Cancer Cell International
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Antitumor activity of the selective cyclooxygenase-2 inhibitor, celecoxib, on breast cancer in Vitro and in Vivo
Cancer Cell International - Tập 12 - Trang 1-8 - 2012
Cyclooxygenase-2(COX-2) promotes carcinogenesis, tumor proliferation, angiogenesis, prevention of apoptosis, and immunosuppression. Meanwhile, COX-2 over-expression has been associated with tumor behavior and prognosis in several cancers. This study investigated the antitumor effects of the selective COX-2 inhibitor, Celecoxib, on breast cancer in vitro and in vivo. Human breast cancer MCF-7 and M...... hiện toàn bộ
SPP1 facilitates cell migration and invasion by targeting COL11A1 in lung adenocarcinoma
Cancer Cell International - Tập 22 - Trang 1-15 - 2022
Secreted phosphoprotein 1 (SPP1), an extracellular secreted glycol phosphoprotein, is closely related to tumor biologies, such as proliferation, migration, and invasion. However, the role and biological function of SPP1 in lung adenocarcinoma (LUAD) was still ambiguous. SPP1 expression in LUAD tissues and its associations with clinical features and prognosis was investigated using meta-analysis, i...... hiện toàn bộ
Mesenchymal stem cells derived from iPSCs expressing interleukin-24 inhibit the growth of melanoma in the tumor-bearing mouse modelAbstract
Background
Interleukin-24 (IL -24 ) is a therapeutic gene for melanoma, which can induce melanoma cell apoptosis. Mesenchymal stem cells (MSCs) show promise as a carrier to delivery anti-cancer factors to tumor tissues. Induced pluripotent... ... hiện toàn bộ
Cancer Cell International - - 2020
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
Cancer Cell International - Tập 23 - Trang 1-27 - 2023
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS signaling enhances cell proliferation in malignancy directly and indirectly by affecting tumor cells and modulating angiogenesis. Cancer development may be influenced by the balance between the ACE/Ang II/AT1R and the AC...... hiện toàn bộ
Analyzing the gene expression profile of pediatric acute myeloid leukemia with real-time PCR arrays
Cancer Cell International - Tập 12 - Trang 1-12 - 2012
The Real-time PCR Array System is the ideal tool for analyzing the expression of a focused panel of genes. In this study, we will analyze the gene expression profile of pediatric acute myeloid leukemia with real-time PCR arrays. Real-time PCR array was designed and tested firstly. Then gene expression profile of 11 pediatric AML and 10 normal controls was analyzed with real-time PCR arrays. We ana...... hiện toàn bộ
Long non-coding RNA LSAMP-1 is down-regulated in non-small cell lung cancer and predicts a poor prognosis
Cancer Cell International - Tập 22 - Trang 1-16 - 2022
Long noncoding RNAs (lncRNAs) are emerging as master regulators for gene expression and thus play a vital role in human tumorigenesis and progression. But the involvement of novel lncRNAs in non-small cell lung cancer (NSCLC) remains largely unelucidated. A total of 170 NSCLC and their adjacent non-tumor tissues were enrolled to detect the expression of Lnc-LSAMP-1 by RT-qPCR. The effects of Lnc-L...... hiện toàn bộ
Low expression of CHRDL1 and SPARCL1 predicts poor prognosis of lung adenocarcinoma based on comprehensive analysis and immunohistochemical validation
Cancer Cell International - Tập 21 - Trang 1-19 - 2021
Exploring the molecular mechanisms of lung adenocarcinoma (LUAD) is beneficial for developing new therapeutic strategies and predicting prognosis. This study was performed to select core genes related to LUAD and to analyze their prognostic value. Microarray datasets from the GEO (GSE75037) and TCGA-LUAD datasets were analyzed to identify differentially coexpressed genes in LUAD using weighted gen...... hiện toàn bộ
The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats
Cancer Cell International - Tập 11 - Trang 1-12 - 2011
This study was designed to evaluate the potential chemopreventive activities of Ginkgo biloba extract (EGb) and Silybum marianum extract (silymarin) against hepatocarcinogenesis induced by N-nitrosodiethylamine (NDEA) in rats. Rats were divided into 6 groups. Group 1 served as normal control rats. Group 2 animals were intragastrically administrated NDEA at a dose of 10 mg/kg five times a week for ...... hiện toàn bộ
Noggin contributes to brain metastatic colonization of lung cancer cells
Cancer Cell International - Tập 23 - Trang 1-12 - 2023
Brain metastasis is a common complication among patients with lung cancer, yet the underlying mechanisms remain unclear. In this study, we aimed to investigate the pathogenesis of brain metastasis in lung cancer. We established highly colonizing metastatic lung cancer cells, A549-M2, through multiple implantations of A549 human lung cancer cells in the carotid artery of athymic nude mice. Compared...... hiện toàn bộ
N6-methyladenosine methylation modification patterns reveal immune profiling in pancreatic adenocarcinoma
Cancer Cell International - Tập 22 - Trang 1-17 - 2022
Several studies have revealed that N6-methyladenosine (m6A) regulation is involved in various biological processes and cancer progression. Nevertheless, the potential effects of m6A modifications in the tumor immune microenvironment (TIME) and on immune regulation in pancreatic adenocarcinoma (PAAD) remains unclear. A consensus clustering algorithm was used to identify different m6A modification p...... hiện toàn bộ
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