Aging and Regeneration in Vertebrates

Abbas, 2010, Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity, Cell Stem Cell, 7, 606, 10.1016/j.stem.2010.09.013 Allsopp, 2003, Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation, Blood, 102, 517, 10.1182/blood-2002-07-2334 Alt, 2012, Aging alters tissue resident mesenchymal stem cell properties, Stem Cell Research, 8, 215, 10.1016/j.scr.2011.11.002 Aoshiba, 2009, Senescence hypothesis for the pathogenetic mechanism of chronic obstructive pulmonary disease, Proceedings of the American Thoracic Society, 6, 596, 10.1513/pats.200904-017RM Baddour, 2012, Organ repair and regeneration: An overview, Birth Defects Research. Part C, Embryo Today, 96, 1, 10.1002/bdrc.21006 Baker, 2011, Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders, Nature, 479, 232, 10.1038/nature10600 Ballard, 2010, Stem cells for heart failure in the aging heart, Heart Failure Reviews, 15, 447, 10.1007/s10741-010-9160-z Barberi, 2013, Age-dependent alteration in muscle regeneration: The critical role of tissue niche, Biogerontology, 14, 273, 10.1007/s10522-013-9429-4 Barton-Davis, 1998, Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function, Proceedings of the National Academy of Sciences of the United States of America, 95, 15603, 10.1073/pnas.95.26.15603 Basu-Roy, 2010, The transcription factor Sox2 is required for osteoblast self-renewal, Cell Death and Differentiation, 17, 1345, 10.1038/cdd.2010.57 Beccafico, 2011, Human muscle satellite cells show age-related differential expression of S100B protein and RAGE, Age (Dordrecht, Netherlands), 33, 523, 10.1007/s11357-010-9197-x Beerman, 2013, Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging, Cell Stem Cell, 12, 413, 10.1016/j.stem.2013.01.017 Beggs, 2004, Alterations in the TGFbeta signaling pathway in myogenic progenitors with age, Aging Cell, 3, 353, 10.1111/j.1474-9728.2004.00135.x Biondo-Simoes Mde, 2006, Effect of aging on liver regeneration in rats, Acta Cirúrgica Brasileira, 21, 197, 10.1590/S0102-86502006000400002 Bjornson, 2012, Notch signaling is necessary to maintain quiescence in adult muscle stem cells, Stem Cells, 30, 232, 10.1002/stem.773 Bocker, 2011, Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging, Blood, 117, e182, 10.1182/blood-2011-01-331926 Boon, 2013, MicroRNA-34a regulates cardiac ageing and function, Nature, 495, 107, 10.1038/nature11919 Brack, 2007, Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis, Science, 317, 807, 10.1126/science.1144090 Brignull, 2009, Feathers and fins: Non-mammalian models for hair cell regeneration, Brain Research, 1277, 12, 10.1016/j.brainres.2009.02.028 Brown, 2013, SIRT3 reverses aging-associated degeneration, Cell Reports, 3, 319, 10.1016/j.celrep.2013.01.005 Buford, 2013, Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults, Journal of Applied Physiology, 10.1152/japplphysiol.01350.2012 Buga, 2011, Brain aging and regeneration after injuries: An organismal approach, Aging and Disease, 2, 64 Carlson, 2007, Loss of stem cell regenerative capacity within aged niches, Aging Cell, 6, 371, 10.1111/j.1474-9726.2007.00286.x Carlson, 2009, Relative roles of TGF-beta1 and Wnt in the systemic regulation and aging of satellite cell responses, Aging Cell, 8, 676, 10.1111/j.1474-9726.2009.00517.x Carlson, 1989, Muscle transplantation between young and old rats: Age of host determines recovery, The American Journal of Physiology, 256, C1262, 10.1152/ajpcell.1989.256.6.C1262 Carlson, 2008, Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells, Nature, 454, 528, 10.1038/nature07034 Cerletti, 2012, Short-term calorie restriction enhances skeletal muscle stem cell function, Cell Stem Cell, 10, 515, 10.1016/j.stem.2012.04.002 Chai, 2012, Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea, Proceedings of the National Academy of Sciences of the United States of America, 109, 8167, 10.1073/pnas.1202774109 Chakkalakal, 2012, The aged niche disrupts muscle stem cell quiescence, Nature, 490, 355, 10.1038/nature11438 Chakravarthy, 2000, IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle, Journal of Applied Physiology, 89, 1365, 10.1152/jappl.2000.89.4.1365 Chambers, 2007, Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation, PLoS Biology, 5, e201, 10.1371/journal.pbio.0050201 Chang, 2007, Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia, Circulation, 116, 2818, 10.1161/CIRCULATIONAHA.107.715847 