Brain
1460-2156
0006-8950
Anh Quốc
Cơ quản chủ quản: Oxford University Press , OXFORD UNIV PRESS
Lĩnh vực:
Neurology (clinical)Medicine (miscellaneous)
Phân tích ảnh hưởng
Thông tin về tạp chí
Brain has published landmark papers in clinical neurology and translational neuroscience since 1878. The Editorial Board reflects the journal's broad coverage and international readership. Accepted articles are posted online within a few weeks of acceptance.
Các bài báo tiêu biểu
Evidence for label-retaining tumour-initiating cells in human glioblastoma
Tập 134 Số 5 - Trang 1331-1343 - 2011
CYP7B1 mutations in pure and complex forms of hereditary spastic paraplegia type 5
Tập 132 Số 6 - Trang 1589-1600 - 2009
Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease
Tập 131 Số 11 - Trang 2851-2859 - 2008
Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury
Tập 131 Số 10 - Trang 2620-2631 - 2008
KONZO, AN EPIDEMIC UPPER MOTOR NEURON DISEASE STUDIED IN TANZANIA
Tập 113 Số 1 - Trang 223-235 - 1990
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings Abstract
Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual coronavirus disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 in order to discuss and begin to understand neurological presentations in patients with suspected COVID-19-related neurological disorders. Detailed clinical and paraclinical data were collected from cases where the diagnosis of COVID-19 was confirmed through RNA PCR, or where the diagnosis was probable/possible according to World Health Organization criteria. Of 43 patients, 29 were SARS-CoV-2 PCR positive and definite, eight probable and six possible. Five major categories emerged: (i) encephalopathies (n = 10) with delirium/psychosis and no distinct MRI or CSF abnormalities, and with 9/10 making a full or partial recovery with supportive care only; (ii) inflammatory CNS syndromes (n = 12) including encephalitis (n = 2, para- or post-infectious), acute disseminated encephalomyelitis (n = 9), with haemorrhage in five, necrosis in one, and myelitis in two, and isolated myelitis (n = 1). Of these, 10 were treated with corticosteroids, and three of these patients also received intravenous immunoglobulin; one made a full recovery, 10 of 12 made a partial recovery, and one patient died; (iii) ischaemic strokes (n = 8) associated with a pro-thrombotic state (four with pulmonary thromboembolism), one of whom died; (iv) peripheral neurological disorders (n = 8), seven with Guillain-Barré syndrome, one with brachial plexopathy, six of eight making a partial and ongoing recovery; and (v) five patients with miscellaneous central disorders who did not fit these categories. SARS-CoV-2 infection is associated with a wide spectrum of neurological syndromes affecting the whole neuraxis, including the cerebral vasculature and, in some cases, responding to immunotherapies. The high incidence of acute disseminated encephalomyelitis, particularly with haemorrhagic change, is striking. This complication was not related to the severity of the respiratory COVID-19 disease. Early recognition, investigation and management of COVID-19-related neurological disease is challenging. Further clinical, neuroradiological, biomarker and neuropathological studies are essential to determine the underlying pathobiological mechanisms that will guide treatment. Longitudinal follow-up studies will be necessary to ascertain the long-term neurological and neuropsychological consequences of this pandemic.
Tập 143 Số 10 - Trang 3104-3120 - 2020
Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients
Tập 124 Số 6 - Trang 1138-1148 - 2001
Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula
Tập 126 Số 11 - Trang 2406-2418 - 2003
Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech
Tập 129 Số 6 - Trang 1385-1398
Re-examining the brain regions crucial for orchestrating speech articulation
Tập 127 Số 7 - Trang 1479-1487 - 2004