Cell Communication and Signaling

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Correction to: Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway
Cell Communication and Signaling - Tập 18 - Trang 1-2 - 2020
Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang, Yong-gang Shi
An amendment to this paper has been published and can be accessed via the original article.
Role of STING in the treatment of non-small cell lung cancer
Cell Communication and Signaling - Tập 22 Số 1
Wilkin Tang, Wenjie Zhou, Mei Ji, Xin Yang
AbstractNon-small cell lung cancer (NSCLC) is a prevalent form of lung cancer. Patients with advanced NSCLC are currently being treated with various therapies, including traditional radiotherapy, chemotherapy, molecular targeted therapies and immunotherapy. However, a considerable proportion of advance patients who cannot benefit from them. Consequently, it is esse...... hiện toàn bộ
Metabolism of asparagine in the physiological state and cancer
Cell Communication and Signaling - - 2024
Qiong Yuan, Liyang Yin, Jun He, Qiting Zeng, Yuxin Liang, Yingying Shen, Xuyu Zu
Asparagine, an important amino acid in mammals, is produced in several organs and is widely used for the production of other nutrients such as glucose, proteins, lipids, and nucleotides. Asparagine has also been reported to play a vital role in the development of cancer cells. Although several types of cancer cells can synthesise asparagine alone, their synthesis levels are insufficient to meet th...... hiện toàn bộ
Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases
Cell Communication and Signaling - Tập 22 - Trang 1-17 - 2024
Xiaotong Xu, Yi Han, Binlong Zhang, Quanzhong Ren, Juan Ma, Sijin Liu
Abnormal inflammatory states in the brain are associated with a variety of brain diseases. The dynamic changes in the number and function of immune cells in cerebrospinal fluid (CSF) are advantageous for the early prediction and diagnosis of immune diseases affecting the brain. The aggregated factors and cells in inflamed CSF may represent candidate targets for therapy. The physiological barriers ...... hiện toàn bộ
Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes
Cell Communication and Signaling - - 2019
Jeremiah Ong’achwa Machuki, Hongyuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Ke‐Xue Li, Zhiwei Zhao, Hong Sun
TLR7 activation by miR-21 promotes renal fibrosis by activating the pro-inflammatory signaling pathway in tubule epithelial cells
Cell Communication and Signaling - Tập 21 - Trang 1-16 - 2023
Jeongwon Kim, Sugyeong Ha, Minjung Son, Doyeon Kim, Mi-Jeong Kim, Bumseok Kim, Donghwan Kim, Hae Young Chung, Ki Wung Chung
Toll-like receptor 7 (TLR7) is an endosomal TLR activated by single-stranded RNA, including endogenous microRNAs. Although TLR7 is known to promote inflammatory responses in pathophysiological conditions, its role in renal fibrosis has not been investigated. Here, we aim to investigate the inflammatory roles of TLR7 in kidney inflammation and fibrosis. TLR7 knockout mice (Tlr7 −/−) subjected to AD...... hiện toàn bộ
Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
Cell Communication and Signaling - Tập 11 Số 1 - 2013
A. Koop, Nadia Sellami, Sabine Adam‐Klages, Marcus Lettau, Dieter Kabelitz, Ottmar Janßen, Hans-Jürgen Heidebrecht
Abstract Background Due to their restricted expression in male germ cells and certain tumors, cancer/testis (CT) antigens are regarded as promising targets for tumor therapy. CT45 is a recently identified nuclear CT antigen that was associated with a severe disease score in Hodgkin’s lymphoma and...... hiện toàn bộ
O-GlcNAc modification: why so intimately associated with phosphorylation?
Cell Communication and Signaling - Tập 9 - Trang 1-4 - 2011
Suresh Mishra, Sudharsana R Ande, Neil W Salter
Post-translational modification of proteins at serine and threonine side chains by β-N-acetylglucosamine (O-GlcNAc) mediated by the enzyme β-N-acetylglucosamine transferase has been emerging as a fundamental regulatory mechanism encompassing a wide range of proteins involved in cell division, metabolism, transcription and cell signaling. Furthermore, an extensive interplay between O-GlcNAc modific...... hiện toàn bộ
Inhibition of cyclin E1 sensitizes hepatocellular carcinoma cells to regorafenib by mcl-1 suppression
Cell Communication and Signaling - Tập 17 - Trang 1-11 - 2019
Jianliang Xu, Fei Huang, Zhicheng Yao, Changchang Jia, Zhiyong Xiong, Hao Liang, Nan Lin, Meihai Deng
To clarify the effects of cylcin E1 expression on HCC tumor progression, we studied the expression of cyclin E1 and inhibitory efficacy of regorafenib and sorafenib in HCC cells, and investigated a potential therapy that combines regorafenib treatment with cyclin E1 inhibition. Western blotting for caspase-3 and Hoechst 33225 staining was used to measure the expression level of apoptosis-related p...... hiện toàn bộ
F0F1 ATP synthase regulates extracellular calcium influx in human neutrophils by interacting with Cav2.3 and modulates neutrophil accumulation in the lipopolysaccharide-challenged lung
Cell Communication and Signaling - Tập 18 - Trang 1-15 - 2020
Baoyi Zhu, Zhengfu Feng, Yan Guo, Tian Zhang, Ai Mai, Zhanfang Kang, Ting Weijen, Dai Wang, Dazhong Yin, Dongxing Zhu, Jun Gao
Neutrophils form the first line of innate host defense against invading microorganisms. We previously showed that F0F1 ATP synthase (F-ATPase), which is widely known as mitochondrial respiratory chain complex V, is expressed in the plasma membrane of human neutrophils and is involved in regulating cell migration. Whether F-ATPase performs cellular functions through other pathways remains unknown. ...... hiện toàn bộ
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