Tag7–Mts1 Complex Activates Chemotaxis of Regulatory T CellsDoklady Biochemistry and Biophysics - Tập 506 - Trang 181-184 - 2022
O. K. Ivanova, T. N. Sharapova, E. A. Romanova, L. P. Sashchenko, D. V. Yashin, G. P. Georgiev
One of the basic features of immune system is the ability to sustain balance
between activation and suppression of effector lymphocytes. In this process a
key role belongs to the subpopulation of cells called regulatory T cells (Treg).
Many cancer and autoimmune diseases are caused by malfunctions of Treg, and
investigation of this subpopulation is important for development of new
therapeutic appr... hiện toàn bộ
HspBP1 in Complex with the Peptide of the Innate Immunity Protein Tag7 is Able to Lyse Tumor Cells Carrying TNFR1 ReceptorDoklady Biochemistry and Biophysics - - Trang 1-5 - 2024
E. A. Romanova, D. M. Yurkina, D. V. Yashin, L. P. Sashchenko, G. P. Georgiev
The search for new cytotoxic agents capable of lysing tumor cells is an
important task in the fight against cancer. Here we have shown that the HspBP1
protein, the chaperone of the heat shock protein Hsp70, is able to form a
complex with the previously discovered peptide (17.1) of the innate immunity
protein Tag7. Experiments using thermophoresis demonstrated that the affinity of
the Tag7 protein ... hiện toàn bộ