Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T CellsDoklady Biochemistry and Biophysics - Tập 506 - Trang 181-184 - 2022
O. K. Ivanova, T. N. Sharapova, E. A. Romanova, L. P. Sashchenko, D. V. Yashin, G. P. Georgiev
One of the basic features of immune system is the ability to sustain balance between activation and suppression of effector lymphocytes. In this process a key role belongs to the subpopulation of cells called regulatory T cells (Treg). Many cancer and autoimmune diseases are caused by malfunctions of Treg, and investigation of this subpopulation is important for development of new therapeutic appr...... hiện toàn bộ
HspBP1 in Complex with the Peptide of the Innate Immunity Protein Tag7 is Able to Lyse Tumor Cells Carrying TNFR1 ReceptorDoklady Biochemistry and Biophysics - - Trang 1-5 - 2024
E. A. Romanova, D. M. Yurkina, D. V. Yashin, L. P. Sashchenko, G. P. Georgiev
The search for new cytotoxic agents capable of lysing tumor cells is an important task in the fight against cancer. Here we have shown that the HspBP1 protein, the chaperone of the heat shock protein Hsp70, is able to form a complex with the previously discovered peptide (17.1) of the innate immunity protein Tag7. Experiments using thermophoresis demonstrated that the affinity of the Tag7 protein ...... hiện toàn bộ
The Effect of Polymetallic Pollution on Ion-Exchange Properties of Barley Root and Shoot Cell WallsDoklady Biochemistry and Biophysics - Tập 501 - Trang 415-418 - 2021
N. R. Meychik, Yu. I. Nikolaeva, O. V. Nikushin, M. A. Kushunina
For the first time we determined the ion-exchange properties of the cell walls (CWs) isolated from roots and shoots of barley plants grown in the conditions of polymetallic pollution. The content of all the types of cation-exchange groups in the CWs was found to be considerably higher in the shoots than in the roots, which resulted in higher metal-binding capacity of the shoot CWs and higher swell...... hiện toàn bộ