Cell Communication and Signaling

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Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes
Cell Communication and Signaling - - 2019
Jeremiah Ong’achwa Machuki, Hongyuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Ke‐Xue Li, Zhiwei Zhao, Hong Sun
TLR7 activation by miR-21 promotes renal fibrosis by activating the pro-inflammatory signaling pathway in tubule epithelial cells
Cell Communication and Signaling - Tập 21 - Trang 1-16 - 2023
Jeongwon Kim, Sugyeong Ha, Minjung Son, Doyeon Kim, Mi-Jeong Kim, Bumseok Kim, Donghwan Kim, Hae Young Chung, Ki Wung Chung
Toll-like receptor 7 (TLR7) is an endosomal TLR activated by single-stranded RNA, including endogenous microRNAs. Although TLR7 is known to promote inflammatory responses in pathophysiological conditions, its role in renal fibrosis has not been investigated. Here, we aim to investigate the inflammatory roles of TLR7 in kidney inflammation and fibrosis. TLR7 knockout mice (Tlr7 −/−) subjected to AD...... hiện toàn bộ
E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway
Cell Communication and Signaling - Tập 20 - Trang 1-16 - 2022
Manman Liang, Lijing Wang, Zhengui Sun, Xingwu Chen, Hanli Wang, Lilong Qin, Wenying Zhao, Biao Geng
Recent studies have indicated that some members of the tripartite motif (TRIM) proteins function as important regulators for non-small cell lung cancer (NSCLC), However, the regulatory mechanism underpinning aberrant expression of TRIM in NSCLC remains unclear. Here we report that TRIM15 plays important roles in NSCLC progression through modulating Keap1-Nrf2 signaling pathway. TRIM15 expression w...... hiện toàn bộ
A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication
Cell Communication and Signaling - Tập 15 - Trang 1-16 - 2017
Venugopal Thayanithy, Patrick O’Hare, Phillip Wong, Xianda Zhao, Clifford J. Steer, Subbaya Subramanian, Emil Lou
Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays are needed to accurately assess the downstream effects of TNT-mediated transfer of cellular signals in vitro. We recently reported a modified transwell assay system designed to te...... hiện toàn bộ
Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway
Cell Communication and Signaling - Tập 11 Số 1 - Trang 1-12 - 2013
Park, Kwang Hwan, Park, Boryung, Yoon, Dong Suk, Kwon, Seung-Hyun, Shin, Dong Min, Lee, Jin Woo, Lee, Hyun Gyu, Shim, Jae-Hyuck, Park, Jeon Han, Lee, Jae Myun
Zinc, an essential trace element, inhibits osteoclast differentiation in vitro and in vivo. The molecular mechanism for the inhibitory effect of zinc, however, is poorly understood. The purpose of this study was to investigate the effect of zinc and determine its molecular mechanism on receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis in mouse bone marrow-derived monocyte cells...... hiện toàn bộ
ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors
Cell Communication and Signaling - - 2020
Min Song, Stacey D. Finley
Abstract Background Angiogenesis plays an important role in the survival of tissues, as blood vessels provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is a prominent strategy in many different settings, including both tissue engineering and cancer treatment. However, not all of the approach...... hiện toàn bộ
The oncogenic mechanisms of the Janus kinase-signal transducer and activator of transcription pathway in digestive tract tumors
Cell Communication and Signaling - Tập 22 Số 1
Ruihong Zhao, Zhangmin Hu, Xiaoli Zhang, Shujuan Huang, Guodong Yu, Zhe Wu, Wei Yu, Juan Liu, Bing Ruan
AbstractDigestive tract tumors are heterogeneous and involve the dysregulation of multiple signaling pathways. The Janus kinase-signal transducer and activator of transcription (JAK–STAT) pathway plays a notable role in the oncogenesis of digestive tract tumors. Typically activated by pro-inflammatory cytokines, it regulates important biological processes, such as ...... hiện toàn bộ
How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP
Cell Communication and Signaling - Tập 20 - Trang 1-26 - 2022
C. A. Heckman, O. M. Ademuyiwa, M. L. Cayer
For many cell types, directional locomotion depends on their maintaining filopodia at the leading edge. Filopodia lack any Ca2+-binding structural protein but respond to store-operated Ca2+ entry (SOCE). SOCE was induced by first replacing the medium with Ca2+-free salt solution with cyclopiazonic acid (CPA). This lowers Ca2+ in the ER and causes stromal interacting molecule (STIM) to be transloca...... hiện toàn bộ
K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3
Cell Communication and Signaling - Tập 22 - Trang 1-23 - 2024
Rebekka Geißert, Angela Lammert, Stefanie Wirth, Rabea Hönig, Dirk Lohfink, Monika Unger, Denis Pek, Konstantin Schlüter, Theresa Scheftschik, Daniel J. Smit, Manfred Jücker, Andre Menke, Klaudia Giehl
K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hyperactivation of effector proteins and downstream signaling pathways. Here, we demonstrate that oncogenic K-Ras(V12) regulates tumor cell migration by activating the phosphatidylinositol 3-kina...... hiện toàn bộ
CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis
Cell Communication and Signaling - Tập 22 - Trang 1-12 - 2024
Li Ma, Huiyi Wang, Xin Huang, Hantao Huang, Yan Peng, Heyu Liu, Xiaoxuan Wang, Zhengguo Cao
Cementoblasts on the tooth-root surface are responsible for cementum formation (cementogenesis) and sensitive to Porphyromonas gingivalis stimulation. We have previously proved transcription factor CXXC-type zinc finger protein 5 (CXXC5) participates in cementogenesis. Here, we aimed to elucidate the mechanism in which CXXC5 regulates P. gingivalis-inhibited cementogenesis from the perspective of ...... hiện toàn bộ
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