Current Neurology and Neuroscience Reports
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Secondary Headaches During Pregnancy: When to Worry
Current Neurology and Neuroscience Reports - - 2019
Headaches in pregnancy are a frequent cause of worry for both patients and
healthcare providers. Physiological changes during this period increase the risk
of a number of secondary headache disorders, and often also have an impact on
primary headache disorders. This article reviews recent research into
distinguishing worrisome vs non-worrisome headache presentations during
pregnancy. Recent resear...
Current Controversies on Wernicke’s Area and its Role in Language
Current Neurology and Neuroscience Reports - Tập 17 - Trang 1-10 - 2017
The aim of the study is to assess historical anatomical and functional
definitions of Wernicke’s area in light of modern lesion and neuroimaging data.
“Wernicke’s area” has become an anatomical label usually applied to the left
posterior superior temporal gyrus and adjacent supramarginal gyrus. Recent
evidence shows that this region is not critical for speech perception or for
word comprehension. ...
Epigenetics of Sleep and Chronobiology
Current Neurology and Neuroscience Reports - Tập 14 - Trang 1-11 - 2014
The circadian clock choreographs fundamental biological rhythms. This system is
comprised of the master circadian pacemaker in the suprachiasmatic nucleus and
associated pacemakers in other tissues that coordinate complex physiological
processes and behaviors, such as sleep, feeding, and metabolism. The molecular
circuitry that underlies these clocks and orchestrates circadian gene expression
has ...
Evidence-Based Management of External Ventricular Drains
Current Neurology and Neuroscience Reports - Tập 19 - Trang 1-8 - 2019
The optimal management of external ventricular drains (EVD) in the setting of
acute brain injury remains controversial. Therefore, we sought to determine
whether there are optimal management approaches based on the current evidence.
We identified 2 recent retrospective studies on the management of EVDs after
subarachnoid hemorrhage (SAH) which showed conflicting results. A multicenter
survey revea...
Current Concepts of Memory Disorder in Epilepsy: Edging Towards a Network Account
Current Neurology and Neuroscience Reports - Tập 17 - Trang 1-9 - 2017
A paradigm shift in contemporary epileptology has been the reframing of both
epilepsy and its comorbid memory disorders as the product of diseased brain
networks. The current review discusses some of the clinical and theoretical
implications that stem from this shift. Some implications of a network
conceptualisation of epilepsy include a need for more widespread cognitive
phenotyping in epilepsy; ...
Management of Spontaneous Intracerebral Hemorrhage
Current Neurology and Neuroscience Reports - Tập 17 - Trang 1-11 - 2017
We review the current evidence for medical and surgical treatments of
spontaneous intracerebral hemorrhage (ICH). Therapy with hemostatic agents (e.g.
factor VIIa and tranexamic acid) if started early after bleeding onset may
reduce hematoma expansion, but their clinical effectiveness has not been shown.
Rapid anticoagulation reversal with prothrombin concentrates (PCC) plus vitamin
K is the first...
Migraine Management in Children
Current Neurology and Neuroscience Reports - Tập 15 - Trang 1-4 - 2015
Migraine management in children relies on understanding the difference between
adult and childhood migraine, being able to identify childhood migraine variants
and knowledge of both the pediatric and adult literature regarding treatment.
Genetics of Neurodegeneration with Brain Iron Accumulation
Current Neurology and Neuroscience Reports - Tập 11 - Trang 254-261 - 2011
The condition originally called Hallervorden-Spatz syndrome is a collection of
related disorders involving abnormal iron accumulation in the basal ganglia,
usually manifesting with a movement disorder. To date, mutations in the
following genes have been associated with neurodegeneration with brain iron
accumulation (NBIA) phenotypes: PANK2, PLA2G6, FA2H, ATP13A2, C2orf37, CP, and
FTL. This collect...
Paediatric Multiple Sclerosis: Update on Diagnostic Criteria, Imaging, Histopathology and Treatment Choices
Current Neurology and Neuroscience Reports - Tập 16 - Trang 1-12 - 2016
Paediatric multiple sclerosis (MS) represents less than 5 % of the MS
population, but patients with paediatric-onset disease reach permanent
disability at a younger age than adult-onset patients. Accurate diagnosis at
presentation and optimal long-term treatment are vital to mitigate ongoing
neuroinflammation and irreversible neurodegeneration. However, it may be
difficult to early differentiate p...
Muscle-Specific Receptor Tyrosine Kinase (MuSK) Myasthenia Gravis
Current Neurology and Neuroscience Reports - Tập 16 - Trang 1-4 - 2016
Autoimmune myasthenia gravis (MG) is the prototypic, antibody-mediated
neuromuscular disease and is characterized by a decrease in the number of
functional acetylcholine receptors (AChR) within the muscle end plate zone of
the neuromuscular junction (NMJ). Although the pathophysiology of AChR-mediated
myasthenia gravis has been extensively studied over the last 40 years since its
original descript...
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