Omalizumab Updosing in Chronic Spontaneous Urticaria: an Overview of Real-World EvidenceClinical Reviews in Allergy - Tập 59 - Trang 38-45 - 2020
Martin Metz, Zahava Vadasz, Emek Kocatürk, Ana M. Giménez-Arnau
Chronic spontaneous urticaria (CSU) is defined as the spontaneous development of itchy hives and/or angioedema due to known or unknown causes that last for at least 6 weeks. At any given time, CSU is believed to affect 0.5–1% of the global population. Omalizumab (a recombinant, humanized anti-immunoglobulin-E antibody) is the only approved treatment for antihistamine refractory CSU. However, ~ 30%...... hiện toàn bộ
New Mechanistic Advances in FcεRI-Mast Cell–Mediated Allergic SignalingClinical Reviews in Allergy - Tập 63 - Trang 431-446 - 2022
Yang Li, Patrick S. C. Leung, M. Eric Gershwin, Junmin Song
Mast cells originate from the CD34+/CD117+ hematopoietic progenitors in the bone marrow, migrate into circulation, and ultimately mature and reside in peripheral tissues. Microbiota/metabolites and certain immune cells (e.g., Treg cells) play a key role in maintaining immune tolerance. Cross-linking of allergen-specific IgE on mast cells activates the high-affinity membrane-bound receptor FcεRI, t...... hiện toàn bộ
Concepts and Clinical Application of Fiberoptic Examination of the Upper AirwayClinical Reviews in Allergy - Tập 6 - Trang 303-320 - 1988
John C. Seiner
Using the RPLS, clinicians now have easier access to areas of the upper airway that heretofore were the exclusive domain of the otolaryngologist often in the surgical suite. Routine inspection of the upper airway can lead to more timely diagnosis of hidden pathology. This results in appropriate referral of patients to the otolaryngologist, promoting a more productive and harmonious working associa...... hiện toàn bộ
The antiphospholipid syndromeClinical Reviews in Allergy - Tập 13 - Trang 39-48 - 1995
E. Nigel Harris
Much more is known about the APLS than 15 yr ago, but more needs to be done. Clinically, major characteristics of the disorder have been defined, but the course of the disease and its relationship to other disorders, such as systemic lupus erythematosus (SLE), need to be defined. Good progress has been made in standardizing anticardiolipin and, to a lesser extent, LA. However, problems with interl...... hiện toàn bộ
Anaphylactoid reactions to narcotic analgesicsClinical Reviews in Allergy - Tập 9 Số 3 - Trang 309-318 - 1991
Fisher, Malcolm M., Harle, David G., Baldo, Brian A.
Athough reports in the literature of severe anaphylactic reactions to narcotics are rare, they occur, and it may be that such reactions are true IgE-mediated reactions, rather than direct histamine release as has been previously believed. Cross-sensitivity between individual opioid derivative members of the fentanyl group od drugs appears likely.
Genetics of Hereditary Angioedema RevisitedClinical Reviews in Allergy - Tập 51 - Trang 170-182 - 2016
Anastasios E. Germenis, Matthaios Speletas
Contemporary genetic research has provided evidences that angioedema represents a diverse family of disorders related to kinin metabolism, with a much greater genetic complexity than was initially considered. Convincing data have also recently been published indicating that the clinical heterogeneity of hereditary angioedema due to C1 inhibitor deficiency (classified as C1-INH-HAE) could be attrib...... hiện toàn bộ