British Journal of Clinical Pharmacology

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Limited predictability of amikacin clearance in extreme premature neonates at birth
British Journal of Clinical Pharmacology - Tập 61 Số 1 - Trang 39-48 - 2006
Karel Allegaert, Brian J. Anderson, Veerle Cossey, Nicholas H. G. Holford
AimIdentify and quantify factors describing variability of amikacin clearance in preterm neonates at birth.MethodsPopulation pharmacokinetics of amikacin were estimated in a cohort of 205 extreme preterm neonates [post conception age (PCA) 27.8, SD 1.8, range 24–30 weeks; weight 1.07, SD 0.34,...... hiện toàn bộ
The use of cimetidine to reduce dapsone‐dependent methaemoglobinaemia in dermatitis herpetiformis patients.
British Journal of Clinical Pharmacology - Tập 34 Số 3 - Trang 244-249 - 1992
Michael D. Coleman, Lesley E. Rhodes, AK Scott, JL Verbov, PS Friedmann, AM Breckenridge, BK Park
1. We have attempted to reduce dapsone‐dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the co‐administration of cimetidine. 2. In comparison with control, i.e. dapsone alone, methaemoglobinaemia due to dapsone fell by 27.3 +/‐ 6.7% and 26.6 +/‐ 5.6% the first and second weeks after commencement of cimetidine administration. The norm...... hiện toàn bộ
Melatonin and cortisol increase after fluvoxamine [letter]
British Journal of Clinical Pharmacology - Tập 22 Số 5 - Trang 620-622 - 1986
K. Demisch, L. Demisch, Bochnik Hj, Thomas Nickelsen, P.-H. Althoff, Κ. Schöffling, R. Rieth
Pharmacokinetics and bioavailability of omeprazole after single and repeated oral administration in healthy subjects.
British Journal of Clinical Pharmacology - Tập 29 Số 5 - Trang 557-563 - 1990
Tommy Andersson, Kerstin Andrén, C. Cederberg, Per-Olof Lagerström, Per Lundborg, Inger Skånberg
1. Ten healthy subjects were given 20 mg omeprazole EC (enteric coated) granules once daily for 8 days. An i.v. tracer dose of [14C]‐omeprazole was given simultaneously with the first and last oral doses and blood sampling was performed thereafter. In order to study the extent of absorption at minimal acid exposure, a single dose of 20 mg omeprazole was also given as a buffered solution, b...... hiện toàn bộ
Bioavailability of dexmedetomidine after extravascular doses in healthy subjects
British Journal of Clinical Pharmacology - Tập 56 Số 6 - Trang 691-693 - 2003
Maarit Anttila, Jani Penttilä, Antti Helminen, Lauri Vuorilehto, Harry Scheinin
Aim  To determine the absolute bioavailability of extravascularly administered dexmedetomidine, a novel a2‐adrenoceptor agonist, in healthy subjects.Methods  Single 2 µg kg−1 doses of dexmedetomidine were given intravenously, intramuscularly, perorally and buccally (where the solution is not swallowed) to 1...... hiện toàn bộ
Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady‐state in healthy subjects
British Journal of Clinical Pharmacology - Tập 56 Số 1 - Trang 39-45 - 2003
Géraldine M. Ferron, Alain Patat, Virginia Parks, Paul Rolan, Steven Troy
Aims  To evaluate potential pharmacokinetic interactions between phenobarbitone and retigabine, a new antiepileptic drug. Methods  Fifteen healthy men received 200 mg of retigabine on day 1. On days 4–32, phenobarbitone 90 mg was administered at 22.00 h. On days 26–32, increasin...... hiện toàn bộ
In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta‐adrenoceptor agonists and theophylline.
British Journal of Clinical Pharmacology - Tập 22 Số 6 - Trang 669-676 - 1986
Roy G. Goldie, Domenico Spina, Peter J. Henry, Karmelo M. Lulich, James W. Paterson
Responses of human bronchial strip preparations to contractile and relaxant agonists were measured in preparations from non‐diseased and from asthmatic lung obtained 3‐15 h post‐mortem. The potencies of carbachol and histamine were approximately two times less in asthmatic than in non‐diseased bronchi. This was statistically significant for carbachol (P less than 0.05), but not for histami...... hiện toàn bộ
Population pharmacokinetics and exposure–response analyses of daratumumab plus pomalidomide/dexamethasone in relapsed or refractory multiple myeloma
British Journal of Clinical Pharmacology - Tập 89 Số 5 - Trang 1640-1655 - 2023
Anne‐Gaëlle Dosne, Xia Li, Man Luo, Ivo P. Nnane, Meletios Α. Dimopoulos, Evangelos Terpos, Pieter Sonneveld, Tobias Kampfenkel, Robin Carson, Himal Amin, Juan Perez Ruixo, Honghui Zhou, Yu‐Nien Sun, Yan Xu
AimA population pharmacokinetic (PPK) model was developed to characterize pharmacokinetics (PK) of subcutaneous or intravenous daratumumab administration in a new indication (i.e., combination with pomalidomide and dexamethasone [D‐Pd] in patients with relapsed or refractory multiple myeloma [RRMM]). Analyses were conducted to explore exposure–response (E...... hiện toàn bộ
In vitro inhibition studies of tolbutamide hydroxylase activity of human liver microsomes by azoles, sulphonamides and quinolines.
British Journal of Clinical Pharmacology - Tập 26 Số 1 - Trang 23-29 - 1988
DJ Back, John Tjia, J Karbwang, J Colbert
1. A number of compounds have been examined for their ability to inhibit tolbutamide hydroxylase activity in human liver microsomes (control value at a substrate concentration of 150 microM being 0.27 +/‐ 0.12 nmol min‐1 mg‐1 protein; mean +/‐ s.d.; n = 7). 2. IC50 (concentration of inhibitor producing 50% inhibition) values were determined for a range of sulphonamides, imidazoles and amin...... hiện toàn bộ
Pharmacokinetics of the trimethoprim‐sulphamethoxazole combination in the elderly.
British Journal of Clinical Pharmacology - Tập 20 Số 6 - Trang 575-581 - 1985
O Varoquaux, D. Lajoie, C. Gobert, P Cordonnier, C. Ducreuzet, M Pays, C Advenier
The pharmacokinetics of a co‐trimoxazole preparation (Bactrim Forte) containing trimethoprim (TMP) 160 mg and sulphamethoxazole (SMZ) 800 mg were determined in six young adults (29.3 +/‐ 4.4 s.d. years) and six elderly people (78.6 +/‐ 6.6 s.d. years). Following oral administration of a single dose, the pharmacokinetic parameters of SMZ and its N4‐ acetylated metabolite (N4SMZ) were simila...... hiện toàn bộ
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