Current Neurology and Neuroscience Reports
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Secondary Headaches During Pregnancy: When to Worry
Current Neurology and Neuroscience Reports - - 2019
Headaches in pregnancy are a frequent cause of worry for both patients and healthcare providers. Physiological changes during this period increase the risk of a number of secondary headache disorders, and often also have an impact on primary headache disorders. This article reviews recent research into distinguishing worrisome vs non-worrisome headache presentations during pregnancy. Recent resear......
Current Controversies on Wernicke’s Area and its Role in Language
Current Neurology and Neuroscience Reports - Tập 17 - Trang 1-10 - 2017
The aim of the study is to assess historical anatomical and functional definitions of Wernicke’s area in light of modern lesion and neuroimaging data. “Wernicke’s area” has become an anatomical label usually applied to the left posterior superior temporal gyrus and adjacent supramarginal gyrus. Recent evidence shows that this region is not critical for speech perception or for word comprehension. ......
Epigenetics of Sleep and Chronobiology
Current Neurology and Neuroscience Reports - Tập 14 - Trang 1-11 - 2014
The circadian clock choreographs fundamental biological rhythms. This system is comprised of the master circadian pacemaker in the suprachiasmatic nucleus and associated pacemakers in other tissues that coordinate complex physiological processes and behaviors, such as sleep, feeding, and metabolism. The molecular circuitry that underlies these clocks and orchestrates circadian gene expression has ......
Evidence-Based Management of External Ventricular Drains
Current Neurology and Neuroscience Reports - Tập 19 - Trang 1-8 - 2019
The optimal management of external ventricular drains (EVD) in the setting of acute brain injury remains controversial. Therefore, we sought to determine whether there are optimal management approaches based on the current evidence. We identified 2 recent retrospective studies on the management of EVDs after subarachnoid hemorrhage (SAH) which showed conflicting results. A multicenter survey revea......
Current Concepts of Memory Disorder in Epilepsy: Edging Towards a Network Account
Current Neurology and Neuroscience Reports - Tập 17 - Trang 1-9 - 2017
A paradigm shift in contemporary epileptology has been the reframing of both epilepsy and its comorbid memory disorders as the product of diseased brain networks. The current review discusses some of the clinical and theoretical implications that stem from this shift. Some implications of a network conceptualisation of epilepsy include a need for more widespread cognitive phenotyping in epilepsy; ......
Management of Spontaneous Intracerebral Hemorrhage
Current Neurology and Neuroscience Reports - Tập 17 - Trang 1-11 - 2017
We review the current evidence for medical and surgical treatments of spontaneous intracerebral hemorrhage (ICH). Therapy with hemostatic agents (e.g. factor VIIa and tranexamic acid) if started early after bleeding onset may reduce hematoma expansion, but their clinical effectiveness has not been shown. Rapid anticoagulation reversal with prothrombin concentrates (PCC) plus vitamin K is the first......
Migraine Management in Children
Current Neurology and Neuroscience Reports - Tập 15 - Trang 1-4 - 2015
Migraine management in children relies on understanding the difference between adult and childhood migraine, being able to identify childhood migraine variants and knowledge of both the pediatric and adult literature regarding treatment.
Genetics of Neurodegeneration with Brain Iron Accumulation
Current Neurology and Neuroscience Reports - Tập 11 - Trang 254-261 - 2011
The condition originally called Hallervorden-Spatz syndrome is a collection of related disorders involving abnormal iron accumulation in the basal ganglia, usually manifesting with a movement disorder. To date, mutations in the following genes have been associated with neurodegeneration with brain iron accumulation (NBIA) phenotypes: PANK2, PLA2G6, FA2H, ATP13A2, C2orf37, CP, and FTL. This collect......
Paediatric Multiple Sclerosis: Update on Diagnostic Criteria, Imaging, Histopathology and Treatment Choices
Current Neurology and Neuroscience Reports - Tập 16 - Trang 1-12 - 2016
Paediatric multiple sclerosis (MS) represents less than 5 % of the MS population, but patients with paediatric-onset disease reach permanent disability at a younger age than adult-onset patients. Accurate diagnosis at presentation and optimal long-term treatment are vital to mitigate ongoing neuroinflammation and irreversible neurodegeneration. However, it may be difficult to early differentiate p......
Muscle-Specific Receptor Tyrosine Kinase (MuSK) Myasthenia Gravis
Current Neurology and Neuroscience Reports - Tập 16 - Trang 1-4 - 2016
Autoimmune myasthenia gravis (MG) is the prototypic, antibody-mediated neuromuscular disease and is characterized by a decrease in the number of functional acetylcholine receptors (AChR) within the muscle end plate zone of the neuromuscular junction (NMJ). Although the pathophysiology of AChR-mediated myasthenia gravis has been extensively studied over the last 40 years since its original descript......
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