Blood

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Reproductive issues in sickle cell disease
Blood - Tập 124 - Trang 3538-3543 - 2014
Kim Smith-Whitley
Abstract As medical advances improve survival, reduce disease-related morbidity, and improve quality of life, reproductive issues will take higher priority in the sickle cell disease (SCD) community. A wide variety of topics are addressed in this chapter, including fertility, gonadal failure, erectile dysfunction, and menstrual issues in SCD. Etiolog...... hiện toàn bộ
Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect
Blood - Tập 104 - Trang 436-443 - 2004
Angela Gismondi, Loredana Cifaldi, Cinzia Mazza, Silvia Giliani, Silvia Parolini, Stefania Morrone, Jordan Jacobelli, Elisabetta Bandiera, Luigi Notarangelo, Angela Santoni
AbstractIn this study we show that Wiskott-Aldrich syndrome protein (WASp), a critical regulator of actin cytoskeleton that belongs to the Scar/WAVE family, plays a crucial role in the control of natural killer (NK) cell cytotoxicity. Analysis of NK cell numbers and cytotoxic activity in patients carrying different mutations in the WASP coding gene indicated that a...... hiện toàn bộ
Excessive production of transforming growth factor-beta by bone marrow stromal cells in B-cell chronic lymphocytic leukemia inhibits growth of hematopoietic precursors and interleukin-6 production
Blood - Tập 82 - Trang 2379-2385 - 1993
L. Lagneaux, A. Delforge, C. Dorval, D. Bron, P. Stryckmans
Abstract To explore the pathogenesis of marrow failure in B-cell type chronic lymphocytic leukemia (B-CLL), we have examined the production of interleukin-6 (IL-6), granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage CSF (GM-CSF) by the adherent cell population of bone marrow (BM) derived from B-CLL patients and their capacity t...... hiện toàn bộ
Mutation Analysis of the Rearranged Immunoglobulin Heavy Chain Genes of Marginal Zone Cell Lymphomas Indicates an Origin From Different Marginal Zone B Lymphocyte Subsets
Blood - Tập 91 - Trang 2381-2386 - 1998
A. Tierens, J. Delabie, S. Pittaluga, A. Driessen, C. DeWolf-Peeters
AbstractMarginal zone cell lymphoma is a recently described entity among the non-Hodgkin's lymphomas. It likely originates from the marginal zone B cells in the spleen and equivalent cells in the lymph node and extranodal tissues. Recent evidence indicates that marginal zone B cells are functionally heterogeneous and may differ with respect to the pattern of somati...... hiện toàn bộ
Abnormal deoxyuridine suppression test in congenital methylmalonic aciduria-homocystinuria without megaloblastic anemia: divergent biochemical and morphological bone marrow manifestations of disordered cobalamin metabolism in man
Blood - Tập 59 - Trang 306-311 - 1982
Ralph Carmel, Stephen I. Goodman
Abstract We studied two brothers (J.R. and M.R.) with the cobalamin D variant of congenital methylmalonic aciduria-homocystinuria, whose previously reported lack of megaloblastic anemia conflicted with current concepts of cobalamin's role in DNA synthesis and the “methyltetrahydrofolate (MTHF) trap” hypothesis. Both subjects were indeed hematological...... hiện toàn bộ
Correlates of spontaneous clearance of hepatitis C virus among people with hemophilia
Blood - Tập 107 - Trang 892-897
Mingdong Zhang, Philip S. Rosenberg, Deborah L. Brown, Liliana Preiss, Barbara A. Konkle, M. Elaine Eyster, James J. Goedert
Long-Term Efficacy and Safety of Recombinant Interferon Alpha-2 Vs. Hydroxyurea in Polycythemia Vera: Preliminary Results from the Three-Year Analysis of the Daliah Trial - a Randomized Controlled Phase III Clinical Trial
Blood - Tập 132 - Trang 580 - 2018
Trine Alma Knudsen, Dennis Lund Hansen, Lukas Frans Ocias, Ole Weis Bjerrum, Mette Brabrand, Daniel El Fassi, Mikael Frederiksen, Lasse Kjær, Thomas Kielsgaard Kristensen, Torben A Kruse, Torben Mourits-Andersen, Peter Møller, Ulrik Malthe Overgaard, Marianne Tang Severinsen, Vibe Skov, Jesper Stentoft, Jørn Starklint, Karin de Stricker, Mads Thomassen, Thomas Stauffer Larsen
Clinical Significance of Monoclonality by Flow Cytometry in Histologically Negative Bone Marrow in Patients with Diffuse B Cell Non Hodgkin’s Lymphoma.
Blood - Tập 106 - Trang 4686 - 2005
Meir Lahav, Michael Lucianski, Judith Radnay, Hava Shapiro, Naomi Gronich, Yosef Manor, Michael Lishner
Abstract Bone marrow (BM) involvement in diffuse large B cell non Hodgkin’s lymphoma (DLBCL) results in stage IV staging and has negative impact on survival. Up to 40% of patients with DLBCL have BM involvement by routine histology of marrow biopsy. The identification of lymphoid monoclonality is widely used in diagnosis of lymphoma, by flow cytometr...... hiện toàn bộ
Synergy between tumor immunotherapy and antiangiogenic therapy
Blood - Tập 102 - Trang 964-971 - 2003
Smita Nair, David Boczkowski, Benjamin Moeller, Mark Dewhirst, Johannes Vieweg, Eli Gilboa
Abstract This study tested the hypothesis that combination of antiangiogenic therapy and tumor immunotherapy of cancer is synergistic. To inhibit angiogenesis, mice were immunized with dendritic cells (DCs) transfected with mRNA that encode products that are preferentially expressed during neoangiogenesis: vascular endothelial growth factor receptor-...... hiện toàn bộ
Markers of Thromboembolic Risk Were Insignificantly Affected By Either Intraosseous or Intravenous Idarucizumab in a Dabigatran-Anticoagulated Porcine Polytrauma Model
Blood - Tập 128 - Trang 2623 - 2016
Markus Honickel, Akman Necib, Hugo ten Cate, Rolf Rossaint, Oliver Grottke
Abstract Introduction: Idarucizumab is a monoclonal humanized antibody fragment (Fab), designed to reverse dabigatran anticoagulation. It is approved for urgent reversal of dabigatran anticoagulant effects in massive bleeding or prior to urgent interventions. It is administered intravenously (i.v.), either as a bolus or a short infusion (2x2.5 g). In...... hiện toàn bộ
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