Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitorsCurrent Controlled Trials in Cardiovascular Medicine - Tập 6 - Trang 1-6 - 2005
Mark A Espeland, Daniel H O'Leary, James G Terry, Timothy Morgan, Greg Evans, Harald Mudra
Surrogate measures for cardiovascular disease events have the potential to increase greatly the efficiency of clinical trials. A leading candidate for such a surrogate is the progression of intima-media thickness (IMT) of the carotid artery; much experience has been gained with this endpoint in trials of HMG-CoA reductase inhibitors (statins). We examine two separate systems of criteria that have ...... hiện toàn bộ
Combining short stent implantation and drug-eluting stenting for routine use yields a low restenosis rateCurrent Controlled Trials in Cardiovascular Medicine - Tập 6 - Trang 1-6 - 2005
Ulrich Dietz, Cheryl Dauer, Heinz Lambertz
Stent length serves as a predictor of restenosis in use of bare metal stents (BMS). This has been demonstrated in a feasibility study that used a single short BMS implant (<9 mm) in a high proportion of lesions; the study observed a low rate of restenosis. We performed a pilot prospective study to investigate in a series of consecutive patients the immediate and long-term effects of implantation o...... hiện toàn bộ
The current status of primary prevention in coronary heart diseaseCurrent Controlled Trials in Cardiovascular Medicine - Tập 2 - Trang 1-14 - 2001
Cornel Pater
During the second part of the twentieth century, research advances caused a substantial decline in the rate of coronary heart disease. The decline lasted from the mid-1960s until the early 1990s and occurred primarily in Western countries. However, an unfavourable trend in coronary heart disease related mortality has gradually developed during the 1990s, with cardiovascular diseases anticipated to...... hiện toàn bộ
A Review of the Adverse Effects of Peripheral Alpha-1 Antagonists in Hypertension TherapyCurrent Controlled Trials in Cardiovascular Medicine - Tập 3 - Trang 1-7 - 2002
Chris L Bryson, Bruce M Psaty
Doxazosin and its role as an antihypertensive agent have come under recent scrutiny as a result of the early termination of that treatment arm in ALLHAT. It is unclear why the cardiovascular (CV) event rate in this randomized, controlled trial (RCT), especially heart failure, is higher in those treated with a doxazosin-based regimen than with a chlorthalidone based-regimen. There has been little w...... hiện toàn bộ
Debate: "How low should LDL cholesterol be lowered for optimum prevention of vascular disease?" Viewpoint: "Below 100 mg/dl"Current Controlled Trials in Cardiovascular Medicine - Tập 2 - Trang 1-4 - 2001
W Virgil Brown
Arteriosclerotic vascular disease manifests as heart disease, stroke, aortic aneurysms, and peripheral vascular disease, and is a growing problem world-wide. The preventive efforts made so far have demonstrated that lowering LDL-C is one action that individuals and populations can do with significant success in delaying the onset of clinical events. Epidemiological studies and small clinical trial...... hiện toàn bộ