Current Controlled Trials in Cardiovascular Medicine
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Beyond the Evidence of the New Hypertension Guidelines. Blood pressure measurement – is it good enough for accurate diagnosis of hypertension? Time might be in, for a paradigm shift (I)Abstract
Despite widespread availability of a large body of evidence in the area of hypertension, the translation of that evidence into viable recommendations aimed at improving the quality of health care is very difficult, sometimes to the point of questionable acceptability and overall credibility of the guidelines advocating those recommendations.... hiện toàn bộ
Current Controlled Trials in Cardiovascular Medicine - - 2005
The Blood Pressure "Uncertainty Range" – a pragmatic approach to overcome current diagnostic uncertainties (II)Abstract
A tremendous amount of scientific evidence regarding the physiology and physiopathology of high blood pressure combined with a sophisticated therapeutic arsenal is at the disposal of the medical community to counteract the overall public health burden of hypertension. Ample evidence has also been gathered from a multitude of large-scale randomize... ... hiện toàn bộ
Current Controlled Trials in Cardiovascular Medicine - - 2005
A Prospective Study of Pravastatin in the Elderly at Risk (PROSPER): Screening Experience and Baseline Characteristics
Current Controlled Trials in Cardiovascular Medicine - Tập 3 - Trang 1-8 - 2002
PROSPER was designed to investigate the benefits of treatment with pravastatin in elderly patients for whom a typical doctor might consider the prescription of statin therapy to be a realistic option. The PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) is a randomised, double blind, placebo-controlled trial to test the hypothesis that treatment with pravastatin (40 mg/day) will r...... hiện toàn bộ
The clopidogrel after surgery for coronary artery disease (CASCADE) randomized controlled trial: clopidogrel and aspirin versus aspirin alone after coronary bypass surgery [NCT00228423]
Current Controlled Trials in Cardiovascular Medicine - Tập 6 - Trang 1-9 - 2005
Saphenous vein graft disease remains a major limitation of coronary artery bypass graft surgery. The process of saphenous vein intimal hyperplasia begins just days after surgical revascularization, setting the stage for graft atherosclerotic disease and its sequalae. Clopidogrel improves outcomes in patients with atherosclerotic disease, and is effective at reducing intimal hyperplasia in animal m...... hiện toàn bộ
Effect of increased convective clearance by on-line hemodiafiltration on all cause and cardiovascular mortality in chronic hemodialysis patients – the Dutch CONvective TRAnsport STudy (CONTRAST): rationale and design of a randomised controlled trial [ISRCTN38365125]
Current Controlled Trials in Cardiovascular Medicine - Tập 6 - Trang 1-10 - 2005
The high incidence of cardiovascular disease in patients with end stage renal disease (ESRD) is related to the accumulation of uremic toxins in the middle and large-middle molecular weight range. As online hemodiafiltration (HDF) removes these molecules more effectively than standard hemodialysis (HD), it has been suggested that online HDF improves survival and cardiovascular outcome. Thus far, no...... hiện toàn bộ
The Myocardial Ischemia Reduction with Acute Cholesterol Lowering trial: MIRACuLous or not, it's time to change current practice
Current Controlled Trials in Cardiovascular Medicine - - 2002
Weight-modification trials in older adults: what should the outcome measure be?
Current Controlled Trials in Cardiovascular Medicine - Tập 3 - Trang 1-8 - 2002
Overweight older adults are often counseled to lose weight, even though there is little evidence of excess mortality in that age group. Overweight and underweight may be more associated with health status than with mortality, but few clinical trials of any kind have been based on maximizing years of healthy life (YHL), as opposed to years of life (YOL). This paper examines the relationship of body...... hiện toàn bộ
Intracoronary radiation for in-stent restenosis
Current Controlled Trials in Cardiovascular Medicine - Tập 2 - Trang 1-3 - 2001
New insights into the effects on blood pressure of diets low in salt and high in fruits and vegetables and low-fat dairy products
Current Controlled Trials in Cardiovascular Medicine - Tập 2 - Trang 1-4 - 2001
Results from the recent Dietary Approaches to Stop Hypertension (DASH)-Sodium trial provide the latest evidence concerning the effects of dietary patterns and sodium intake on blood pressure. Participants ate either the DASH diet (high in fruits, vegetables and low-fat dairy products, and reduced in saturated and total fat) or a typical US diet. Within each diet arm, participants ate higher, inter...... hiện toàn bộ
A Review of the Adverse Effects of Peripheral Alpha-1 Antagonists in Hypertension Therapy
Current Controlled Trials in Cardiovascular Medicine - Tập 3 - Trang 1-7 - 2002
Doxazosin and its role as an antihypertensive agent have come under recent scrutiny as a result of the early termination of that treatment arm in ALLHAT. It is unclear why the cardiovascular (CV) event rate in this randomized, controlled trial (RCT), especially heart failure, is higher in those treated with a doxazosin-based regimen than with a chlorthalidone based-regimen. There has been little w...... hiện toàn bộ
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