ChemBioChem

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Antibody Induction Directed against the Tumor‐Associated MUC4 Glycoprotein
ChemBioChem - Tập 16 Số 6 - Trang 959-967 - 2015
Hui Cai, Björn Palitzsch, Sebastian Hartmann, Natascha Stergiou, Horst Kunz, Edgar Schmitt, Ulrika Westerlind
AbstractMucin glycoproteins are important diagnostic and therapeutic targets for cancer treatment. Although several strategies have been developed to explore anti‐tumor vaccines based on MUC1 glycopeptides, only few studies have focused on vaccines directed against the tumor‐associated MUC4 glycoprotein. MUC4 is an important tumor marker overexpressed in lung cance...... hiện toàn bộ
Monovalent Ion Dependence of Neomycin B Binding to an RNA Aptamer Characterized by Spectroscopic Methods
ChemBioChem - Tập 8 Số 10 - Trang 1137-1145 - 2007
Sabine Stampfl, Adelheid Lempradl, Gottfried Koehler, Renée Schroeder
AbstractUnderstanding the interactions of small molecules like antibiotics with RNA is a prerequisite for the development of novel drugs. In this study we address structural and thermodynamic features of such interactions by using a simple model system: the binding of the highly charged antibiotic neomycin B to a short hairpin RNA molecule. Nucleotide A16, which ac...... hiện toàn bộ
The Ether Lipid Inositol‐C2‐PAF is a Potent Inhibitor of Cell Proliferation in HaCaT Cells
ChemBioChem - Tập 7 Số 3 - Trang 441-449 - 2006
Annette Fischer, Dieter Müller, Martin Zimmermann‐Kordmann, Burkhard Kleuser, Michael Mickeleit, Stephan Laabs, Werner Löwe, Frédéric Cantagrel, Werner Reutter, Kerstin Danker
AbstractThe search for specific anticancer drugs that do not interfere with DNA synthesis or influence the cytoskeleton has led to the development of modified phospholipids with antiproliferative properties. These compounds cause remodeling of the structure and function of plasma membranes. Recently, we described novel compounds, the glycosidated phospholipids, tha...... hiện toàn bộ
New p32/gC1qR Ligands for Targeted Tumor Drug Delivery
ChemBioChem - Tập 17 Số 7 - Trang 570-575 - 2016
Lauri Paasonen, Shweta Sharma, Gary B. Braun, Venkata Ramana Kotamraju, Thomas D.Y. Chung, Yugang Dong, Kazuki N. Sugahara, Marjo Yliperttula, Bainan Wu, Maurizio Pellecchia, Erkki Ruoslahti, Tambet Teesalu
AbstractCell surface p32, the target of LyP‐1 homing peptide, is upregulated in tumors and atherosclerotic plaques and has been widely used as a receptor for systemic delivery of payloads. Here, we identified an improved LyP‐1‐mimicking peptide (TT1, CKRGARSTC). We used this peptide in a fluorescence polarization‐based high‐throughput screening of a 50 000‐compound...... hiện toàn bộ
Ultrasensitive Detection of DNA by PNA and Nanoparticle‐Enhanced Surface Plasmon Resonance Imaging
ChemBioChem - Tập 9 Số 13 - Trang 2067-2070 - 2008
Roberta D’Agata, Roberto Corradini, Giuseppe Grasso, Rosangela Marchelli, Giuseppe Spoto
CloN6, a Novel Methyltransferase Catalysing the Methylation of the Pyrrole‐2‐carboxyl Moiety of Clorobiocin
ChemBioChem - Tập 4 Số 8 - Trang 768-773 - 2003
Lucia Westrich, Lutz Heide, Shu‐Ming Li
AbstractThe aminocoumarin antibiotic clorobiocin contains a 5‐methylpyrrole‐2‐carboxylic acid unit. This pyrrole unit is derived from L‐proline, and it would be expected that its 5‐methyl group should be introduced by a methylation reaction. However, sequence analysis of the clorobiocin biosynthetic gene cluster did not reveal a gene...... hiện toàn bộ
Role of Endonucleases XPF and XPG in Nucleotide Excision Repair of Platinated DNA and Cisplatin/Oxaliplatin Cytotoxicity
ChemBioChem - Tập 12 Số 7 - Trang 1115-1123 - 2011
Nora Kulak, Wee Han Ang, Guangyu Zhu, MyatNoeZin Myint, Stephen J. Lippard
AbstractResistance of tumor cells to platinum anticancer agents poses a major problem in cancer chemotherapy. One of the mechanisms associated with platinum‐based drug resistance is the enhanced capacity of the cell to carry out nucleotide excision repair (NER) on platinum‐damaged DNA. Endonucleases XPF and XPG are critical components of NER, responsible for excisi...... hiện toàn bộ
Chemical Synthesis and Biological Screening of 2‐Aminoimidazole‐Based Bacterial and Fungal Antibiofilm Agents
ChemBioChem - Tập 11 Số 3 - Trang 396-410 - 2010
Steven A. Rogers, Joseph D. Bero, Christian Melander
AbstractA collection of 2‐aminoimidazole/triazole amides has been synthesized and screened for antibiofilm activity. This class of small molecules was found to modulate the biofilm activity of Pseudomonas aeruginosa, a multidrug‐resistant strain of Acinetobacter baumannii (MDRAB), a methicillin‐resi...... hiện toàn bộ
Discovery of Chromone‐Based Inhibitors of the Transcription Factor STAT5
ChemBioChem - Tập 9 Số 5 - Trang 723-727 - 2008
Judith Müller, Bianca Sperl, Wolfgang Reindl, Anke Kiessling, Thorsten Berg
Disruption of Transcriptionally Active Stat3 Dimers with Non‐phosphorylated, Salicylic Acid‐Based Small Molecules: Potent in vitro and Tumor Cell Activities
ChemBioChem - Tập 10 Số 12 - Trang 1959-1964 - 2009
Steven Fletcher, Jagdeep Singh, Xiaolei Zhang, Peibin Yue, Brent D. G. Page, Sumaiya Sharmeen, Vijay Shahani, Wei Zhao, Aaron D. Schimmer, James Turkson, Patrick T. Gunning
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