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Reproductive issues in sickle cell disease
Blood - Tập 124 - Trang 3538-3543 - 2014
Kim Smith-Whitley
Abstract As medical advances improve survival, reduce disease-related morbidity, and improve quality of life, reproductive issues will take higher priority in the sickle cell disease (SCD) community. A wide variety of topics are addressed in this chapter, including fertility, gonadal failure, erectile dysfunction, and menstrual issues in SCD. Etiologies of impaired male fertility are multifactoria... hiện toàn bộ
An Empirical Classification of Chronic Pain Subgroups in Pediatric Sickle Cell Disease: A Cluster-Analytic Approach
Blood - Tập 138 - Trang 491 - 2021
Soumitri Sil, Alison Manikowski, Mallory Schneider, Lindsey L Cohen, Carlton D. Dampier
Abstract Introduction: Youth with sickle cell disease (SCD) and chronic pain are a heterogeneous group with variability in their daily pain experience and physical and psychosocial functioning. We aimed to 1) empirically derive chronic pain subgroups based on sensory pain characteristics using cluster analysis within a sample of youth with chronic SCD pain, and 2) investigate derived subgroups for... hiện toàn bộ
Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect
Blood - Tập 104 - Trang 436-443 - 2004
Angela Gismondi, Loredana Cifaldi, Cinzia Mazza, Silvia Giliani, Silvia Parolini, Stefania Morrone, Jordan Jacobelli, Elisabetta Bandiera, Luigi Notarangelo, Angela Santoni
AbstractIn this study we show that Wiskott-Aldrich syndrome protein (WASp), a critical regulator of actin cytoskeleton that belongs to the Scar/WAVE family, plays a crucial role in the control of natural killer (NK) cell cytotoxicity. Analysis of NK cell numbers and cytotoxic activity in patients carrying different mutations in the WASP coding gene indicated that although the percentage of NK cell... hiện toàn bộ
Efficient Binding, but Moderate Modulation, of Human Dendritic Cell Functions by Milatuzumab, a Humanized Anti-CD74 Monoclonal Antibody
Blood - Tập 112 - Trang 2649 - 2008
Xiaochuan Chen, Chien-Hsing Chang, David Goldenberg
Abstract Milatuzumab (hLL1, Immunomedics, Inc.), a humanized anti-CD74 immunoglobulin-G monoclonal antibody (MAb), has been shown to have therapeutic activity against CD74-expressing B-cell malignancies in vitro and in xenografts models, and is in clinical evaluation as a therapeutic MAb for non-Hodgkin lymphoma, chronic lymphocytic leukemia, and multiple myeloma. Since it is unclear whether this ... hiện toàn bộ
Hand-mirror lymphocytes in infectious mononucleosis
Blood - Tập 55 - Trang 925-930 - 1980
William J. Thomas, Kazue Yasaka, DM Strong, CM Woodruff, Sanford A. Stass, Harold R. Schumacher
Abstract The identification of a morphologically unique lymphocyte in the peripheral blood of patients with infectious mononucleosis (IM) led to additional studies. Examination of Wright-stained smears of EDTA anticoagulated blood obtained from 25 patients with IM at presentation revealed significantly increased (p less than 0.0001) percentages of hand-mirror lymphocytes (HML) (mean 9.2%) compared... hiện toàn bộ
Excessive production of transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production
Blood - Tập 82 - Trang 2379-2385 - 1993
L. Lagneaux, A. Delforge, C. Dorval, D. Bron, P. Stryckmans
Abstract To explore the pathogenesis of marrow failure in B-cell type chronic lymphocytic leukemia (B-CLL), we have examined the production of interleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage CSF (GM-CSF) by the adherent cell population of bone marrow (BM) derived from B-CLL patients and their capacity to support hematopoietic cell proliferation. Lipo... hiện toàn bộ
Regulation of release of hepatocyte growth factor from human promyelocytic leukemia cells, HL-60, by 1,25-dihydroxyvitamin D3, 12-O- tetradecanoylphorbol 13-acetate, and dibutyryl cyclic adenosine monophosphate
Blood - Tập 82 - Trang 53-59 - 1993
Masaaki Inaba, Hidenori Koyama, Masayuki Hino, Senji Okuno, Makoto Terada, Yoshiki Nishizawa, Tomoyoshi Nishino, Hirotoshi Morii
Hepatocyte growth factor (HGF) secreted from human promyelocytic leukemia cell line, HL-60, is indistinguishable from HGF in human plasma and its release is significantly stimulated by 12-O- tetradecanoylphorbol-13-acetate (TPA), a differentiation-inducer of HL- 60 cells into monocytes/macrophages (Nishino T et al: Biochem Biophys Res Commun 181:323, 1991). TPA stimulated HGF release from the cell... hiện toàn bộ
Combination Of Indoleamine 2,3-Dioxygenase Inhibitor and Cytotoxic Agents Is a Novel Therapeutic Option For Non-Hodgkin Lymphoma
Blood - Tập 122 - Trang 4408 - 2013
Nobuhiko Nakamura, Takeshi Hara, Yuhei Shibata, Takuro Matsumoto, Ryoko Mabuchi, Hiroshi Nakamura, Junichi Kitagawa, Nobuhiro Kanemura, Naoe Goto, Masahito Shimizu, Hisashi Tsurumi, Hisataka Moriwaki
Background Indoleamine 2,3-dioxygenase (IDO) catalyzes the rate-limiting step in the catabolism of tryptophan along the kynurenine pathway. In tumors, increased IDO activity inhibits T cell and natural killer cell proliferation and induces apoptosis. We have previously reported that IDO expression in lymphoma cells and serum concentration of kynurenine in diffuse large B-cell lymphoma are useful p... hiện toàn bộ
Mutation Analysis of the Rearranged Immunoglobulin Heavy Chain Genes of Marginal Zone Cell Lymphomas Indicates an Origin From Different Marginal Zone B Lymphocyte Subsets
Blood - Tập 91 - Trang 2381-2386 - 1998
A. Tierens, J. Delabie, S. Pittaluga, A. Driessen, C. DeWolf-Peeters
AbstractMarginal zone cell lymphoma is a recently described entity among the non-Hodgkin's lymphomas. It likely originates from the marginal zone B cells in the spleen and equivalent cells in the lymph node and extranodal tissues. Recent evidence indicates that marginal zone B cells are functionally heterogeneous and may differ with respect to the pattern of somatic hypermutation in their Ig varia... hiện toàn bộ
EVI1 Expression Predicts Poor Survival in Acute Myeloid Leukemia Patients Undergoing Allogeneic Hematopoietic Cell Transplantation with Myeloblastic Conditioning
Blood - Tập 124 - Trang 5308 - 2014
Xuefeng He, Suning Chen, Wu Depei, Aining Sun
Abstract The ecotropic viral integreation site 1 (EVI1 or MECOM) gene mapping to chromosome 3q26 exerts significant oncogene biological effects of anti-apoptosis, proliferation and differentiation on hematopoietic cells. It is considered as a poor prognostic factor in acute myeloid leukemia (AML). EVI1 positive AML accounts for about 10% of de novo AML pts. The remission rate and long time survive... hiện toàn bộ
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