The Microbiome and Bone and Joint Disease

Current Rheumatology Reports - Tập 19 - Trang 1-6 - 2017
Christopher J. Hernandez1,2,3
1Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, USA
2Meinig School of Biomedical Engineering, Cornell University, Ithaca, USA
3Hospital for Special Surgery, New York, USA

Tóm tắt

Changes in the constituents and activity of the microbiome have been associated with a number of conditions linked to bone and joint disease. This review concentrates on ways in which the microbiome is known to influence osteoarthritis and osteoporosis. Animal studies have demonstrated that changes in the microbiome can mediate the effects of obesity on cartilage degeneration. Additionally, the microbiome influences the amount of the bone (bone quantity), as well as bone tissue material properties (bone quality). Early clinical findings support the effects of the microbiome on osteoporosis and osteoarthritis. Although animal studies implicate the microbiome in the development of bone and joint disease, available results are limited and can be conflicting. Further investigation of the mechanisms linking from changes in the microbiome to alterations in the bones and joints are necessary.

Tài liệu tham khảo

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