Canadian Journal of Physiology and Pharmacology
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Exercise and vascular function: how much is too much?Exercise is a powerful therapy for preventing the onset of and slowing the progression of cardiovascular disease. Increased shear stress during exercise improves vascular homeostasis by both decreasing reactive oxygen species and increasing nitric oxide bioavailability in the endothelium. While these observations are well accepted as they apply to individuals at risk for cardiovascular dis... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 92 Số 7 - Trang 551-557 - 2014
Relationship between oxidative phosphorylation and adenine nucleotide translocase activity of two populations of cardiac mitochondria and mechanical recovery of ischemic hearts following reperfusion The possible relationship of the atractyloside-sensitive adenine nucleotide translocase activity, oxidative phosphorylation, and the recovery of ventricular contractility following reperfusion of the ischemic isolated rat heart was studied. Five minutes of total global ischemia without reperfusion produced a significant depression in adenine nucleotide translocase in subsarcolemmal mitoch... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 67 Số 7 - Trang 704-709 - 1989
Fucoidan reduces inflammatory response in a rat model of hepatic ischemia–reperfusion injury Ischemia–reperfusion (I/R) injury after a liver transplant is a major cause of severe complications that lead to graft dysfunction. Fucoidan, a complex of sulfated polysaccharides derived from marine brown algae, demonstrated antiapoptotic as well as potential anti-inflammatory properties in previous studies. Fucoidan has also shown protective effects on I/R-injured kidney and heart. Howe... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 93 Số 11 - Trang 999-1005 - 2015
Modulation of inhibition in the hippocampus in vivo The nature and mechanisms of septohippocampal transmission have been elucidated by taking advantage of an in situ preparation in experiments with Sprague–Dawley rats under urethane. Both extracellular field potentials and intracellular recordings were made in CA1–3 regions of the hippocampus; and the hippocampal commissure and medial septum stimulated to evoke synaptic activity. Using mus... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 63 Số 7 - Trang 838-842 - 1985
Ca2+ channel antagonist actions in bladder smooth muscle: comparative pharmacologic and [3H]nitrendipine binding studies The actions of a series of 15 Ca2+ channel antagonists including D-6(X), nifedipine, and diltiazem were examined against K+ depolarization and muscarinic receptor induced responses in guinea pig bladder smooth muscle. Responses of bladder are very dependent upon extracellular Ca2+ and sensitive to the Ca2+ ... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 63 Số 5 - Trang 453-462 - 1985
Influence of physical activity and dietary restraint on resting energy expenditure in young nonobese females An understanding of the physiological and behavioral determinants of resting energy requirements is important to nutritional considerations in females. We examined the influence of endurance training and self-reported dietary restraint on resting metabolic rate and fasting plasma hormones in 44 nonobese females characterized for body composition, maximal aerobic power [Formula: see text],... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 69 Số 3 - Trang 320-326 - 1991
Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid, previously L-686,708) is a potent inhibitor of leukotriene (LT) biosynthesis in intact human and elicited rat polymorphonuclear leukocytes (PMNLs) (IC50 values 3.1 and 6.1 nM, respectively) and in human, squirrel monkey, and rat whole blood (IC50... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 70 Số 6 - Trang 799-807 - 1992
Rapid axonal transport in Xenopus nerve in divalent cation free media An investigation was made of the effects of bathing media low in divalent cations on rapid axonal transport in the sciatic nerve of the amphibian Xenopus laevis. The anterograde transport of a pulse of [35 S]methionine proteins was observed using a multiple proportional counter as the detector. Organelles undergoing anterograde and retrograde transport were detected by... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 63 Số 10 - Trang 1279-1290 - 1985
Effect of ethanol tolerance on release of acetylcholine and norepinephrine by rat cerebral cortex slices The release of acetylcholine (ACh) by rat cerebral cortex slices, with and without electrical stimulation, and the effect of ethanol (EtOH) on this release were examined during the acquisition and loss of EtOH tolerance in vivo. ACh was measured by pyrolytic monodemethylation and gas–liquid chromatography. Electrical stimulation of control slices in medium containing diisopropyl phosphofl... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 55 Số 4 - Trang 758-768 - 1977
Voltage-dependent calcium fluxes in skeletal muscle transverse tubule membranes in the range of late afterpotentials Calcium flux responses mediated by voltage-dependent calcium channels have been studied in transverse tubule membrane vesicles from rabbit skeletal muscle. Vesicles were loaded with 45 Ca2+ , and membrane potentials were generated by establishing potassium gradients across the membrane in the presence of valinomycin. After the membranes were polariz... ... hiện toàn bộ
Canadian Journal of Physiology and Pharmacology - Tập 71 Số 7 - Trang 518-521 - 1993
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