Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone DiseaseCurrent Osteoporosis Reports - Tập 15 - Trang 532-541 - 2017
Michelle M. McDonald, Jesus Delgado-Calle
This review provides a summary of the current knowledge on Sost/sclerostin in cancers targeting the bone, discusses novel observations regarding its potential as a therapeutic approach to treat cancer-induced bone loss, and proposes future research needed to fully understand the potential of therapeutic approaches that modulate sclerostin function. Accumulating evidence shows that sclerostin expre...... hiện toàn bộ
Type 2 Diabetes Mellitus and Vertebral Fracture RiskCurrent Osteoporosis Reports - - 2021
Fjorda Koromani, Samuel Ghatan, Mandy van Hoek, M. Carola Zillikens, Edwin H.G. Oei, Fernando Rivadeneira, Ling Oei
Abstract
Purpose of Review
The purpose of this review is to summarize the recently published evidence concerning vertebral fracture risk in individuals with diabetes mellitus.
Recent Findings
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Genetic Pleiotropy of Bone-Related Phenotypes: Insights from OsteoporosisCurrent Osteoporosis Reports - Tập 18 - Trang 606-619 - 2020
M. A. Christou, E. E. Ntzani, D. Karasik
We summarize recent evidence on the shared genetics within and outside the musculoskeletal system (mostly related to bone density and osteoporosis). Osteoporosis is determined by an interplay between multiple genetic and environmental factors. Significant progress has been made regarding its genetic background revealing a number of robustly validated loci and respective pathways. However, pleiotro...... hiện toàn bộ
Clinical relevance of diagnosing vertebral fractures by vertebral fracture assessmentCurrent Osteoporosis Reports - Tập 7 - Trang 103-106 - 2009
Marleen S. van Brussel, Willem F. Lems
Low bone mineral density and the presence of vertebral fractures are independent predictors for future vertebral and non-vertebral fractures. Combining the conventional measurement of bone mineral density of spine and hips with the morphometry of the thoracal and lumbar vertebrae on lateral images using dual energy x-ray absorptiometry scanners, a technique called vertebral fracture assessment, fa...... hiện toàn bộ
The relationship between bone mineral density and fracture riskCurrent Osteoporosis Reports - Tập 3 - Trang 57-63 - 2005
Michael R. McClung
Osteoporosis is a disorder characterized by low bone density and impaired bone strength which is an important risk factor for fracture in older adults. The diagnosis of osteoporosis in postmenopausal women is now based on bone density testing by dual energy x-ray absorptiometry but not other methodologies. However, a specific but arbitrary diagnostic threshold must be distinguished from a strategy...... hiện toàn bộ
The Interrelationship Between Diabetes, IL-17 and Bone LossCurrent Osteoporosis Reports - Tập 18 - Trang 23-31 - 2020
Zhen Huang, Xiyan Pei, Dana T. Graves
Diabetes has a detrimental effect on bone, increasing the risk of fracture and formation of osteolytic lesions such as those seen in periodontitis. Several diabetic complications are caused by diabetes-enhanced inflammation. This review examines mechanisms by which IL-17 contributes to diabetes-enhanced periodontitis and other effects of IL-17 on bone. IL-17 upregulates anti-bacterial defenses, ye...... hiện toàn bộ