Current Opinion in Lipidology

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Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance
Current Opinion in Lipidology - Tập 19 Số 1 - Trang 16-24 - 2008
Kimber L. Stanhope, Peter J. Havel
Connecting mTORC1 signaling to SREBP-1 activation
Current Opinion in Lipidology - Tập 23 Số 3 - Trang 226-234 - 2012
Inan Bakan, Mathieu Laplante
An update on alcohol and atherosclerosis
Current Opinion in Lipidology - Tập 15 Số 6 - Trang 673-680 - 2004
Joseph M Li, Kenneth J. Mukamal
Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin
Current Opinion in Lipidology - Tập 13 Số 1 - Trang 51-59 - 2002
Peter J. Havel
Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies
Current Opinion in Lipidology - Tập 29 Số 3 - Trang 218-223 - 2018
Hanrui Zhang
Purpose of reviewLysosomal acid lipase (LAL), encoded by theLIPAgene, is an essential lysosomal enzyme that hydrolyzes cholesteryl ester and triglyceride delivered to the lysosome. This review highlights the novel pathophysiological role of LAL, the functional genomic discoveries ofLIPAas a risk locus for coronary heart diseases (CHD), and the clinical advance in therapies for LAL deficiency.Recent findingsThe essential role of LAL in lipid metabolism has been confirmed in human and mice with LAL deficiency. In humans, loss-of-function mutations ofLIPAcause rare lysosomal disorders, Wolman disease, and cholesteryl ester storage disease, in which LAL enzyme replacement therapy has shown significant benefits in a phase 3 clinical trial. Recent studies have revealed the role of LAL-mediated lysosomal lipolysis in regulating macrophage M2 polarization, lipid mediator production, VLDL secretion, lysosomal function and autophagy, extracellular degradation of aggregated-LDL, and adipose tissue lipolysis. Genome-wide association studies and functional genomic studies have identifiedLIPAas a risk locus for CHD, but the causal variants and mechanisms remain to be determined.SummaryDespite years of research, our understanding of LAL is incomplete. Future studies will continue to focus on the key pathophysiological functions of LAL in health and diseases including CHD.
ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins
Current Opinion in Lipidology - Tập 11 Số 3 - Trang 253-260 - 2000
John F. Oram, Ashley M. Vaughan
Scavenger receptor Bl and cholesterol trafficking
Current Opinion in Lipidology - Tập 10 Số 4 - Trang 329-340 - 1999
David L. Williams, Margery A. Connelly, Ryan E. Temel, Snehasikta Swarnakar, Michael C. Phillips, Margarita de la Llera-Moya, George H. Rothblat
HDL and LDL cholesterol significantly influence β-cell function in type 2 diabetes mellitus
Current Opinion in Lipidology - Tập 21 Số 3 - Trang 178-185 - 2010
Janine K. Kruit, Liam R. Brunham, C. Bruce Verchere, Michael R. Hayden
Reverse cholesterol transport fluxes
Current Opinion in Lipidology - Tập 25 Số 1 - Trang 40-47 - 2014
Marc K. Hellerstein, Scott Turner
Cholesterol metabolism in the brain
Current Opinion in Lipidology - Tập 12 Số 2 - Trang 105-112 - 2001
John Dietschy, Stephen D. Turley
Tổng số: 35   
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