ClinTransMed, AB
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A comparative analysis of protein targets of withdrawn cardiovascular drugs in human and mouse
ClinTransMed, AB - Tập 2 - Trang 1-9 - 2012
Mouse is widely used in animal testing of cardiovascular disease. However, a large number of cardiovascular drugs that have been experimentally proved to work well on mouse were withdrawn because they caused adverse side effects in human. In this study, we investigate whether binding patterns of withdrawn cardiovascular drugs are conserved between mouse and human through computational dockings and...... hiện toàn bộ
A distinct metabolic signature predicts development of fasting plasma glucose
ClinTransMed, AB - - 2012
Mathematical morphology-based approach to the enhancement of morphological features in medical images
ClinTransMed, AB - Tập 1 - Trang 1-10 - 2011
Medical image processing is essential in many fields of medical research and clinical practice because it greatly facilitates early and accurate detection and diagnosis of diseases. In particular, contrast enhancement is important for optimal image quality and visibility. This paper proposes a new image processing method for enhancing morphological features of masses and other abnormalities in med...... hiện toàn bộ
A systematic analysis of a mi-RNA inter-pathway regulatory motif
ClinTransMed, AB - Tập 3 - Trang 1-14 - 2013
The continuing discovery of new types and functions of small non-coding RNAs is suggesting the presence of regulatory mechanisms far more complex than the ones currently used to study and design Gene Regulatory Networks. Just focusing on the roles of micro RNAs (miRNAs), they have been found to be part of several intra-pathway regulatory motifs. However, inter-pathway regulatory mechanisms have be...... hiện toàn bộ
Splitting random forest (SRF) for determining compact sets of genes that distinguish between cancer subtypes
ClinTransMed, AB - Tập 2 - Trang 1-12 - 2012
The identification of very small subsets of predictive variables is an important toπc that has not often been considered in the literature. In order to discover highly predictive yet compact gene set classifiers from whole genome expression data, a non-parametric, iterative algorithm, Splitting Random Forest (SRF), was developed to robustly identify genes that distinguish between molecular subtype...... hiện toàn bộ
Protein co-expression network analysis (ProCoNA)
ClinTransMed, AB - Tập 3 - Trang 1-10 - 2013
Biological networks are important for elucidating disease etiology due to their ability to model complex high dimensional data and biological systems. Proteomics provides a critical data source for such models, but currently lacks robust de novo methods for network construction, which could bring important insights in systems biology. We have evaluated the construction of network models using meth...... hiện toàn bộ
A dynamic model for tumour growth and metastasis formation
ClinTransMed, AB - Tập 2 - Trang 1-11 - 2012
A simple and fast computational model to describe the dynamics of tumour growth and metastasis formation is presented. The model is based on the calculation of successive generations of tumour cells and enables one to describe biologically important entities like tumour volume, time point of 1st metastatic growth or number of metastatic colonies at a given time. The model entirely relies on the ch...... hiện toàn bộ
Plot protein: visualization of mutations
ClinTransMed, AB - Tập 3 - Trang 1-4 - 2013
Next-generation sequencing has enabled examination of variation at the DNA sequence level and can be further enhanced by evaluation of the variants at the protein level. One powerful method is to visualize these data often revealing patterns not immediately apparent in a text version of the same data. Many investigators are interested in knowing where their amino acid changes reside within a prote...... hiện toàn bộ
Comparative efficacy and acceptability of five anti-tubercular drugs in treatment of multidrug resistant tuberculosis: a network meta-analysis
ClinTransMed, AB - Tập 5 - Trang 1-9 - 2015
Multidrug resistant tuberculosis (MDR-TB) is a serious form of tuberculosis (TB). There is no recognized effective treatment for MDR-TB, although there are a number of publications that have reported positive results for MDR-TB. We performed a network meta-analysis to assess the efficacy and acceptability of potential antitubercular drugs. We conducted a network meta-analysis of randomized control...... hiện toàn bộ
Analysis of the salivary microbiome using culture-independent techniques
ClinTransMed, AB - - 2012
The salivary microbiota is a potential diagnostic indicator of several diseases. Culture-independent techniques are required to study the salivary microbial community since many of its members have not been cultivated. We explored the bacterial community composition in the saliva sample using metagenomic whole genome shotgun (WGS) sequencing, the extraction of 16S rRNA gene fragments from metageno...... hiện toàn bộ
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