Dermatology

  1018-8665

  1421-9832

  Thụy Sĩ

Cơ quản chủ quản:  KARGER , S. Karger AG

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Dermatology

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Published since 1893, Dermatology provides a worldwide survey of clinical and investigative dermatology. Original papers report clinical and laboratory findings. In order to inform readers of the implications of recent research, reviews prepared by invited, internationally recognized scientists are regularly featured. In addition, the journal publishes papers on novel treatments, surgical pearls, consensus guidelines and industry news. Dermatology offers the analytical dermatologist a broad range of information, from practical problem solving to a deeper mechanistic understanding of skin diseases, while at the same time providing space for further hypotheses that may help to find new solutions to old problems. The journal publishes contributions from across the globe on a wide range of skin-related topics including epidemiology, skin biology, clinical dermatology, and therapy. It enjoys a high reputation in the field of dermatology.

Các bài báo tiêu biểu

Oral Isotretinoin in HIV-Positive Women with Acne: Report of Three Cases
Tập 196 Số 1 - Trang 163-164 - 1998
M. Harms, M. Péchère, J. Krischer, E Studer, Jean‐Hilaire Saurat
Paronychia with Pyogenic Granuloma in a Child Treated with Indinavir: The Retinoid-Mediated Side Effect Theory Revisited
Tập 200 Số 1 - Trang 40-42 - 2000
Jörn Oliver Sass, B. Jakob-Sölder, Andreas Heitger, Georg Tzimas, Mario Sarcletti
<b>Background:</b> The introduction of HIV-1 protease inhibitors into the treatment of patients infected with HIV-1 has had a major influence on clinical practice. However, the use of protease inhibitors is frequently associated with the development of resistance and several side effects and interactions with other drugs have been reported. <b>Observations:</b> We present the first pediatric patient with paronychia with pyogenic granuloma associated with the administration of the protease inhibitor indinavir. Clinical findings are discussed in view of a possible interference of indinavir with endogenous retinoid metabolism. <b>Conclusion:</b> Considerable evidence advocates the mediation of indinavir side effects by impaired oxidative metabolism of retinoic acid through the inhibition of cytochromes P450 3A by indinavir rather than by impaired formation of 9-cis-retinoic acid.
HIV-Associated Eosinophilic Folliculitis and Follicular Mucinosis
Tập 197 Số 2 - Trang 178-180 - 1998
G.F. Buezo, Javier Fraga, Patricia Abajo, Lívia Teresa Moreira Rios, E. Daudén, Amaro García‐Díez
The term HIV-associated eosinophilic folliculitis (EF) designates an idiopathic dermatitis that appears in HIV-infected patients with different clinical manifestations but with a distinctive histological feature characterized by a predominantly eosinophilic infiltrate in the follicular infundibula. On the other side, follicular mucinosis (FM) is a reaction pattern in the follicular epithelium, characterized by a mucinous degeneration of the outer sheath of follicles and sebaceous glands. It has been described in association with a variety of unrelated conditions. We report 2 HIV-infected patients with a pruritic papular eruption. Histopathological study revealed the coexistence of EF and FM. To our knowledge, this is the first report that describes this association. The possible relationship between these two entities is discussed.
Lipodystrophia centrifugalis abdominalis juvenilis
Tập 164 Số 2 - Trang 95-100 - 1982
Sungnack Lee, W Houh, Young Keun Kim, Soo Ill Chun, Baik Kee Cho
