating the innate immune response
EMBO Molecular Medicine - Tập 7 Số 5 - Trang 547-561 - 2015
James Chan, Graeme E. Glass, Adel Ersek, Andrew Freidin, Graham V. Williams, Kate H.C. Gowers, Ana Isabel Espirito Santo, Rosemary Jeffery, W Otto, Richard Poulsom, Marc Feldmann, Sara M. Rankin, Nicole J. Horwood, Jagdeep Nanchahal
AbstractThe mechanism by which trauma initiates healing remains unclear. Precise understanding of these events may define interventions for accelerating healing that could be translated to the clinical arena. We previously reported that addition of low‐dose recombinant human TNF (rh... hiện toàn bộ
Functional genomics identifies five distinct molecular subtypes with clinical relevance and pathways for growth control in epithelial ovarian cancer
EMBO Molecular Medicine - Tập 5 Số 7 - Trang 1051-1066 - 2013
Tuan Zea Tan, Qing Hao Miow, Ruby Yun‐Ju Huang, M. K. Wong, Jieru Ye, Jieying Amelia Lau, Meng Wu, Luqman Hakim Bin Abdul Hadi, Richie Soong, Mahesh Choolani, Ben Davidson, Jahn M. Nesland, Lingzhi Wang, Noriomi Matsumura, Masaki Mandai, Ikuo Konishi, Boon Cher Goh, Jeffrey T. Chang, Jean Paul Thiery, Seiichi Mori
AbstractEpithelial ovarian cancer (EOC) is hallmarked by a high degree of heterogeneity. To address this heterogeneity, a classification scheme was developed based on gene expression patterns of 1538 tumours. Five, biologically distinct subgroups — Epi‐A, Epi‐B, Mes, Stem‐A and Stem‐B — exhibited significantly distinct clinicopathological ch...... hiện toàn bộ
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