Clinical and Molecular Allergy
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Management of the patient with allergic and immunological disorders in the pandemic COVID-19 era
Clinical and Molecular Allergy - Tập 18 - Trang 1-7 - 2020
The pandemic COVID-19 abruptly exploded, taking most health professionals around the world unprepared. Italy, the first European country to be hit violently, was forced to activate the lockdown in mid-February 2020. At the time of the spread, a high number of victims were quickly registered, especially in the regions of Northern Italy which have a high rate of highly-polluting production activitie......
Chitinase 3-like-1 is produced by human Th17 cells and correlates with the level of inflammation in juvenile idiopathic arthritis patients
Clinical and Molecular Allergy - Tập 14 - Trang 1-9 - 2016
CHI3L1 is a chitinase-like protein without enzymatic activity, produced by activated macrophages, chondrocytes, neutrophils. Recent studies on arthritis, asthma, and inflammatory bowel diseases suggest that chitinases are important in inflammatory processes and tissue remodeling, but their production by human T cells, has never been reported. A microarray analysis of gene expression profile was pe......
Rituximab in refractory sarcoidosis: a single centre experience
Clinical and Molecular Allergy - Tập 13 - Trang 1-5 - 2015
Sarcoidosis is a granulomatous disease whose outcome varies from spontaneous remission to chronic refractory disease. Provided that steroids represent the gold standard as a first line treatment, many immune suppressants drugs are currently used in the disease management. However, refractory disease is still a great challenge. Rituximab is an anti-CD20 chimeric monoclonal antibody, currently used ......
The silent sinus syndrome: protean manifestations of a rare upper respiratory disorder revisitedAbstract
Silent Sinus Syndrome (SSS) is known to be a rare clinical condition, characterized by spontaneous and progressive enophthalmos and hypoglobus associated with atelectasis of the maxillary sinus and alteration of the orbital floor. Most of the patients with this syndrome present with ophthalmological complaints without any nasal sinus symptoms, an... ...
Clinical and Molecular Allergy - - 2013
Sensitization profile in patients with respiratory allergic diseases: differences between conventional and molecular diagnosis (a cross-sectional study)
Clinical and Molecular Allergy - Tập 17 - Trang 1-9 - 2019
Component-resolved diagnosis (CRD) allows to identify single molecular allergen components, and constitutes a routine practice in many allergy units. However, skin prick test (SPT) remains the technique of choice in many otorhinolaryngology departments, thus increasing the risk of using inadequate immunotherapies in patients with respiratory allergies. This study aimed to compare sensitization pro......
Skin microbiota of first cousins affected by psoriasis and atopic dermatitis
Clinical and Molecular Allergy - Tập 14 - Trang 1-11 - 2016
Psoriasis and atopic dermatitis (AD) are chronic inflammatory skin diseases, which negatively influence the quality of life. In the last years, several evidences highlighted the pivotal role of skin bacteria in worsening the symptomatology of AD and psoriasis. In the present study we evaluated the skin microbiota composition in accurately selected subjects affected by (AD) and psoriasis.
Three f......
PPI adverse drugs reactions: a retrospective study
Clinical and Molecular Allergy - Tập 17 Số 1 - 2019
Association between HMGB1 and asthma: a literature review
Clinical and Molecular Allergy - Tập 15 - Trang 1-9 - 2017
Recently, some studies demonstrated that HMGB1, as proinflammatory mediator belonging to the alarmin family, has a key role in different acute and chronic immune disorders. Asthma is a complex disease characterised by recurrent and reversible airflow obstruction associated to airway hyper-responsiveness and airway inflammation. This literature review aims to analyse advances on HMGB1 role, employm......
Rapid clinical improvement of atopic dermatitis in an Omalizumab treated patient
Clinical and Molecular Allergy - Tập 17 - Trang 1-3 - 2019
Atopic dermatitis is a chronic inflammatory skin disorder, whose symptoms and severity grossly depend on individual trigger factors. The majority of patients are satisfactorily treated with emollients together with topical and systemic therapies. However, treatment failure or long-term side effects with conventional treatment options can be a significant clinical problem. Recently, novel therapeut......
The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
Clinical and Molecular Allergy - Tập 19 - Trang 1-10 - 2021
The concern of today's communities is to find a way to prevent or treat COVID-19 and reduce its symptoms in the patients. However, the genetic mutations and more resistant strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge; the designed vaccines and adjuvant therapies would potentially control the symptoms and severity of COVID-19. The most important complication of thi......
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