Cell Regeneration
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Defining synthetic surfaces for human pluripotent stem cell culture
Cell Regeneration - Tập 2 - Trang 1-17 - 2013
Human pluripotent stem cells (hPSCs) are able to self-renew indefinitely and to differentiate into all adult cell types. hPSCs therefore show potential for application to drug screening, disease modelling and cellular therapies. In order to meet this potential, culture conditions must be developed that are consistent, defined, scalable, free of animal products and that facilitate stable self-renew......
miRNA in cardiac development and regenerationAbstract Ischemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of proliferation, making it impossible to regenerate the heart after injuries such as myocardial infarction. MicroRNAs (miRNAs), a class of non-coding singl... ...
Cell Regeneration -
OSKM-mediated reversible reprogramming of cardiomyocytes regenerates injured myocardium
Cell Regeneration - Tập 11 - Trang 1-3 - 2022
Cellular reprogramming has rapidly become a promising methodology to generate new cardiomyocytes from non-cardiomyocyte cell types. Using the transient expression of OSKM factors, Chen et al. demonstrate a unique reprogramming strategy involving the modulation of the resident adult cardiomyocyte identity to an immature proliferative state (Science 373:1537–40, 2021). This OSKM-mediated reversion r......
Stem cell therapy for amyotrophic lateral sclerosis
Cell Regeneration - Tập 4 - Trang 1-7 - 2015
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by the loss of motor neurons. Currently, no effective therapy is available to treat ALS, except for Riluzole, which has only limited clinical benefits. Stem-cell-based therapy has been intensively and extensively studied as a potential novel treatment strategy for ALS and has been shown to be effective, at leas......
IL-6/gp130 signaling: a key unlocking regenerationAbstract Liver is an organ with notable capacity of regeneration. Reprogramming of hepatocytes towards an immature state is one of the important mechanisms for hepatocyte replenishment. Inflammatory response mediated by IL-6 and its family cytokines has been widely reported closely related with tissue regeneration in myriads of organs. Recently Hui and colleagues re... ...
Cell Regeneration - Tập 12 Số 1
Mesenchymal stem cells in the treatment of osteogenesis imperfecta
Cell Regeneration - Tập 12 - Trang 1-21 - 2023
Osteogenesis imperfecta (OI) is a disease caused by mutations in different genes resulting in mild, severe, or lethal forms. With no cure, researchers have investigated the use of cell therapy to correct the underlying molecular defects of OI. Mesenchymal stem cells (MSCs) are of particular interest because of their differentiation capacity, immunomodulatory effects, and their ability to migrate t......
Generation of knockout rabbits using transcription activator-like effector nucleases
Cell Regeneration - Tập 3 - Trang 3:3 - 2014
Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration
Cell Regeneration - Tập 11 - Trang 1-13 - 2022
Myocardial regeneration has been considered a promising option for the treatment of adult myocardial injuries. Previously, a chick early amniotic fluid (ceAF) preparation was shown to contain growth-related factors that promoted embryonic growth and cellular proliferation, though the nature of the components within ceAF were not fully defined. Here we tested whether this ceAF preparation is simila......
Molecular mechanisms of neurite regeneration and repair: insights from C. elegans and Drosophila
Cell Regeneration - Tập 12 - Trang 1-11 - 2023
The difficulties of injured and degenerated neurons to regenerate neurites and regain functions are more significant than in other body tissues, making neurodegenerative and related diseases hard to cure. Uncovering the secrets of neural regeneration and how this process may be inhibited after injury will provide insights into novel management and potential treatments for these diseases. Caenorhab......
From wound response to repair – lessons from C. elegans
Cell Regeneration - Tập 10 - Trang 1-10 - 2021
As a result of evolution, the ability to repair wounds allows organisms to combat environment insults. Although the general process of wound healing at the tissue level has been described for decades, the detailed molecular mechanisms regarding the early wound response and rapid wound repair at the cellular level remain little understood. Caenorhabditis elegans is a model organism widely used in t......
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