Blood Cancer Journal

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IL-10 induces the development of immunosuppressive CD14+HLA-DRlow/− monocytes in B-cell non-Hodgkin lymphoma
Blood Cancer Journal - Tập 5 Số 7 - Trang e328-e328
B Xiu, Yi Lin, D M Grote, Steven C. Ziesmer, Michael P. Gustafson, Meridean Maas, Z. Zhang, Allan B. Dietz, Luis F. Porrata, Anne J. Novak, A-B Liang, Z-Z Yang, S. Ansell
AbstractThe biological role of monocytes and macrophages in B-cell non-Hodgkin lymphoma (NHL) is not fully understood. We have previously reported that monocytes from patients with B-cell NHL have an immunosuppressive CD14+HLA-DRlow/− phenotype that correlates with a poor prognosis. However, the underlying mechanism by whic...... hiện toàn bộ
NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair
Blood Cancer Journal - Tập 5 Số 5 - Trang e311-e311
Kathleen M. Bone, P Wang, Fang Wu, Chenming Wu, L Li, Julinor Bacani, Susan E. Andrew, Rai‐Hua Lai
AbstractThe vast majority of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ALCL) tumors express the characteristic oncogenic fusion protein NPM-ALK, which mediates tumorigenesis by exerting its constitutive tyrosine kinase activity on various substrates. We recently identified MSH2, a protein central to DNA mismatch repair (MMR), as a nove...... hiện toàn bộ
Myelofibrosis Treatment Algorithm 2018
Blood Cancer Journal - Tập 8 Số 8
Ayalew Tefferi, Paola Guglielmelli, Animesh Pardanani, Alessandro M. Vannucchi
AbstractTwo novel prognostic systems for primary myelofibrosis (PMF) were recently unveiled: GIPSS (genetically inspired prognostic scoring system) and MIPSS70 (mutation-enhanced international prognostic scoring system for transplant-age patients). GIPSS is based exclusively on genetic markers: mutations and karyotype. MIPSS70 includes mutations and clinical risk f...... hiện toàn bộ
Investigating heredity in cutaneous T-cell lymphoma in a unique cohort of Danish twins
Blood Cancer Journal - Tập 7 Số 1 - Trang e517-e517
Niels Ødum, Lise M. Lindahl, Mette Wod, Thorbjørn Krejsgaard, Axel Skytthe, Anders Woetmann, Lars Iversen, Kaare Christensen
CAR-T cell therapy: current limitations and potential strategies
Blood Cancer Journal - Tập 11 Số 4
Robert C. Sterner, Rosalie M. Sterner
AbstractChimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer treatment. Although treatment with CAR-T cells has produced remarkable clinical responses with certain subsets of B cell leukemia or lymphoma, many challenges limit the therapeutic efficacy of CAR-T cells in solid tumors and hematological malignancies. Barriers to effecti...... hiện toàn bộ
Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors
Blood Cancer Journal - Tập 6 Số 9 - Trang e469-e469
Geoffroy Venton, Mileidys Pérez‐Alea, Céline Baier, Guy Fournet, G Quash, Yasmine Labiad, G Martín, F. Sanderson, Pascale Poullin, Pierre Suchon, Laure Farnault, Cong Tu Nguyen, C. L. Brunet, İsmail Çeylan, Régis Costello
AbstractThe vast majority of patients with acute myeloid leukemia (AML) achieve complete remission (CR) after standard induction chemotherapy. However, the majority subsequently relapse and die of the disease. A leukemia stem cell (LSC) paradigm has been invoked to explain this failure of CR to reliably translate into cure. Indeed, LSCs are highly enriched in CD34+...... hiện toàn bộ
Final results of a phase 1b study of the safety and efficacy of the PI3Kδ inhibitor acalisib (GS-9820) in relapsed/refractory lymphoid malignancies
Blood Cancer Journal - Tập 8 Số 2
Arnon P. Kater, Sanne H. Tonino, Menno Spiering, Martine E.D. Chamuleau, Roberto Liu, Adeboye H. Adewoye, Jun Gao, Lyndah Dreiling, Yan Xin, Jeanette K. Doorduijn, Marie José Kersten
Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts
Blood Cancer Journal - Tập 6 Số 8 - Trang e458-e458
Marc Cartellieri, Anja Feldmann, Stefanie Koristka, Claudia Arndt, Simon Loff, Armin Ehninger, Malte von Bonin, Elham Pishali Bejestani, Gerhard Ehninger, Michael Bachmann
AbstractThe adoptive transfer of CD19-specific chimeric antigen receptor engineered T cells (CAR T cells) resulted in encouraging clinical trials in indolent B-cell malignancies. However, they also show the limitations of this fascinating technology: CAR T cells can lead to even life-threatening off-tumor, on-target side effects if CAR T cells crossreact with healt...... hiện toàn bộ
Different effect of hydroxyurea and phlebotomy on prevention of arterial and venous thrombosis in Polycythemia Vera
Blood Cancer Journal - Tập 8 Số 12
Tiziano Barbui, Valerio De Stefano, Arianna Ghirardi, Arianna Masciulli, Guido Finazzi, Alessandro M. Vannucchi
Hydroxyurea prevents arterial and late venous thrombotic recurrences in patients with myeloproliferative neoplasms but fails in the splanchnic venous district. Pooled analysis of 1500 cases
Blood Cancer Journal - Tập 8 Số 11
Valerio De Stefano, Elena Rossi, Alessandra Carobbio, Arianna Ghirardi, Silvia Betti, Guido Finazzi, Alessandro M. Vannucchi, Tiziano Barbui
AbstractWe collected 1500 patients with myeloproliferative neoplasms (MPN) and arterial or venous thrombosis (935/565), pooling three independent cohorts previously reported. Long-term treatment with antiplatelet drugs or vitamin K-antagonists (VKA) was given to 1391 (92.7%) patients; 975 (65%) patients received hydroxyurea (HU). We recorded 348 recurrences (venous...... hiện toàn bộ
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