Canadian Journal of Physiology and Pharmacology

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Effects of gaseous anesthetics and ultrashort and short-acting barbiturates on human blood platelet free cytosolic calcium: relevance to their effects on platelet aggregation
Canadian Journal of Physiology and Pharmacology - Tập 70 Số 8 - Trang 1161-1166 - 1992
Richard B. Philp, Pooja Arora, Donald J.L. McIver
The effects of elevated pressures (to 6 atmospheres absolute (ATA)) of nitrous oxide (N2O) and of xenon (Xe), and barbiturates on platelet free cytosolic calcium ([Ca2+]i) and platelet aggregation were studied. N2O inhibited the ADP-induced rise in [Ca2+]i whereas Xe had no effect. Neither affected basal levels. Pentobarbital and methohexital had little effect on basal or stimulated levels in the ... hiện toàn bộ
Effects of some naturally occurring prostanoids and some cyclooxygenase inhibitors on the contractility of the human lower uterine segment in vitro
Canadian Journal of Physiology and Pharmacology - Tập 72 Số 8 - Trang 870-874 - 1994
Denis Crankshaw, R.Y. Dyal
The contractility of strips of human lower segment myometrium obtained from elective cesarean section performed at term of pregnancy was studied in vitro. The effects of indomethacin and tiaprofen upon spontaneous contractile activity were examined. Concentration–effect curves for PGD2, PGE2, PGF2α, 6-keto-PGE1, and 6-keto-PGF1α, were constructed in the presence of indomethacin. Neither indomethac... hiện toàn bộ
Endothelin-1 induces neutrophil recruitment in adaptive inflammation via TNFα and CXCL1/CXCR2 in mice
Canadian Journal of Physiology and Pharmacology - Tập 90 Số 2 - Trang 187-199 - 2012
Ana C. Zarpelon, Larissa G. Pinto, Thiago M. Cunha, Sílvio M. Vieira, Vanessa Carregaro, Guilherme R. Souza, João S. Silva, S. H. Ferreira, Fernando Q. Cunha, Waldiceu A. Verri
Endothelin mediates neutrophil recruitment during innate inflammation. Herein we address whether endothelin-1 (ET-1) is involved in neutrophil recruitment in adaptive inflammation in mice, and its mechanisms. Pharmacological treatments were used to determine the role of endothelin in neutrophil recruitment to the peritoneal cavity of mice challenged with antigen (ovalbumin) or ET-1. Levels of ET-1... hiện toàn bộ
The role of Granzyme B in atheromatous diseasesThis paper is one of a selection of papers published in this Special Issue, entitled Young Investigators' Forum.
Canadian Journal of Physiology and Pharmacology - Tập 85 Số 1 - Trang 89-95 - 2007
Ciara M. Chamberlain, David J. Granville
The mechanism and role of apoptotic cell death in the pathogenesis of atheromatous diseases is an area of intense research. Atherosclerosis is an inflammatory disease and as such, immune-mediated cell killing plays an important role. Recent studies have suggested that Granzyme B and perforin play an important role in atherogenesis. The current manuscript reviews our current understanding pertainin... hiện toàn bộ
Characterization of Ca2+release from heterogeneous Ca2+stores in sarcoplasmic reticulum isolated from arterial and gastric smooth muscle
Canadian Journal of Physiology and Pharmacology - Tập 80 Số 6 - Trang 588-603 - 2002
Marguerite A. Stout, Luc Raeymaekers, Humbert De Smedt, R. Casteels
Ca2+transport was investigated in vesicles of sarcoplasmic reticulum subfractionated from bovine main pulmonary artery and porcine gastric antrum using digitonin binding and zonal density gradient centrifugation. Gradient fractions recovered at 15–33% sucrose were studied as the sarcoplasmic reticulum component using Fluo-3 fluorescence or45Ca2+Millipore filtration. Thapsigargin blocked active Ca2... hiện toàn bộ
Involvement of UTP in protection of cardiomyocytes from hypoxic stressThis article is one of a selection of papers from the NATO Advanced Research Workshop on Translational Knowledge for Heart Health (published in part 2 of a 2-part Special Issue).
Canadian Journal of Physiology and Pharmacology - Tập 87 Số 4 - Trang 287-299 - 2009
Asher Shainberg, Smadar Yitzhaki, Or Golan, Kenneth A. Jacobson, Edith Hochhauser
Massive amounts of nucleotides are released during ischemia in the cardiovascular system. Although the effect of the purine nucleotide ATP has been intensively studied in myocardial infarction, the cardioprotective role of the pyrimidine nucleotide UTP is still unclear, especially in the cardiovascular system. The purpose of our study was to elucidate the protective effects of UTP receptor activat... hiện toàn bộ
Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female rats
Canadian Journal of Physiology and Pharmacology - Tập 86 Số 5 - Trang 240-248 - 2008
Narattaphol Charoenphandhu, Jarinthorn Teerapornpuntakit, Mei Methawasin, Kannikar Wongdee, Kanogwun Thongchote, Nateetip Krishnamra
Hyperprolactinemia caused by physiological or pathological conditions, such as those occurring during lactation and prolactinoma, respectively, results in progressive osteopenia. The underlying mechanisms, however, are controversial. Prolactin (PRL) may directly attenuate the functions of osteoblasts, since these bone cells express PRL receptors. The present study therefore aimed to investigate th... hiện toàn bộ
Actions of excitatory amino acids on mesencephalic trigeminal neurons
Canadian Journal of Physiology and Pharmacology - Tập 76 Số 9 - Trang 900-908 - 1998
Kenneth A. Pelkey, Kenneth C. Marshall
Mesencephalic trigeminal (MeV) neurons are primary sensory neurons of which the cell soma is located within the brainstem, and is associated with synaptic contacts. In previous studies it has been reported that these cells are resistant to kainic acid excitotoxicity, and have little or no responsiveness to exogenously applied glutamate or selective agonists. In an in vitro slice preparation with i... hiện toàn bộ
Canine colonic circular muscle generates action potentials without the pacemaker component
Canadian Journal of Physiology and Pharmacology - Tập 72 Số 1 - Trang 70-81 - 1994
L W Liu, Jan D. Huizinga
Two dominant types of action potentials in canine colon are slow wave type action potentials (slow waves) and spike-like action potentials (SLAPs). The slow waves, originating at the submuscular surface where a network of interstitial cells of Cajal (ICCs) is found, possess a pacemaker component. Activation of the pacemaker component is insensitive to voltage changes and L-type calcium channel blo... hiện toàn bộ
Excitability of canine colon circular muscle disconnected from the network of interstitial cells of Cajal
Canadian Journal of Physiology and Pharmacology - Tập 70 Số 2 - Trang 289-295 - 1992
L W Liu, E. E. Daniel, Jan D. Huizinga
The 6 cpm omnipresent slow waves recorded in the circular muscle (CM) layer of canine colon are generated at the submucosal surface of the CM layer. After removal of the submucosal network of interstitial cells of Cajal (ICC), 66% of the CM preparations (25 of 38) were quiescent in Krebs solution. In the presence of carbachol, seven of nine of these spontaneously quiescent CM preparations demonstr... hiện toàn bộ
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