Canadian Journal of Physiology and Pharmacology

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Endothelin-1 induces neutrophil recruitment in adaptive inflammation via TNFα and CXCL1/CXCR2 in mice
Canadian Journal of Physiology and Pharmacology - Tập 90 Số 2 - Trang 187-199 - 2012
Ana C. Zarpelon, Larissa G. Pinto, Thiago M. Cunha, Sílvio M. Vieira, Vanessa Carregaro, Guilherme R. Souza, João S. Silva, S. H. Ferreira, Fernando Q. Cunha, Waldiceu A. Verri
Endothelin mediates neutrophil recruitment during innate inflammation. Herein we address whether endothelin-1 (ET-1) is involved in neutrophil recruitment in adaptive inflammation in mice, and its mechanisms. Pharmacological treatments were used to determine the role of endothelin in neutrophil recruitment to the peritoneal cavity of mice challenged with antigen (ovalbumin) or ET-1. Levels...... hiện toàn bộ
Actions of excitatory amino acids on mesencephalic trigeminal neurons
Canadian Journal of Physiology and Pharmacology - Tập 76 Số 9 - Trang 900-908 - 1998
Kenneth A. Pelkey, Kenneth C. Marshall
Mesencephalic trigeminal (MeV) neurons are primary sensory neurons of which the cell soma is located within the brainstem, and is associated with synaptic contacts. In previous studies it has been reported that these cells are resistant to kainic acid excitotoxicity, and have little or no responsiveness to exogenously applied glutamate or selective agonists. In an in vitro slice preparati...... hiện toàn bộ
A comparative study of the inhibition of hepatic aldehyde dehydrogenases in the rat by methyltetrazolethiol, calcium carbimide, and disulfiram
Canadian Journal of Physiology and Pharmacology - Tập 63 Số 5 - Trang 438-443 - 1985
James F. Brien, Glen S. Tam, Roger Cameron, Nancy A. E. Steenaart, Christopher W. Loomis
Methyltetrazolethiol (1-methyl-5-mercapto-1,2,3,4-tetrazole, MTT) is a heterocyclic substituent of the cephalosporin antibiotics, cefamandole, cefoperazone, and moxalactam. Pretreatment of rats with MTT has been reported to increase blood acetaldehyde concentration after ethanol administration. The time course of MTT-induced inhibition of hepatic aldehyde dehydrogenases (ALDH) was determi...... hiện toàn bộ
The coactivation of antagonist muscles
Canadian Journal of Physiology and Pharmacology - Tập 59 Số 7 - Trang 733-747 - 1981
Allan M. Smith
Since Sherrington's convincing demonstration of the reciprocal innervation of opposing muscles, it has generally been thought that antagonist muscles are inactive during most voluntary movements. However, more recent evidence suggests that excitation of Renshaw cells may facilitate antagonist coactivation whereas excitation of Ia inhibitory neurons can induce reciprocal inhibition. A body...... hiện toàn bộ
Effect of aldosterone on vascular angiotensin II receptors in the rat
Canadian Journal of Physiology and Pharmacology - Tập 63 Số 12 - Trang 1522-1527 - 1985
Ernesto L. Schiffrin, Douglas J. Franks, Jolanta Gutkowska
The effect of aldosterone on the density and affinity of binding sites for 125I-labelled angiotensin II was investigated in a particulate fraction prepared from the rat mesenteric arteriolar arcades. The infusion of aldosterone 6.6 μg/h intraperitoneally via Alzet osmotic minipumps for 6 d produced an increase in the density of binding sites for 125... hiện toàn bộ
Influence of thromboxane inhibition on the severity of myocardial ischemia in cats
Canadian Journal of Physiology and Pharmacology - Tập 58 Số 3 - Trang 294-300 - 1980
Edward F. Smith, David J. Lefer, J B Smith
The effects of thromboxane (Tx) inhibition or arachidonic acid (AA) infusion were studied in anesthetized cats during acute myocardial ischemia (MI). AA (7.2 mg kg−1 h−1) or imidazole (25 mg kg−1 h−1) infusions were initiated 30 min after occlusion of the left anterior descending coronary artery. Assessmen...... hiện toàn bộ
Postmenopausal bone mineral density: relationship to calcium intake,calcium absorption, residual estrogen, body composition, and physical activity
Canadian Journal of Physiology and Pharmacology - Tập 74 Số 8 - Trang 911-917 - 1996
Patricia Hoover, Colin E. Webber, Lesley Beaumont, Jennifer Blake
Effects of traditionally used anxiolytic botanicals on enzymes of the γ-aminobutyric acid (GABA) systemThis article is one of a selection of papers published in this special issue (part 1 of 2) on the Safety and Efficacy of Natural Health Products.
Canadian Journal of Physiology and Pharmacology - Tập 85 Số 9 - Trang 933-942 - 2007
Rosalie Awad, Dylan Levac, P. Cybulska, Zul Merali, Vance L. Trudeau, John T. Arnason
In Canada, the use of botanical natural health products (NHPs) for anxiety disorders is on the rise, and a critical evaluation of their safety and efficacy is required. The purpose of this study was to determine whether commercially available botanicals directly affect the primary brain enzymes responsible for γ-aminobutyric acid (GABA) metabolism. Anxiolytic plants may interact with eith...... hiện toàn bộ
Kinins and their receptors in hyperalgesia
Canadian Journal of Physiology and Pharmacology - Tập 75 Số 6 - Trang 704-712 - 1997
A. Dray
Effects of Furosemide and Ethacrynic Acid on Cation Transport Across Phospholipid Bilayer Membranes
Canadian Journal of Physiology and Pharmacology - Tập 52 Số 5 - Trang 930-941 - 1974
Mervyn Singer
Phosphatidylcholine vesicles acquire a negative surface charge in the presence of furosemide or ethacrynic acid. In addition, these same vesicles also display a higher efflux rate for 22Na and 86Rb when exposed to these two diuretics. The experiments reported in this study indicate that the increased cation permeability is due to the creation of t...... hiện toàn bộ
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