Cell Communication and Signaling
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FZD5 prevents epithelial-mesenchymal transition in gastric cancer
Cell Communication and Signaling - - 2021
Frizzled (FZD) proteins function as receptors for WNT ligands. Members in FZD family including FZD2, FZD4, FZD7, FZD8 and FZD10 have been demonstrated to mediate cancer cell epithelial-mesenchymal transition (EMT). CCLE and TCGA databases were interrogated to reveal the association of FZD5 with EMT. EMT was analyzed by investigating the alterations in CDH1 (E-cadherin), VIM (Vimentin) and ZEB1 exp...... hiện toàn bộ
Drug induced modulation of T cell activation and differentiation in atopic dermatitis patients
Cell Communication and Signaling - Tập 7 - Trang 1-1 - 2009
Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways
Cell Communication and Signaling - Tập 13 - Trang 1-13 - 2015
Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric diseases but also with several extragastric diseases. The clinical outcomes caused by H. pylori infection are considered to be associated with a complex combination of host susceptibility, environmental factors and bacterial isolates. Infections involving H. pylori strains that...... hiện toàn bộ
CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis
Cell Communication and Signaling - Tập 22 - Trang 1-12 - 2024
Cementoblasts on the tooth-root surface are responsible for cementum formation (cementogenesis) and sensitive to Porphyromonas gingivalis stimulation. We have previously proved transcription factor CXXC-type zinc finger protein 5 (CXXC5) participates in cementogenesis. Here, we aimed to elucidate the mechanism in which CXXC5 regulates P. gingivalis-inhibited cementogenesis from the perspective of ...... hiện toàn bộ
PVT1 signals an androgen-dependent transcriptional repression program in prostate cancer cells and a set of the repressed genes predicts high-risk tumors
Cell Communication and Signaling - Tập 19 - Trang 1-16 - 2021
Androgen receptor (AR) and polycomb repressive complex 2 (PRC2) are known to co-occupy the loci of genes that are downregulated by androgen-stimulus. Long intergenic non-coding RNA (lincRNA) PVT1 is an overexpressed oncogene that is associated with AR in LNCaP prostate cancer cells, and with PRC2 in HeLa and many other types of cancer cells. The possible involvement of PVT1 in mediating androgen-i...... hiện toàn bộ
Cancer/testis antigen 45 is expressed in a nuclear speckles-like pattern in human tumor cell lines
Cell Communication and Signaling - Tập 7 - Trang 1-1 - 2009
Immune checkpoint regulator PD-L1 expression on tumor cells by contacting CD11b positive bone marrow derived stromal cells
Cell Communication and Signaling - Tập 13 - Trang 1-12 - 2015
Expression of programmed cell death ligand 1 (PD-L1) is an important process by which tumor cells suppress antitumor immunity in the tumor microenvironment. Bone marrow (BM)–derived immune cells are an important component of the tumor microenvironment. However, the link between PD-L1 induction on tumor cells and communication with BM cells is unknown. This study demonstrates that BM cells have a d...... hiện toàn bộ
Serine phosphorylation regulates paxillin turnover during cell migration
Cell Communication and Signaling - Tập 4 - Trang 1-12 - 2006
Paxillin acts as an adaptor protein that localizes to focal adhesion. This protein is regulated during cell migration by phosphorylation on tyrosine, serine and threonine residues. Most of these phosphorylations have been implicated in the regulation of different steps of cell migration. The two major phosphorylation sites of paxillin in response to adhesion to an extracellular matrix are serines ...... hiện toàn bộ
Correction: PSF functions as a repressor of hypoxia-induced angiogenesis by promoting mitochondrial function
Cell Communication and Signaling - Tập 21 - Trang 1-2 - 2023
7-Ketocholesterol modulates intercellular communication through gap-junction in bovine lens epithelial cells
Cell Communication and Signaling - Tập 2 - Trang 1-10 - 2004
Connexin43 (Cx43) is an integral membrane protein that forms intercellular channels called gap junctions. Intercellular communication in the eye lens relies on an extensive network of gap junctions essential for the maintenance of lens transparency. The association of Cx43 with cholesterol enriched lipid raft domains was recently demonstrated. The objective of this study is to assess if products o...... hiện toàn bộ
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