British Journal of Clinical Pharmacology

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
The use of cimetidine to reduce dapsone‐dependent methaemoglobinaemia in dermatitis herpetiformis patients.
British Journal of Clinical Pharmacology - Tập 34 Số 3 - Trang 244-249 - 1992
Michael D. Coleman, Lesley E. Rhodes, AK Scott, JL Verbov, PS Friedmann, AM Breckenridge, BK Park
1. We have attempted to reduce dapsone‐dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the co‐administration of cimetidine. 2. In comparison with control, i.e. dapsone alone, methaemoglobinaemia due to dapsone fell by 27.3 +/‐ 6.7% and 26.6 +/‐ 5.6% the first and second weeks after commencement of cimetidine administration. The norm...... hiện toàn bộ
Melatonin and cortisol increase after fluvoxamine [letter]
British Journal of Clinical Pharmacology - Tập 22 Số 5 - Trang 620-622 - 1986
K. Demisch, L. Demisch, Bochnik Hj, Thomas Nickelsen, P.-H. Althoff, Κ. Schöffling, R. Rieth
Bioavailability of dexmedetomidine after extravascular doses in healthy subjects
British Journal of Clinical Pharmacology - Tập 56 Số 6 - Trang 691-693 - 2003
Maarit Anttila, Jani Penttilä, Antti Helminen, Lauri Vuorilehto, Harry Scheinin
Aim  To determine the absolute bioavailability of extravascularly administered dexmedetomidine, a novel a2‐adrenoceptor agonist, in healthy subjects.Methods  Single 2 µg kg−1 doses of dexmedetomidine were given intravenously, intramuscularly, perorally and buccally (where the solution is not swallowed) to 1...... hiện toàn bộ
Lack of pharmacokinetic interaction between retigabine and phenobarbitone at steady‐state in healthy subjects
British Journal of Clinical Pharmacology - Tập 56 Số 1 - Trang 39-45 - 2003
Géraldine M. Ferron, Alain Patat, Virginia Parks, Paul Rolan, Steven Troy
Aims  To evaluate potential pharmacokinetic interactions between phenobarbitone and retigabine, a new antiepileptic drug. Methods  Fifteen healthy men received 200 mg of retigabine on day 1. On days 4–32, phenobarbitone 90 mg was administered at 22.00 h. On days 26–32, increasin...... hiện toàn bộ
Cotrimoxazole as an inhibitor of oxidative drug metabolism: effects of trimethoprim and sulphamethoxazole separately and combined on tolbutamide disposition.
British Journal of Clinical Pharmacology - Tập 20 Số 5 - Trang 482-485 - 1985
LM Wing, John O. Miners
The effect of separate pretreatments with cotrimoxazole, sulphamethoxazole and trimethoprim on the disposition of tolbutamide was studied in seven healthy males. Tolbutamide 500 mg intravenously was administered on four separate occasions‐as a control without pretreatment and on the seventh day of separate twice daily administration of cotrimoxazole (sulphamethoxazole 800 mg plus trimethop...... hiện toàn bộ
Urinary coproporphyrin I/(I + III) ratio as a surrogate for MRP2 or other transporter activities involved in methotrexate clearance
British Journal of Clinical Pharmacology - Tập 78 Số 2 - Trang 329-342 - 2014
Isabelle Aimone‐Gastin, Noël Zahr, Amélie Le Gouge, Jean‐Sébastien Hulot, Caroline Houillier, Khê Hoang‐Xuan, Emmanuel Gyan, Séverine Lissandre, Sylvain Choquet, Chantal Le Guellec
AimsThe urinary coproporphyrin I/(I + III) ratio may be a surrogate for MRP2 activity. We conducted a prospec...... hiện toàn bộ
Determinants of the elimination of methotrexate and 7‐hydroxy‐methotrexate following high‐dose infusional therapy to cancer patients
British Journal of Clinical Pharmacology - Tập 62 Số 1 - Trang 71-80 - 2006
Markus Joerger, Alwin D. R. Huitema, H.J.G.D. van den Bongard, Paul Baas, Jan H. Schornagel, Jan H.M. Schellens, Jos H. Beijnen
AimsTo characterize determinants of the elimination of methotrexate (MTX) and 7‐hydroxy‐methotrexate (7‐OH‐MTX) in patients receiving high‐dose MTX therapy (HDMTX).Methods24 and 48‐h blood samples from 76 patients receiving HDMTX (dose range 300 mg m−2 to 12 g m−...... hiện toàn bộ
Safety, tolerability and pharmacokinetics of higher‐dose mizoribine in healthy male volunteers
British Journal of Clinical Pharmacology - Tập 63 Số 4 - Trang 459-468 - 2007
Daria Stypinski, Mohammad Obaidi, Michelle D. Combs, Meg Weber, Adrian Stewart, Hiroaki Ishikawa
AimsMizoribine is an oral immunosuppressive agent approved in several countries for prevention of rejection in renal transplantation. Its therapeutic window is based on trough concentrations staying at ≥0.5 but <3 µg ml−1. It has been postulated that as renal function returns to normal, higher doses may be needed to maintain effica...... hiện toàn bộ
The effects of lacidipine on the steady/state plasma concentrations of simvastatin in healthy subjects
British Journal of Clinical Pharmacology - Tập 51 Số 2 - Trang 147-152 - 2001
Luigi Ziviani, Lucio Da Ros, Lisa Squassante, Stefano Milleri, Mauro Cugola, Laura Iavarone
Aims Lacidipine, a long acting 2, 4‐dihydropyridine calcium channel antagonist is frequently administered with cholesterol lowering agents, particularly in elderly populations. The effects of lacidipine on the pharmacokinetics of simvastatin were investigated, since they share the CYP3A4 pathway for metabolism. Methods...... hiện toàn bộ
Evidence for involvement of human CYP3A in the 3‐hydroxylation of quinine
British Journal of Clinical Pharmacology - Tập 43 Số 3 - Trang 245-252 - 1997
H. Zhang, P. F. Coville, Robert Walker, John O. Miners, Donald Birkett, Sompon Wanwimolruk
Aims Our previous studies using in vitro hepatic microsomal preparations suggested that the hepatic metabolism of quinine to form the major metabolite 3‐hydroxyquinine is most likely catalysed by human P450 3A (CYP3A). The present study was carried out to investigate the kinetics and to identify and further characterise the human liver...... hiện toàn bộ
Tổng số: 131   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10