Chen, 2010, Extracellular matrix provides an optimal niche for the maintenance and propagation of mesenchymal stem cells, Birth Defects Research. Part C, Embryo Today, 90, 45, 10.1002/bdrc.20171 Chen, 2003, Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction, Experimental Hematology, 31, 1097, 10.1016/S0301-472X(03)00238-8 Chen, 2009, mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells, Science Signaling, 2, ra75, 10.1126/scisignal.2000559 Chen, 1999, p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti, Development, 126, 1581, 10.1242/dev.126.8.1581 Chen, 2010, Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription, Hepatology, 51, 953 Choudhury, 2007, Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation, Nature Genetics, 39, 99, 10.1038/ng1937 Chuikov, 2010, Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress, Nature Cell Biology, 12, 999, 10.1038/ncb2101 Conboy, 2003, Notch-mediated restoration of regenerative potential to aged muscle, Science, 302, 1575, 10.1126/science.1087573 Conboy, 2005, Rejuvenation of aged progenitor cells by exposure to a young systemic environment, Nature, 433, 760, 10.1038/nature03260 Conboy, 2012, Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches, Cell Cycle, 11, 2260, 10.4161/cc.20437 Cortet, 2011, Bone repair in osteoporotic bone: Postmenopausal and cortisone-induced osteoporosis, Osteoporosis International, 22, 2007, 10.1007/s00198-011-1612-3 Coutu, 2011, Inhibition of cellular senescence by developmentally regulated FGF receptors in mesenchymal stem cells, Blood, 117, 6801, 10.1182/blood-2010-12-321539 Dawes, 2013, Age-related differences in signaling efficiency of human lens cells underpin differential wound healing response rates following cataract surgery, Investigative Ophthalmology & Visual Science, 54, 333, 10.1167/iovs.12-10425 Day, 2010, The depletion of skeletal muscle satellite cells with age is concomitant with reduced capacity of single progenitors to produce reserve progeny, Developmental Biology, 340, 330, 10.1016/j.ydbio.2010.01.006 De Barros, 2013, Aging-related decrease of human ASC angiogenic potential is reversed by hypoxia preconditioning through ROS production, Molecular Therapy, 21, 399, 10.1038/mt.2012.213 de Girolamo, 2009, Human adipose-derived stem cells isolated from young and elderly women: Their differentiation potential and scaffold interaction during in vitro osteoblastic differentiation, Cytotherapy, 11, 793, 10.3109/14653240903079393 de Haan, 1997, Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity, Blood, 89, 1543, 10.1182/blood.V89.5.1543 de Magalhaes, 2005, Genomes optimize reproduction: Aging as a consequence of the developmental program, Physiology (Bethesda), 20, 252, 10.1152/physiol.00010.2005 Decary, 1997, Replicative potential and telomere length in human skeletal muscle: Implications for satellite cell-mediated gene therapy, Human Gene Therapy, 8, 1429, 10.1089/hum.1997.8.12-1429 Duffy, 2012, Myelin-derived ephrinB3 restricts axonal regeneration and recovery after adult CNS injury, Proceedings of the National Academy of Sciences of the United States of America, 109, 5063, 10.1073/pnas.1113953109 Dumble, 2007, The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging, Blood, 109, 1736, 10.1182/blood-2006-03-010413 Edelberg, 2002, Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function, Circulation Research, 90, E89, 10.1161/01.RES.0000020861.20064.7E Efimenko, 2011, Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning, Journal of Translational Medicine, 9, 10, 10.1186/1479-5876-9-10 Eguchi, 2011, Regenerative capacity in newts is not altered by repeated regeneration and ageing, Nature Communications, 2, 384, 10.1038/ncomms1389 Felice, 2013, Effect of aging on metabolic pathways in endothelial progenitor cells, Current Pharmaceutical Design, 19, 2351, 10.2174/1381612811319130003 Feng, 2013, Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression, The Biochemical Journal, 450, 459, 10.1042/BJ20120924 Ferron, 2009, Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis, The Journal of Neuroscience, 29, 14394, 10.1523/JNEUROSCI.3836-09.2009 Ferron, 2004, Telomere shortening and chromosomal instability abrogates proliferation of adult but not embryonic neural stem cells, Development, 131, 4059, 10.1242/dev.01215 Fulle, 2005, Age-dependent imbalance of the antioxidative system in human satellite