Mutation Analysis of the Rearranged Immunoglobulin Heavy Chain Genes of Marginal Zone Cell Lymphomas Indicates an Origin From Different Marginal Zone B Lymphocyte Subsets

Harris, 1994, A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group., Blood, 84, 1361, 10.1182/blood.V84.5.1361.1361 Schmid, 1992, Splenic marginal zone cell lymphoma., Am J Surg Pathol, 16, 455, 10.1097/00000478-199205000-00004 Hammer, 1996, Splenic marginal zone lymphoma. A distinct B-cell neoplasm., Am J Surg Pathol, 20, 613, 10.1097/00000478-199605000-00008 Sheibani, 1986, Monocytoid B-cell lymphoma: A novel B-cell neoplasm., Am J Pathol, 124, 310 Isaacson, 1983, Malignant lymphoma of mucosa-associated lymphoid tissue. A distinctive type of B-cell lymphoma., Cancer, 52, 1410, 10.1002/1097-0142(19831015)52:8<1410::AID-CNCR2820520813>3.0.CO;2-3 Isaacson, 1984, Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue., Cancer, 53, 2512, 10.1002/1097-0142(19840601)53:11<2515::AID-CNCR2820531125>3.0.CO;2-C Parvade, 1995, Low grade B-cell lymphomas of the splenic marginal zone: A clinicopathologic and immunohistochemical study of 14 cases., Histopathology, 27, 129, 10.1111/j.1365-2559.1995.tb00021.x Wu, 1996, Splenic marginal zone cell lymphoma. An immunophenotypic and molecular study of five cases., Am J Clin Pathol, 105, 277, 10.1093/ajcp/105.3.277 Isaacson, 1987, Malignant lymphoma of mucosa-associated lymphoid tissue., Histopathology, 11, 445, 10.1111/j.1365-2559.1987.tb02654.x Wotherspoon, 1992, Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue., Cancer Genet Cytogenet, 58, 35, 10.1016/0165-4608(92)90130-Z Dierlamm, 1996, Marginal zone B cell lymphomas of different sites share similar cytogenetic and morphologic features., Blood, 87, 299, 10.1182/blood.V87.1.299.299 MacLennan, 1991, Marginal zone B cells respond to both polysaccharide antigens and protein antigens., Res Immunol, 142, 436, 10.1016/0923-2494(91)90089-2 Dunn-Walters, 1995, Analysis of mutations in immunoglobulin heavy chain variable genes of microdissected marginal zone (MGZ) B cells suggests that the MZG of human spleen is a reservoir of memory B cells., J Exp Med, 182, 559, 10.1084/jem.182.2.559 Dunn-Walters, 1996, Sequence analysis of rearranged Ig VH genes from microdissected human Peyer's patch marginal zone B cells., Immunology, 88, 618 Amlot, 1985, Impaired human antibody response to the thymus-independent antigen, DNA-Ficoll, after splenectomy. Implications for post splenectomy infections., Lancet, 1, 1008, 10.1016/S0140-6736(85)91613-7 Küppers, 1993, Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections., EMBO J, 12, 4955, 10.1002/j.1460-2075.1993.tb06189.x Smith, 1986, Fluorescence detection in automated DNA sequence analysis., Nature, 321, 674, 10.1038/321674a0 Chang, 1994, The CDR 1 sequences of a major proportion of germline IG VH genes are inherently susceptible to amino acid replacement., Immunol Today, 15, 367, 10.1016/0167-5699(94)90175-9 Cook, 1995, The human immunoglobulin VH repertoire., Immunol Today, 16, 237, 10.1016/0167-5699(95)80166-9 Hsu, 1995, Preferential utilization of the VH4 gene family by diffuse large-cell lymphoma., Blood, 86, 3072, 10.1182/blood.V86.8.3072.3072 Moazzeni, 1994, Biased utilization of immunoglobulin variable region heavy- and light chain genes by the malignant CD5- B lymphocytes from patient with Burkitt's lymphoma., Int J Cancer, 58, 226, 10.1002/ijc.2910580214 Qin, 1995, Somatic hypermutation in low-grade mucosa-associated lymphoid tissue-type B-cell lymphoma., Blood, 86, 3528, 