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Current Topics in Developmental Biology

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Germ cells undergo epigenome reprogramming for proper development of the next generation. The achievement of in vitro germ cell derivation from human and mouse pluripotent stem cells and further differentiation in a plane culture and in aggregation with gonadal somatic cells offers unprecedented opportunities for investigation of the germ cell development. Moreover, advances in low-input/single-ce...... hiện toàn bộ
#In vitro gametogenesis #PGCLCs #DNA methylation #Histone modification #Chromatin remodeling #Imprint #Single-cell genomics