Current Oncology Reports
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Current status of sporadic and neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors
Current Oncology Reports - Tập 11 - Trang 322-328 - 2009
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft tissue sarcomas that rarely occur in the general population but have a lifetime incidence of 8% to 13% in those with neurofibromatosis type 1 (NF1). Complete surgical resection is the standard treatment for MPNSTs. Unresectable MPNSTs carry a poor prognosis, and survival appears to be worse in NF1-associated tumors than i......
The Potential Role of Symptom Questionnaires in Palliative and Supportive Cancer Care Delivery
Current Oncology Reports - Tập 19 - Trang 1-6 - 2017
The American Society of Clinical Oncology (ASCO) palliative care recommendations have been updated into a full guideline. Symptom questionnaires—completed and reviewed with patients during care delivery—are poised to play a large role in this guideline because they provide a more comprehensive understanding of symptoms. This article provides an overview of the guideline and describes how symptom q......
Risk assessment models to estimate cancer probabilities
Current Oncology Reports - Tập 9 - Trang 503-508 - 2008
Cancer risk has become a significant research topic due to an increase in statistical risk models built to predict cancer incidence or mortality. Over the past 3 years, 15 models on the development of different types of cancer, including breast, colorectal, prostate, gastric, lung, ovarian, pancreatic, testicular, and skin, have been published. Risk assessment models are dynamic; they need to be u......
Clinical studies of angiogenesis inhibitors: The university of texas md anderson center trial of human endostatin
Current Oncology Reports - Tập 3 - Trang 131-140 - 2001
Most solid-tumor malignancies remain incurable. Novel agents that target and counteract biologic mechanisms are now being developed. It is hoped that these drugs will allow for more effective, less toxic cancer treatments and long-term maintenance approaches. One important class of agents functions by an anti-angiogenic mechanism, targeting the blood vessel supply of the tumor and inhibiting tumor......
Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?
Current Oncology Reports - Tập 24 - Trang 1337-1349 - 2022
Antagonists of mu-opioid receptor role in cancer progression remains to be elucidated. The objective of this review was to summarize the available evidence on antagonists of mu-opioid receptor effect on tumor progression and prognosis in different types of cancers and an evaluation of the available findings on their mechanism of action. We have found studies related to methylnaltrexone (MNTX) and ......
Chimeric Antigen Receptor–Engineered T Cell Therapy in Lymphoma
Current Oncology Reports - Tập 21 - Trang 1-7 - 2019
Chimeric antigen receptor (CAR) T cells are a form of adoptive therapy employing autologous T cells engineered with an artificial receptor, able to recognize tumor antigens through an HLA-independent mechanism. We will review data on safety and efficacy outcomes with CAR T cell therapy in lymphomas. Multicenter trials evaluating three CAR T cell products targeting CD19 have shown that they are hig......
The Need to Examine Metastatic Tissue at the Time of Progression of Breast Cancer: Is Re-biopsy a Necessity or a Luxury?
Current Oncology Reports - Tập 13 - Trang 17-25 - 2010
Knowledge of estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor-2 (HER2) status is necessary for determining the optimal treatment of breast cancer patients. At the same time, the discordance between marker profiles (ER/PR and HER2) of primary and metastatic breast cancer is well documented. Whether discordant cases are secondary to “clonal selection” in......
Androgen Deprivation Therapy and Cognitive Function in Prostate Cancer
Current Oncology Reports - Tập 22 - Trang 1-10 - 2020
Androgen deprivation therapy (ADT) is widely used in prostate cancer. Interest in assessing how ADT impacts cognition is growing. Studies in animals and humans suggest that androgens may affect cognitive function. However, extant studies utilizing common neurocognitive tests have not consistently demonstrated ADT-induced cognitive impairment. Retrospective analyses investigating the association be......
CAR-T Therapies in Solid Tumors: Opportunities and Challenges
Abstract
Purpose of Review
This review will discuss the challenges facing chimeric antigen receptor (CAR)-T cell application for solid tumors and opportunities to overcome these obstacles. In addition, this review will examine therapies that are in development for pediatric solid tumors. ... ...
Current Oncology Reports - - 2023
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