cells, Experimental Gerontology, 40, 189, 10.1016/j.exger.2004.11.006 Furrer, 2011, Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway, Proceedings of the National Academy of Sciences of the United States of America, 108, 2945, 10.1073/pnas.1012531108 Furutachi, 2013, p57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis, The EMBO Journal, 32, 970, 10.1038/emboj.2013.50 Gan, 2005, The interactions between cigarette smoking and reduced lung function on systemic inflammation, Chest, 127, 558, 10.1378/chest.127.2.558 Gan, 2008, mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization, Proceedings of the National Academy of Sciences of the United States of America, 105, 19384, 10.1073/pnas.0810584105 Garcia-Prat, 2013, Functional dysregulation of stem cells during aging: A focus on skeletal muscle stem cells, The FEBS Journal, 280, 4051, 10.1111/febs.12221 Gibson, 1983, Age-related differences in absolute numbers of skeletal muscle satellite cells, Muscle & Nerve, 6, 574, 10.1002/mus.880060807 Gutmann, 1976, Regeneration and transplantation of muscles in old rats and between young and old rats, Life Sciences, 18, 109, 10.1016/0024-3205(76)90280-0 Haga, 2010, p66(Shc) has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism, Laboratory Investigation, 90, 1718, 10.1038/labinvest.2010.119 Han, 2012, Nanog reverses the effects of organismal aging on mesenchymal stem cell proliferation and myogenic differentiation potential, Stem Cells, 30, 2746, 10.1002/stem.1223 Hao, 2005, Short telomeres, even in the presence of telomerase, limit tissue renewal capacity, Cell, 123, 1121, 10.1016/j.cell.2005.11.020 Hayashi, 2010, Expression patterns of FGF receptors in the developing mammalian cochlea, Developmental Dynamics, 239, 1019, 10.1002/dvdy.22236 He, 2009, Aging decreases expression and activity of glutathione peroxidase-1 in human endothelial progenitor cells, Microvascular Research, 78, 447, 10.1016/j.mvr.2009.08.009 He, 2012, Aging profoundly delays functional recovery from gustatory nerve injury, Neuroscience, 209, 208, 10.1016/j.neuroscience.2012.02.012 Heiss, 2005, Impaired progenitor cell activity in age-related endothelial dysfunction, Journal of the American College of Cardiology, 45, 1441, 10.1016/j.jacc.2004.12.074 Hejtmancik, 2004, Molecular genetics of age-related cataract, Experimental Eye Research, 79, 3, 10.1016/j.exer.2004.03.014 Henry, 2010, Molecular and cellular aspects of amphibian lens regeneration, Progress in Retinal and Eye Research, 29, 543, 10.1016/j.preteyeres.2010.07.002 Herbig, 2004, Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a), Molecular Cell, 14, 501, 10.1016/S1097-2765(04)00256-4 Hidalgo, 2012, Ezh1 Is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest, Cell Stem Cell, 11, 649, 10.1016/j.stem.2012.08.001 Hirano, 2012, Clinical trial of regeneration of aged vocal folds with growth factor therapy, Laryngoscope, 122, 327, 10.1002/lary.22393 Hoetzer, 2007, Aging, exercise, and endothelial progenitor cell clonogenic and migratory capacity in men, Journal of Applied Physiology, 102, 847, 10.1152/japplphysiol.01183.2006 Huang, 2011, Overlapping and distinct pRb pathways in the mammalian auditory and vestibular organs, Cell Cycle, 10, 337, 10.4161/cc.10.2.14640 Hutter, 2000, Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 55, B125, 10.1093/gerona/55.3.B125 Ishigami, 1993, Effect of aging on EGF stimulated DNA synthesis and EGF receptor levels in primary cultured rat hepatocytes, Biochemical and Biophysical Research Communications, 196, 181, 10.1006/bbrc.1993.2232 Ito, 2004, Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells, Nature, 431, 997, 10.1038/nature02989 Ito, 2006, Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells, Nature Medicine, 12, 446, 10.1038/nm1388 Ito, 2007, FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2, Biochemical and Biophysical Research Communications, 359, 108, 10.1016/j.bbrc.2007.05.067 Itou, 2012, Life-long preservation of the regenerative capacity in the fin and heart in zebrafish, Biol Open, 1, 739, 10.1242/bio.20121057 Jaerve, 2012, Age-dependent modulation of cortical transcriptomes in spinal cord injury and repair, PLoS One, 7, e49812, 10.1371/journal.pone.0049812 Jakob, 2013, Bone tissue engineering in osteoporosis, Maturitas, 75, 118, 10.1016/j.maturitas.2013.03.004 Jakob, 2012, In situ guided tissue regeneration in musculoskeletal