Current Rheumatology Reports
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Economic Theory and Self-Reported Measures of Presenteeism in Musculoskeletal Disease
Current Rheumatology Reports - Tập 18 - Trang 1-15 - 2016
This study had two objectives: to describe the historical development of self-reported presenteeism instruments that can be used to identify and measure presenteeism as a result of musculoskeletal disease (MSD) and to identify if, and how many of these, presenteeism instruments are underpinned by economic theory. Systematic search methods were applied to identify self-report instruments used to qu......
Perioperative Infection in the Patient with Rheumatic Disease
Current Rheumatology Reports - Tập 15 - Trang 1-6 - 2013
The risk of infection accompanies the benefits of surgery. Immunomodulatory chronic illnesses may increase the risk of surgical infections. Surgical patients with rheumatologic illness need close preoperative assessment regarding their infection risks (fixed and modifiable), which vary on the basis of the proposed procedure, specific rheumatologic illness, and underlying comorbidities. Modificatio......
The role of nonsteroidal anti-inflammatory medications and exercise in the treatment of ankylosing spondylitis
Current Rheumatology Reports - Tập 8 - Trang 255-259 - 2006
Ankylosing spondylitis (AS) is a chronic systemic rheumatic disease that primarily affects the sacroiliac joints and spine. Even with the development of tumor necrosis factor-α inhibitors, which have revolutionized the treatment of this disease, the combination of nonsteroidal anti-inflammatory drugs (NSAIDs), physical therapy, and a life-long exercise program still form the first step in its mana......
Current Concepts and Future Directions of Minimally Invasive Treatment for Knee Pain
Current Rheumatology Reports - Tập 20 - Trang 1-10 - 2018
The purpose of this paper is to review the percutaneous interventions available for the treatment of osteoarthrosis of the knee that address pain and prolong the time to arthroplasty. Corticosteroid injection and viscosupplementation have been the most studied, but there is still no consensus about their value. Thermal nerve ablation, including both radiofrequency ablation and cryoneurolysis, is a......
Epigenetics for Clinicians from the Perspective of Pediatric Rheumatic Diseases
Current Rheumatology Reports - - 2020
Epigenetic Variability in Systemic Lupus Erythematosus: What We Learned from Genome-Wide DNA Methylation Studies
Current Rheumatology Reports - Tập 19 - Trang 1-10 - 2017
DNA methylation has emerged as an important contributing factor in the pathogenesis of systemic lupus erythematosus (SLE). Here, we describe the DNA methylation patterns identified in SLE and how these epigenetic changes can influence disease susceptibility, clinical heterogeneity, and disease flares. Several genome-wide DNA methylation studies have been recently completed in SLE. Important observ......
Treatment of psoriasis with intramuscular alefacept
Current Rheumatology Reports - Tập 6 Số 4 - Trang 290-290 - 2004
The Microbiome and Bone and Joint Disease
Current Rheumatology Reports - Tập 19 - Trang 1-6 - 2017
Changes in the constituents and activity of the microbiome have been associated with a number of conditions linked to bone and joint disease. This review concentrates on ways in which the microbiome is known to influence osteoarthritis and osteoporosis. Animal studies have demonstrated that changes in the microbiome can mediate the effects of obesity on cartilage degeneration. Additionally, the mi......
The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis
Current Rheumatology Reports - Tập 18 - Trang 1-9 - 2016
The past decade has witnessed many advances in the understanding of sirtuin biology and related regulatory circuits supporting the capacity of these proteins to serve as energy-sensing molecules that contribute to healthspan in various tissues, including articular cartilage. Hence, there has been a significant increase in new investigations that aim to elucidate the mechanisms of sirtuin function ......
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