Clinical Reviews in Allergy
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Immunologic Adverse Effects of Biologics for the Treatment of Atopy
Clinical Reviews in Allergy - Tập 59 - Trang 220-230 - 2019
The use of biologic agents as therapies for atopic diseases such as asthma and atopic dermatitis has increased greatly in recent years. The biological agents used to treat atopic diseases are for the most part monoclonal antibodies that suppress the immune response and reduce inflammation by targeting particular cytokines or other molecules involved in Th1, Th2, or Th17 immune reactions. Various s......
Blood Clotting and the Pathogenesis of Types I and II Hereditary AngioedemaAbstract The plasma contact system is the initiator of the intrinsic pathway of coagulation and the main producer of the inflammatory peptide bradykinin. When plasma is exposed to a negatively charged surface the two enzymes factor XII (FXII) and plasma prekallikrein (PK) bind to the surface alongside the co-factor high molecular weight kininogen (HK), where PK is n... ...
Clinical Reviews in Allergy - Tập 60 Số 3 - Trang 348-356 - 2021
Medical treatment of primary biliary cirrhosis and primary sclerosing cholangitis
Clinical Reviews in Allergy - Tập 28 - Trang 135-145 - 2005
Chronic cholestasis is the main feature of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC), the most common chronic cholestatic liver diseases in adults. Although the etiology of both diseases remains poorly understood, auto-immune processes appear to be important, particularly in PBC. PBC and PSC usually slowly progress to cirrhosis, liver failure, and death, unless liver......
Autoimmunity to Type VII Collagen: Epidermolysis Bullosa Acquisita
Clinical Reviews in Allergy - Tập 33 - Trang 78-84 - 2007
Epidermolysis bullosa acquisita (EBA) is an acquired, autoimmune, mechanobullous disease with clinical features reminiscent of genetic dystrophic epidermolysis bullosa (DEB). EBA patients have skin fragility, blisters, scars, and milia formation. DEB is due to a genetic defect in the gene-encoding type VII collagen, which makes anchoring fibrils, structures that attach the epidermis and its underl......
Biopsies in patients with intrathoracic disease
Clinical Reviews in Allergy - Tập 8 - Trang 333-360 - 1990
Lupus Nephritis in Colombians: Contrasts and Comparisons with Other Populations
Clinical Reviews in Allergy - Tập 40 - Trang 199-207 - 2011
Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematosus (SLE) since it is the major predictor of poor prognosis. The purpose of this study was to examine the clinical and immunological characteristics associated with LN development during the course of SLE in Colombians. Therefore, patients with SLE followed at five different referral centers in Medellin, Bogo......
International perspectives on controversial practices in allergic diseases
Clinical Reviews in Allergy - Tập 14 Số 3 - Trang 271-287 - 1996
Molecular Biology of Atopic Dermatitis
Clinical Reviews in Allergy - Tập 47 - Trang 193-218 - 2014
Atopic dermatitis (AD) is a chronic inflammatory skin disease with specific genetic and immunological mechanisms. The rapid development of new techniques in molecular biology had ushered in new discoveries on the role of cytokines, chemokines, and immune cells in the pathogenesis of AD. New polymorphisms of AD are continually being reported in different populations. The physical and immunological ......
Onset and outcome of asthma in older adults
Clinical Reviews in Allergy - Tập 22 - Trang 53-65 - 2002
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