Current Osteoporosis Reports

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Current Care and Investigational Therapies in Achondroplasia
Current Osteoporosis Reports - Tập 15 - Trang 53-60 - 2017
Sheila Unger, Luisa Bonafé, Elvire Gouze
The goal of this review is to evaluate the management options for achondroplasia, the most common non-lethal skeletal dysplasia. This disease is characterized by short stature and a variety of complications, some of which can be quite severe. Despite several attempts to standardize care, there is still no widely accepted consensus. This is in part due to absence of concrete data on the incidence o...... hiện toàn bộ
Co-managed Care: The Gold Standard for Geriatric Fracture Care
Current Osteoporosis Reports - Tập 10 - Trang 312-316 - 2012
Natasha T. O’Malley, Stephen L. Kates
With a worldwide aging population, the incidence and consequences of geriatric fractures are assuming an increasing importance to health care providers and institutions. Studies have shown that optimal efficient management ensures the best outcome for the patient, at the least cost to the institution. A review of the recent literature was performed to establish the current best evidence ie, gold s...... hiện toàn bộ
From relative risk to absolute fracture risk calculation: The FRAX algorithm
Current Osteoporosis Reports - Tập 7 - Trang 77-83 - 2009
Eugene V. McCloskey, Helena Johansson, Anders Oden, John A. Kanis
FRAX is a computer-based algorithm that provides models for the assessment of fracture probability in men and women (http://www.shef.ac.uk/FRAX...... hiện toàn bộ
Use of Strontium as a Treatment Method for Osteoporosis
Current Osteoporosis Reports - Tập 9 Số 1 - Trang 25-30 - 2011
Bernard Cortet
Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease
Current Osteoporosis Reports - Tập 15 - Trang 532-541 - 2017
Michelle M. McDonald, Jesus Delgado-Calle
This review provides a summary of the current knowledge on Sost/sclerostin in cancers targeting the bone, discusses novel observations regarding its potential as a therapeutic approach to treat cancer-induced bone loss, and proposes future research needed to fully understand the potential of therapeutic approaches that modulate sclerostin function. Accumulating evidence shows that sclerostin expre...... hiện toàn bộ
Type 2 Diabetes Mellitus and Vertebral Fracture Risk
Current Osteoporosis Reports - - 2021
Fjorda Koromani, Samuel Ghatan, Mandy van Hoek, M. Carola Zillikens, Edwin H.G. Oei, Fernando Rivadeneira, Ling Oei
Abstract Purpose of Review The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus. Recent Findings ... hiện toàn bộ
Genetic Pleiotropy of Bone-Related Phenotypes: Insights from Osteoporosis
Current Osteoporosis Reports - Tập 18 - Trang 606-619 - 2020
M. A. Christou, E. E. Ntzani, D. Karasik
We summarize recent evidence on the shared genetics within and outside the musculoskeletal system (mostly related to bone density and osteoporosis). Osteoporosis is determined by an interplay between multiple genetic and environmental factors. Significant progress has been made regarding its genetic background revealing a number of robustly validated loci and respective pathways. However, pleiotro...... hiện toàn bộ
Combination therapy for osteoporosis: Considerations and controversy
Current Osteoporosis Reports - Tập 3 - Trang 150-154 - 2005
Neil Binkley, Diane Krueger
Combination therapy, the simultaneous use of two pharmaceutical agents with the goal being reduction of fracture risk, is an area of substantial clinical interest. This paper summarizes the rationale, existing clinical trials data, and other considerations relevant to combination therapy for osteoporosis. Combinations of antiresorbers (eg, estrogen plus bisphosphonates) produce greater increases i...... hiện toàn bộ
Targeting Cell Senescence for the Treatment of Age-Related Bone Loss
Current Osteoporosis Reports - Tập 17 - Trang 70-85 - 2019
Robert J. Pignolo, Rebekah M. Samsonraj, Susan F. Law, Haitao Wang, Abhishek Chandra
We review cell senescence in the context of age-related bone loss by broadly discussing aging mechanisms in bone, currently known inducers and markers of senescence, the senescence-associated secretory phenotype (SASP), and the emerging roles of senescence in bone homeostasis and pathology. Cellular senescence is a state of irreversible cell cycle arrest induced by insults or stressors including t...... hiện toàn bộ
Cancer-associated bone disease
Current Osteoporosis Reports - Tập 5 Số 3 - Trang 120-127 - 2007
Sue A. Brown, Theresa A. Guise
Tổng số: 714   
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