Cancer Cell International

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PESV represses non-small cell lung cancer cell malignancy through circ_0016760 under hypoxia
Cancer Cell International - - 2021
Hong Zhang, Haojian Zhang, Jinmin Zhu, Huan Liu, Qin Zhou
Abstract Background Non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancers, which is the most common malignant tumor worldwide. Polypeptide extract from scorpion venom (PESV) has been reported to inhibit NSCLC process. The present study aims to reveal the roles of PESV in NSCL...... hiện toàn bộ
High CFP score indicates poor prognosis and chemoradiotherapy response in LARC patients
Cancer Cell International - Tập 21 - Trang 1-11 - 2021
Siyi Lu, Zhenzhen Liu, Bingyan Wang, Fei Li, Yan Meng, Junwei Wang, Yuxia Wang, Hao Wang, Xin Zhou, Wei Fu
Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis and tumor response in locally advanced rectal cancer (LARC) patients. This study aims to explore the prognostic and predictive role of carcinoembryonic antigen (CEA), the Fibrinogen-Albumin Ratio Index (FARI), the Prognostic Nutritional Index (PNI) in LARC patients and compared them wi...... hiện toàn bộ
Sự biểu hiện quá mức của lncRNA HOXA11-AS thúc đẩy quá trình chuyển đổi biểu mô - mesenchymal bằng cách ức chế miR-200b trong ung thư phổi không tế bào nhỏ Dịch bởi AI
Cancer Cell International - Tập 17 - Trang 1-11 - 2017
Jian-Hui Chen, Li-Yang Zhou, Suo Xu, Yu-Long Zheng, Yu-Feng Wan, Cheng-Ping Hu
Các nghiên cứu gần đây đã xác nhận rằng các RNA không mã hóa dài (lncRNAs) liên quan đến nhiều chức năng sinh học và đóng vai trò quan trọng trong sự tiến triển của ung thư ở người, nghiên cứu này nhằm mục đích phát hiện mối liên hệ giữa RNA không mã hóa dài HOXA11-AS và quá trình chuyển đổi biểu mô - mesenchymal (EMT) trong ung thư phổi không tế bào nhỏ (NSCLC). Mức độ biểu hiện của lncRNA HOXA11...... hiện toàn bộ
Monoclonal antibodies and chimeric antigen receptor (CAR) T cells in the treatment of colorectal cancer
Cancer Cell International -
Ketao Jin, Bin Chen, Yu-Yao Liu, Huanrong Lan, Jinsong Yan
AbstractColorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer deaths worldwide. Besides common therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, novel therapeutic approaches, including immunotherapy, have been an advent in CRC treatment. The immunotherapy approaches try to elicit patients` immune respo...... hiện toàn bộ
Knockdown of PGM1 enhances anticancer effects of orlistat in gastric cancer under glucose deprivation
Cancer Cell International - Tập 21 - Trang 1-15 - 2021
Bo Cao, Huan Deng, Hao Cui, Ruiyang Zhao, Hanghang Li, Bo Wei, Lin Chen
Phosphoglucomutase 1 (PGM1) acts as an important regulator in glucose metabolism. However, the role of PGM1 in gastric cancer (GC) remains unclear. This study aims to investigate the role of PGM1 and develop novel regimens based on metabolic reprogramming in GC. Correlation and enrichment analyses of PGM1 were conducted based on The Cancer Genome Atlas database. Data derived from the Kaplan–Meier ...... hiện toàn bộ
Correction to: The predictive value of dynamic monitoring of peripheral blood lymphocyte to monocyte ratio in patients with extranodal NK/T cell lymphoma
Cancer Cell International - Tập 20 Số 1 - 2020
Shengnan Zhang, Mengjuan Li, Fangfang Yuan, Lin Chen, Ruihua Mi, Xudong Wei, Yongping Song, Qingsong Yin
After publication of our article [1] it was highlighted by the authors that the type of this article was primary research, instead of review.
Immune modulation in malignant pleural effusion: from microenvironment to therapeutic implications
Cancer Cell International -
Shengfang Ge, Yuwei Zhao, Jun Liang, Zhongning He, Kai Li, Guanghui Zhang, Hua Bai, Hongliang Zheng, Qiujun Guo, Runzhi Qi, Siyan Zhan
AbstractImmune microenvironment and immunotherapy have become the focus and frontier of tumor research, and the immune checkpoint inhibitors has provided novel strategies for tumor treatment. Malignant pleural effusion (MPE) is a common end-stage manifestation of lung cancer, malignant pleural mesothelioma and other thoracic malignancies, which is invasive and ofte...... hiện toàn bộ
Synaptopodin-2: a potential tumor suppressor
Cancer Cell International - Tập 23 Số 1
Zheng Zhao, Yongfei Song
AbstractInitially identified as an actin-binding protein containing a PSD95-DLG-ZO1 Domain (PZD domain), Synaptopodin 2 (SYNPO2) has long been considered a structural protein ubiquitously expressed in muscular tissues. However, emerging evidence suggests that SYNPO2 performs diverse functions in cancers in addition to its role in microfilament assembly. In most can...... hiện toàn bộ
circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade
Cancer Cell International - Tập 21 - Trang 1-20 - 2021
San-Gang Wu, Ping Zhou, Jian-Xian Chen, Jian Lei, Li Hua, Yong Dong, Min Hu, Chen-Lu Lian, Li-Chao Yang, Juan Zhou
Precise quantification of microRNA is challenging since circulating mRNA and rRNA in the blood are usually degraded. Therefore, it is necessary to identify specific biomarkers for ovarian cancer. This study aimed to investigate candidate circular RNAs (circRNAs) involved in the pathogenic process of ovarian cancer after inhibition of chromodomain helicase DNA binding protein 1-like (CHD1L) and the...... hiện toàn bộ
Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16
Cancer Cell International - Tập 21 Số 1 - 2021
Wanshun Liu, Binyu Wang, Ao Duan, Kai Shen, Qi Zhang, Xiangming Tang, Yongzhong Wei, Jian Tang, Sheng Zhang
Abstract Background Osteosarcoma (OS) is a malignant tumor originating from mesenchymal stem cells, and has an extremely high fatality rate and ability to metastasize. Although mounting evidence suggests that miR-769-5p is strongly associated with the malignant progression and poor prognosis of vari...... hiện toàn bộ
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