diseases and aging: Implementing pathology into tailored tissue engineering strategies, Cell and Tissue Research, 347, 725, 10.1007/s00441-011-1237-z Jang, 2011, Skeletal muscle stem cells: Effects of aging and metabolism on muscle regenerative function, Cold Spring Harbor Symposia on Quantitative Biology, 76, 101, 10.1101/sqb.2011.76.010652 Janzen, 2006, Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a, Nature, 443, 421, 10.1038/nature05159 Jaskelioff, 2011, Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice, Nature, 469, 102, 10.1038/nature09603 Jejurikar, 2006, Aging increases the susceptibility of skeletal muscle derived satellite cells to apoptosis, Experimental Gerontology, 41, 828, 10.1016/j.exger.2006.06.053 Jin, 2011, The reduction of SIRT1 in livers of old mice leads to impaired body homeostasis and to inhibition of liver proliferation, Hepatology, 54, 989, 10.1002/hep.24471 Jin, 2003, Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice, Aging Cell, 2, 175, 10.1046/j.1474-9728.2003.00046.x Ju, 2007, Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment, Nature Medicine, 13, 742, 10.1038/nm1578 Kamat, 2008, Reduced expression of epidermal growth factor receptors in rat liver during aging, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63, 683, 10.1093/gerona/63.7.683 Kapetanaki, 2013, Influence of age on wound healing and fibrosis, The Journal of Pathology, 229, 310, 10.1002/path.4122 Karagiannides, 2001, Altered expression of C/EBP family members results in decreased adipogenesis with aging, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 280, R1772, 10.1152/ajpregu.2001.280.6.R1772 Kelley, 1993, The developing organ of Corti contains retinoic acid and forms supernumerary hair cells in response to exogenous retinoic acid in culture, Development, 119, 1041, 10.1242/dev.119.4.1041 Kelly, 2012, Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo, The Journal of Neuroscience, 32, 6699, 10.1523/JNEUROSCI.5420-11.2012 Kovacheva, 2010, Testosterone supplementation reverses sarcopenia in aging through regulation of myostatin, c-Jun NH2-terminal kinase, Notch, and Akt signaling pathways, Endocrinology, 151, 628, 10.1210/en.2009-1177 Krupczak-Hollis, 2003, Growth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b, Hepatology, 38, 1552, 10.1016/j.hep.2003.08.052 Kuhn, 1996, Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation, The Journal of Neuroscience, 16, 2027, 10.1523/JNEUROSCI.16-06-02027.1996 Kushner, 2011, Aging is associated with a proapoptotic endothelial progenitor cell phenotype, Journal of Vascular Research, 48, 408, 10.1159/000324837 Kushner, 2009, Aging and endothelial progenitor cell telomere length in healthy men, Clinical Chemistry and Laboratory Medicine, 47, 47, 10.1515/CCLM.2009.016 Laine, 2007, p19(Ink4d) and p21(Cip1) collaborate to maintain the postmitotic state of auditory hair cells, their codeletion leading to DNA damage and p53-mediated apoptosis, The Journal of Neuroscience, 27, 1434, 10.1523/JNEUROSCI.4956-06.2007 Lee, 1996, Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells, Hearing Research, 94, 1, 10.1016/0378-5955(95)00220-0 Lee, 2000, Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats, Journal of Molecular Neuroscience, 15, 99, 10.1385/JMN:15:2:99 Lee, 2012, Effects of aging on thyroarytenoid muscle regeneration, Laryngoscope, 122, 2800, 10.1002/lary.23589 Lee, 2010, mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion, Cell Stem Cell, 7, 593, 10.1016/j.stem.2010.09.015 Lefebvre, 1993, Retinoic acid stimulates regeneration of mammalian auditory hair cells, Science, 260, 692, 10.1126/science.8480180 Lie, 2005, Wnt signalling regulates adult hippocampal neurogenesis, Nature, 437, 1370, 10.1038/nature04108 Liu, 2012, Age-dependent in vivo conversion of mouse cochlear pillar and Deiters' cells to immature hair cells by Atoh1 ectopic expression, The Journal of Neuroscience, 32, 6600, 10.1523/JNEUROSCI.0818-12.2012 Liu, 2009, p53 regulates hematopoietic stem cell quiescence, Cell Stem Cell, 4, 37, 10.1016/j.stem.2008.11.006 Liu, 1994, Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta, Investigative Ophthalmology & Visual Science, 35, 388 Liu, 2010, FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells, Blood, 116, 4806, 10.1182/blood-2010-06-288589 Liu, 2012, Regulation of p27Kip1 by Sox2 maintains quiescence of inner pillar cells in the murine