Cardiovascular Toxicology

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Beneficial Effects of Ozone Therapy on Oxidative Stress, Cardiac Functions and Clinical Findings in Patients with Heart Failure Reduced Ejection Fraction
Cardiovascular Toxicology - Tập 17 - Trang 426-433 - 2017
Mutlu Buyuklu, Fatih Mehmet Kandemir, Turan Set, Eftal Murat Bakırcı, Husnu Degirmenci, Hikmet Hamur, Ergun Topal, Sefa Kucukler, Kultigin Turkmen
The aim of study was to determine the effects of ozone therapy on the oxidative stress, cardiac functions and clinical findings in patients with heart failure reduced ejection fraction (HFrEF). A total of 40 patients with New York Heart Association 2 and 3 HF with left ventricular ejection fraction (LVEF) <35%, and 40 subjects without HF as control group were included in the study. Patients with H...... hiện toàn bộ
The Effect of Emergency Department Visits and Inflammatory Markers on One-Year Mortality in Patients with Heart Failure
Cardiovascular Toxicology - Tập 21 - Trang 49-58 - 2020
Ataman Köse, Ahmet Çelik, Ersin Altınsoy, Seyran Bozkurt Babus, Semra Erdoğan
The neurohumoral and inflammatory pathways proposed for the development and progression of heart failure (HF) remain up-to-date. We aimed to investigate the effect of emergency department (ED) visits and inflammatory markers on mortality in HF patients. Two-hundred patients with stable chronic HF followed by the cardiology clinic were included in this study. The patients were divided into two grou...... hiện toàn bộ
Attenuation of Cardiomyocyte Hypertrophy via Depletion Myh7 using CASAAV
Cardiovascular Toxicology - Tập 21 - Trang 255-264 - 2020
Peng Yue, Shutao Xia, Gang Wu, Lei Liu, Kaiyu Zhou, Hongyu Liao, Jiawen Li, Xiaolan Zheng, Yuxuan Guo, Yimin Hua, Donghui Zhang, Yifei Li
Myh7 is a classic biomarker for cardiac remodeling and a potential target to attenuate cardiomyocyte (CM) hypertrophy. This study aimed to identify the dominant function of Myh7 after birth and determine whether its removal would affect CM maturation or contribute to reversal of pathological hypertrophy phenotypes. The CASAAV (CRISPR/Cas9-AAV9-based somatic mutagenesis) technique was used to deple...... hiện toàn bộ
Purine Bases Oxidation and Repair Following Permethrin Insecticide Treatment in Rat Heart Cells
Cardiovascular Toxicology - Tập 10 - Trang 199-207 - 2010
M. S. Dhivya Vadhana, Cinzia Nasuti, Rosita Gabbianelli
Pollutants including insecticides have been recently reported to be a risk factor involved in various diseases. Permethrin, a member of the family of synthetic pyrethroids, is widely used as insecticide in agriculture and other domestic applications. To investigate possible cardiotoxicity, we had examined different concentrations of permethrin on the freshly isolated rat heart cells using the alka...... hiện toàn bộ
Zinc Antagonizes Homocysteine-Induced Fetal Heart Defects in Rats
Cardiovascular Toxicology - Tập 9 - Trang 151-159 - 2009
Xiaoyu He, Xinru Hong, Fang Zeng, Fenhong Kang, Li Li, Qinghua Sun
It has been suggested that zinc may have a protective role against heart defects during fetal development. We investigated the effects of zinc on the development of fetal cardiac malformations induced by homocysteine. Pregnant Sprague–Dawley rats were randomized into one of five groups: control (C), homocysteine (H), homocysteine + zinc (Z), homocysteine + folic acid (F), or homocysteine + zinc + ...... hiện toàn bộ
Vitamin E attenuates myocardial ischemia-reperfusion injury in murine AIDS
Cardiovascular Toxicology - Tập 2 - Trang 119-127 - 2002
Yinhong Chen, Grace Davis-Gorman, Ronald Ross Watson, Paul F. McDonagh
The incidence of myocardial infarction in patients who have the aquired immunodeficiency syndrome (AIDS) is increasing. However, no effective therapeutic agents have been discovered to reduce myocardial ischemia-reperfusion (I/R) injury in pathologies associated with AIDS. The aim of this study was to determine if infarct size is increased in murine AIDS after I/R injury and if I/R injury could be...... hiện toàn bộ
Anti-fibrotic Actions of Roselle Extract in Rat Model of Myocardial Infarction
Cardiovascular Toxicology - Tập 19 - Trang 72-81 - 2018
Shafreena Shaukat Ali, Siti Fatimah Azaharah Mohamed, Nur Hafiqah Rozalei, Yap Wei Boon, Satirah Zainalabidin
Heart failure-associated morbidity and mortality is largely attributable to extensive and unregulated cardiac remodelling. Roselle (Hibiscus sabdariffa) calyces are enriched with natural polyphenols known for antioxidant and anti-hypertensive effects, yet its effects on early cardiac remodelling in post myocardial infarction (MI) setting are still unclear. Thus, the aim of this study was to invest...... hiện toàn bộ
Protection by flavonoids against anthracycline cardiotoxicity: from chemistry to clinical trials
Cardiovascular Toxicology - Tập 7 - Trang 154-159 - 2007
Aalt Bast, Guido R. M. M. Haenen, Anna M. E. Bruynzeel, Wim J. F. Van der Vijgh
Cardiotoxic side-effects of doxorubicin limit the clinical use of this anti-cancer agent. Iron chelators have been studied as protectors against doxorubicin-induced cardiotoxicity. These iron chelators do not provide optimal protection and have certain drawbacks. We therefore looked for new protectors and decided that these new compounds should combine iron chelating and antioxidant activity. Flav...... hiện toàn bộ
Prohypertensive Effect of Gestational Personal Exposure to Fine Particulate Matter. Prospective Cohort Study in Non-smoking and Non-obese Pregnant Women
Cardiovascular Toxicology - Tập 12 Số 3 - Trang 216-225 - 2012
W Jedrychowski, Frederica P. Perera, U Maugeri, John D. Spengler, Elżbieta Mróz, Elżbieta Flak, Laura Stigter, Renata Majewska, Irena Kaim, Agata Sowa, Ryszard Jacek
Bilirubin Attenuates Bufadienolide-Induced Ventricular Arrhythmias and Cardiac Dysfunction in Guinea-Pigs by Reducing Elevated Intracellular Na+ Levels
Cardiovascular Toxicology - - 2012
Hongyue Ma, Junfeng Zhang, Jiejun Jiang, Jing Zhou, Hao Xu, Zhenlin Zhan, Qinan Wu, Jin‐Ao Duan
Tổng số: 705   
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