British Journal of Clinical Pharmacology

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Limited predictability of amikacin clearance in extreme premature neonates at birth
British Journal of Clinical Pharmacology - Tập 61 Số 1 - Trang 39-48 - 2006
Karel Allegaert, Brian J. Anderson, Veerle Cossey, Nicholas H. G. Holford
AimIdentify and quantify factors describing variability of amikacin clearance in preterm neonates at birth.MethodsPopulation pharmacokinetics of amikacin were estimated in a cohort of 205 extreme preterm neonates [post conception age (PCA) 27.8, SD 1.8, range 24–30 weeks; weight 1.07, SD 0.34, range 0.45–1.98 kg, postnatal age < 72 h]. Covariate analysis included weight, PCA, Apgar score, prophyla... hiện toàn bộ
Intravenous indometacin in preterm infants with symptomatic patent ductus arteriosus. A population pharmacokinetic study
British Journal of Clinical Pharmacology - Tập 58 Số 3 - Trang 249-258 - 2004
J. M. Smyth, Paul S. Collier, M Darwish, Jeffrey S. Millership, Henry L. Halliday, S. Petersen, James C. McElnay
AimsTo characterize the population pharmacokinetics of indometacin in preterm infants with symptomatic patent ductus arteriosus and to investigate the influence of various factors on the response to treatment.MethodsData were collected from 35 infants (gestational age 25–34 weeks; postnatal age 1–77 days) in neonatal units in Belfast and Copenhagen. Infants received an initial course of up to thre... hiện toàn bộ
Cerebrospinal fluid pharmacokinetics of paracetamol after intravenous propacetamol in a former preterm infant
British Journal of Clinical Pharmacology - Tập 57 Số 2 - Trang 224-225 - 2004
Karel Allegaert, René Verbesselt, H. Devlieger, Jan de Hoon, Dick Tibboel
Dose estimation for children
British Journal of Clinical Pharmacology - Tập 56 Số 5 - Trang 489-493 - 2003
Nigel S. Baber, Deborah Pritchard
The use of cimetidine to reduce dapsone‐dependent methaemoglobinaemia in dermatitis herpetiformis patients.
British Journal of Clinical Pharmacology - Tập 34 Số 3 - Trang 244-249 - 1992
Michael D. Coleman, Lesley E. Rhodes, AK Scott, JL Verbov, PS Friedmann, AM Breckenridge, BK Park
1. We have attempted to reduce dapsone‐dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the co‐administration of cimetidine. 2. In comparison with control, i.e. dapsone alone, methaemoglobinaemia due to dapsone fell by 27.3 +/‐ 6.7% and 26.6 +/‐ 5.6% the first and second weeks after commencement of cimetidine administration. The normally cya... hiện toàn bộ
An investigation of the role of metabolism in dapsone‐induced methaemoglobinaemia using a two compartment in vitro test system.
British Journal of Clinical Pharmacology - Tập 30 Số 6 - Trang 829-838 - 1990
Malcolm D. Tingle, Michael D. Coleman, BK Park
1. We have utilized a two compartment system in which two teflon chambers are separated by a semi‐permeable membrane in order to investigate the role of metabolism in dapsone‐induced methaemoglobinaemia. Compartment A contained a drug metabolizing system (microsomes prepared from human liver +/‐ NADPH), whilst compartment B contained target cells (human red cells). 2. Incubation of dapsone (1‐ 100... hiện toàn bộ
Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin
British Journal of Clinical Pharmacology - Tập 64 Số 4 - Trang 517-526 - 2007
Caroline M. Forrest, Gillian Mackay, Nicholas Stoy, Trevor W. Stone, L. Gail Darlington
What is already known about this subject • There is good evidence that oxidative stress, associated with the generation of free radicals, is a major contributor to joint damage in rheumatoid arthritis.• It is also well established that melatonin is one of the most powerful, endogenous free radical scavengers, and it is very safe for human use.• We have therefore examined whether melatonin might be... hiện toàn bộ
Melatonin and cortisol increase after fluvoxamine [letter]
British Journal of Clinical Pharmacology - Tập 22 Số 5 - Trang 620-622 - 1986
K. Demisch, L. Demisch, Bochnik Hj, Thomas Nickelsen, P.-H. Althoff, Κ. Schöffling, R. Rieth
Pharmacokinetics and bioavailability of omeprazole after single and repeated oral administration in healthy subjects.
British Journal of Clinical Pharmacology - Tập 29 Số 5 - Trang 557-563 - 1990
Tommy Andersson, Kerstin Andrén, C. Cederberg, Per-Olof Lagerström, Per Lundborg, Inger Skånberg
1. Ten healthy subjects were given 20 mg omeprazole EC (enteric coated) granules once daily for 8 days. An i.v. tracer dose of [14C]‐omeprazole was given simultaneously with the first and last oral doses and blood sampling was performed thereafter. In order to study the extent of absorption at minimal acid exposure, a single dose of 20 mg omeprazole was also given as a buffered solution, before an... hiện toàn bộ
Bioavailability of dexmedetomidine after extravascular doses in healthy subjects
British Journal of Clinical Pharmacology - Tập 56 Số 6 - Trang 691-693 - 2003
Maarit Anttila, Jani Penttilä, Antti Helminen, Lauri Vuorilehto, Harry Scheinin
Aim  To determine the absolute bioavailability of extravascularly administered dexmedetomidine, a novel a2‐adrenoceptor agonist, in healthy subjects.Methods  Single 2 µg kg−1 doses of dexmedetomidine were given intravenously, intramuscularly, perorally and buccally (where the solution is not swallowed) to 12 healthy male subjects. The drug concentration‐time data were analysed using linear one‐com... hiện toàn bộ
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