Current Protein and Peptide Science
Công bố khoa học tiêu biểu
Sắp xếp:
Virtual Screening in Drug Discovery - A Computational Perspective
Current Protein and Peptide Science - Tập 8 Số 4 - Trang 329-351 - 2007
Design and Structure of Peptide and Peptidomimetic Antagonists of Protein- Protein Interaction
Current Protein and Peptide Science - Tập 6 Số 2 - Trang 151-169 - 2005
PlantPIs – An Interactive Web Resource on Plant Protease Inhibitors
Current Protein and Peptide Science - Tập 12 Số 5 - Trang 448-454 - 2011
Structure-based Druggability Assessment of Anti-virulence Targets from Pseudomonas aeruginosa
Antimicrobial Resistance (AMR) represents a serious threat to health and the global economy.
However, interest in antibacterial drug development has decreased substantially in recent decades.
Meanwhile, anti-virulence drug development has emerged as an attractive alternative to fight AMR. Although
several macromolecular targets have been explored for this goal, their druggability is a vital
piece of information that has been overlooked. This review explores this subject by showing how structure-
based freely available in silico tools, such as PockDrug and FTMap, might be useful for designing
novel inhibitors of the pyocyanin biosynthesis pathway and improving the potency/selectivity of compounds
that target the Pseudomonas aeruginosa quorum sensing mechanism. The information provided
by hotspot analysis, along with binding site features, reveals novel druggable targets (PhzA and PhzS)
that remain largely unexplored. However, it also highlights that in silico druggability prediction tools
have several limitations that might be overcome in the near future. Meanwhile, anti-virulence drug targets
should be assessed by complementary methods, such as the combined use of FTMap/PockDrug,
once the consensus druggability classification reduces the risk of wasting resources on undruggable proteins.
Current Protein and Peptide Science - Tập 20 Số 12 - Trang 1189-1203 - 2019
Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease
Current Protein and Peptide Science - Tập 19 Số 12 - Trang 1180-1188 - 2018
Formation Mechanism of Insulin Fibrils and Structural Aspects of the Insulin Fibrillation Process
Current Protein and Peptide Science - Tập 10 Số 5 - Trang 509-528 - 2009
Copper Binding Extrinsic to the Octarepeat Region in the Prion Protein
Current Protein and Peptide Science - Tập 10 Số 5 - Trang 529-535 - 2009
Tổng số: 7
- 1