Cell Communication and Signaling

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Correction to: Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway
Cell Communication and Signaling - Tập 18 - Trang 1-2 - 2020
Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang, Yong-gang Shi
An amendment to this paper has been published and can be accessed via the original article.
A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology
Cell Communication and Signaling - Tập 21 Số 1
Patrícia Gomes, Cristian Bodo, Carlos Nogueras‐Ortiz, Martina Samiotaki, Minghao Chen, Carina Soares‐Cunha, Joana M Silva, Bárbara Coimbra, George Stamatakis, Liliana Santos, George Panayotou, Foteini Tzouanou, Clarissa L. Waites, Christos Gatsogiannis, Nuno Sousa, Dimitrios Kapogiannis, Bruno Costa-Silva, Ioannis Sotiropoulos
Abstract Background Extracellular vesicles (EVs), including small EVs (sEVs) such as exosomes, exhibit great potential for the diagnosis and treatment of brain disorders, representing a valuable tool for precision medicine. The latter demands high-quality human biospecimens, especially in complex di...... hiện toàn bộ
The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation in Helicobacter pylori-associated gastritis by regulating ROS and autophagy
Cell Communication and Signaling - Tập 21 - Trang 1-16 - 2023
Qiao Yu, Huiying Shi, Zhen Ding, Zhe Wang, Hailing Yao, Rong Lin
The NLRP3 inflammasome activation is the molecular basis of Helicobacter pylori (Hp)-associated gastritis. Tripartite motif (TRIM) 31 is involved in diverse pathological events. However, whether TRIM31 plays a role in the activation of NLRP3 inflammasome in Hp infection is not clarified. A mouse model of chronic Hp infection was established, and the gastric tissues were subjected to the polymerase...... hiện toàn bộ
Role of STING in the treatment of non-small cell lung cancer
Cell Communication and Signaling - Tập 22 Số 1
Wilkin Tang, Wenjie Zhou, Mei Ji, Xin Yang
AbstractNon-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. However, a considerable proportion of advance patients who cannot benefit from them. Consequently, it is esse...... hiện toàn bộ
The ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells
Cell Communication and Signaling - - 2022
Ning Ding, Pibao Li, Huiqing Li, Lei Y, Zengzhen Zhang
Abstract Background Ezrin/radixin/moesin (ERM) proteins are members of the protein 4.1 superfamily and function as linkers that connect the actin cytoskeleton to the plasma membrane of cells. ERM also play critical role in the Lipopolysaccharide (LPS)-induced inflammatory response. However, the sign...... hiện toàn bộ
Metabolism of asparagine in the physiological state and cancer
Cell Communication and Signaling - - 2024
Qiong Yuan, Liyang Yin, Jun He, Qiting Zeng, Yuxin Liang, Yingying Shen, Xuyu Zu
Asparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides. Asparagine has also been reported to play a vital role in the development of cancer cells. Although several types of cancer cells can synthesise asparagine alone, their synthesis levels are insufficient to meet th...... hiện toàn bộ
Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases
Cell Communication and Signaling - Tập 22 - Trang 1-17 - 2024
Xiaotong Xu, Yi Han, Binlong Zhang, Quanzhong Ren, Juan Ma, Sijin Liu
Abnormal inflammatory states in the brain are associated with a variety of brain diseases. The dynamic changes in the number and function of immune cells in cerebrospinal fluid (CSF) are advantageous for the early prediction and diagnosis of immune diseases affecting the brain. The aggregated factors and cells in inflamed CSF may represent candidate targets for therapy. The physiological barriers ...... hiện toàn bộ
TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy
Cell Communication and Signaling - Tập 18 - Trang 1-11 - 2020
Adam S. Dayoub, Rolf A. Brekken
Immunotherapy for cancer is making impressive strides at improving survival of a subset of cancer patients. To increase the breadth of patients that benefit from immunotherapy, new strategies that combat the immunosuppressive microenvironment of tumors are needed. Phosphatidylserine (PS) signaling is exploited by tumors to enhance tumor immune evasion and thus strategies to inhibit PS-mediated imm...... hiện toàn bộ
Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
Cell Communication and Signaling - Tập 17 - Trang 1-15 - 2019
Jiang-Jiang Qin, Xiang-Dong Cheng, Jia Zhang, Wei-Dong Zhang
Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate of metastasis and low rate of survival. Despite the advances in understanding this devastating disease, PC still accounts for 3% of all cancers and causes almost 7% of death of cancer patients. Recent studies have demonstrated that the transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) and its key n...... hiện toàn bộ
Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes
Cell Communication and Signaling - - 2019
Jeremiah Ong’achwa Machuki, Hongyuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Ke‐Xue Li, Zhiwei Zhao, Hong Sun
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