Cardiovascular Toxicology
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Beneficial Role of Some Natural Products to Attenuate the Diabetic Cardiomyopathy Through Nrf2 Pathway in Cell Culture and Animal Models
Cardiovascular Toxicology - Tập 18 - Trang 199-205 - 2017
Diabetic cardiomyopathy, as one of the main cardiac complications in diabetic patients, is identified to connect with oxidative stress that is due to interruption in balance between reactive oxygen species or/and reactive nitrogen species generation and their clearance by antioxidant protection systems. Transcription factor the nuclear factor erythroid 2-related factor 2 (Nrf2) plays a significant......
The Protective Effects of Pharmacologic Postconditioning of Hydroalcoholic Extract of Nigella sativa on Functional Activities and Oxidative Stress Injury During Ischemia–Reperfusion in Isolated Rat Heart
Cardiovascular Toxicology - Tập 20 - Trang 130-138 - 2019
Oxidative stress is known to act as the trigger of cardiac damage during ischemia–reperfusion (I/R) injury. Postconditioning (PoC) is employed to minimize the consequences of ischemia at the onset of reperfusion. Regarding the well-known antioxidant properties of Nigella sativa (Ns), the aim of this study was to investigate whether Nigella sativa postconditioning (Ns-PoC) could reduce IRI by lower......
Other uses of dexrazoxane: savene, the first proven antidote against anthracycline extravasation injuries
Cardiovascular Toxicology - Tập 7 - Trang 151-153 - 2007
Dexrazoxane has been in clinical use for more than 25 years for prevention of cardiotoxicity in anthracycline based anticancer therapy. However, we discovered another property of the compound, i.e. the ability to prevent the devastating tissue necrosis after accidental extravasation of anthracyclines. The preclinical and clinical studies leading to the clinical implementation of Savene™ (dexrazoxa......
Energy Drinks and Myocardial Ischemia: A Review of Case Reports
Cardiovascular Toxicology - Tập 16 - Trang 207-212 - 2015
The use and abuse of energy drinks (EDs) is constantly increasing worldwide. We performed a systematic search in Medline, Scopus and Web of Science to identify evidence about the potential link between these beverages and myocardial ischemia. Overall, 8 case reports could be detected, all of which described a realistic association between large intake of EDs and episodes of myocardial ischemia. In......
NQO1 C609T Polymorphism is Associated with Coronary Artery Disease in a Gender-Dependent Manner
Cardiovascular Toxicology - Tập 17 - Trang 35-41 - 2015
Findings on the association of NQO1 C609T polymorphism in the NQO1 gene and cardiovascular disease susceptibility are controversial. The objective of the current study was to examine the relationship between this polymorphism and the presence and severity of angiographically determined coronary artery disease (CAD). One-hundred and forty-five patients with newly diagnosed angiographically document......
Application of data mining for examining polypharmacy and adverse effects in cardiology patients
Cardiovascular Toxicology - Tập 1 - Trang 177-179 - 2001
This article comments upon the use of data mining tools to examine clinical data. Many cardiovascular patients have co-morbid diseases that put them at risk for polypharmacy, or severe adverse reactions from the interactions of multiple medications. Clinical trials typically use too few patients with stringent inclusion/exclusion criteria that prevent an examination of the issue of polypharmacy. H......
Protective Effect of Curcumin, Chrysin and Thymoquinone Injection on Trastuzumab-Induced Cardiotoxicity via Mitochondrial Protection
Cardiovascular Toxicology - Tập 22 - Trang 663-675 - 2022
Mitochondrial dysfunction may lead to cardiomyocyte death in trastuzumab (TZM)-induced cardiotoxicity. Accordingly, this study was designed to evaluate the mitochondrial protective effects of curcumin, chrysin and thymoquinone alone in TZM-induced cardiotoxicity in the rats. Forty-eight male adult Wistar rats were divided into eight groups: control group (normal saline), TZM group (2.5 mg/kg I.P. ......
Prenatal Ethanol Exposure Alters Ventricular Myocyte Contractile Function in the Offspring of Rats
Cardiovascular Toxicology - Tập 1 Số 3 - Trang 215-224
Diosmin Prevents Isoproterenol-Induced Heart Mitochondrial Oxidative Stress in Rats
Cardiovascular Toxicology - Tập 18 - Trang 120-130 - 2017
Cardiac mitochondrial oxidative stress causes mitochondrial damage that plays an important role in the pathology of myocardial infarction. The preventive effects of diosmin on cardiac mitochondrial oxidative stress in isoproterenol-induced myocardial infarcted rats were evaluated. Rats were pretreated with diosmin (10 mg/kg body weight) daily for 10 days. Myocardial infarction was induced in rats ......
Peripheral Administration of Nitroglycerin in Pulseless Ventricular Tachycardia due to Cocaine-Induced Coronary Vasospasm
Cardiovascular Toxicology - Tập 21 - Trang 490-493 - 2021
Cocaine use accounts for 40% of the annual drug use related emergency department visits in the United States. Cocaine use is hence recognized as a major health problem. Cocaine blocks the presynaptic reuptake of norepinephrine and dopamine. The resulting increased adrenergic activity leads to vasoconstriction. Additionally, via various mechanisms, cocaine leads to a prothrombotic state and increas......
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