auditory sensory epithelium, The Journal of Neuroscience, 32, 10530, 10.1523/JNEUROSCI.0686-12.2012 Loffredo, 2013, Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy, Cell, 153, 828, 10.1016/j.cell.2013.04.015 Lopez-Otin, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039 Lowenheim, 1999, Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti, Proceedings of the National Academy of Sciences of the United States of America, 96, 4084, 10.1073/pnas.96.7.4084 Luo, 1993, Acidic and basic FGF mRNA expression in the adult and developing rat cochlea, Hearing Research, 69, 182, 10.1016/0378-5955(93)90106-B Madonna, 2011, Age-dependent impairment of number and angiogenic potential of adipose tissue-derived progenitor cells, European Journal of Clinical Investigation, 41, 126, 10.1111/j.1365-2362.2010.02384.x Magee, 2012, Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression, Cell Stem Cell, 11, 415, 10.1016/j.stem.2012.05.026 Marin, 2013, Endothelial aging associated with oxidative stress can be modulated by a healthy mediterranean diet, International Journal of Molecular Sciences, 14, 8869, 10.3390/ijms14058869 Marti, 1993, Handling of epidermal growth factor and number of epidermal growth factor receptors are changed in aged male rats, Hepatology, 18, 1432, 10.1002/hep.1840180623 Maryanovich, 2012, The ATM-BID pathway regulates quiescence and survival of haematopoietic stem cells, Nature Cell Biology, 14, 535, 10.1038/ncb2468 Marzetti, 2008, Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle, Mechanisms of Ageing and Development, 129, 542, 10.1016/j.mad.2008.05.005 Maslov, 2004, Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice, The Journal of Neuroscience, 24, 1726, 10.1523/JNEUROSCI.4608-03.2004 Mattson, 2006, Ageing and neuronal vulnerability, Nature Reviews. Neuroscience, 7, 278, 10.1038/nrn1886 McGeachie, 1995, Retarded myogenic cell replication in regenerating skeletal muscles of old mice: An autoradiographic study in young and old BALBc and SJL/J mice, Cell and Tissue Research, 280, 277, 10.1007/BF00307799 Miranda, 2012, Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling, Aging Cell, 11, 542, 10.1111/j.1474-9726.2012.00816.x Miyamoto, 2007, Foxo3a is essential for maintenance of the hematopoietic stem cell pool, Cell Stem Cell, 1, 101, 10.1016/j.stem.2007.02.001 Mohsin, 2011, Empowering adult stem cells for myocardial regeneration, Circulation Research, 109, 1415, 10.1161/CIRCRESAHA.111.243071 Molofsky, 2005, Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways, Genes & Development, 19, 1432, 10.1101/gad.1299505 Molofsky, 2006, Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing, Nature, 443, 448, 10.1038/nature05091 Mortensen, 2011, The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance, The Journal of Experimental Medicine, 208, 455, 10.1084/jem.20101145 Musaro, 2001, Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle, Nature Genetics, 27, 195, 10.1038/84839 Naito, 2012, Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes, Cell, 149, 1298, 10.1016/j.cell.2012.03.047 Nijnik, 2007, DNA repair is limiting for haematopoietic stem cells during ageing, Nature, 447, 686, 10.1038/nature05875 Nishino, 2008, Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression, Cell, 135, 227, 10.1016/j.cell.2008.09.017 Norddahl, 2011, Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging, Cell Stem Cell, 8, 499, 10.1016/j.stem.2011.03.009 Oesterle, 2011, p27(Kip1) is required to maintain proliferative quiescence in the adult cochlea and pituitary, Cell Cycle, 10, 1237, 10.4161/cc.10.8.15301 Ou, 2010, Fibroblast growth factor-2 stimulates the proliferation of mesenchyme-derived progenitor cells from aging mouse and human bone, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 65, 1051, 10.1093/gerona/glq114 Paik, 2009, FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis, Cell Stem Cell, 5, 540, 10.1016/j.stem.2009.09.013 Pajcini, 2010, Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle, Cell Stem Cell, 7, 198, 10.1016/j.stem.2010.05.022 Paliouras, 2012, Mammalian target of rapamycin signaling is a key regulator of the transit-amplifying progenitor pool in the adult and aging forebrain, The Journal of Neuroscience, 32, 15012, 10.1523/JNEUROSCI.2248-12.2012 Paliwal, 2012, Age dependent increase in the levels of osteopontin inhibits skeletal muscle regeneration, Aging (Albany NY), 4, 553, 