Current Controlled Trials in Cardiovascular Medicine
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Beyond the Evidence of the New Hypertension Guidelines. Blood pressure measurement – is it good enough for accurate diagnosis of hypertension? Time might be in, for a paradigm shift (I)
- 2005
Abstract Despite widespread availability of a large body of evidence in the area
of hypertension, the translation of that evidence into viable recommendations
aimed at improving the quality of health care is very difficult, sometimes to
the point of questionable acceptability and overall credibility of the
guidelines advocating those recommendations. The scientific community world-wide
and especia...
The Blood Pressure "Uncertainty Range" – a pragmatic approach to overcome current diagnostic uncertainties (II)
- 2005
Abstract A tremendous amount of scientific evidence regarding the physiology and
physiopathology of high blood pressure combined with a sophisticated therapeutic
arsenal is at the disposal of the medical community to counteract the overall
public health burden of hypertension. Ample evidence has also been gathered from
a multitude of large-scale randomized trials indicating the beneficial effects
...
Long-term vitamin E supplementation fails to reduce lipid peroxidation in people at cardiovascular risk: analysis of underlying factors
Tập 3 Số 1 - 2002
Fundamental deficiencies in the megatrial methodology
Tập 2 - Trang 1-6 - 2001
The fundamental methodological deficiency of megatrials is deliberate reduction
of experimental control in order to maximize recruitment and compliance of
subjects. Hence, typical megatrials recruit pathologically and prognostically
heterogeneous subjects, and protocols typically fail to exclude significant
confounders. Therefore, most megatrials do not test a scientific hypothesis, nor
are they i...