The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment Tập 21 Số 1
Asieh Emami Nejad, Simin Najafgholian, Alireza Rostami, Alireza Sistani, Samaneh Shojaeifar, Mojgan Esparvarinha, Reza Nedaeinia, Shaghayegh Haghjooy Javanmard, Marjan Taherian, Mojtaba Ahmadlou, Rasoul Salehi, Bahman Sadeghi, Mostafa Manian
AbstractHypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor. It has been reported that tumor hypoxia can: activate angiogenesis, thereby enhancing invasiveness and risk of metastasis; increase su...... hiện toàn bộ Preclinical evaluation of the proteasome inhibitor bortezomib in cancer therapy Tập 5 Số 1 - 2005
Mario Boccadoro, Gareth J. Morgan, Jamie Cavenagh
AbstractBortezomib is a highly selective, reversible inhibitor of the 26S proteasome that is indicated for single-agent use in the treatment of patients with multiple myeloma who have received at least 2 prior therapies and are progressing on their most recent therapy. Clinical investigations have been completed or are under way to evaluate the safety and efficacy ...... hiện toàn bộ Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in Vitro and in Vivo Tập 12 - Trang 1-8 - 2012
Zhi-Jun Dai, Xiao-Bin Ma, Hua-Feng Kang, Jie Gao, Wei-Li Min, Hai-Tao Guan, Yan Diao, Wang-Feng Lu, Xi-Jing Wang
Cyclooxygenase-2(COX-2) promotes carcinogenesis, tumor proliferation, angiogenesis, prevention of apoptosis, and immunosuppression. Meanwhile, COX-2 over-expression has been associated with tumor behavior and prognosis in several cancers. This study investigated the antitumor effects of the selective COX-2 inhibitor, Celecoxib, on breast cancer in vitro and in vivo. Human breast cancer MCF-7 and M...... hiện toàn bộ Role of the Hypoxia-inducible factor-1 alpha induced autophagy in the conversion of non-stem pancreatic cancer cells into CD133+ pancreatic cancer stem-like cells - 2013
Haitao Zhu, Dongqing Wang, Yanfang Liu, Zhaoliang Su, Lirong Zhang, Fangfang Chen, Yuepeng Zhou, Yingying Wu, Ming Yu, Zhijian Zhang, Gang Shao
Roles of sphingosine-1-phosphate signaling in cancer - 2019
Peng Wang, Yonghui Yuan, L Wenda, Hongshan Zhong, Ke Xu, Xun Qi
AbstractThe potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in numerous cellular processes, including angiogenesis and cell survival, proliferation, and migration. It is formed by one of two sphingosine kinases (SphKs), SphK1 and SphK2. These enzymes largely exert their various biological and pathophysiological actions through one of fi...... hiện toàn bộ