10.18632/aging.100477 Palmer, 1999, Age-dependent decline in mitogenic stimulation of hepatocytes. Reduced association between Shc and the epidermal growth factor receptor is coupled to decreased activation of Raf and extracellular signal-regulated kinases, The Journal of Biological Chemistry, 274, 11424, 10.1074/jbc.274.16.11424 Park, 2003, Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells, Nature, 423, 302, 10.1038/nature01587 Park, 2013, Improvement of cognitive function and physical activity of aging mice by human neural stem cells over-expressing choline acetyltransferase, Neurobiology of Aging, 34, 2639, 10.1016/j.neurobiolaging.2013.04.026 Paxson, 2011, Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation, PLoS One, 6, e23232, 10.1371/journal.pone.0023232 Phillips, 2005, Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction, The FASEB Journal, 19, 668, 10.1096/fj.04-2870fje Pickles, 1997, The expression of messenger RNAs coding for growth factors, their receptors, and eph-class receptor tyrosine kinases in normal and ototoxically damaged chick cochleae, Developmental Neuroscience, 19, 476, 10.1159/000111245 Pineda, 2013, Vascular-derived TGF-beta increases in the stem cell niche and perturbs neurogenesis during aging and following irradiation in the adult mouse brain, EMBO Molecular Medicine, 5, 548, 10.1002/emmm.201202197 Porrello, 2011, Transient regenerative potential of the neonatal mouse heart, Science, 331, 1078, 10.1126/science.1200708 Rauscher, 2003, Aging, progenitor cell exhaustion, and atherosclerosis, Circulation, 108, 457, 10.1161/01.CIR.0000082924.75945.48 Renault, 2009, FoxO3 regulates neural stem cell homeostasis, Cell Stem Cell, 5, 527, 10.1016/j.stem.2009.09.014 Renault, 2002, Regenerative potential of human skeletal muscle during aging, Aging Cell, 1, 132, 10.1046/j.1474-9728.2002.00017.x Roberts, 1986, Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro, Proceedings of the National Academy of Sciences of the United States of America, 83, 4167, 10.1073/pnas.83.12.4167 Rocha-Sanchez, 2011, Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells, The Journal of Neuroscience, 31, 8883, 10.1523/JNEUROSCI.5821-10.2011 Rossi, 2007, Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age, Nature, 447, 725, 10.1038/nature05862 Ruckh, 2012, Rejuvenation of regeneration in the aging central nervous system, Cell Stem Cell, 10, 96, 10.1016/j.stem.2011.11.019 Rupp, 2013, The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice, Synapse, 67, 382, 10.1002/syn.21648 Saito, 2012, Comparison of regeneration of the chorda tympani nerve and gustatory function recovery after severing the nerve between pediatric and adult patients, Otology & Neurotology, 33, 1567, 10.1097/MAO.0b013e3182713997 Sanchez Alvarado, 2012, Cellular hyperproliferation and cancer as evolutionary variables, Current Biology, 22, R772, 10.1016/j.cub.2012.08.008 Sawada, 1989, Hepatocytes from old rats retain responsiveness of c-myc expression to EGF in primary culture but do not enter S phase, Experimental Cell Research, 181, 584, 10.1016/0014-4827(89)90115-8 Schellenberg, 2011, Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks, Aging (Albany NY), 3, 873, 10.18632/aging.100391 Schmuck, 2011, Caloric restriction attenuates the age-associated increase of adipose-derived stem cells but further reduces their proliferative capacity, Age (Dordrecht, Netherlands), 33, 107, 10.1007/s11357-010-9166-4 Schmucker, 2011, Liver regeneration and aging: A current perspective, Curr Gerontol Geriatr Res, 2011, 526379, 10.1155/2011/526379 Seib, 2013, Loss of Dickkopf-1 restores neurogenesis in old age and counteracts cognitive decline, Cell Stem Cell, 12, 204, 10.1016/j.stem.2012.11.010 Senyo, 2013, Mammalian heart renewal by pre-existing cardiomyocytes, Nature, 493, 433, 10.1038/nature11682 Serra, 2013, Testosterone improves the regeneration of old and young mouse skeletal muscle, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 68, 17, 10.1093/gerona/gls083 Shefer, 2010, Reduced satellite cell numbers and myogenic capacity in aging can be alleviated by endurance exercise, PLoS One, 5, e13307, 10.1371/journal.pone.0013307 Shetty, 2005, Stem/progenitor cell proliferation factors FGF-2, IGF-1, and VEGF exhibit early decline during the course of aging in the hippocampus: Role of astrocytes, Glia, 51, 173, 10.1002/glia.20187 Signer, 2013, Mechanisms that