Blood Cancer Journal

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Preclinical development of CD126 CAR-T cells with broad antitumor activity
Blood Cancer Journal - Tập 11 Số 1
AK Mishra, Iris Kemler, David Dingli
AbstractChimeric antigen receptor T (CAR-T) cell therapy is a transformative approach to cancer eradication. CAR-T is expensive partly due to the restricted use of each CAR construct for specific tumors. Thus, a CAR construct with broad antitumor activity can be advantageous. We identified that CD126 is expressed by many hematologic and solid tumors, including mult...... hiện toàn bộ
Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia
Blood Cancer Journal - Tập 8 Số 6
Isabelle Laverdière, Meaghan Boileau, Andrea Neumann, Héloïse Frison, Amanda Mitchell, Stanley Ng, Jean Wang, Mark D. Minden, Kolja Eppert
AbstractTherapy for acute myeloid leukemia (AML) involves intense cytotoxic treatment and yet approximately 70% of AML are refractory to initial therapy or eventually relapse. This is at least partially driven by the chemo-resistant nature of the leukemic stem cells (LSCs) that sustain the disease, and therefore novel anti-LSC therapies could decrease relapses and ...... hiện toàn bộ
EZH2 alterations in follicular lymphoma: biological and clinical correlations
Blood Cancer Journal - Tập 7 Số 4 - Trang e555-e555
Sarah Huet, Luc Xerri, Bruno Tesson, Sylvain Mareschal, Sébastien Taix, Lénaïg Mescam-Mancini, Emilie Sohier, Marjorie Carrère, Julien Lazarovici, Olivier Casasnovas, Laurie Tonon, Sandrine Boyault, Sandrine Hayette, Corinne Haïoun, Bettina Fabiani, Alain Viari, Fabrice Jardin, Gilles Salles
AbstractThe histone methyltransferase EZH2 has an essential role in the development of follicular lymphoma (FL). Recurrent gain-of-function mutations inEZH2have been described in 25% of FL patients and induce aberrant methylation of histone H3 lysine 27 (H3K27). We evaluated the role ofEZH2genomic gains in FL bi...... hiện toàn bộ
IL-10 induces the development of immunosuppressive CD14+HLA-DRlow/− monocytes in B-cell non-Hodgkin lymphoma
Blood Cancer Journal - Tập 5 Số 7 - Trang e328-e328
B Xiu, Yi Lin, D M Grote, Steven C. Ziesmer, Michael P. Gustafson, Meridean Maas, Z. Zhang, Allan B. Dietz, Luis F. Porrata, Anne J. Novak, A-B Liang, Z-Z Yang, S. Ansell
AbstractThe biological role of monocytes and macrophages in B-cell non-Hodgkin lymphoma (NHL) is not fully understood. We have previously reported that monocytes from patients with B-cell NHL have an immunosuppressive CD14+HLA-DRlow/− phenotype that correlates with a poor prognosis. However, the underlying mechanism by whic...... hiện toàn bộ
NPM-ALK mediates phosphorylation of MSH2 at tyrosine 238, creating a functional deficiency in MSH2 and the loss of mismatch repair
Blood Cancer Journal - Tập 5 Số 5 - Trang e311-e311
Kathleen M. Bone, P Wang, Fang Wu, Chenming Wu, L Li, Julinor Bacani, Susan E. Andrew, Rai‐Hua Lai
AbstractThe vast majority of anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK+ALCL) tumors express the characteristic oncogenic fusion protein NPM-ALK, which mediates tumorigenesis by exerting its constitutive tyrosine kinase activity on various substrates. We recently identified MSH2, a protein central to DNA mismatch repair (MMR), as a nove...... hiện toàn bộ
Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts
Blood Cancer Journal - Tập 6 Số 8 - Trang e458-e458
Marc Cartellieri, Anja Feldmann, Stefanie Koristka, Claudia Arndt, Simon Loff, Armin Ehninger, Malte von Bonin, Elham Pishali Bejestani, Gerhard Ehninger, Michael Bachmann
AbstractThe adoptive transfer of CD19-specific chimeric antigen receptor engineered T cells (CAR T cells) resulted in encouraging clinical trials in indolent B-cell malignancies. However, they also show the limitations of this fascinating technology: CAR T cells can lead to even life-threatening off-tumor, on-target side effects if CAR T cells crossreact with healt...... hiện toàn bộ
Differences in genomic patterns and clinical outcomes between African-American and White patients with myelodysplastic syndromes
Blood Cancer Journal - Tập 7 Số 9 - Trang e602-e602
Aziz Nazha, Karam Al-Issa, B Przychodzen, Nour Abuhadra, Cassandra M. Hirsch, Jaroslaw P. Maciejewski, Mikkael A. Sekeres
Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors
Blood Cancer Journal - Tập 6 Số 9 - Trang e469-e469
Geoffroy Venton, Mileidys Pérez‐Alea, Céline Baier, Guy Fournet, G Quash, Yasmine Labiad, G Martín, F. Sanderson, Pascale Poullin, Pierre Suchon, Laure Farnault, Cong Tu Nguyen, C. L. Brunet, İsmail Çeylan, Régis Costello
AbstractThe vast majority of patients with acute myeloid leukemia (AML) achieve complete remission (CR) after standard induction chemotherapy. However, the majority subsequently relapse and die of the disease. A leukemia stem cell (LSC) paradigm has been invoked to explain this failure of CR to reliably translate into cure. Indeed, LSCs are highly enriched in CD34+...... hiện toàn bộ
Final results of a phase 1b study of the safety and efficacy of the PI3Kδ inhibitor acalisib (GS-9820) in relapsed/refractory lymphoid malignancies
Blood Cancer Journal - Tập 8 Số 2
Arnon P. Kater, Sanne H. Tonino, Menno Spiering, Martine E.D. Chamuleau, Roberto Liu, Adeboye H. Adewoye, Jun Gao, Lyndah Dreiling, Yan Xin, Jeanette K. Doorduijn, Marie José Kersten
Myelofibrosis Treatment Algorithm 2018
Blood Cancer Journal - Tập 8 Số 8
Ayalew Tefferi, Paola Guglielmelli, Animesh Pardanani, Alessandro M. Vannucchi
AbstractTwo novel prognostic systems for primary myelofibrosis (PMF) were recently unveiled: GIPSS (genetically inspired prognostic scoring system) and MIPSS70 (mutation-enhanced international prognostic scoring system for transplant-age patients). GIPSS is based exclusively on genetic markers: mutations and karyotype. MIPSS70 includes mutations and clinical risk f...... hiện toàn bộ
Tổng số: 17   
  • 1
  • 2