Cell Communication and Signaling

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Understanding immune microenvironment alterations in the brain to improve the diagnosis and treatment of diverse brain diseases
Cell Communication and Signaling - Tập 22 - Trang 1-17 - 2024
Xiaotong Xu, Yi Han, Binlong Zhang, Quanzhong Ren, Juan Ma, Sijin Liu
Abnormal inflammatory states in the brain are associated with a variety of brain diseases. The dynamic changes in the number and function of immune cells in cerebrospinal fluid (CSF) are advantageous for the early prediction and diagnosis of immune diseases affecting the brain. The aggregated factors and cells in inflamed CSF may represent candidate targets for therapy. The physiological barriers ...... hiện toàn bộ
Estrogen regulation of cardiac cAMP-L-type Ca2+ channel pathway modulates sex differences in basal contraction and responses to β2AR-mediated stress in left ventricular apical myocytes
Cell Communication and Signaling - - 2019
Jeremiah Ong’achwa Machuki, Hongyuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Ke‐Xue Li, Zhiwei Zhao, Hong Sun
TLR7 activation by miR-21 promotes renal fibrosis by activating the pro-inflammatory signaling pathway in tubule epithelial cells
Cell Communication and Signaling - Tập 21 - Trang 1-16 - 2023
Jeongwon Kim, Sugyeong Ha, Minjung Son, Doyeon Kim, Mi-Jeong Kim, Bumseok Kim, Donghwan Kim, Hae Young Chung, Ki Wung Chung
Toll-like receptor 7 (TLR7) is an endosomal TLR activated by single-stranded RNA, including endogenous microRNAs. Although TLR7 is known to promote inflammatory responses in pathophysiological conditions, its role in renal fibrosis has not been investigated. Here, we aim to investigate the inflammatory roles of TLR7 in kidney inflammation and fibrosis. TLR7 knockout mice (Tlr7 −/−) subjected to AD...... hiện toàn bộ
Down-regulation of the cancer/testis antigen 45 (CT45) is associated with altered tumor cell morphology, adhesion and migration
Cell Communication and Signaling - Tập 11 Số 1 - 2013
A. Koop, Nadia Sellami, Sabine Adam‐Klages, Marcus Lettau, Dieter Kabelitz, Ottmar Janßen, Hans-Jürgen Heidebrecht
Abstract Background Due to their restricted expression in male germ cells and certain tumors, cancer/testis (CT) antigens are regarded as promising targets for tumor therapy. CT45 is a recently identified nuclear CT antigen that was associated with a severe disease score in Hodgkin’s lymphoma and...... hiện toàn bộ
F0F1 ATP synthase regulates extracellular calcium influx in human neutrophils by interacting with Cav2.3 and modulates neutrophil accumulation in the lipopolysaccharide-challenged lung
Cell Communication and Signaling - Tập 18 - Trang 1-15 - 2020
Baoyi Zhu, Zhengfu Feng, Yan Guo, Tian Zhang, Ai Mai, Zhanfang Kang, Ting Weijen, Dai Wang, Dazhong Yin, Dongxing Zhu, Jun Gao
Neutrophils form the first line of innate host defense against invading microorganisms. We previously showed that F0F1 ATP synthase (F-ATPase), which is widely known as mitochondrial respiratory chain complex V, is expressed in the plasma membrane of human neutrophils and is involved in regulating cell migration. Whether F-ATPase performs cellular functions through other pathways remains unknown. ...... hiện toàn bộ
E3 ligase TRIM15 facilitates non-small cell lung cancer progression through mediating Keap1-Nrf2 signaling pathway
Cell Communication and Signaling - Tập 20 - Trang 1-16 - 2022
Manman Liang, Lijing Wang, Zhengui Sun, Xingwu Chen, Hanli Wang, Lilong Qin, Wenying Zhao, Biao Geng
Recent studies have indicated that some members of the tripartite motif (TRIM) proteins function as important regulators for non-small cell lung cancer (NSCLC), However, the regulatory mechanism underpinning aberrant expression of TRIM in NSCLC remains unclear. Here we report that TRIM15 plays important roles in NSCLC progression through modulating Keap1-Nrf2 signaling pathway. TRIM15 expression w...... hiện toàn bộ
A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication
Cell Communication and Signaling - Tập 15 - Trang 1-16 - 2017
Venugopal Thayanithy, Patrick O’Hare, Phillip Wong, Xianda Zhao, Clifford J. Steer, Subbaya Subramanian, Emil Lou
Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. Valid assays are needed to accurately assess the downstream effects of TNT-mediated transfer of cellular signals in vitro. We recently reported a modified transwell assay system designed to te...... hiện toàn bộ
Zinc inhibits osteoclast differentiation by suppression of Ca2+-Calcineurin-NFATc1 signaling pathway
Cell Communication and Signaling - Tập 11 Số 1 - Trang 1-12 - 2013
Park, Kwang Hwan, Park, Boryung, Yoon, Dong Suk, Kwon, Seung-Hyun, Shin, Dong Min, Lee, Jin Woo, Lee, Hyun Gyu, Shim, Jae-Hyuck, Park, Jeon Han, Lee, Jae Myun
Zinc, an essential trace element, inhibits osteoclast differentiation in vitro and in vivo. The molecular mechanism for the inhibitory effect of zinc, however, is poorly understood. The purpose of this study was to investigate the effect of zinc and determine its molecular mechanism on receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis in mouse bone marrow-derived monocyte cells...... hiện toàn bộ
ERK and Akt exhibit distinct signaling responses following stimulation by pro-angiogenic factors
Cell Communication and Signaling - - 2020
Min Song, Stacey D. Finley
Abstract Background Angiogenesis plays an important role in the survival of tissues, as blood vessels provide oxygen and nutrients required by the resident cells. Thus, targeting angiogenesis is a prominent strategy in many different settings, including both tissue engineering and cancer treatment. However, not all of the approach...... hiện toàn bộ
The oncogenic mechanisms of the Janus kinase-signal transducer and activator of transcription pathway in digestive tract tumors
Cell Communication and Signaling - Tập 22 Số 1
Ruihong Zhao, Zhangmin Hu, Xiaoli Zhang, Shujuan Huang, Guodong Yu, Zhe Wu, Wei Yu, Juan Liu, Bing Ruan
AbstractDigestive tract tumors are heterogeneous and involve the dysregulation of multiple signaling pathways. The Janus kinase-signal transducer and activator of transcription (JAK–STAT) pathway plays a notable role in the oncogenesis of digestive tract tumors. Typically activated by pro-inflammatory cytokines, it regulates important biological processes, such as ...... hiện toàn bộ
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