Current Cancer Drug Targets
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Voltage-Dependent Potassium Channels Kv1.3 and Kv1.5 in Human Cancer
Current Cancer Drug Targets - Tập 9 Số 8 - Trang 904-914 - 2009
Advances in Nano Drugs for Cancer Chemotherapy
Current Cancer Drug Targets - Tập 11 Số 2 - Trang 135-146 - 2011
Non-Homologous DNA End Joining in Anticancer Therapy
Current Cancer Drug Targets - Tập 7 Số 3 - Trang 243-250 - 2007
Myeloid-Derived Suppressor Cells: General Characteristics and Relevance to Clinical Management of Pancreatic Cancer
Current Cancer Drug Targets - Tập 11 Số 6 - Trang 734-751 - 2011
Targeted Therapy for Advanced Prostate Cancer: Inhibition of the PI3K/Akt/mTOR Pathway
Current Cancer Drug Targets - Tập 9 Số 2 - Trang 237-249 - 2009
Old and New Approaches to Target the Hsp90 Chaperone The 90-kDa heat shock protein (Hsp90) is a molecular chaperone that ensures cellular proteostasis by maintaining the folding, stabilization, activation, and degradation of over 400 client proteins. Hsp90 is not only critical for routine protein maintenance in healthy cells, but also during states of cellular stress, such as cancer and neurodegenerative diseases. Due to its ability to affect phosphorylation of numerous client proteins, inhibition of Hsp90 has been an attractive anticancer approach since the early 1990’s, when researchers identified a druggable target on the amino terminus of Hsp90 for a variety of cancers. Since then, 17 Hsp90 inhibitors that target the chaperone’s Nterminal domain, have entered clinical trials. None, however, have been approved thus far by the FDA as a cancer monotherapy. In these trials, a major limitation observed with Hsp90 inhibition at the N-terminal domain was dose-limiting toxicities and relatively poor pharmacokinetic profiles. Despite this, preclinical and clinical research continues to show that Hsp90 inhibitors effectively target cancer cell death and decrease tumor progression supporting the rationale for the development of novel Hsp90 inhibitors. Here, we present an in-depth overview of the Hsp90 inhibitors used in clinical trials. Finally, we present current shifts in the field related to targeting the carboxy-terminal domain of Hsp90 as well as to the development of isoform-selective inhibitors as a means to bypass the pitfalls of current Hsp90 inhibitors and improve clinical trial outcomes.
Current Cancer Drug Targets - Tập 20 Số 4 - Trang 253-270 - 2020
Co-formulation of P-glycoprotein Substrate and Inhibitor in Nanocarriers: An Emerging Strategy for Cancer Chemotherapy
Current Cancer Drug Targets - Tập 14 Số 5 - Trang 419-433 - 2014
Cancer Stem Cells in Prostate Cancer Chemoresistance
Current Cancer Drug Targets - Tập 14 Số 3 - Trang 225-240 - 2014
Caspase-Independent Pathways of Programmed Cell Death: The Unraveling of New Targets of Cancer Therapy?
Current Cancer Drug Targets - Tập 9 Số 6 - Trang 717-728 - 2009
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