regulate stem cell aging and life span, Cell Stem Cell, 12, 152, 10.1016/j.stem.2013.01.001 Singh, 2011, Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 66, 944, 10.1093/gerona/glr094 Singh, 2013, Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance, The Journal of Experimental Medicine, 210, 987, 10.1084/jem.20121608 Smythe, 2008, Age influences the early events of skeletal muscle regeneration: Studies of whole muscle grafts transplanted between young (8 weeks) and old (13-21 months) mice, Experimental Gerontology, 43, 550, 10.1016/j.exger.2008.02.005 Solchaga, 2010, Fibroblast growth factor-2 enhances proliferation and delays loss of chondrogenic potential in human adult bone-marrow-derived mesenchymal stem cells, Tissue Engineering. Part A, 16, 1009, 10.1089/ten.tea.2009.0100 Sousounis, 2013, Transcriptome analysis of newt lens regeneration reveals distinct gradients in gene expression patterns, PLoS One, 8, e61445, 10.1371/journal.pone.0061445 Sousounis, 2013, A microarray analysis of gene expression patterns during early phases of newt lens regeneration, Molecular Vision, 19, 135 Sousounis, 2012, Patterns of gene expression in microarrays and expressed sequence tags from normal and cataractous lenses, Human Genomics, 6, 14, 10.1186/1479-7364-6-14 Stoll, 2011, Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism, The Journal of Biological Chemistry, 286, 38592, 10.1074/jbc.M111.252171 Suetsugu-Maki, 2012, Lens regeneration in axolotl: New evidence of developmental plasticity, BMC Biology, 10, 103, 10.1186/1741-7007-10-103 Sun, 2012, Neonatal transfer of membrane-bound stem cell factor improves survival and heart function in aged mice after myocardial ischemia, Human Gene Therapy, 23, 1280, 10.1089/hum.2012.063 Suyama, 2012, Purinergic signaling promotes proliferation of adult mouse subventricular zone cells, The Journal of Neuroscience, 32, 9238, 10.1523/JNEUROSCI.4001-11.2012 Sweet, 2011, Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear, Developmental Biology, 358, 113, 10.1016/j.ydbio.2011.07.019 Takubo, 2010, Regulation of the HIF-1alpha level is essential for hematopoietic stem cells, Cell Stem Cell, 7, 391, 10.1016/j.stem.2010.06.020 Taylor, 2005, Hair cell regeneration in sensory epithelia from the inner ear of a urodele amphibian, The Journal of Comparative Neurology, 484, 105, 10.1002/cne.20450 TeKippe, 2003, Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice, Experimental Hematology, 31, 521, 10.1016/S0301-472X(03)00072-9 Teramoto, 2007, Aging, the aging lung, and senile emphysema are different, American Journal of Respiratory and Critical Care Medicine, 175, 197, 10.1164/ajrccm.175.2.197 Thum, 2007, Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1, Circulation Research, 100, 434, 10.1161/01.RES.0000257912.78915.af Timchenko, 2009, Aging and liver regeneration, Trends in Endocrinology and Metabolism, 20, 171, 10.1016/j.tem.2009.01.005 Torres-Gonzalez, 2012, Role of endoplasmic reticulum stress in age-related susceptibility to lung fibrosis, American Journal of Respiratory Cell and Molecular Biology, 46, 748, 10.1165/rcmb.2011-0224OC Tothova, 2007, FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress, Cell, 128, 325, 10.1016/j.cell.2007.01.003 Tropepe, 1999, Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon, Developmental Biology, 208, 166, 10.1006/dbio.1998.9192 Turgeon, 2012, Protection against vascular aging in Nox2-deficient mice: Impact on endothelial progenitor cells and reparative neovascularization, Atherosclerosis, 223, 122, 10.1016/j.atherosclerosis.2012.05.003 Vaziri, 1996, From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging, Experimental Gerontology, 31, 295, 10.1016/0531-5565(95)02025-X Vaziri, 1994, Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age, Proceedings of the National Academy of Sciences of the United States of America, 91, 9857, 10.1073/pnas.91.21.9857 Villeda, 2011, The ageing systemic milieu negatively regulates neurogenesis and cognitive function, Nature, 477, 90, 10.1038/nature10357 Wahlestedt, 2013, An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state, Blood, 121, 4257, 10.1182/blood-2012-11-469080 Walters, 2013, Postnatal development, maturation and aging in the mouse cochlea and their effects on hair cell regeneration, Hearing Research, 297, 68, 10.1016/j.heares.2012.11.009 Wang, 2002, Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression, The