Vitiligo: A Review Tập 236 Số 6 - Trang 571-592 - 2020
Christina Bergqvist, Khaled Ezzedine
Vitiligo, a common depigmenting skin disorder, has an estimated prevalence of 0.5–2% of the population worldwide. The disease is characterized by the selective loss of melanocytes which results in typical nonscaly, chalky-white macules. In recent years, considerable progress has been made in our understanding of the pathogenesis of vitiligo which is now clearly classified as an autoimmune ...... hiện toàn bộ
Cardiovascular Disease and Risk Factors among Psoriasis Patients in Two US Healthcare Databases, 2001–2002 Tập 217 Số 1 - Trang 27-37 - 2008
Alexa B. Kimball, Don Robinson, Ying Wu, Cynthia Guzzo, Newman Yeilding, Clark Paramore, Kathy Fraeman, M Bala
<i>Background:</i> Cardiovascular diseases or risk factors (CVDR) seem to be more common in psoriasis patients than in the general population. <i>Objective:</i> We assessed the relationship of psoriasis with CVDR by analysis of healthcare claims data using a cross-sectional, prevalence-based study design. <i>Patients and Methods:</i> The IMS Health and M...... hiện toàn bộ
Cornified Cell Envelope Tập 180 Số 4 - Trang 201-211 - 1990
Daniel Hohl
The cornified cell envelope (CE) is a highly insoluble structure on the inside of the plasma membrane of terminally differentiated keratinocytes. The cellular and molecular biology of the CE is outlined and new areas of research involving the CE are reviewed focussing on morphological and biochemical connections, the sequential gene expression during terminal differentiation, the interacti...... hiện toàn bộ
Randomized Double-Blind Multicenter Study Comparing Acitretin-PUVA, Etretinate-PUVA and Placebo-PUVA in the Treatment of Severe Psoriasis Tập 177 Số 4 - Trang 218-224 - 1988
J H Saurat, J.-M. Geiger, P Amblard, J.-C. Béani, A Boulanger, A Claudy, E. Frenk, J J Guilhou, E Grosshans, Y. Mérot
A randomized double-blind study was designed with 65 patients in order to clarify two points: (1) does addition of a retinoid to psoralen-ultra violet A photochemotherapy (PUVA) of severe psoriasis decrease the UVA energy required to achieve remission, and (2) is there a difference between two retinoids, i.e. etretinate and acitretin. Acitretin-PUVA treatment was significantly superior to ...... hiện toàn bộ
Mu-Opiate Receptor and Beta-Endorphin Expression in Nerve Endings and Keratinocytes in Human Skin Tập 209 Số 3 - Trang 183-189 - 2004
Mei Bigliardi‐Qi, Lazar T. Sumanovski, S.A. Büchner, T Rufli, Paul L. Bigliardi
We have previously shown that human epidermal keratinocytes express a functionally active µ-opiate receptor, which adds a new dimension to the recently developed research in neuroimmunodermatology and neurogenic inflammation in skin diseases. Human keratinocytes specifically bind and also produce β-endorphin, the endogenous µ-opiate receptor ligand. Using confocal imaging microscopy, we co...... hiện toàn bộ
Acitretin (Ro 10-1670, Etretin): Overall Evaluation of Clinical Studies Tập 176 Số 4 - Trang 182-190 - 1988
J.-M. Geiger, B M Czarnetzki
Acitretin (Ro 10-1670, etretin) is the free acid derivative of etretinate. This compound possesses a much shorter half-life of elimination than etretinate and was therefore proposed for clinical development. A total of 635 patients with various dermatoses were studied in 12 main clinical trials performed in Europe and in the United States. It was shown that acitretin is effective in the tr...... hiện toàn bộ
Erythematous Eruption of the Palms and Soles Associated with Mitotane Therapy Tập 148 Số 2 - Trang 90-92 - 1974
Richard L. Zuehlke
An unusual eruption was observed in a man being treated with mitotane. His palms and soles developed an erythematous, edematous, partially petechial rash, which was present primarily in areas subjected to pressure. The patient experienced pruritus, burning, and tenderness in areas of the eruption.