Current Osteoporosis Reports
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Current Care and Investigational Therapies in Achondroplasia
Current Osteoporosis Reports - Tập 15 - Trang 53-60 - 2017
The goal of this review is to evaluate the management options for
achondroplasia, the most common non-lethal skeletal dysplasia. This disease is
characterized by short stature and a variety of complications, some of which can
be quite severe. Despite several attempts to standardize care, there is still no
widely accepted consensus. This is in part due to absence of concrete data on
the incidence o...
Co-managed Care: The Gold Standard for Geriatric Fracture Care
Current Osteoporosis Reports - Tập 10 - Trang 312-316 - 2012
With a worldwide aging population, the incidence and consequences of geriatric
fractures are assuming an increasing importance to health care providers and
institutions. Studies have shown that optimal efficient management ensures the
best outcome for the patient, at the least cost to the institution. A review of
the recent literature was performed to establish the current best evidence ie,
gold s...
From relative risk to absolute fracture risk calculation: The FRAX algorithm
Current Osteoporosis Reports - Tập 7 - Trang 77-83 - 2009
FRAX is a computer-based algorithm that provides models for the assessment of
fracture probability in men and women (http://www.shef.ac.uk/FRAX). The approach
uses easily obtained clinical risk factors to estimate 10-year fracture
probability, with or without femoral neck bone mineral density (BMD), to enhance
fracture risk prediction. It has been constructed using primary data from
population-bas...
Use of Strontium as a Treatment Method for Osteoporosis
Current Osteoporosis Reports - Tập 9 Số 1 - Trang 25-30 - 2011
Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease
Current Osteoporosis Reports - Tập 15 - Trang 532-541 - 2017
This review provides a summary of the current knowledge on Sost/sclerostin in
cancers targeting the bone, discusses novel observations regarding its potential
as a therapeutic approach to treat cancer-induced bone loss, and proposes future
research needed to fully understand the potential of therapeutic approaches that
modulate sclerostin function. Accumulating evidence shows that sclerostin
expre...
Type 2 Diabetes Mellitus and Vertebral Fracture Risk
Current Osteoporosis Reports - - 2021
Abstract Purpose of Review The purpose of this review is to summarize the
recently published evidence concerning vertebral fracture risk in individuals
with diabetes mellitus. Recent Findings Vertebral fracture risk is increased in
individuals with T2DM. The presence of vertebral fractures in T2DM is associated
with increased non-vertebral fracture risk and mortality. TBS could be helpful
to estim...
Genetic Pleiotropy of Bone-Related Phenotypes: Insights from Osteoporosis
Current Osteoporosis Reports - Tập 18 - Trang 606-619 - 2020
We summarize recent evidence on the shared genetics within and outside the
musculoskeletal system (mostly related to bone density and osteoporosis).
Osteoporosis is determined by an interplay between multiple genetic and
environmental factors. Significant progress has been made regarding its genetic
background revealing a number of robustly validated loci and respective
pathways. However, pleiotro...
Combination therapy for osteoporosis: Considerations and controversy
Current Osteoporosis Reports - Tập 3 - Trang 150-154 - 2005
Combination therapy, the simultaneous use of two pharmaceutical agents with the
goal being reduction of fracture risk, is an area of substantial clinical
interest. This paper summarizes the rationale, existing clinical trials data,
and other considerations relevant to combination therapy for osteoporosis.
Combinations of antiresorbers (eg, estrogen plus bisphosphonates) produce
greater increases i...
Targeting Cell Senescence for the Treatment of Age-Related Bone Loss
Current Osteoporosis Reports - Tập 17 - Trang 70-85 - 2019
We review cell senescence in the context of age-related bone loss by broadly
discussing aging mechanisms in bone, currently known inducers and markers of
senescence, the senescence-associated secretory phenotype (SASP), and the
emerging roles of senescence in bone homeostasis and pathology. Cellular
senescence is a state of irreversible cell cycle arrest induced by insults or
stressors including t...
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