Drugs
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Indinavir
Drugs - Tập 58 - Trang 1165-1203 - 2012
Indinavir is a protease inhibitor used in the treatment of patients with HIV infection. Combination antiretroviral therapy with indinavir plus 2 nucleoside reverse transcriptase inhibitors (NRTIs) is associated with greater reductions in viral load, greater increases in CD4+ cell counts, and reduced morbidity and mortality when compared with 2 NRTIs alone. In the landmark clinical trial ACTG 320, ...... hiện toàn bộ
Parenteral-Oral Switch in the Management of Paediatric Pneumonia
Drugs - Tập 47 Số Supplement 3 - Trang 43-51 - 1994
In Search of the Optimal Antithrombotic Regimen for Intracerebral Hemorrhage Survivors with Atrial Fibrillation
Drugs - Tập 82 - Trang 965-977 - 2022
Spontaneous intracerebral hemorrhage (ICH) constitutes 10–15% of all strokes, and is a significant cause of mortality and morbidity. Survivors of ICH, especially those with atrial fibrillation (AF), are at risk for both recurrent hemorrhagic and ischemic cerebrovascular events. A conundrum in the field of vascular neurology, neurosurgery, and cardiology has been the decision to initiate or resume ...... hiện toàn bộ
Current Options in the Prevention of Thromboembolic Disease
Drugs - Tập 64 Số 1 - Trang 1-5 - 2004
Significant advances in the pharmacological prophylaxis of venous thromboembolism have occurred since warfarin and unfractionated heparin were introduced for this indication nearly 60 years ago. Despite these advances, coumarin derivatives such as warfarin remain the only orally active anticoagulants available for prophylaxis in venous thromboembolism. Although administered orally, coumarin deriva...... hiện toàn bộ
Pharmacokinetic Optimisation of Sustained-Release Bupropion for Smoking Cessation
Drugs - Tập 62 - Trang 11-24 - 2012
Sustained-release bupropion (bupropion SR) is a unique, non-nicotine smoking cessation aid that is hypothesised to act upon neurological pathways involved in nicotine dependence. Pharmacokinetic and metabolism studies reveal that bupropion SR is metabolised by multiple pathways with no single pathway predominating. When one pathway is inhibited, others are available to compensate. Therefore, only ...... hiện toàn bộ
ACE Inhibitors in the Prevention and Therapy of Diabetic Nephropathy
Drugs - Tập 39 - Trang 639-645 - 2012
The Treatment of Glaucoma: Role of β-Blocking Agents
Drugs - Tập 18 - Trang 25-32 - 2012
The sudden development of a red painful eye with blurred vision may be an acute attack of angle closure glaucoma which requires emergency attention. Once the attack is controlled with medication, surgical intervention with a peripheral iridectomy is indicated to relieve relative pupillary block. Eyes subject to angle closure glaucoma are anatomically different with ‘crowded’ anterior segments. In ...... hiện toàn bộ
The Problem of Non-Compliance in Long-Term Antihypertensive Therapy
Drugs - Tập 11 - Trang 86-90 - 2012
Of 1,593 subjects admitted to the Australian National Blood Pressure Study 1 to 2 years ago, a substantial number (391 or 24.5%) ceased attending, in 85% of cases voluntarily. Withdrawal rates were very high in the first 4 months, settling to 5% per annum by the second year. Extrapolation to clinical practice is hazardous but contributory factors elicited by questionnaire suggest certain managemen...... hiện toàn bộ
Linzagolix: First Approval
Drugs - Tập 82 - Trang 1317-1325 - 2022
Linzagolix (Yselty®) is an orally administered, selective, non-peptide small molecule gonadotrophin releasing hormone (GnRH) receptor antagonist that is being developed by Kissei Pharmaceutical for the treatment of uterine fibroids and endometriosis in women of reproductive age. Linzagolix binds to and blocks the GnRH receptor in the pituitary gland, modulating the hypothalamic pituitary-gonadal a...... hiện toàn bộ
Cefetamet Pivoxil in the Treatment of Pharyngitis/Tonsillitis in Children and Adults
Drugs - Tập 47 - Trang 27-34 - 2012
Between 15 and 35% of pharyngeal infections are attributable to Group A β-haemolytic streptococci. Streptococcal pharyngitis is one of the most common infections in adolescents and children. A specific diagnosis of pharyngitis can be obtained only by isolating organisms in culture. The current treatment of choice for streptococcal pharyngitis/tonsillitis is a 10-day course of phenoxymethylpenicill...... hiện toàn bộ
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