Current Opinion in Lipidology
1473-6535
0957-9672
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Cơ quản chủ quản: LIPPINCOTT WILLIAMS & WILKINS , Lippincott Williams and Wilkins Ltd.
Lĩnh vực:
GeneticsCardiology and Cardiovascular MedicineMolecular BiologyCell BiologyEndocrinology, Diabetes and MetabolismNutrition and Dietetics
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Thông tin về tạp chí
With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.
Các bài báo tiêu biểu
Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance
Tập 19 Số 1 - Trang 16-24 - 2008
Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin
Tập 13 Số 1 - Trang 51-59 - 2002
Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies Purpose of review Lysosomal acid lipase (LAL), encoded by theLIPA gene, is an essential lysosomal enzyme that hydrolyzes cholesteryl ester and triglyceride delivered to the lysosome. This review highlights the novel pathophysiological role of LAL, the functional genomic discoveries ofLIPA as a risk locus for coronary heart diseases (CHD), and the clinical advance in therapies for LAL deficiency. Recent findings The essential role of LAL in lipid metabolism has been confirmed in human and mice with LAL deficiency. In humans, loss-of-function mutations ofLIPA cause rare lysosomal disorders, Wolman disease, and cholesteryl ester storage disease, in which LAL enzyme replacement therapy has shown significant benefits in a phase 3 clinical trial. Recent studies have revealed the role of LAL-mediated lysosomal lipolysis in regulating macrophage M2 polarization, lipid mediator production, VLDL secretion, lysosomal function and autophagy, extracellular degradation of aggregated-LDL, and adipose tissue lipolysis. Genome-wide association studies and functional genomic studies have identifiedLIPA as a risk locus for CHD, but the causal variants and mechanisms remain to be determined. Summary Despite years of research, our understanding of LAL is incomplete. Future studies will continue to focus on the key pathophysiological functions of LAL in health and diseases including CHD.
Tập 29 Số 3 - Trang 218-223 - 2018
ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins
Tập 11 Số 3 - Trang 253-260 - 2000
HDL and LDL cholesterol significantly influence β-cell function in type 2 diabetes mellitus
Tập 21 Số 3 - Trang 178-185 - 2010