Growth-hormone-releasing Hormone as a Prognostic Biomarker and Therapeutic Target in Gastrointestinal Cancer

Current Cancer Drug Targets - Tập 23 Số 5 - Trang 346-353 - 2023
Amir Avan1,2,3,4, Shima Mehrabadi4, Mahla Velayati4, Nima Zafari4, Seyed Mahdi Hassanian1,4, Majid Ghayour‐Mobarhan1,4, Gordon A. Ferns2, Majid Khazaei1,4
1Basic Sciences Research Institute, Mashhad University of Medical Sciences, Mashhad, 91886-17871, Iran
2Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH, UK
3Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
4Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Tóm tắt

Abstract: Gastrointestinal cancers are prevalent cancers in the world with a poor prognosis, causing about one-half of all cancer deaths in the world. Unfortunately, there is no effective treatment for GI cancers. GHRH and GHRH receptors (GHRH-R) are expressed in various tumoral tissues and cell lines. The inhibition of GHRH-R is a new area of research because it provides a possible means of treating several types of cancer. Recent publications have reported GHRH and GHRH-R expressions in breast, pancreatic, prostate, colon, gastric, ovarian, and lung cancers, along with promising data about the use of GHRH antagonists in the treatment of different cancers. This review aims to summarize the recent studies on the relationship between GHRH and GI cancers and assess whether this hormone can be our target for therapy or used as a prognostic marker for GI cancers.

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