Deutsche Zeitschrift für Nervenheilkunde
1432-1459
0367-004x
Cơ quản chủ quản: Springer Heidelberg , D. Steinkopff-Verlag
Lĩnh vực:
NeurologyNeurology (clinical)
Phân tích ảnh hưởng
Thông tin về tạp chí
Các bài báo tiêu biểu
Progression of parkinsonism in multiple system atrophy
Tập 252 - Trang 91-96 - 2005
Progression of parkinsonian motor impairment is usually rapid and relentless in multiple system atrophy (MSA). However, it may also be subject to considerable variation. Prospective natural history studies using validated rating scales are required to accurately determine the progression of parkinsonism in MSA. To assess the progression of parkinsonism in patients with the Parkinson variant of MSA. Parkinsonian motor impairment was assessed on regular therapy at two time points (mean follow-up 11.8 months, SD 1.4) using the Hoehn and Yahr scale (H&Y), the Schwab and England ADL scale (SES) and the motor examination section of the UPDRS (UPDRS-III) in 38 patients with clinically probable MSA-P. We examined 38 patients with probable MSA-P (mean age 63.2 years, SD 7.4; mean disease duration 4.1 years, SD 3.0). The mean difference of UPDRS-III between baseline and follow-up was 10.8 (95% CI 8.6–12.9), consistent with an average annual 28.3 % increase of UPDRS-III baseline scores. Several variables were associated with faster progression of parkinsonism including low baseline global motor disability as assessed by H&Y and SES, low baseline UPDRS III score, and short disease duration. UPDRS-III progression was unrelated to gender, age at symptom onset, and age at baseline visit. This is the first observational study on UPDRS rates of decline in MSA. The observed 28.6% annual increase of UPDRSIII scores illustrates the rapid progression of motor impairment in MSA. Furthermore,motor progression appeared to be accelerated during the early disease stages.Our data allow sample size calculations that may be helpful for the planning of future therapeutic trials.
Increased aneurysm wall permeability colocalized with low wall shear stress in unruptured saccular intracranial aneurysm
Tập 269 - Trang 2715-2719 - 2021
Aneurysm wall permeability has recently emerged as an in vivo marker of aneurysm wall remodeling. We sought to study the spatial relationship between hemodynamic forces derived from 4D-flow MRI and aneurysm wall permeability by DCE-MRI in a region-based analysis of unruptured saccular intracranial aneurysms (IAs). We performed 4D-flow MRI and DCE-MRI on patients with unruptured IAs of ≥ 5 mm to measure hemodynamic parameters, including wall shear stress (WSS), oscillatory shear index (OSI), WSS temporal (WSSGt) and spatial (WSSGs) gradient, and aneurysm wall permeability (Ktrans) in different sectors of aneurysm wall defined by evenly distributed radial lines emitted from the aneurysm center. The spatial association between Ktrans and hemodynamic parameters measured at the sector level was evaluated. Thirty-one patients were scanned. Ktrans not only varied between aneurysms but also demonstrated spatial heterogeneity within an aneurysm. Among all 159 sectors, higher Ktrans was associated with lower WSS, which was seen in both Spearman’s correlation analysis (rho = − 0.18, p = 0.025) and linear regression analysis using generalized estimating equation to account for correlations between multiple sectors of the same aneurysm (regression coefficient = − 0.33, p = 0.006). Aneurysm wall permeability by DCE-MRI was shown to be spatially heterogenous in unruptured saccular IAs and associated with local WSS by 4D-flow MRI.
Miller–Fisher-like syndrome related to SARS-CoV-2 infection (COVID 19)
Tập 267 Số 9 - Trang 2495-2496 - 2020
Guillain-Barré syndrome following COVID-19: new infection, old complication?
Tập 267 Số 7 - Trang 1877-1879 - 2020
Survival and outcome in 73 anti-Hu positive patients with paraneoplastic encephalomyelitis/sensory neuronopathy
Tập 249 Số 6 - Trang 745-753 - 2002
Untersuchungen des Liquor cerebrospinalis mit dem Zeißschen Spektrographen für Chemiker
Tập 111 - Trang 5-18 - 1929
Next-generation sequencing: a decisive diagnostic aid for atypical Wilson’s disease
Tập 269 - Trang 6664-6666 - 2022