Endothelin-1 induces neutrophil recruitment in adaptive inflammation via TNFα and CXCL1/CXCR2 in miceCanadian Journal of Physiology and Pharmacology - Tập 90 Số 2 - Trang 187-199 - 2012
Ana C. Zarpelon, Larissa G. Pinto, Thiago M. Cunha, Sílvio M. Vieira, Vanessa Carregaro, Guilherme R. Souza, João S. Silva, S. H. Ferreira, Fernando Q. Cunha, Waldiceu A. Verri
Endothelin mediates neutrophil recruitment during innate inflammation. Herein we address whether endothelin-1 (ET-1) is involved in neutrophil recruitment in adaptive inflammation in mice, and its mechanisms. Pharmacological treatments were used to determine the role of endothelin in neutrophil recruitment to the peritoneal cavity of mice challenged with antigen (ovalbumin) or ET-1. Levels...... hiện toàn bộ
Prolactin decreases expression of Runx2, osteoprotegerin, and RANKL in primary osteoblasts derived from tibiae of adult female ratsCanadian Journal of Physiology and Pharmacology - Tập 86 Số 5 - Trang 240-248 - 2008
Narattaphol Charoenphandhu, Jarinthorn Teerapornpuntakit, Mei Methawasin, Kannikar Wongdee, Kanogwun Thongchote, Nateetip Krishnamra
Hyperprolactinemia caused by physiological or pathological conditions, such as those occurring during lactation and prolactinoma, respectively, results in progressive osteopenia. The underlying mechanisms, however, are controversial. Prolactin (PRL) may directly attenuate the functions of osteoblasts, since these bone cells express PRL receptors. The present study therefore aimed to inves...... hiện toàn bộ
Actions of excitatory amino acids on mesencephalic trigeminal neuronsCanadian Journal of Physiology and Pharmacology - Tập 76 Số 9 - Trang 900-908 - 1998
Kenneth A. Pelkey, Kenneth C. Marshall
Mesencephalic trigeminal (MeV) neurons are primary sensory neurons of which the cell soma is located within the brainstem, and is associated with synaptic contacts. In previous studies it has been reported that these cells are resistant to kainic acid excitotoxicity, and have little or no responsiveness to exogenously applied glutamate or selective agonists. In an in vitro slice preparati...... hiện toàn bộ
Canine colonic circular muscle generates action potentials without the pacemaker componentCanadian Journal of Physiology and Pharmacology - Tập 72 Số 1 - Trang 70-81 - 1994
L W Liu, Jan D. Huizinga
Two dominant types of action potentials in canine colon are slow wave type action potentials (slow waves) and spike-like action potentials (SLAPs). The slow waves, originating at the submuscular surface where a network of interstitial cells of Cajal (ICCs) is found, possess a pacemaker component. Activation of the pacemaker component is insensitive to voltage changes and L-type calcium ch...... hiện toàn bộ
Excitability of canine colon circular muscle disconnected from the network of interstitial cells of CajalCanadian Journal of Physiology and Pharmacology - Tập 70 Số 2 - Trang 289-295 - 1992
L W Liu, E. E. Daniel, Jan D. Huizinga
The 6 cpm omnipresent slow waves recorded in the circular muscle (CM) layer of canine colon are generated at the submucosal surface of the CM layer. After removal of the submucosal network of interstitial cells of Cajal (ICC), 66% of the CM preparations (25 of 38) were quiescent in Krebs solution. In the presence of carbachol, seven of nine of these spontaneously quiescent CM preparations...... hiện toàn bộ