Current Protein and Peptide Science

  1389-2037

  1875-5550

  Các Tiểu vuơng quốc Ả Rập Thống nhất

Cơ quản chủ quản:  BENTHAM SCIENCE PUBL LTD , Bentham Science Publishers B.V.

Lĩnh vực:
BiochemistryMedicine (miscellaneous)Molecular BiologyCell Biology

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Current Protein & Peptide Science publishes full-length/mini review articles on specific aspects involving proteins, peptides, and interactions between the enzymes, the binding interactions of hormones and their receptors; the properties of transcription factors and other molecules that regulate gene expression; the reactions leading to the immune response; the process of signal transduction; the structure and function of proteins involved in the cytoskeleton and molecular motors; the properties of membrane channels and transporters; and the generation and storage of metabolic energy. In addition, reviews of experimental studies of protein folding and design are given special emphasis. Manuscripts submitted to Current Protein and Peptide Science should cover a field by discussing research from the leading laboratories in a field and should pose questions for future studies. Original papers, research articles and letter articles/short communications are not considered for publication in Current Protein & Peptide Science.

Các bài báo tiêu biểu

Virtual Screening in Drug Discovery - A Computational Perspective
Tập 8 Số 4 - Trang 329-351 - 2007
A. Srinivas Reddy, Supriya Pati, Praveen K. Potukuchi, Pradeep Hiriyur Nagaraj, G. Narahari Sastry
Design and Structure of Peptide and Peptidomimetic Antagonists of Protein- Protein Interaction
Tập 6 Số 2 - Trang 151-169 - 2005
Laurel O. Sillerud, Richard S. Larson
PlantPIs – An Interactive Web Resource on Plant Protease Inhibitors
Tập 12 Số 5 - Trang 448-454 - 2011
Arianna Consiglio, Giorgio Grillo, Flavio Licciulli, Luigi R. Ceci, Sabino Liuni, Nicola Losito, Mariateresa Volpicella, Raffaele Gallerani, Francesca De Leo
Structure-based Druggability Assessment of Anti-virulence Targets from Pseudomonas aeruginosa
Tập 20 Số 12 - Trang 1189-1203 - 2019
Thamires Quadros Froes, Regina L. Baldini, Sándor Vajda, Marcelo Santos Castilho
Antimicrobial Resistance (AMR) represents a serious threat to health and the global economy. However, interest in antibacterial drug development has decreased substantially in recent decades. Meanwhile, anti-virulence drug development has emerged as an attractive alternative to fight AMR. Although several macromolecular targets have been explored for this goal, their druggability is a vital piece of information that has been overlooked. This review explores this subject by showing how structure- based freely available in silico tools, such as PockDrug and FTMap, might be useful for designing novel inhibitors of the pyocyanin biosynthesis pathway and improving the potency/selectivity of compounds that target the Pseudomonas aeruginosa quorum sensing mechanism. The information provided by hotspot analysis, along with binding site features, reveals novel druggable targets (PhzA and PhzS) that remain largely unexplored. However, it also highlights that in silico druggability prediction tools have several limitations that might be overcome in the near future. Meanwhile, anti-virulence drug targets should be assessed by complementary methods, such as the combined use of FTMap/PockDrug, once the consensus druggability classification reduces the risk of wasting resources on undruggable proteins.
Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease
Tập 19 Số 12 - Trang 1180-1188 - 2018
Lisbell D. Estrada, Luciana Oliveira-Cruz, Daniel Cabrera
Formation Mechanism of Insulin Fibrils and Structural Aspects of the Insulin Fibrillation Process
Tập 10 Số 5 - Trang 509-528 - 2009
Minna Groenning, Sven Frøkjær, Bente Vestergaard
Copper Binding Extrinsic to the Octarepeat Region in the Prion Protein
Tập 10 Số 5 - Trang 529-535 - 2009
Éric Walter, Daniel J. Stevens, Ann R. Spevacek, Micah P. Visconte, Andrew Dei Rossi, Glenn L. Millhauser