8 Korean children exhibited well-defined depressed lesions of the skin accompanied by slight redness of the surrounding area. First these lesions appeared in the inguinal area and then spread peripherally to the navel region and the ipsilateral vulval area. In these 8 cases, 7 occurred in girls and 1 in a boy. The age of onset ranged from 2 to 9 years. Biopsy specimens taken from the well-depressed area showed a decrease in or absence of, subcutaneous fat and a mild inflammatory infiltrate of lymphocytes and histiocytes in the lower dermis and subcutis. These 8 cases are the first, to our knowledge, to be reported outside Japan and considering the age of onset of the dermatosis it is not confined to infants. Therefore, we would like to describe this entity under the title of lipodystrophia centrifugalis abdominalis juvenilis instead of lipodystrophia centrifugalis abdominalis infantilis.
Lipo-Atrophia Annularis, an Abnormal Vulnerability of the Fatty Tissue
Tập 134 Số 2 - Trang 107-112 - 1967
W. Bruinsma
Alopecia areata during Interferon Alpha-2b/Ribavirin Therapy
Tập 205 Số 3 - Trang 300-301 - 2002
N. Agesta, Rosa Zabala, J.L. Díaz-Pérez
Cutaneous Reactions in Patients with Chronic Hepatitis C Treated with Peginterferon and Ribavirin
Tập 228 Số 1 - Trang 42-46 - 2014
Ivana Patrk, Miro Morović, Anamarija Markulin, Jogen Patrk
<b><i>Background/Objective:</i></b> Peginterferon alfa and ribavirin could cause various cutaneous reactions. Treatment-related cutaneous reactions are common, and treatable complications can contribute to the treatment discontinuation. <b><i>Methods:</i></b> We performed a 6-year prospective study of cutaneous reactions in 271 patients with chronic hepatitis C treated with peginterferon and ribavirin. <b><i>Results:</i></b> Cutaneous reactions of mild to moderate degree were seen in 36 (13.3%) patients: localized cutaneous reactions in 7 (2.6%) patients, generalized reactions - pruritus, skin xerosis and eczematous changes - in 28 (10.3%) patients, alopecia in 11 (4.1%) patients; exacerbation of lichen planus was seen in 1 patient. <b><i>Conclusion:</i></b> The study showed a relatively low prevalence of cutaneous reactions without the need for discontinuation of any of the drugs used. These reactions correlated only with the age of the patients and treatment duration. This finding is of particular importance with regard to the recently introduced direct-acting antivirals in the treatment of hepatitis C virus infection, which can cause a very severe form of cutaneous reactions.
Alopecia areata Induced by Adjuvant Treatment with Alpha-Interferon in Malignant Melanoma?
Tập 209 Số 3 - Trang 249-250 - 2004
Peter Radny, Jürgen Bauer, Ulrich M. Caroli, Thomas Eigentler, Anne Kamin, Gisela Metzler, Claus Garbe
Structure and Function of Human Stratum corneum under Deformation
Tập 205 Số 4 - Trang 353-357 - 2002
Jean‐Luc Lévêque, P. Hallégot, J. Doucet, Gérald Pierard
<i>Background:</i> The stratum corneum (SC) has an important barrier function. The effect of a mechanical stress applied to the SC is controversial on this important physiological parameter. <i>Objective and Methods:</i> To assess both in vitro and in vivo the structure and function of human SC submitted to controlled strains, we measured the transepidermal water loss (TEWL), in vivo, on human skin submitted to controlled strains ranging from 0 to 20% extension imposed by a Densi-score device. We also looked at the structure of the SC by means of X-ray diffraction and transmission electron microscopy. <i>Results:</i> Transmission electron microscopy and X-ray diffraction analysis were performed on harvested and stretched human SC. TEWL was not significantly influenced by the relative deformation applied to the skin. At high strain (60%) imposed in vitro to the SC, lipid bilayers and corneosomes were detached from corneocytes. Only rare corneosomes showed internal disruption. X-ray analysis did not reveal modifications in the supramolecular organization of intercellular lipids while stretching the SC. <i>Conclusion:</i> Submitting human SC to an extension force up to 20% elongation does not significantly alter the barrier function.
Human Herpesvirus 7 in Patients with Pityriasis rosea
Tập 195 Số 4 - Trang 374-378 - 1997
Francesco Drago, E. Ranieri, Fabiana Malaguti, M.L. Battifoglio, E. Losi, A. Reborn