10.1182/blood.V86.9.3528.bloodjournal8693528 Du, 1996, Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in the clonal expansion., Leukemia, 10, 1190 Du, 1996, Intestinal dissemination of gastric mucosa-associated tissue lymphoma., Blood, 88, 4445, 10.1182/blood.V88.12.4445.bloodjournal88124445 Bahler, 1997, Ongoing mutations in salivary gland mucosa-associated lymphoid tissue-type lymphomas., Blood, 89, 3335, 10.1182/blood.V89.9.3335 Viale, 1994, Regulation of VH gene expression is a lineage-specific developmental marker., Eur J Immunol, 24, 1353, 10.1002/eji.1830240617 Zhu, 1995, Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes., Blood, 85, 1603, 10.1182/blood.V85.6.1603.bloodjournal8561603 Melo, 1987, Splenic B cell lymphoma with circulating villous lymphocytes: Differential diagnosis of B cell leukemias with large spleens., J Clin Pathol, 40, 642, 10.1136/jcp.40.6.642 Pittaluga, 1996, “Small” B-cell non-Hodgkin's lymphomas presenting with splenomegaly are either mantle cell lymphoma or marginal zone cell lymphoma. A study based on histology, immunocytochemistry and cytogenetic analysis., Am J Surg Pathol, 20, 211, 10.1097/00000478-199602000-00010 Isaacson, 1994, The histopathology of splenic lymphoma with villous lymphocytes., Blood, 84, 3828, 10.1182/blood.V84.11.3828.bloodjournal84113828 Küppers, 1996, Molecular Ig gene analysis reveals that monocytoid B cell lymphoma is a malignancy of mature B cells carrying somatically mutated V region genes and suggests that rearrangement of the kappa-deleting element (resulting in deletion of the Ig kappa enhancers) abolishes somatic hypermutation in the human., Eur J Immunol, 26, 1794, 10.1002/eji.1830260820 Kepler, 1993, Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation., Immunol Today, 14, 412, 10.1016/0167-5699(93)90145-B Klein, 1997, Evidence for a large compartment of IgM-expressing memory B cells in humans., Blood, 89, 1288, 10.1182/blood.V89.4.1288 Liu, 1992, Germinal centers in T-cell-dependent antibody responses., Immunol Today, 13, 17, 10.1016/0167-5699(92)90199-H Berek, 1993, Somatic mutation and memory., Curr Opin Immunol, 5, 218, 10.1016/0952-7915(93)90007-F Wilson, 1992, What limits affinity maturation of antibodies in Xenopus—The rate of somatic mutation or the ability to select mutant?, EMBO J, 11, 4337, 10.1002/j.1460-2075.1992.tb05533.x Reynaud, 1995, Hypermutation generating the sheep immunoglobulin repertoire is an antigen-independent process., Cell, 80, 115, 10.1016/0092-8674(95)90456-5 Hummel, 1994, Mantle cell lymphomas express VH genes with no or very little somatic mutations like the physiologic cells of the follicle mantle., Blood, 84, 403, 10.1182/blood.V84.2.403.403 Pratt, 1989, IgV region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation., J Immunol, 143, 699, 10.4049/jimmunol.143.2.699 Timens, 1989, Immaturity of the human splenic marginal zone in infancy., J Immunol, 143, 3200, 10.4049/jimmunol.143.10.3200 Wotherspoon, 1991, Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma., Lancet, 338, 1175, 10.1016/0140-6736(91)92035-Z Hussel, 1993, The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori., Lancet, 342, 571, 10.1016/0140-6736(93)91408-E Tomlinson, 1992, The repertoire of human germline Vh segments reveals about fifty groups of Vh segments with different hypervariable loops., J Mol Biol, 227, 776, 10.1016/0022-2836(92)90223-7 Matsuda, 1993, Structure and physical map of 64 variable segments in the 3′ 0.8-megabase region of the human immunoglobulin heavy-chain locus., Nature Genet, 3, 88, 10.1038/ng0193-88