Drugs

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Lanreotide Autogel®: A Review of its Use in the Treatment of Patients with Acromegaly
Drugs - Tập 74 - Trang 1673-1691 - 2014
Celeste B. Burness, Sohita Dhillon, Susan J. Keam
Lanreotide Autogel® (ATG) [Somatuline® Autogel®, Somatuline® Depot®] is a prolonged-release, supersaturated aqueous gel formulation of the somatostatin analogue lanreotide acetate that acts via somatostatin receptors to reduce both growth hormone and insulin-like growth factor-I levels. It is indicated for the treatment of patients with acromegaly who have had an inadequate response to or cannot b...... hiện toàn bộ
The Role of Lipid-Lowering Therapy in Multiple Risk Factor Management
Drugs - Tập 56 - Trang 1-7 - 2012
Ricardo J. Esper
Epidemiological studies have demonstrated that the risk of death from coronary heart disease (CHD) increases in parallel with increasing serum cholesterol levels. The risk is highest in patients with severely elevated cholesterol levels [i.e. >6.2 mmol/L (240 mg/dl)]. However, even in patients with serum cholesterol levels of 4.7 to 5.7 mmol/L (180 to 220 mg/dl), mortality from CHD is 30 to 70% hi...... hiện toàn bộ
Opioid-Induced Bowel Dysfunction
Drugs - Tập 72 Số 14 - Trang 1847-1865 - 2012
Christina Brock, Søren Schou Olesen, Anne Estrup Olesen, Jens Brøndum Frøkjær, Trine Andresen, Asbjørn Mohr Drewes
Problems in the Treatment of Urinary Tract Infections
Drugs - Tập 19 - Trang 190-194 - 2012
Kenneth F. Fairley, Judith A. Whitworth
Abuse and Misuse of Pregabalin and Gabapentin
Drugs - Tập 77 Số 4 - Trang 403-426 - 2017
Kirk E. Evoy, Megan D. Morrison, Stephen R. Saklad
Targeting Hyperglycaemia with Anti-Obesity Drugs: Time for a Paradigm Shift?
Drugs - Tập 73 - Trang 1649-1651 - 2013
Andrew J. Krentz, Marcus Hompesch
Semaglutide: First Global Approval
Drugs - Tập 78 - Trang 275-284 - 2018
Sohita Dhillon
Novo Nordisk has developed a subcutaneous formulation of semaglutide (Ozempic®), a modified human glucagon-like peptide-1 (GLP-1) analogue, for the treatment of type 2 diabetes mellitus. It has been developed using Novo Nordisk’s proprietary protein-acylation technology, and is administered using an injection device. Semaglutide lowers blood glucose by stimulating the release of insulin and also l...... hiện toàn bộ
Biochemistry and Pharmacology of the Renin-Angiotensin System
Drugs - Tập 39 - Trang 21-31 - 2012
C. I. Johnston
Knowledge of the structure, function and distribution of the components of the renin-angiotensin-aldosterone system (RAS) and the integrated physiological role of this hormonal system is rapidly increasing, although many questions remain unanswered. The primary structure and localisation of RAS such as renin, prorenin, angiotensinogen, angiotensin-converting enzyme (ACE) and the angiotensins have ...... hiện toàn bộ
Azithromycin
Drugs - Tập 51 - Trang 483-505 - 2012
Christopher J. Dunn, Lee B. Barradell
The azalide antibacterial agent azithromycin is a semisynthetic acid-stable erythromycin derivative with an expanded spectrum of activity and improved tissue pharmacokinetic characteristics relative to erythromycin. The drug is noted for its activity against some Gram-negative organisms associated with respiratory tract infections, particularly Haemophilus influenzae. Azithromyc...... hiện toàn bộ
Gut Hormones as Potential New Targets for Appetite Regulation and the Treatment of Obesity
Drugs - Tập 68 - Trang 147-163 - 2012
Benjamin C. T. Field, Alison M. Wren, Dunstan Cooke, Stephen R. Bloom
Food intake and bodyweight are tightly regulated by the brainstem, hypothalamus and reward circuits. These centres integrate diverse cognitive inputs with humoral and neuronal signals of nutritional status. Our knowledge of the role of gut hormones in this complex homeostatic system has expanded enormously in recent years. This review discusses both the role of gut hormones in appetite regulation,...... hiện toàn bộ
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