ChemBioChem

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Antibody Induction Directed against the Tumor‐Associated MUC4 Glycoprotein
ChemBioChem - Tập 16 Số 6 - Trang 959-967 - 2015
Hui Cai, Björn Palitzsch, Sebastian Hartmann, Natascha Stergiou, Horst Kunz, Edgar Schmitt, Ulrika Westerlind
AbstractMucin glycoproteins are important diagnostic and therapeutic targets for cancer treatment. Although several strategies have been developed to explore anti‐tumor vaccines based on MUC1 glycopeptides, only few studies have focused on vaccines directed against the tumor‐associated MUC4 glycoprotein. MUC4 is an important tumor marker overexpressed in lung cancer and uniquely expressed in pancr... hiện toàn bộ
Using Fluorous Amino Acids to Modulate the Biological Activity of an Antimicrobial Peptide
ChemBioChem - Tập 9 Số 3 - Trang 370-373 - 2008
Lindsey M. Gottler, Hyang‐Yeol Lee, Charles E. Shelburne, Ayyalusamy Ramamoorthy, E. Neil G. Marsh
Porphyrin Derivatives for Telomere Binding and Telomerase Inhibition
ChemBioChem - Tập 6 Số 1 - Trang 123-132 - 2005
Isabelle M. Dixon, Frédéric Lopez, Jean‐Pierre Estève, Águeda M. Tejera, Marı́a A. Blasco, Geneviève Pratviel, Bernard Meunier
AbstractThe capacity of G‐quadruplex ligands to stabilize four‐stranded DNA makes them able to inhibit telomerase, which is involved in tumour cell proliferation. A series of cationic metalloporphyrin derivatives was prepared by making variations on a meso‐tetrakis(4‐N‐methyl‐pyridiniumyl)porphyrin skeleton (TMPyP). The DNA binding properties of nickel(II) and manganese(III) porphyrins were studie... hiện toàn bộ
Cell‐Free Exploration of the Natural Product Chemical Space
ChemBioChem - Tập 22 Số 1 - Trang 84-91 - 2021
Jonathan W. Bogart, Maria D. Cabezas, Bastian Vögeli, Derek A. Wong, Ashty S. Karim, Michael C. Jewett
AbstractNatural products and secondary metabolites comprise an indispensable resource from living organisms that have transformed areas of medicine, agriculture, and biotechnology. Recent advances in high‐throughput DNA sequencing and computational analysis suggest that the vast majority of natural products remain undiscovered. To accelerate the natural product discovery pipeline, cell‐free metabo... hiện toàn bộ
Monovalent Ion Dependence of Neomycin B Binding to an RNA Aptamer Characterized by Spectroscopic Methods
ChemBioChem - Tập 8 Số 10 - Trang 1137-1145 - 2007
Sabine Stampfl, Adelheid Lempradl, Gottfried Koehler, Renée Schroeder
AbstractUnderstanding the interactions of small molecules like antibiotics with RNA is a prerequisite for the development of novel drugs. In this study we address structural and thermodynamic features of such interactions by using a simple model system: the binding of the highly charged antibiotic neomycin B to a short hairpin RNA molecule. Nucleotide A16, which acts as a flap over the neomycin B ... hiện toàn bộ
The Ether Lipid Inositol‐C2‐PAF is a Potent Inhibitor of Cell Proliferation in HaCaT Cells
ChemBioChem - Tập 7 Số 3 - Trang 441-449 - 2006
Annette Fischer, Dieter Müller, Martin Zimmermann‐Kordmann, Burkhard Kleuser, Michael Mickeleit, Stephan Laabs, Werner Löwe, Frédéric Cantagrel, Werner Reutter, Kerstin Danker
AbstractThe search for specific anticancer drugs that do not interfere with DNA synthesis or influence the cytoskeleton has led to the development of modified phospholipids with antiproliferative properties. These compounds cause remodeling of the structure and function of plasma membranes. Recently, we described novel compounds, the glycosidated phospholipids, that surprisingly inhibit cell proli... hiện toàn bộ
New p32/gC1qR Ligands for Targeted Tumor Drug Delivery
ChemBioChem - Tập 17 Số 7 - Trang 570-575 - 2016
Lauri Paasonen, Shweta Sharma, Gary B. Braun, Venkata Ramana Kotamraju, Thomas D.Y. Chung, Yugang Dong, Kazuki N. Sugahara, Marjo Yliperttula, Bainan Wu, Maurizio Pellecchia, Erkki Ruoslahti, Tambet Teesalu
AbstractCell surface p32, the target of LyP‐1 homing peptide, is upregulated in tumors and atherosclerotic plaques and has been widely used as a receptor for systemic delivery of payloads. Here, we identified an improved LyP‐1‐mimicking peptide (TT1, CKRGARSTC). We used this peptide in a fluorescence polarization‐based high‐throughput screening of a 50 000‐compound chemical library and identified ... hiện toàn bộ
Ultrasensitive Detection of DNA by PNA and Nanoparticle‐Enhanced Surface Plasmon Resonance Imaging
ChemBioChem - Tập 9 Số 13 - Trang 2067-2070 - 2008
Roberta D’Agata, Roberto Corradini, Giuseppe Grasso, Rosangela Marchelli, Giuseppe Spoto
NMR Spectroscopy of Paramagnetic Metalloproteins
ChemBioChem - Tập 6 Số 9 - Trang 1536-1549 - 2005
Ivano Bertini, Claudio Luchinat, Giacomo Parigi, Roberta Pierattelli
AbstractThis article deals with the solution structure determination of paramagnetic metalloproteins by NMR spectroscopy. These proteins were believed not to be suitable for NMR investigations for structure determination until a decade ago, but eventually novel experiments and software protocols were developed, with the aim of making the approach suitable for the goal and as user‐friendly and safe... hiện toàn bộ
Probing the Dimerization Interface of Leishmania infantum Trypanothione Reductase with Site‐Directed Mutagenesis and Short Peptides
ChemBioChem - Tập 14 Số 10 - Trang 1212-1217 - 2013
Miguel Toro-Londoño, Pedro A. Sánchez‐Murcia, David F. Moreno, Marta Ruiz‐Santaquiteria, Juan F. Álzate, Ana Negri, María‐José Camarasa, Federico Gago, Sonsoles Velázquez, Antonio Jiménez-Ruı́z
Tổng số: 87   
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