Clinical and Experimental Pharmacology and Physiology

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Icaritin inhibits the invasion and epithelial‐to‐mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF‐1α signalling
Clinical and Experimental Pharmacology and Physiology - Tập 42 Số 12 - Trang 1296-1307 - 2015
Bo Xu, Chuanwu Jiang, Hongxing Han, Hong Liu, Ming Tang, Longxi Liu, Wenyan Ji, Xuechao Lu, Xiuli Yang, Yunxu Zhang, Yongji Liu
SummaryIcaritin, a hydrolytic product of icariin from the Epimedium genus, exerts anti‐tumour effects on a variety of tumour cell types, mainly by inhibiting cell proliferation and inducing apoptosis. However, little is known about the role of icaritin in cancer invasion and epithelial‐to‐mesenchymal transition (... hiện toàn bộ
Gastric cancer management: Kinases as a target therapy
Clinical and Experimental Pharmacology and Physiology - Tập 44 Số 6 - Trang 613-622 - 2017
Batoul Farran, Susanne Müller, Raquel Carvalho Montenegro
SummaryThe molecular diagnostics revolution has reshaped the practice of oncology by facilitating the identification of genetic, epigenetic and proteomic modifications correlated with cancer, thus delineating ‘oncomaps’ for various cancer types. These advances have enhanced our understanding of gastric cancer, one of the most fatal diseases worldwide, and culminate...... hiện toàn bộ
Endothelium‐Independent Relaxation Induced By Histamine In Human Dorsal Penile Artery
Clinical and Experimental Pharmacology and Physiology - Tập 27 Số 7 - Trang 500-507 - 2000
Ana Cristina Martı́nez, Dolores Prieto, Rafaela Raposo, Jose Angel Delgado, Luis Resel, Albino García‐Sacristán, Sara Benedito
SUMMARY1. In vitro preparations of human dorsal penile arteries were used to evaluate the effect of histamine and to characterize the histamine receptors involved in the response.2. Cumulative administration of histamine induced a concentration‐dependent relaxation in precontracted arteries. The H1 re...... hiện toàn bộ
CARDIOVASCULAR EFFECTS OF RILMENIDINE, A NEW α2‐ADRENOCEPTOR AGONIST, AND CLONIDINE IN CONSCIOUS SPONTANEOUSLY HYPERTENSIVE RATS
Clinical and Experimental Pharmacology and Physiology - Tập 16 Số 11 - Trang 837-848 - 1989
Frederick Sannajust, C. Julien, Christian Barrès, Catherine Cerutti, E. Koenig‐Bérardd̊, J Sassard
SUMMARY1. The acute and chronic effects of rilmenidine, a partial agonist of α1‐ and α2‐adrenoceptors with antihypertensive properties, were compared to those of clonidine on blood pressure (BP), heart rate (HR) and the urinary excretion of catecholamines, which was used as an index of sympathetic activity....... hiện toàn bộ
Pathological responses of rat skeletal muscle to a single subcutaneous injection of a toxin isolated from the venom of the Australian tiger snake, Notechis scutatus scutatus
Clinical and Experimental Pharmacology and Physiology - Tập 2 Số 5 - Trang 383-404 - 1975
John B. Harris, Margaret A. Johnson, Evert Karlsson
SUMMARY1. The pathology of mammalian skeletal muscle following a single subcutaneous injection of a purified toxin from the venom of the Australian tiger snake, Notechis scutatus scutatus, has been investigated.2. The toxin was injected into the antero‐lateral aspect of one hind limb of rats and the effects of the injecti...... hiện toàn bộ
Khám phá curcumin, một thành phần của nghệ và những hoạt động sinh học kỳ diệu của nó Dịch bởi AI
Clinical and Experimental Pharmacology and Physiology - Tập 39 Số 3 - Trang 283-299 - 2012
Subash C. Gupta, Sridevi Patchva, Wonil Koh, Bharat B. Aggarwal
Tóm tắt1. Curcumin là thành phần hoạt tính của gia vị nghệ và đã được tiêu dùng cho mục đích y học từ hàng nghìn năm nay. Khoa học hiện đại đã chỉ ra rằng curcumin điều chỉnh nhiều phân tử tín hiệu khác nhau, bao gồm các phân tử gây viêm, yếu tố phiên mã, enzym, protein kinase, protein reductase, protein mang, protein giúp tế bào sống sót, protein kháng thuốc, phân...... hiện toàn bộ
#curcumin #nghệ #hoạt động sinh học #cứu chữa bệnh #kháng viêm #chống oxy hóa #kháng khuẩn #thực phẩm chức năng #thử nghiệm lâm sàng #phân tử tín hiệu
DIABETIC RETINOPATHY: EARLY FUNCTIONAL CHANGES
Clinical and Experimental Pharmacology and Physiology - Tập 24 Số 9-10 - Trang 785-788 - 1997
Valerie A. Alder, Er‐Ning Su, Dao‐Yi Yu, Stephen J. Cringle, Paula K. Yu
SUMMARY1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes.2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determined after 5 weeks of sust...... hiện toàn bộ
The role of oxidative stress in renovascular hypertension
Clinical and Experimental Pharmacology and Physiology - Tập 38 Số 2 - Trang 144-152 - 2011
Ruy R. Campos, Elizabeth Barbosa Oliveira‐Sales, Érika E. Nishi, Mírian Aparecida Boim, Miriam Sterman Dolnikoff, Cássia T. Bergamaschi
Summary1. There is mounting evidence that increased oxidative stress and sympathetic nerve activity play important roles in renovascular hypertension. In the present review, we focus on the importance of oxidative stress in two distinct populations of neurons involved with cardiovascular regulation: those of the rostral ventrolateral medulla (RVLM) and those of the...... hiện toàn bộ
Familial And Acquired Long QT Syndrome And The Cardiac Rapid Delayed Rectifier Potassium Current
Clinical and Experimental Pharmacology and Physiology - Tập 27 Số 10 - Trang 753-766 - 2000
Harry J. Witchel, Jules C. Hancox
SUMMARY1. Long QT syndrome (LQTS) is a cardiac disorder characterized by syncope, seizures and sudden death; it can be congenital, idiopathic, or iatrogenic.2. Long QT syndrome is so‐named because of the connection observed between the distinctive polymorphic ventricular tachycardia torsade de pointes and prolongation of ...... hiện toàn bộ
Gastric acid is the key modulator in the pathogenesis of non‐steroidal anti‐inflammatory drug‐induced ulceration in rats
Clinical and Experimental Pharmacology and Physiology - Tập 37 Số 7 - Trang 654-661 - 2010
J. Michael Zinkievich, Sunil George, Shalinee Jha, Jyotirmoy Nandi, Robert A. Levine
Summary1. In the present study, we investigated the role of gastric acid (GA) secretion on non‐steroidal anti‐inflammatory drug (NSAID)‐induced ulcerogenesis in vivo. Rats were administered single oral doses of selective cyclo‐oxygenase (COX)‐1 (SC‐560; 2.5 mg/kg), COX‐2 (DFU; 25 mg/kg) or non‐selective COX (indomethacin; 25 mg/kg) inhibi...... hiện toàn bộ
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