Cell Communication and Signaling
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Correction to: Platelets promote breast cancer cell MCF-7 metastasis by direct interaction: surface integrin α2β1-contacting-mediated activation of Wnt-β-catenin pathway
Cell Communication and Signaling - Tập 18 - Trang 1-2 - 2020
An amendment to this paper has been published and can be accessed via the
original article.
A novel isolation method for spontaneously released extracellular vesicles from brain tissue and its implications for stress-driven brain pathology
Cell Communication and Signaling - Tập 21 Số 1
Abstract Background Extracellular vesicles (EVs), including small EVs (sEVs)
such as exosomes, exhibit great potential for the diagnosis and treatment of
brain disorders, representing a valuable tool for precision medicine. The latter
demands high-quality human biospecimens, especially in complex disorders in
which pathological and specimen heterogeneity, as well as diverse individual
clinical pro...
The E3 ubiquitin ligase TRIM31 attenuates NLRP3 inflammasome activation in Helicobacter pylori-associated gastritis by regulating ROS and autophagy
Cell Communication and Signaling - Tập 21 - Trang 1-16 - 2023
The NLRP3 inflammasome activation is the molecular basis of Helicobacter pylori
(Hp)-associated gastritis. Tripartite motif (TRIM) 31 is involved in diverse
pathological events. However, whether TRIM31 plays a role in the activation of
NLRP3 inflammasome in Hp infection is not clarified. A mouse model of chronic Hp
infection was established, and the gastric tissues were subjected to the
polymerase...
Role of STING in the treatment of non-small cell lung cancer
Cell Communication and Signaling - Tập 22 Số 1
AbstractNon-small cell lung cancer (NSCLC) is a prevalent form of lung cancer.
Patients with advanced NSCLC are currently being treated with various therapies,
including traditional radiotherapy, chemotherapy, molecular targeted therapies
and immunotherapy. However, a considerable proportion of advance patients who
cannot benefit from them. Consequently, it is essential to identify a novel
researc...
The ROCK-ezrin signaling pathway mediates LPS-induced cytokine production in pulmonary alveolar epithelial cells
Cell Communication and Signaling - - 2022
Abstract Background Ezrin/radixin/moesin (ERM) proteins are members of the
protein 4.1 superfamily and function as linkers that connect the actin
cytoskeleton to the plasma membrane of cells. ERM also play critical role in the
Lipopolysaccharide (LPS)-induced inflammatory response. However, the signaling
mechanisms involved in this process remain unclear. In this study, we aimed to
investigate the...
Metabolism of asparagine in the physiological state and cancer
Cell Communication and Signaling - - 2024
Asparagine, an important amino acid in mammals, is produced in several organs
and is widely used for the production of other nutrients such as glucose,
proteins, lipids, and nucleotides. Asparagine has also been reported to play a
vital role in the development of cancer cells. Although several types of cancer
cells can synthesise asparagine alone, their synthesis levels are insufficient
to meet th...
Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases
Cell Communication and Signaling - Tập 22 - Trang 1-17 - 2024
Abnormal inflammatory states in the brain are associated with a variety of brain
diseases. The dynamic changes in the number and function of immune cells in
cerebrospinal fluid (CSF) are advantageous for the early prediction and
diagnosis of immune diseases affecting the brain. The aggregated factors and
cells in inflamed CSF may represent candidate targets for therapy. The
physiological barriers ...
TIMs, TAMs, and PS- antibody targeting: implications for cancer immunotherapy
Cell Communication and Signaling - Tập 18 - Trang 1-11 - 2020
Immunotherapy for cancer is making impressive strides at improving survival of a
subset of cancer patients. To increase the breadth of patients that benefit from
immunotherapy, new strategies that combat the immunosuppressive microenvironment
of tumors are needed. Phosphatidylserine (PS) signaling is exploited by tumors
to enhance tumor immune evasion and thus strategies to inhibit PS-mediated
imm...
Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
Cell Communication and Signaling - Tập 17 - Trang 1-15 - 2019
Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate
of metastasis and low rate of survival. Despite the advances in understanding
this devastating disease, PC still accounts for 3% of all cancers and causes
almost 7% of death of cancer patients. Recent studies have demonstrated that the
transcription factor nuclear factor-erythroid 2-related factor 2 (Nrf2) and its
key n...
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