Cell Biology and Toxicology
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Influence of age, sex and strain on the in vitro induction of unscheduled dna synthesis in rat hepatocyte primary cultures
Cell Biology and Toxicology - Tập 3 - Trang 113-125 - 1987
The activity of chemical-induced unscheduled DNA synthesis was evaluated in hepatocyte primary cultures from Fischer 344 and Sprague-Dawley rats over a period of two years. In this two-year study hepatocytes from both sexes and strains were prepared from animals 2, 8, 14, 20 and 25 months of age and UDS was measured by autoradiography following treatment with N-methyl-AP-vitro-N-nitrosoguanidine a......
Pyrene acts as a cocarcinogen with the carcinogens benzo [a] pyrene, β-propiolactone and radiation in the induction of malignant transformation in cultured mouse fibroblasts; soybean extract containing the Bowman-Birk inhibitor acts as an anticarcinogen
Cell Biology and Toxicology - Tập 2 - Trang 21-32 - 1986
Pyrene was found to act as a cocarcinogen in the induction of transformation of cultured Balb/c3T3 cells by three different types of carcinogens: a direct acting chemical carcinogen, β-propiolactone, a chemical carcinogen requiring metabolic activation, benzo[a]pyrene, and a physical carcinogen (60Co) gamma radiation. Since pyrene enhanced transformation in vitro by approximately the same amount f......
Identification of oxidative stress and responsive genes of HepG2 cells exposed to quinocetone, and compared with its metabolites
Cell Biology and Toxicology - - 2014
Molecular basis of active copper resistance mechanisms in Gram-negative bacteria
Cell Biology and Toxicology - Tập 29 - Trang 397-405 - 2013
Copper is a metallic element that is crucial for cell metabolism; however, in extended concentrations, it is toxic for all living organisms. The dual nature of copper has forced organisms, including bacteria, to keep a tight hold on cellular copper content. This challenge has led to the evolution of complex mechanisms that on one hand enable them to deliver the essential element and on the other t......
Biochemical, morphological and flow cytometric evaluation of the effects of hexachlorobenzene on rat liver
Cell Biology and Toxicology - Tập 6 - Trang 185-203 - 1990
This study investigated the ability of HCB (0.1% in the diet for 15 days) to cause early changes in the cellular ploidy of rat liver. Treatment caused marked hepatomegaly, increase of microsomal proteins and cytochrome P-450 content and reduction of hepatocyte microviscosity. Microscopic examination showed that the hepatocytes were enlarged, with hyaline cytoplasm and vacuoles. The size distributi......
Interindividual differences in initial DNA repair capacity when evaluating H2O2-induced DNA damage in extended-term cultures of human lymphocytes using the comet assay
Cell Biology and Toxicology - Tập 23 - Trang 401-411 - 2007
It has been suggested that extended-term cultures of human lymphocytes could be used as a complement to cell lines based on transformed cells when testing the genotoxicity of chemicals. To investigate whether the pattern of induced DNA damage and its subsequent repair differs significantly between cultures based on different blood donors, hydrogen peroxide (H2O2)-induced DNA damage was measured in......
YTHDC1 promotes the malignant progression of gastric cancer by promoting ROD1 translocation to the nucleus
Cell Biology and Toxicology - - 2024
RNA-binding proteins (RBPs) make vital impacts on tumor progression and are important potential targets for tumor treatment. Previous studies have shown that RBP regulator of differentiation 1 (ROD1), enriched in the nucleus, is abnormally expressed and functions as a splicing factor in tumors; however, the mechanism underlying its involvement in gastric cancer (GC) is unknown. In this study, ROD1......
Effect of cellular glutathione depletion on cadmium-induced cytotoxicity in human lung carcinoma cells
Cell Biology and Toxicology - Tập 3 - Trang 347-360 - 1987
The effect of glutathione depletion on cellular toxicity of cadmium was investigated in a subpopulation (T27) of human lung carcinoma A549 cells with coordinately high glutathione levels and Cd++-resistance. Cellular glutathione levels were depleted by exposing the cells to diethyl maleate or buthionine sulfoximine. Depletion was dose-dependent. Exposure of the cells to 0.5 mM diethyl maleate for ......
Intracellular distribution of tamoxifen in resistant human breast adenocarcinoma cells using tamoxifen–eosin association
Cell Biology and Toxicology - - 1998
A tamoxifen-resistant cell line (MCF7TAM) was established from tamoxifen-sensitive MCF-7 human breast cancer cells expressing estrogen receptors. Though the resistant cell line grows in the presence of tamoxifen, estrogen receptors continue to be expressed at similar levels as in the parental cell line. However, estrogen receptors appeared to be altered in the resistant cell line since important d......
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