Cell Regeneration

Công bố khoa học tiêu biểu

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Advanced cryopreservation engineering strategies: the critical step to utilize stem cell products
Cell Regeneration - Tập 12 Số 1
Xiaohu Wang, Enyu Wang, Gang Zhao
AbstractWith the rapid development of stem cell-related therapies and regenerative medicine, the clinical application of stem cell products is on the rise. However, ensuring the effectiveness of these products after storage and transportation remains a challenge in the transformation to clinical trials. Cryopreservation technology allows for the long-term storage o...... hiện toàn bộ
Mapping a mammalian adult adrenal gland hierarchy across species by microwell-seq
Cell Regeneration - Tập 9 - Trang 1-12 - 2020
Shujing Lai, Lifeng Ma, Weigao E, Fang Ye, Haide Chen, Xiaoping Han, Guoji Guo
Recently, single-cell RNA-seq technologies have been rapidly updated, leading to a revolution in biology. We previously developed Microwell-seq, a cost-effective and high-throughput single cell RNA sequencing(scRNA-seq) method with a very simple device. Most cDNA libraries are sequenced using an expensive Illumina platform. Here, we present the first report showing combined Microwell-seq and BGI M...... hiện toàn bộ
Pluripotency and its layers of complexity
Cell Regeneration - Tập 1 - Trang 1-10 - 2012
Jolene Ooi, Pentao Liu
Pluripotency is depicted by a self-renewing state that can competently differentiate to form the three germ layers. Different stages of early murine development can be captured on a petri dish, delineating a spectrum of pluripotent states, ranging from embryonic stem cells, embryonic germ cells to epiblast stem cells. Anomalous cell populations displaying signs of pluripotency have also been uncov...... hiện toàn bộ
Immunomodulatory and Antioxidative potentials of adipose-derived Mesenchymal stem cells isolated from breast versus abdominal tissue: a comparative study
Cell Regeneration - Tập 9 Số 1 - 2020
Nourhan Abu-Shahba, Mohamed Mahmoud, Mazen Abdel-Rasheed, Yasmine Darwish, Ahmad AbdelKhaliq, Eman Mohammed, Mahmoud ElHefnawi, Osama Azmy
Abstract Background Adipose-derived stem cells (ASCs) are considered ideal candidates for both research and cellular therapy due to ease of access, large yield, feasibility, and efficacy in preclinical and clinical studies. Unlike the subcutaneous abdominal fat depot, breast ASCs features are still not well recognized, limiting th...... hiện toàn bộ
Các chiến lược kích thích nhằm điều chỉnh điện và từ của tế bào và mô Dịch bởi AI
Cell Regeneration -
Salah Omer, Kaitlyn H. McKnight, Lai Sang Young, Shang Song
Tóm tắtCác hiện tượng điện đóng vai trò quan trọng trong nhiều quá trình sinh học, bao gồm tín hiệu tế bào, sự phát triển sớm của phôi, phục hồi và tái cấu trúc mô, và sự phát triển của các sinh vật. Các hiệu ứng điện và từ đã được nghiên cứu trên nhiều chiến lược kích thích và loại tế bào khác nhau liên quan đến chức năng tế bào và điều trị bệnh. Trong bài viết tổ...... hiện toàn bộ
Role of Oct4 in the early embryo development
Cell Regeneration - Tập 3 - Trang 1-10 - 2014
Guangming Wu, Hans R Schöler
Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem cells (ESCs) or their differentiation into trophoblast. Oct4 of maternal origin is postulated to play critical role in defining totipotency and inducing pluripotency during embryonic development. However, the geneti...... hiện toàn bộ
Defining synthetic surfaces for human pluripotent stem cell culture
Cell Regeneration - Tập 2 - Trang 1-17 - 2013
Jack W Lambshead, Laurence Meagher, Carmel O'Brien, Andrew L Laslett
Human pluripotent stem cells (hPSCs) are able to self-renew indefinitely and to differentiate into all adult cell types. hPSCs therefore show potential for application to drug screening, disease modelling and cellular therapies. In order to meet this potential, culture conditions must be developed that are consistent, defined, scalable, free of animal products and that facilitate stable self-renew...... hiện toàn bộ
Evolutionary insights into heart regeneration
Cell Regeneration - Tập 9 - Trang 1-2 - 2020
Jing-Wei Xiong
Some lower vertebrates such as zebrafish and axolotl have incredible cardiac regenerative potential while mammals have very limited ones. Comparative studies among species have revealed that cardiomyocyte polyploidy, endothermy, and injury-induced activation of certain transcriptional factors including AP1 complexes are critical for cardiomyocyte proliferation and heart regeneration during animal ...... hiện toàn bộ
miRNA in cardiac development and regeneration
Cell Regeneration -
Zhaohui Ouyang, Ke Wei
AbstractIschemic heart disease is one of the main causes of morbidity and mortality in the world. In adult mammalian hearts, most cardiomyocytes are terminally differentiated and have extremely limited capacity of proliferation, making it impossible to regenerate the heart after injuries such as myocardial infarction. MicroRNAs (miRNAs), a class of non-coding singl...... hiện toàn bộ
Generation of tooth-like structures from integration-free human urine induced pluripotent stem cells
Cell Regeneration - Tập 2 - Trang 1-8 - 2013
Jinglei Cai, Yanmei Zhang, Pengfei Liu, Shubin Chen, Xuan Wu, Yuhua Sun, Ang Li, Ke Huang, Rongping Luo, Lihui Wang, Ying Liu, Ting Zhou, Shicheng Wei, Guangjin Pan, Duanqing Pei
Tooth is vital not only for a good smile, but also good health. Yet, we lose tooth regularly due to accidents or diseases. An ideal solution to this problem is to regenerate tooth with patients’ own cells. Here we describe the generation of tooth-like structures from integration-free human urine induced pluripotent stem cells (ifhU-iPSCs). We first differentiated ifhU-iPSCs to epithelial sheets, w...... hiện toàn bộ
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