Canadian Journal of Anaesthesia

Methoxyflurane anaesthesia in dogs produced respiratory depression, a gradual moderate decline in blood pressure with minimal changes in heart rate, and no significant effect on blood glucose or plasria adrenaline and noradrenaline levels. Hypercarbia induced an immediate hypotensive response-and caused sigruficant increases in both catecholamines; haemorrhage was followed by significant increases in plasma adrenaline. Blood glucose increased as a result of hypercarbia and haemorrhage during methoxyfluran0e anaesthesia.

To compare the efficacy of acupressure wrist bands and ondansetron for the prevention of postoperative nausea and vomiting (PONV). One hundred and fifty ASA I–II, patients undergoing elective laparoscopic cholecystectomy were included in a randomized, prospective, double-blind and placebo-controlled study. Patients were divided into three groups of SO. Group I was the control; Group II received ondansetron 4 mgiv just prior to induction of anesthesia; in Group III acupressure wristbands were applied at the P6 points. Acupressure wrist bands were placed inappropriately in Groups I and II. The acupressure wrist bands were applied 30 min prior to induction of anesthesia and removed six hours following surgery. Anesthesia was standardized. PONV were evaluated separately as none, mild, moderate or severe within six hours of patients’ arrival in the postanesthesia care unit and then at 24 hr after surgery by a blinded observer. If patients vomited more than once, they were given 4 mg ondansetroniv as the rescue antiemetic. Results were analyzed by Ztest. AP value of < 0.05 was taken as significant. The incidence of PONV and the requirement of rescue medication were significantly lower in both the acupressure and ondansetron groups during the first six hours. Acupressure at P6 causes a significant reduction in the incidence of PONV and the requirement for rescue medication in the first six hours following laparoscopic cholecystectomy, similar to that of ondansetron 4 mgiv.