Current Opinion in Lipidology
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Sắp xếp:
Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance
Current Opinion in Lipidology - Tập 19 Số 1 - Trang 16-24 - 2008
Connecting mTORC1 signaling to SREBP-1 activation
Current Opinion in Lipidology - Tập 23 Số 3 - Trang 226-234 - 2012
An update on alcohol and atherosclerosis
Current Opinion in Lipidology - Tập 15 Số 6 - Trang 673-680 - 2004
Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin
Current Opinion in Lipidology - Tập 13 Số 1 - Trang 51-59 - 2002
Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies Purpose of review Lysosomal acid lipase (LAL), encoded by theLIPA gene, is an essential lysosomal enzyme that hydrolyzes cholesteryl ester and triglyceride delivered to the lysosome. This review highlights the novel pathophysiological role of LAL, the functional genomic discoveries ofLIPA as a risk locus for coronary heart diseases (CHD), and the clinical advance in therapies for LAL deficiency. Recent findings The essential role of LAL in lipid metabolism has been confirmed in human and mice with LAL deficiency. In humans, loss-of-function mutations ofLIPA cause rare lysosomal disorders, Wolman disease, and cholesteryl ester storage disease, in which LAL enzyme replacement therapy has shown significant benefits in a phase 3 clinical trial. Recent studies have revealed the role of LAL-mediated lysosomal lipolysis in regulating macrophage M2 polarization, lipid mediator production, VLDL secretion, lysosomal function and autophagy, extracellular degradation of aggregated-LDL, and adipose tissue lipolysis. Genome-wide association studies and functional genomic studies have identifiedLIPA as a risk locus for CHD, but the causal variants and mechanisms remain to be determined. Summary Despite years of research, our understanding of LAL is incomplete. Future studies will continue to focus on the key pathophysiological functions of LAL in health and diseases including CHD.
Current Opinion in Lipidology - Tập 29 Số 3 - Trang 218-223 - 2018
ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins
Current Opinion in Lipidology - Tập 11 Số 3 - Trang 253-260 - 2000
Scavenger receptor Bl and cholesterol trafficking
Current Opinion in Lipidology - Tập 10 Số 4 - Trang 329-340 - 1999
HDL and LDL cholesterol significantly influence β-cell function in type 2 diabetes mellitus
Current Opinion in Lipidology - Tập 21 Số 3 - Trang 178-185 - 2010
Reverse cholesterol transport fluxes
Current Opinion in Lipidology - Tập 25 Số 1 - Trang 40-47 - 2014
Cholesterol metabolism in the brain
Current Opinion in Lipidology - Tập 12 Số 2 - Trang 105-112 - 2001
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