CAR-T cell therapy: current limitations and potential strategies Tập 11 Số 4
Robert C. Sterner, Rosalie M. Sterner
AbstractChimeric antigen receptor (CAR)-T cell therapy is a revolutionary new pillar in cancer treatment. Although treatment with CAR-T cells has produced remarkable clinical responses with certain subsets of B cell leukemia or lymphoma, many challenges limit the therapeutic efficacy of CAR-T cells in solid tumors and hematological malignancies. Barriers to effecti...... hiện toàn bộ Switching CAR T cells on and off: a novel modular platform for retargeting of T cells to AML blasts Tập 6 Số 8 - Trang e458-e458
Marc Cartellieri, Anja Feldmann, Stefanie Koristka, Claudia Arndt, Simon Loff, Armin Ehninger, Malte von Bonin, Elham Pishali Bejestani, Gerhard Ehninger, Michael Bachmann
AbstractThe adoptive transfer of CD19-specific chimeric antigen receptor engineered T cells (CAR T cells) resulted in encouraging clinical trials in indolent B-cell malignancies. However, they also show the limitations of this fascinating technology: CAR T cells can lead to even life-threatening off-tumor, on-target side effects if CAR T cells crossreact with healt...... hiện toàn bộ IL-10 induces the development of immunosuppressive CD14+HLA-DRlow/− monocytes in B-cell non-Hodgkin lymphoma Tập 5 Số 7 - Trang e328-e328
B Xiu, Yi Lin, D M Grote, Steven C. Ziesmer, Michael P. Gustafson, Meridean Maas, Z. Zhang, Allan B. Dietz, Luis F. Porrata, Anne J. Novak, A-B Liang, Z-Z Yang, S. Ansell
AbstractThe biological role of monocytes and macrophages in B-cell non-Hodgkin lymphoma (NHL) is not fully understood. We have previously reported that monocytes from patients with B-cell NHL have an immunosuppressive CD14+HLA-DRlow/− phenotype that correlates with a poor prognosis. However, the underlying mechanism by whic...... hiện toàn bộ EZH2 alterations in follicular lymphoma: biological and clinical correlations Tập 7 Số 4 - Trang e555-e555
Sarah Huet, Luc Xerri, Bruno Tesson, Sylvain Mareschal, Sébastien Taix, Lénaïg Mescam-Mancini, Emilie Sohier, Marjorie Carrère, Julien Lazarovici, Olivier Casasnovas, Laurie Tonon, Sandrine Boyault, Sandrine Hayette, Corinne Haïoun, Bettina Fabiani, Alain Viari, Fabrice Jardin, Gilles Salles
AbstractThe histone methyltransferase EZH2 has an essential role in the development of follicular lymphoma (FL). Recurrent gain-of-function mutations inEZH2have been described in 25% of FL patients and induce aberrant methylation of histone H3 lysine 27 (H3K27). We evaluated the role ofEZH2genomic gains in FL bi...... hiện toàn bộ Leukemic stem cell signatures identify novel therapeutics targeting acute myeloid leukemia Tập 8 Số 6
Isabelle Laverdière, Meaghan Boileau, Andrea Neumann, Héloïse Frison, Amanda Mitchell, Stanley Ng, Jean Wang, Mark D. Minden, Kolja Eppert
AbstractTherapy for acute myeloid leukemia (AML) involves intense cytotoxic treatment and yet approximately 70% of AML are refractory to initial therapy or eventually relapse. This is at least partially driven by the chemo-resistant nature of the leukemic stem cells (LSCs) that sustain the disease, and therefore novel anti-LSC therapies could decrease relapses and ...... hiện toàn bộ Aldehyde dehydrogenases inhibition eradicates leukemia stem cells while sparing normal progenitors Tập 6 Số 9 - Trang e469-e469
Geoffroy Venton, Mileidys Pérez‐Alea, Céline Baier, Guy Fournet, G Quash, Yasmine Labiad, G Martín, F. Sanderson, Pascale Poullin, Pierre Suchon, Laure Farnault, Cong Tu Nguyen, C. L. Brunet, İsmail Çeylan, Régis Costello
AbstractThe vast majority of patients with acute myeloid leukemia (AML) achieve complete remission (CR) after standard induction chemotherapy. However, the majority subsequently relapse and die of the disease. A leukemia stem cell (LSC) paradigm has been invoked to explain this failure of CR to reliably translate into cure. Indeed, LSCs are highly enriched in CD34+...... hiện toàn bộ Myelofibrosis Treatment Algorithm 2018 Tập 8 Số 8
Ayalew Tefferi, Paola Guglielmelli, Animesh Pardanani, Alessandro M. Vannucchi
AbstractTwo novel prognostic systems for primary myelofibrosis (PMF) were recently unveiled: GIPSS (genetically inspired prognostic scoring system) and MIPSS70 (mutation-enhanced international prognostic scoring system for transplant-age patients). GIPSS is based exclusively on genetic markers: mutations and karyotype. MIPSS70 includes mutations and clinical risk f...... hiện toàn bộ