Clinical and Experimental Pharmacology and Physiology

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MicroRNAs and apoptosis: implications in the molecular therapy of human disease
Clinical and Experimental Pharmacology and Physiology - Tập 36 Số 10 - Trang 951-960 - 2009
Baofeng Yang, Yanjie Lu, Zhiguo Wang
Summary1. MicroRNAs (miRNAs), the small non‐coding RNAs of approximately 22 nucleotides, are now recognized as a very large family present throughout the genomes of plants and metazoans. These small transcripts modulate protein expression by binding to complementary or partially complementary target protein‐coding mRNAs and targeting them for degradation or transla...... hiện toàn bộ
Synthesis, characterization, molecular modelling and biological evaluation of thieno‐pyrimidinone methanesulphonamide thio‐derivatives as non‐steroidal anti‐inflammatory agents
Clinical and Experimental Pharmacology and Physiology - Tập 45 Số 9 - Trang 952-960 - 2018
Adriana Carol Eleonora Graziano, Giovanna Pannuzzo, Ettore Salemi, Andrea Santagati, Rosanna Avola, Emanuele Longo, Venera Cardile
SummaryThis study reports the synthesis, molecular docking and biological evaluation of eight (5‐8 and 5a‐8a) newly synthesized thieno‐pyrimidinone methanesulphonamide thio‐derivatives. The synthetic route used to prepare the new isomers thioaryl and thio‐cycloesyl derivativ...... hiện toàn bộ
RELATIONSHIP BETWEEN THE DOSE‐RESPONSE EFFECTS OF DIAZEPAM AND CLOBAZAM ON ELECTROENCEPHALOGRAPHIC PARAMETERS AND ON KINDLED AMYGDALOID SEIZURE ACTIVITY IN RATS
Clinical and Experimental Pharmacology and Physiology - Tập 15 Số 10 - Trang 753-764 - 1988
Q.L. Genghis Harris, Stephen J. Lewis, Nicole A. Young, Frank Vajda, Bevyn Jarrott
SUMMARY1. The possibility that the anticonvulsant activity of the benzodiazepines, diazepam and clobazam, is related to changes in EEG parameters, particularly β activity, was investigated in amygdaloid kindled rats.2. The effects of diazepam (1, 2, 4, 8 and 16 μmol/kg), administered intraperitoneally (i.p.), clobazam (1, 2, 4, 8, 16 and 32 μmol/kg...... hiện toàn bộ
ART AND SCIENCE OF PHOTODYNAMIC THERAPY
Clinical and Experimental Pharmacology and Physiology - Tập 33 Số 5-6 - Trang 551-556 - 2006
Shazib Pervaiz, Malini Olivo
Ferulic acid improves lipid and glucose homeostasis in high‐fat diet‐induced obese mice
Clinical and Experimental Pharmacology and Physiology - Tập 43 Số 2 - Trang 242-250 - 2016
Jarinyaporn Naowaboot, Pritsana Piyabhan, Narongsuk Munkong, Wason Parklak, Patchareewan Pannangpetch
SummaryFerulic acid (FA) is a plant phenolic acid that has several pharmacological effects including antihyperglycaemic activity. Thus, the objective of this study is to investigate the effect of FA on glucose and lipid metabolism in high‐fat ...... hiện toàn bộ
MECHANOSENSORY PERCEPTION: ARE THERE CONTRIBUTIONS FROM BONE‐ASSOCIATED RECEPTORS?
Clinical and Experimental Pharmacology and Physiology - Tập 32 Số 1-2 - Trang 100-108 - 2005
M. J. Rowe, David J. Tracey, David A. Mahns, V. Sahai, Jason J. Ivanusic
SUMMARY1. The identity of the receptors and afferent nerve fibres that mediate the sense of touch varies somewhat with body location. Those that have been most intensively characterized are associated with the distal glabrous skin of the limbs and, in primates, mediate the sense of touch in the fingertips and palms. In this glabrous skin region, there appear to be ...... hiện toàn bộ
Icaritin inhibits the invasion and epithelial‐to‐mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF‐1α signalling
Clinical and Experimental Pharmacology and Physiology - Tập 42 Số 12 - Trang 1296-1307 - 2015
Bo Xu, Chuanwu Jiang, Hongxing Han, Hong Liu, Ming Tang, Longxi Liu, Wenyan Ji, Xuechao Lu, Xiuli Yang, Yunxu Zhang, Yongji Liu
SummaryIcaritin, a hydrolytic product of icariin from the Epimedium genus, exerts anti‐tumour effects on a variety of tumour cell types, mainly by inhibiting cell proliferation and inducing apoptosis. However, little is known about the role of icaritin in cancer invasion and epithelial‐to‐mesenchymal transition (... hiện toàn bộ
CEREBRAL UPTAKE OF DRUGS IN HUMANS
Clinical and Experimental Pharmacology and Physiology - Tập 34 Số 8 - Trang 695-701 - 2007
Richard N. Upton
SUMMARY Drugs that target the central nervous system (CNS) are under‐represented in the pharmacopoeia because of the difficulties of overcoming passive and active defences of the blood–brain barrier (BBB). Methods have been developed in drug discovery to make decisions about whether a compound crosses t...... hiện toàn bộ
REGULATORS OF ADULT NEUROGENESIS IN THE HEALTHY AND DISEASED BRAIN
Clinical and Experimental Pharmacology and Physiology - Tập 34 Số 5-6 - Trang 533-545 - 2007
Helen Grote, Anthony J. Hannan
Gastric cancer management: Kinases as a target therapy
Clinical and Experimental Pharmacology and Physiology - Tập 44 Số 6 - Trang 613-622 - 2017
Batoul Farran, Susanne Müller, Raquel Carvalho Montenegro
SummaryThe molecular diagnostics revolution has reshaped the practice of oncology by facilitating the identification of genetic, epigenetic and proteomic modifications correlated with cancer, thus delineating ‘oncomaps’ for various cancer types. These advances have enhanced our understanding of gastric cancer, one of the most fatal diseases worldwide, and culminate...... hiện toàn bộ
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