Canadian Journal of Gastroenterology and Hepatology

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How Can the Current Strategies for Helicobacter pylori Eradication Therapy be Improved?
Canadian Journal of Gastroenterology and Hepatology - Tập 17 Số B - 2003
Alexander C. Ford, Paul Moayyedi
BACKGROUND: The use of Helicobacter pylori eradication therapy is advocated in an increasing variety of situations. It is therefore important to optimise current strategies to eradicate H pylori infectionOBJECTIVES: To define the optimum dosage, drugs and duration of proton pump inhibitor (PPI) triple therapy.METHODS: A review of the literature was performed to identify randomized controlled trial... hiện toàn bộ
Thrombocytopenia in Liver Disease
Canadian Journal of Gastroenterology and Hepatology - Tập 14 Số D - 2000
Markus Peck‐Radosavljevic
Moderate thrombocytopenia is a frequent finding in cirrhosis of the liver and well tolerated in most instances. The pathophysiology of thrombocytopenia in liver disease has long been associated with the concept of hypersplenism, where portal hypertension was thought to cause pooling and sequestration of all corpuscular elements of the blood, predominantly thrombocytes in the enlarged spleen. The c... hiện toàn bộ
Natural History of Nonalcoholic Fatty Liver Disease: Implications for Clinical Practice and an Individualized Approach
Canadian Journal of Gastroenterology and Hepatology - Tập 2020 - Trang 1-10 - 2020
Ivica Grgurević, Kristian Podrug, Ivana Mikolašević, Michał Kukla, Anita Madir, Emmanuel Tsochatzis
Nonalcoholic fatty liver disease (NAFLD) is becoming the most prevalent liver disease worldwide, associated with epidemics of overweight and resulting metabolic syndrome (MetS). Around 20–30% of patients with NAFLD develop progressive liver fibrosis, which is the most important predictor of liver-related and overall morbidity and mortality. In contrast to classical understanding, no significant as... hiện toàn bộ
Role of NLRP3 Inflammasome in the Progression of NAFLD to NASH
Canadian Journal of Gastroenterology and Hepatology - Tập 2016 - Trang 1-7 - 2016
Xingyong Wan, Chengfu Xu, Chaohui Yu, Youming Li
Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major public health problem worldwide. Nonalcoholic steatohepatitis (NASH) is an advanced form of NAFLD that may progress to cirrhosis and hepatocellular carcinoma. The pathogenesis of disease progression from NAFLD to NASH has not been fully understood. Immunological mechanisms that have been increasingly recognized in the disease ... hiện toàn bộ
Postliver Transplant Allograft Reinfection with a Lamivudine‐Resistant Strain of Hepatitis B Virus: Long Term Follow‐up
Canadian Journal of Gastroenterology and Hepatology - Tập 12 Số 2 - Trang 125-129 - 1998
Eric M. Yoshida, Mang Ma, Jennifer Davis, Karl Fischer, Norman M. Kneteman, Siegfried R. Erb, D. Lorne Tyrrell, Vincent G. Bain
Lamivudine is a nucleoside analogue with efficacy in the suppression of hepatitis B viral (HBV) replication. In a previously reported study, lamivudine was administered to patients with chronic, actively replicating HBV infection who subsequently underwent liver transplantation. Patients became serum HBV DNA‐negative in response to lamivudine before transplantation, which was continued in the post... hiện toàn bộ
Physician Global Assessments or Blood tests do not Predict Mucosal Disease Activity in Ulcerative Colitis
Canadian Journal of Gastroenterology and Hepatology - Tập 28 Số 6 - Trang 325-329 - 2014
Mayur Brahmania, Çharles N. Bernstein
BACKGROUND: Mucosal healing has been proposed as the therapeutic end point in the treatment of patients with ulcerative colitis (UC).OBJECTIVE: To investigate the relationship between physician global assessment (PGA) and laboratory blood tests (complete blood count, ferritin, C-reactive protein, albumin) and endoscopic findings in UC to determine whether they could be adequate surrogates for endo... hiện toàn bộ
Treatment Algorithm for Chronic Idiopathic Constipation and Constipation-Predominant Irritable Bowel Syndrome Derived from a Canadian National Survey and Needs Assessment on Choices of Therapeutic Agents
Canadian Journal of Gastroenterology and Hepatology - Tập 2017 - Trang 1-11 - 2017
Yvonne Tse, David Armstrong, Christopher N. Andrews, Alain Bitton, Brian Bressler, John K. Marshall, Louis W. C. Liu
Background. Chronic idiopathic constipation (CIC) and constipation-predominant irritable bowel syndrome (IBS-C) are common functional lower gastrointestinal disorders that impair patients’ quality of life. In a national survey, we aimed to evaluate (1) Canadian physician practice patterns in the utilization of therapeutic agents listed in the new ACG and AGA guidelines; (2) physicians satisfaction... hiện toàn bộ
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