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Reproductive issues in sickle cell disease
Blood - Tập 124 - Trang 3538-3543 - 2014
Kim Smith-Whitley
Abstract As medical advances improve survival, reduce disease-related morbidity, and improve quality of life, reproductive issues will take higher priority in the sickle cell disease (SCD) community. A wide variety of topics are addressed in this chapter, including fertility, gonadal failure, erectile dysfunction, and menstrual issues in SCD. Etiolog...... hiện toàn bộ
Impaired natural and CD16-mediated NK cell cytotoxicity in patients with WAS and XLT: ability of IL-2 to correct NK cell functional defect
Blood - Tập 104 - Trang 436-443 - 2004
Angela Gismondi, Loredana Cifaldi, Cinzia Mazza, Silvia Giliani, Silvia Parolini, Stefania Morrone, Jordan Jacobelli, Elisabetta Bandiera, Luigi Notarangelo, Angela Santoni
AbstractIn this study we show that Wiskott-Aldrich syndrome protein (WASp), a critical regulator of actin cytoskeleton that belongs to the Scar/WAVE family, plays a crucial role in the control of natural killer (NK) cell cytotoxicity. Analysis of NK cell numbers and cytotoxic activity in patients carrying different mutations in the WASP coding gene indicated that a...... hiện toàn bộ
Mutation Analysis of the Rearranged Immunoglobulin Heavy Chain Genes of Marginal Zone Cell Lymphomas Indicates an Origin From Different Marginal Zone B Lymphocyte Subsets
Blood - Tập 91 - Trang 2381-2386 - 1998
A. Tierens, J. Delabie, S. Pittaluga, A. Driessen, C. DeWolf-Peeters
AbstractMarginal zone cell lymphoma is a recently described entity among the non-Hodgkin's lymphomas. It likely originates from the marginal zone B cells in the spleen and equivalent cells in the lymph node and extranodal tissues. Recent evidence indicates that marginal zone B cells are functionally heterogeneous and may differ with respect to the pattern of somati...... hiện toàn bộ
Abnormal deoxyuridine suppression test in congenital methylmalonic aciduria-homocystinuria without megaloblastic anemia: divergent biochemical and morphological bone marrow manifestations of disordered cobalamin metabolism in man
Blood - Tập 59 - Trang 306-311 - 1982
Ralph Carmel, Stephen I. Goodman
Abstract We studied two brothers (J.R. and M.R.) with the cobalamin D variant of congenital methylmalonic aciduria-homocystinuria, whose previously reported lack of megaloblastic anemia conflicted with current concepts of cobalamin's role in DNA synthesis and the “methyltetrahydrofolate (MTHF) trap” hypothesis. Both subjects were indeed hematological...... hiện toàn bộ
Long-Term Efficacy and Safety of Recombinant Interferon Alpha-2 Vs. Hydroxyurea in Polycythemia Vera: Preliminary Results from the Three-Year Analysis of the Daliah Trial - a Randomized Controlled Phase III Clinical Trial
Blood - Tập 132 - Trang 580 - 2018
Trine Alma Knudsen, Dennis Lund Hansen, Lukas Frans Ocias, Ole Weis Bjerrum, Mette Brabrand, Daniel El Fassi, Mikael Frederiksen, Lasse Kjær, Thomas Kielsgaard Kristensen, Torben A Kruse, Torben Mourits-Andersen, Peter Møller, Ulrik Malthe Overgaard, Marianne Tang Severinsen, Vibe Skov, Jesper Stentoft, Jørn Starklint, Karin de Stricker, Mads Thomassen, Thomas Stauffer Larsen
Clinical Significance of Monoclonality by Flow Cytometry in Histologically Negative Bone Marrow in Patients with Diffuse B Cell Non Hodgkin’s Lymphoma.
Blood - Tập 106 - Trang 4686 - 2005
Meir Lahav, Michael Lucianski, Judith Radnay, Hava Shapiro, Naomi Gronich, Yosef Manor, Michael Lishner
Abstract Bone marrow (BM) involvement in diffuse large B cell non Hodgkin’s lymphoma (DLBCL) results in stage IV staging and has negative impact on survival. Up to 40% of patients with DLBCL have BM involvement by routine histology of marrow biopsy. The identification of lymphoid monoclonality is widely used in diagnosis of lymphoma, by flow cytometr...... hiện toàn bộ
Early Diagnosis of Neutropenic Enterocolitis by Ultrasound Sonography.
Blood - Tập 114 - Trang 4742 - 2009
Edoardo Benedetti, Federico Simonetti, Francesco Caracciolo, Federico Papineschi, Benedetto Bruno, Matteo Pelosini, Daniele Focosi, Sara Galimberti, Mario Petrini
Abstract Abstract 4742 Introduction Neutropenic enterocolitis (NEC) is a life threatening complication of chemotherapy in leukemic and solid tumor patients with an incidence ranging from 2.6% to 33%. It is a necrotizing inflammatory disease that mo...... hiện toàn bộ
Comparison of Autologous Stem Cell Transplantation Versus Haplo-Identical Donor Stem Cell Transplantation for Favorable- and Intermediate-Risk Acute Myeloid Leukemia Patients in First Complete Remission
Blood - Tập 130 - Trang 4595 - 2017
Jia Chen, Lingyi Yang, Yi Fan, Xiuli Wang, Yang Xu, Feng Chen, Ying Wang, Xiang Zhang, Tiemei Song, Su-Ning Chen, Depei Wu
CD43 processing and nuclear translocation of CD43 cytoplasmic tail are required for cell homeostasis
Blood - Tập 114 - Trang 3567-3577 - 2009
Wooseok Seo, Hermann J. Ziltener
AbstractThe sialomucin CD43 is highly expressed on most hematopoietic cells. In this study, we show that the CD43 ectodomain is shed from murine granulocytes, mast cells, and T cells, but not from macrophages. To study the significance of CD43 shedding, we constructed 2 CD43/34 chimeras in which the CD43 membrane-proximal or transmembrane domain was swapped with th...... hiện toàn bộ
Epigenetic Regulation of Lipid Signalling Pathways In Low-Risk MDS Patients During Azacitidine Treatment
Blood - Tập 116 - Trang 233 - 2010
Matilde Y Follo, Sara Mongiorgi, Cristina Clissa, Carla Filì, Chiara Colombi, Michele Baccarani, Giovanni Martinelli, Domenico Russo, Lucia Manzoli, Alberto M Martelli, Carlo Finelli, Lucio Cocco
Abstract Abstract 233 Azacitidine, a DNA methyltransferase inhibitor currently used for the treatment of higher-risk myelodysplastic syndromes (MDS) patients, was shown to delay the evolution into acute myeloid leukemia (AML) and prolong overall survival (Fenaux P et al, Lancet Oncol 2009). In addition, azacitidine has...... hiện toàn bộ
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