Cell Biology and Toxicology
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Pyrene acts as a cocarcinogen with the carcinogens benzo [a] pyrene, β-propiolactone and radiation in the induction of malignant transformation in cultured mouse fibroblasts; soybean extract containing the Bowman-Birk inhibitor acts as an anticarcinogen
Cell Biology and Toxicology - Tập 2 - Trang 21-32 - 1986
Pyrene was found to act as a cocarcinogen in the induction of transformation of cultured Balb/c3T3 cells by three different types of carcinogens: a direct acting chemical carcinogen, β-propiolactone, a chemical carcinogen requiring metabolic activation, benzo[a]pyrene, and a physical carcinogen (60Co) gamma radiation. Since pyrene enhanced transformation in vitro by approximately the same amount f......
Identification of oxidative stress and responsive genes of HepG2 cells exposed to quinocetone, and compared with its metabolites
Cell Biology and Toxicology - - 2014
Molecular basis of active copper resistance mechanisms in Gram-negative bacteria
Cell Biology and Toxicology - Tập 29 - Trang 397-405 - 2013
Copper is a metallic element that is crucial for cell metabolism; however, in extended concentrations, it is toxic for all living organisms. The dual nature of copper has forced organisms, including bacteria, to keep a tight hold on cellular copper content. This challenge has led to the evolution of complex mechanisms that on one hand enable them to deliver the essential element and on the other t......
Biochemical, morphological and flow cytometric evaluation of the effects of hexachlorobenzene on rat liver
Cell Biology and Toxicology - Tập 6 - Trang 185-203 - 1990
This study investigated the ability of HCB (0.1% in the diet for 15 days) to cause early changes in the cellular ploidy of rat liver. Treatment caused marked hepatomegaly, increase of microsomal proteins and cytochrome P-450 content and reduction of hepatocyte microviscosity. Microscopic examination showed that the hepatocytes were enlarged, with hyaline cytoplasm and vacuoles. The size distributi......
Interindividual differences in initial DNA repair capacity when evaluating H2O2-induced DNA damage in extended-term cultures of human lymphocytes using the comet assay
Cell Biology and Toxicology - Tập 23 - Trang 401-411 - 2007
It has been suggested that extended-term cultures of human lymphocytes could be used as a complement to cell lines based on transformed cells when testing the genotoxicity of chemicals. To investigate whether the pattern of induced DNA damage and its subsequent repair differs significantly between cultures based on different blood donors, hydrogen peroxide (H2O2)-induced DNA damage was measured in......
Intracellular distribution of tamoxifen in resistant human breast adenocarcinoma cells using tamoxifen–eosin association
Cell Biology and Toxicology - - 1998
A tamoxifen-resistant cell line (MCF7TAM) was established from tamoxifen-sensitive MCF-7 human breast cancer cells expressing estrogen receptors. Though the resistant cell line grows in the presence of tamoxifen, estrogen receptors continue to be expressed at similar levels as in the parental cell line. However, estrogen receptors appeared to be altered in the resistant cell line since important d......
Newin vitro fluorimetric microtitration assays for toxicological screening of drugs
Cell Biology and Toxicology - Tập 10 - Trang 329-337 - 1994
Flow cytometry has been widely used to quantify fluorescent probes in cell culture. However, FCM is not adapted to toxicological screenings due to the cost, the length and the poor reproducibility of this technique. Moreover, several multicenter studies have preferred microtitration methodologies for drug screening. A new fluorimetric technology has been designed that is sensitive and adapted to d......
Gestational bisphenol A exposure induces fatty liver development in male offspring mice through the inhibition of HNF1b and upregulation of PPARγAbstract Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) associated with non-alcoholic fatty liver disease (NAFLD). The effects of gestational BPA exposure on hepatic lipid accumulation in offspring are not fully understood. Here, we investigate the sex-dependent effects of gestational BPA exposure on hepatic lipid and glucose metabolism in the offspring... ...
Cell Biology and Toxicology - - 2021
Hsp70 expression in monocytes from patients with peripheral arterial disease and healthy controls
Cell Biology and Toxicology - Tập 26 - Trang 215-223 - 2009
Heat shock proteins (HSP) are induced during cellular stress. Their role is to chaperone cellular proteins giving protection from denaturation and ultimately preventing cell death. Monocytes are key cells involved in atherosclerosis and are highly responsive to HSP induction. Therefore, we wished to examine monocyte Hsp70 expression and induction in patients with peripheral arterial disease (PAD) ......
Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchiceine: Focus on PXR, CAR, and GR in primary human hepatocytes
Cell Biology and Toxicology - Tập 23 - Trang 141-141 - 2006
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