Bone and Joint Research

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The use of rats and mice as animal models inex vivobone growth and development studies
Bone and Joint Research - Tập 5 Số 12 - Trang 610-618 - 2016
Adamu Abdul Abubakar, Noordin Mohamed Mustapha, T. I. Azmi, Ubedullah Kaka, Loqman Mohamad Yusof
In vivo animal experimentation has been one of the cornerstones of biological and biomedical research, particularly in the field of clinical medicine and pharmaceuticals. The conventional in vivo model system is invariably associated with high production costs and strict ethical considerations. These limitations led to the evolution of an ex vivo model system which partially or completely surmount... hiện toàn bộ
Outcomes following fractured neck of femur in an Australian metropolitan teaching hospital
Bone and Joint Research - Tập 2 Số 8 - Trang 162-168 - 2013
Ping Han Chia, L. Gualano, Siven Seevanayagam, Laurence Weinberg
Objectives To determine the morbidity and mortality outcomes of patients presenting with a fractured neck of femur in an Australian context. Peri-operative variables related to unfavourable outcomes were identified to allow planning of intervention strategies for improving peri-operative care. Methods We performed a retrospective observational study of 185 consecutive adult patients admitted to an... hiện toàn bộ
MRI of articular cartilage at microscopic resolution
Bone and Joint Research - Tập 2 Số 1 - Trang 9-17 - 2013
Yang Xia
This review briefly summarises some of the definitive studies of articular cartilage by microscopic MRI (µMRI) that were conducted with the highest spatial resolutions. The article has four major sections. The first section introduces the cartilage tissue, MRI and µMRI, and the concept of image contrast in MRI. The second section describes the characteristic profiles of three relaxation times (T1,... hiện toàn bộ
Enhancement of fracture healing in the rat, modulated by compounds that stimulate inducible nitric oxide synthase
Bone and Joint Research - Tập 6 Số 2 - Trang 90-97 - 2017
Rebecca Rajfer, A. Kılıç, Andrew S. Neviaser, Leah M. Schulte, Su M Hlaing, Jose Landeros, Mónica G. Ferrini, Edward Ebramzadeh, So Hyun Park
ObjectivesWe investigated the effects on fracture healing of two up-regulators of inducible nitric oxide synthase (iNOS) in a rat model of an open femoral osteotomy: tadalafil, a phosphodiesterase inhibitor, and the recently reported nutraceutical, COMB-4 (consisting of L-citrulline, Paullinia cupana, ginger and muira puama), given orally for either 14 or 42 days.Materials and MethodsUnilateral fe... hiện toàn bộ
Altered expression of microRNA during fracture healing in diabetic rats
Bone and Joint Research - Tập 7 Số 2 - Trang 139-147 - 2018
Shunsuke Takahara, S. Y. Lee, Takashi Iwakura, Keisuke Oe, Tomoaki Fukui, Etsuko Okumachi, Takahiro Waki, Michio Arakura, Yoshitada Sakai, Kotaro Nishida, Ryosuke Kuroda, Takahiro Niikura
ObjectivesDiabetes mellitus (DM) is known to impair fracture healing. Increasing evidence suggests that some microRNA (miRNA) is involved in the pathophysiology of diabetes and its complications. We hypothesized that the functions of miRNA and changes to their patterns of expression may be implicated in the pathogenesis of impaired fracture healing in DM.MethodsClosed transverse fractures were cre... hiện toàn bộ
Age-related differences in the neck strength of adolescent rugby players
Bone and Joint Research - Tập 1 Số 7 - Trang 152-157 - 2012
David F. Hamilton, Don Gatherer, P Jenkins, J. G. B. MacLean, James D. Hutchison, R.W. Nutton, Hamish Simpson
Objectives To evaluate the neck strength of school-aged rugby players, and to define the relationship with proxy physical measures with a view to predicting neck strength. Methods Cross-sectional cohort study involving 382 rugby playing schoolchildren at three Scottish schools (all male, aged between 12 and 18 years). Outcome measures included maximal isometric neck extension, weight, height, grip... hiện toàn bộ
Patient-reported outcome measures after total knee arthroplasty
Bone and Joint Research - Tập 4 Số 7 - Trang 120-127 - 2015
Prem N. Ramkumar, Joshua D. Harris, Philip C. Noble
Objectives A lack of connection between surgeons and patients in evaluating the outcome of total knee arthroplasty (TKA) has led to the search for the ideal patient-reported outcome measure (PROM) to evaluate these procedures. We hypothesised that the desired psychometric properties of the ideal outcome tool have not been uniformly addressed in studies describing TKA PROMS. Methods A systematic re... hiện toàn bộ
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