Journal of Biological Chemistry, 277, 44310, 10.1074/jbc.M207510200 Wang, 2001, Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevent age-related proliferation defects in regenerating liver, Proceedings of the National Academy of Sciences of the United States of America, 98, 11468, 10.1073/pnas.201360898 Warr, 2013, FOXO3A directs a protective autophagy program in haematopoietic stem cells, Nature, 494, 323, 10.1038/nature11895 Weber, 2008, Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells, Proceedings of the National Academy of Sciences of the United States of America, 105, 781, 10.1073/pnas.0708061105 White, 2012, EGFR signaling is required for regenerative proliferation in the cochlea: Conservation in birds and mammals, Developmental Biology, 363, 191, 10.1016/j.ydbio.2011.12.035 Williamson, 2013, Age-related impairment of endothelial progenitor cell migration correlates with structural alterations of heparan sulfate proteoglycans, Aging Cell, 12, 139, 10.1111/acel.12031 Williamson, 2012, Endothelial progenitor cells enter the aging arena, Frontiers in Physiology, 3, 30, 10.3389/fphys.2012.00030 Xia, 2011, Physical exercise attenuates age-associated reduction in endothelium-reparative capacity of endothelial progenitor cells by increasing CXCR4/JAK-2 signaling in healthy men, Aging Cell, 11, 111, 10.1111/j.1474-9726.2011.00758.x Xia, 2012, Age-related decline in reendothelialization capacity of human endothelial progenitor cells is restored by shear stress, Hypertension, 59, 1225, 10.1161/HYPERTENSIONAHA.111.179820 Xu, 2009, Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 64, 731, 10.1093/gerona/glp040 Yahata, 2011, Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells, Blood, 118, 2941, 10.1182/blood-2011-01-330050 Yalcin, 2008, Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells, The Journal of Biological Chemistry, 283, 25692, 10.1074/jbc.M800517200 Yang, 2012, Effect of BDNF-plasma-collagen matrix controlled delivery system on the behavior of adult rats neural stem cells, Journal of Biomedical Materials Research. Part A, 101, 599, 10.4028/www.scientific.net/AMR.482-484.599 Yang, 2011, Regular exercise-induced increased number and activity of circulating endothelial progenitor cells attenuates age-related decline in arterial elasticity in healthy men, International Journal of Cardiology, 165, 247, 10.1016/j.ijcard.2011.08.055 Yao, 2013, Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: Effects of aging and family genetic background, Stem Cell Research, 10, 361, 10.1016/j.scr.2013.01.006 Yu, 2010, In vivo proliferation of postmitotic cochlear supporting cells by acute ablation of the retinoblastoma protein in neonatal mice, The Journal of Neuroscience, 30, 5927, 10.1523/JNEUROSCI.5989-09.2010 Yuan, 2012, Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology, 47, 329, 10.1016/j.exger.2012.02.006 Zhang, 2006, PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention, Nature, 441, 518, 10.1038/nature04747 Zhang, 2008, Cytokines regulating hematopoietic stem cell function, Current Opinion in Hematology, 15, 307, 10.1097/MOH.0b013e3283007db5 Zheng, 2007, Impact of aging on rat bone marrow-derived stem cell chondrogenesis, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 62, 136, 10.1093/gerona/62.2.136 Zhou, 2008, Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts, Aging Cell, 7, 335, 10.1111/j.1474-9726.2008.00377.x Zhou, 2011, Epithelial cell senescence impairs repair process and exacerbates inflammation after airway injury, Respiratory Research, 12, 78, 10.1186/1465-9921-12-78 Zhu, 2013, MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2, Circulation Research, 112, 152, 10.1161/CIRCRESAHA.112.280016 Zhu, 2007, Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: Consequences in aging muscle and therapeutic strategies for muscular dystrophies, Aging Cell, 6, 515, 10.1111/j.1474-9726.2007.00306.x Zine, 2000, Spatial expression patterns of epidermal growth factor receptor gene transcripts in the postnatal mammalian cochlea, Hearing Research, 141, 19, 10.1016/S0378-5955(99)00203-8 Zou, 2013, Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers, Science, 340, 372, 10.1126/science.1231321 Zwetsloot, 2013, Non-passaged muscle precursor cells from 32-month old rat skeletal muscle have delayed proliferation and differentiation, Cell Proliferation, 46, 45, 10.1111/cpr.12007